SYM - BACSU - GREMLIN Contacts

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SYM - Methionine--tRNA ligase

UniProt:	P37465	Sequences: MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGFDVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKRHKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPDSGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAVSRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEIVRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDELRYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGAVTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDPAKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQLKDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFMDVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTNLKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	664 (535)
Sequences:	13488 (6817)
Seq/√Len:	294.7

ECOLI - SYM SYV SYI SYL
BACSU - SYM SYV SYI SYL
HALSA - SYM SYV SYI SYL
SULSO - SYM SYV SYI SYL2 SYL1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
39_K	44_F	5.961	1.00
182_D	186_K	3.716	1.00
410_A	426_T	3.697	1.00
117_N	290_A	3.593	1.00
113_K	116_D	3.573	1.00
42_K	412_E	3.537	1.00
130_S	161_S	3.395	1.00
186_K	190_E	3.198	1.00
468_R	472_V	3.140	1.00
34_A	339_L	3.125	1.00
62_K	65_Q	2.998	1.00
124_E	169_K	2.987	1.00
176_R	179_K	2.957	1.00
122_L	171_E	2.890	1.00
6_N	44_F	2.815	1.00
265_W	288_L	2.785	1.00
124_E	171_E	2.767	1.00
413_K	417_N	2.738	1.00
189_E	206_N	2.725	1.00
328_R	352_P	2.670	1.00
109_K	113_K	2.656	1.00
112_Q	116_D	2.625	1.00
194_F	298_Q	2.620	1.00
133_D	161_S	2.545	1.00
415_M	477_F	2.539	1.00
130_S	158_S	2.539	1.00
404_A	469_I	2.537	1.00
158_S	161_S	2.487	1.00
409_K	413_K	2.452	1.00
130_S	133_D	2.449	1.00
189_E	201_K	2.421	1.00
39_K	42_K	2.363	1.00
268_D	297_K	2.357	1.00
66_E	76_R	2.334	1.00
82_Q	86_K	2.313	1.00
45_D	263_K	2.307	1.00
132_P	163_H	2.287	1.00
308_K	351_T	2.276	1.00
20_K	80_D	2.270	1.00
186_K	189_E	2.268	1.00
412_E	499_W	2.258	1.00
45_D	264_Y	2.201	1.00
36_A	46_V	2.194	1.00
38_Y	42_K	2.189	1.00
148_N	152_E	2.177	1.00
183_R	292_D	2.175	1.00
189_E	210_K	2.173	1.00
40_R	91_S	2.166	1.00
534_G	537_Q	2.151	1.00
412_E	416_E	2.137	1.00
185_L	210_K	2.122	1.00
113_K	117_N	2.102	1.00
402_S	510_D	2.096	1.00
89_E	480_K	2.095	1.00
419_E	422_V	2.058	1.00
103_H	249_T	2.052	1.00
38_Y	412_E	2.049	1.00
308_K	353_E	2.025	1.00
258_D	262_Q	2.004	1.00
403_V	432_S	1.975	1.00
126_E	169_K	1.970	1.00
474_L	482_P	1.959	1.00
133_D	158_S	1.943	1.00
10_I	36_A	1.928	1.00
371_L	467_L	1.910	1.00
7_T	45_D	1.906	1.00
87_Q	327_E	1.904	1.00
408_V	473_L	1.902	1.00
80_D	83_K	1.884	1.00
198_E	201_K	1.874	1.00
371_L	485_M	1.861	1.00
178_G	182_D	1.857	1.00
364_A	478_L	1.853	1.00
535_K	539_S	1.849	1.00
41_L	472_V	1.843	1.00
132_P	161_S	1.841	1.00
79_A	82_Q	1.818	1.00
324_T	327_E	1.816	1.00
