GREMLIN Database
XPAC - Protein XpaC
UniProt: P37467 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 204 (196)
Sequences: 185 (157)
Seq/√Len: 11.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_Y162_L4.8711.00
83_K136_D4.3531.00
134_T179_D3.4470.98
134_T141_L3.2480.97
117_T131_F3.2260.97
73_I125_Y3.1500.96
80_A135_L2.8740.93
100_F169_L2.7450.92
164_E199_K2.6920.91
41_L186_D2.5800.89
69_E199_K2.4630.86
87_L139_V2.4570.86
17_T21_I2.3060.82
141_L198_A2.0950.75
86_R143_E2.0510.74
141_L179_D2.0500.74
96_S131_F2.0350.73
73_I124_F2.0280.73
112_R151_H2.0180.73
132_Y141_L1.9470.70
38_V41_L1.9380.69
130_F135_L1.9300.69
20_F174_K1.9170.68
96_S159_S1.8810.67
28_G106_M1.8760.67
151_H184_M1.7840.63
131_F169_L1.7670.62
22_G37_I1.7650.62
29_L39_Y1.7140.59
37_I42_A1.7110.59
60_L183_A1.6990.59
179_D198_A1.6960.59
148_L152_P1.6640.57
37_I45_A1.6300.55
148_L180_L1.6190.55
162_L166_R1.6120.55
17_T42_A1.5730.53
132_Y179_D1.5680.52
44_G91_L1.5350.51
113_I180_L1.5320.51
138_V145_Y1.4990.49
134_T187_E1.4660.48
44_G123_R1.4420.46
21_I82_Q1.4370.46
23_I42_A1.4330.46
100_F131_F1.4210.45
22_G97_I1.3760.43
34_F49_I1.3750.43
123_R126_Q1.3710.43
18_F40_G1.3690.43
13_T109_I1.3680.43
81_R164_E1.3660.43
64_E97_I1.3410.42
142_T175_R1.3250.41
49_I157_E1.3120.40
53_W57_R1.3040.40
65_L90_A1.2970.39
127_A159_S1.2950.39
34_F197_A1.2790.39
66_T105_E1.2620.38
100_F117_T1.2540.38
151_H158_L1.2390.37
134_T198_A1.2270.36
148_L165_T1.2260.36
22_G26_F1.2200.36
73_I180_L1.2180.36
178_E188_I1.1990.35
52_I126_Q1.1990.35
87_L198_A1.1940.35
109_I173_T1.1890.35
87_L142_T1.1770.34
96_S103_N1.1760.34
96_S117_T1.1760.34
138_V162_L1.1630.33
7_F10_W1.1500.33
131_F165_T1.1460.33
124_F148_L1.1270.32
132_Y198_A1.1140.31
115_L167_I1.1040.31
95_K148_L1.0950.31
131_F180_L1.0890.30
60_L136_D1.0850.30
27_F68_R1.0720.30
103_N117_T1.0700.30
25_S86_R1.0680.29
96_S100_F1.0640.29
73_I148_L1.0540.29
14_S169_L1.0440.29
129_R172_L1.0420.28
16_A22_G1.0410.28
67_G169_L1.0290.28
39_Y111_R1.0250.28
99_M133_Q1.0190.28
137_S161_S1.0110.27
107_L176_L1.0050.27
36_S52_I1.0000.27
37_I202_L0.9980.27
113_I183_A0.9910.26
114_Y131_F0.9900.26
102_Q128_E0.9880.26
117_T148_L0.9810.26
54_N69_E0.9760.26
101_K131_F0.9740.26
21_I24_L0.9640.25
77_L114_Y0.9600.25
34_F170_T0.9530.25
22_G33_I0.9490.25
72_Y132_Y0.9470.25
71_A171_E0.9330.24
77_L148_L0.9290.24
64_E114_Y0.9230.24
20_F155_S0.9190.24
92_F155_S0.9130.24
148_L191_L0.9110.24
103_N111_R0.9080.23
184_M195_L0.9060.23
23_I41_L0.9000.23
21_I37_I0.8920.23
43_S46_A0.8910.23
79_E104_A0.8850.23
126_Q183_A0.8800.23
148_L151_H0.8790.22
17_T33_I0.8760.22
131_F148_L0.8760.22
101_K105_E0.8740.22
111_R114_Y0.8710.22
23_I34_F0.8690.22
14_S20_F0.8660.22
128_E179_D0.8610.22
80_A195_L0.8580.22
102_Q192_Q0.8560.22
42_A68_R0.8560.22
14_S33_I0.8530.22
25_S120_E0.8480.21
21_I182_Q0.8480.21
30_N48_Y0.8470.21
100_F132_Y0.8470.21
111_R164_E0.8430.21
64_E138_V0.8360.21
43_S105_E0.8350.21
18_F41_L0.8320.21
147_F180_L0.8260.21
168_T185_G0.8130.20
162_L195_L0.8130.20
10_W39_Y0.8100.20
70_Y73_I0.8090.20
24_L42_A0.8050.20
73_I128_E0.7980.20
46_A78_E0.7940.20
137_S140_E0.7920.20
155_S164_E0.7900.20
145_Y194_E0.7840.19
103_N106_M0.7830.19
158_L165_T0.7810.19
