GREMLIN Database
VEG - Protein Veg
UniProt: P37466 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 86 (76)
Sequences: 322 (160)
Seq/√Len: 18.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_A49_Q3.6831.00
9_K13_D2.7740.98
31_T67_I2.7530.98
41_T74_L2.2670.94
50_L60_V2.1420.92
12_L38_L2.0430.90
45_V63_S1.9880.88
16_L21_T1.9220.87
22_L72_V1.8560.85
20_L60_V1.8470.84
13_D41_T1.8410.84
26_G32_I1.7540.81
33_E52_Q1.5710.73
10_R23_K1.4820.68
63_S74_L1.4230.65
30_K38_L1.4030.64
71_T74_L1.3550.61
56_S74_L1.3400.60
33_E72_V1.3390.60
8_I38_L1.2780.57
52_Q55_N1.2650.56
63_S78_D1.2550.55
42_Y72_V1.2290.54
9_K41_T1.2280.54
9_K12_L1.2270.54
6_S54_E1.2230.53
67_I73_E1.1980.52
47_V59_R1.1830.51
34_R50_L1.1440.48
18_K78_D1.1370.48
24_A42_Y1.1130.47
21_T33_E1.0890.45
35_S44_S1.0720.44
18_K37_I1.0650.44
15_N18_K1.0560.43
4_T29_R1.0530.43
33_E73_E1.0360.42
16_L24_A1.0210.41
20_L55_N1.0000.40
51_D58_E0.9890.39
32_I45_V0.9870.39
21_T42_Y0.9770.38
9_K57_F0.9760.38
5_L39_A0.9620.37
25_N42_Y0.9550.37
34_R45_V0.9530.37
34_R58_E0.9430.36
7_D55_N0.9240.35
52_Q57_F0.9160.35
49_Q76_F0.9110.35
29_R65_A0.8940.34
45_V62_Y0.8790.33
22_L76_F0.8730.32
59_R70_E0.8700.32
11_S71_T0.8650.32
40_E65_A0.8530.31
23_K72_V0.8490.31
31_T75_T0.8410.31
25_N32_I0.8410.31
21_T73_E0.8250.30
24_A36_G0.8200.30
5_L78_D0.8110.29
20_L33_E0.8110.29
65_A71_T0.8070.29
19_R72_V0.8010.29
57_F61_S0.8000.29
21_T53_D0.7710.27
50_L53_D0.7660.27
37_I53_D0.7560.26
22_L37_I0.7560.26
16_L39_A0.7540.26
19_R60_V0.7390.26
41_T65_A0.7340.25
45_V55_N0.7310.25
11_S58_E0.7280.25
53_D75_T0.7270.25
14_G19_R0.7090.24
18_K31_T0.7050.24
67_I71_T0.7050.24
30_K34_R0.7030.24
3_K37_I0.6980.24
19_R32_I0.6980.24
48_I62_Y0.6950.24
34_R38_L0.6730.23
56_S60_V0.6660.22
38_L59_R0.6580.22
54_E67_I0.6560.22
3_K15_N0.6370.21
11_S78_D0.6350.21
26_G30_K0.6250.21
6_S34_R0.6190.20
70_E73_E0.6140.20
9_K78_D0.6120.20
20_L31_T0.6120.20
23_K33_E0.6080.20
62_Y67_I0.6030.20
5_L13_D0.6020.20
13_D22_L0.5920.19
14_G65_A0.5820.19
44_S68_L0.5770.19
11_S20_L0.5690.18
3_K67_I0.5690.18
30_K56_S0.5550.18
10_R63_S0.5530.18
18_K75_T0.5520.18
18_K53_D0.5400.17
5_L32_I0.5330.17
6_S11_S0.5300.17
45_V61_S0.5300.17
12_L50_L0.5170.17
25_N72_V0.5070.16
21_T35_S0.5070.16
15_N37_I0.5010.16
5_L33_E0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fb9A 1 0.907 100 0.205 Contact Map
1ib8A 1 0.8488 48.7 0.898 Contact Map
1y96A 1 0.9186 35.2 0.906 Contact Map
4h75A 1 0.5581 16.5 0.92 Contact Map
4mzgB 1 0.593 14.6 0.922 Contact Map
2d6fA 2 0.7907 13.4 0.923 Contact Map
4ic7E 1 0.5116 11.6 0.925 Contact Map
1zq1A 2 0.8605 11.2 0.925 Contact Map
3zey4 1 0.907 10.6 0.926 Contact Map
2au3A 1 0.9419 9.4 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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