73_I77_L0.7700.19
69_E110_V0.7680.19
59_F120_E0.7610.19
124_F191_L0.7580.19
10_W55_A0.7530.18
66_T87_L0.7510.18
109_I146_A0.7480.18
121_P130_F0.7430.18
86_R110_V0.7420.18
8_L46_A0.7400.18
9_V170_T0.7380.18
34_F56_R0.7380.18
27_F157_E0.7360.18
111_R188_I0.7310.18
65_L69_E0.7260.18
60_L70_Y0.7190.18
42_A182_Q0.7190.18
128_E168_T0.7190.18
84_M154_K0.7180.17
101_K180_L0.7130.17
163_S183_A0.7110.17
135_L139_V0.7090.17
55_A75_K0.7080.17
69_E189_D0.7060.17
73_I131_F0.7050.17
76_N114_Y0.7020.17
104_A197_A0.7020.17
144_K151_H0.7020.17
21_I115_L0.7000.17
92_F106_M0.7000.17
153_K184_M0.6970.17
63_H117_T0.6960.17
87_L135_L0.6960.17
77_L139_V0.6940.17
129_R133_Q0.6930.17
27_F32_S0.6860.17
68_R181_T0.6860.17
146_A184_M0.6820.17
47_V109_I0.6800.16
25_S29_L0.6790.16
16_A39_Y0.6740.16
117_T180_L0.6720.16
118_K128_E0.6710.16
149_S163_S0.6650.16
20_F150_S0.6640.16
87_L112_R0.6590.16
141_L195_L0.6570.16
138_V169_L0.6530.16
102_Q105_E0.6510.16
108_R198_A0.6500.16
16_A33_I0.6450.16
132_Y137_S0.6450.16
59_F89_K0.6430.15
87_L172_L0.6410.15
35_L47_V0.6400.15
145_Y150_S0.6390.15
34_F38_V0.6360.15
44_G120_E0.6340.15
93_Q202_L0.6330.15
85_V129_R0.6330.15
191_L194_E0.6320.15
76_N119_K0.6300.15
62_K66_T0.6300.15
187_E191_L0.6290.15
39_Y47_V0.6280.15
99_M134_T0.6230.15
138_V173_T0.6220.15
161_S192_Q0.6190.15
165_T191_L0.6160.15
155_S189_D0.6130.15
17_T39_Y0.6130.15
53_W58_L0.6100.15
137_S198_A0.6080.15
70_Y124_F0.6080.15
79_E185_G0.6050.15
59_F168_T0.6030.14
12_L156_K0.5980.14
7_F11_S0.5970.14
17_T51_G0.5930.14
32_S58_L0.5910.14
94_A157_E0.5880.14
19_V71_A0.5870.14
69_E127_A0.5860.14
9_V13_T0.5830.14
18_F48_Y0.5830.14
98_Q132_Y0.5820.14
76_N132_Y0.5790.14
18_F39_Y0.5730.14
99_M140_E0.5730.14
14_S32_S0.5720.14
100_F106_M0.5720.14
124_F131_F0.5710.14
75_K139_V0.5690.14
80_A139_V0.5680.14
34_F82_Q0.5670.14
144_K177_E0.5640.14
127_A196_D0.5630.14
38_V170_T0.5570.13
144_K158_L0.5560.13
14_S49_I0.5550.13
73_I76_N0.5540.13
64_E159_S0.5530.13
23_I48_Y0.5520.13
66_T150_S0.5520.13
81_R112_R0.5490.13
60_L111_R0.5490.13
77_L183_A0.5480.13
102_Q108_R0.5440.13
91_L100_F0.5420.13
87_L107_L0.5420.13
110_V183_A0.5380.13
39_Y166_R0.5330.13
50_A111_R0.5300.13
41_L182_Q0.5280.13
100_F128_E0.5280.13
80_A86_R0.5270.13
120_E197_A0.5220.13
22_G31_Q0.5200.13
70_Y169_L0.5190.13
12_L82_Q0.5150.13
184_M188_I0.5140.12
39_Y53_W0.5140.12
35_L50_A0.5140.12
132_Y168_T0.5130.12
13_T105_E0.5120.12
73_I151_H0.5120.12
48_Y155_S0.5070.12
23_I189_D0.5040.12
65_L152_P0.5040.12
65_L176_L0.5040.12
33_I67_G0.5040.12
79_E83_K0.5030.12
81_R142_T0.5030.12
35_L65_L0.5030.12
19_V26_F0.5030.12
102_Q149_S0.5020.12
62_K192_Q0.5010.12
106_M176_L0.5010.12
18_F51_G0.5010.12
114_Y136_D0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1d2tA 5 0.3578 34.6 0.945 Contact Map
4cbcA 3 0.1863 33.2 0.946 Contact Map
4q4gX 1 0 28.4 0.947 Contact Map
4w6vA 1 0.2843 22.5 0.95 Contact Map
4qinA 2 0.7745 21.7 0.95 Contact Map
4ev6A 3 0.2843 20.3 0.951 Contact Map
3pjsK 4 0.4706 18.9 0.952 Contact Map
4k1pA 1 0.7108 17.9 0.952 Contact Map
3d5aX 1 0.4559 17.2 0.953 Contact Map
2a01A 1 0.4216 15.2 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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