298_Q	418_M	1.809	1.00
228_K	232_N	1.808	1.00
325_L	334_L	1.793	1.00
423_A	477_F	1.759	1.00
252_G	255_T	1.755	1.00
406_E	510_D	1.754	1.00
39_K	416_E	1.752	1.00
400_L	466_S	1.746	1.00
187_Y	190_E	1.741	1.00
506_G	509_K	1.734	1.00
407_T	430_L	1.729	1.00
431_I	470_S	1.721	1.00
498_A	501_S	1.711	1.00
259_E	262_Q	1.692	1.00
183_R	186_K	1.691	1.00
401_T	465_E	1.680	1.00
176_R	215_D	1.674	1.00
187_Y	289_M	1.671	1.00
426_T	429_Q	1.669	1.00
403_V	406_E	1.666	1.00
72_E	76_R	1.664	1.00
414_A	426_T	1.618	1.00
468_R	491_I	1.608	1.00
38_Y	416_E	1.599	1.00
472_V	497_K	1.595	1.00
382_F	385_Q	1.595	1.00
37_R	479_T	1.585	1.00
54_E	99_T	1.585	1.00
32_G	271_L	1.581	1.00
409_K	502_I	1.571	1.00
397_D	437_Y	1.563	1.00
60_Q	64_E	1.556	1.00
185_L	205_I	1.552	1.00
434_T	466_S	1.548	1.00
402_S	406_E	1.546	1.00
323_V	327_E	1.545	1.00
183_R	289_M	1.520	1.00
364_A	481_T	1.519	1.00
414_A	422_V	1.519	1.00
398_H	506_G	1.507	1.00
157_K	164_P	1.502	1.00
105_V	255_T	1.494	1.00
114_L	290_A	1.478	1.00
101_K	105_V	1.477	1.00
119_D	180_Y	1.476	1.00
404_A	466_S	1.476	1.00
408_V	469_I	1.475	1.00
146_E	152_E	1.473	1.00
406_E	410_A	1.440	1.00
143_V	159_P	1.431	1.00
469_I	472_V	1.429	1.00
82_Q	97_R	1.422	1.00
131_I	163_H	1.421	1.00
79_A	83_K	1.421	1.00
404_A	408_V	1.420	1.00
378_I	464_A	1.416	1.00
537_Q	540_A	1.412	1.00
67_N	71_Q	1.399	1.00
405_E	408_V	1.397	1.00
277_V	301_A	1.395	1.00
471_A	485_M	1.392	1.00
196_Q	298_Q	1.391	1.00
128_W	167_L	1.375	1.00
469_I	473_L	1.374	1.00
126_E	167_L	1.368	1.00
324_T	328_R	1.365	1.00
29_T	85_W	1.359	1.00
403_V	407_T	1.357	1.00
110_V	291_L	1.354	1.00
67_N	70_P	1.342	1.00
392_A	454_E	1.338	1.00
442_A	445_V	1.334	1.00
117_N	292_D	1.331	1.00
146_E	154_I	1.331	1.00
520_F	524_E	1.322	1.00
42_K	416_E	1.321	1.00
29_T	90_I	1.313	1.00
415_M	423_A	1.307	1.00
382_F	457_R	1.298	1.00
158_S	163_H	1.289	1.00
321_D	324_T	1.288	1.00
328_R	356_V	1.267	1.00
513_V	516_G	1.266	1.00
52_T	82_Q	1.260	1.00
125_Y	174_F	1.257	1.00
409_K	504_A	1.255	1.00
5_N	45_D	1.254	1.00
206_N	210_K	1.249	1.00
41_L	475_Q	1.238	1.00
119_D	179_K	1.238	1.00
114_L	287_M	1.231	1.00
256_E	262_Q	1.228	1.00
394_T	397_D	1.228	1.00
411_Y	423_A	1.227	1.00
393_V	462_H	1.225	1.00
181_A	185_L	1.225	1.00
536_M	539_S	1.224	1.00
36_A	91_S	1.223	1.00
179_K	182_D	1.221	1.00
83_K	87_Q	1.220	1.00
540_A	544_E	1.217	1.00
353_E	356_V	1.216	1.00
410_A	413_K	1.211	1.00
404_A	430_L	1.202	1.00
68_I	76_R	1.200	1.00
130_S	163_H	1.190	1.00
281_T	299_V	1.188	1.00
411_Y	473_L	1.187	1.00
424_L	477_F	1.182	1.00
512_K	528_E	1.178	1.00
72_E	75_D	1.178	1.00
407_T	426_T	1.175	1.00
120_I	218_V	1.174	1.00
75_D	79_A	1.172	1.00
471_A	482_P	1.171	1.00
231_E	234_K	1.170	1.00
87_Q	323_V	1.168	1.00
541_P	544_E	1.166	1.00
490_G	494_E	1.166	1.00
525_A	545_E	1.165	1.00
408_V	412_E	1.165	1.00
83_K	86_K	1.164	1.00
444_W	459_V	1.163	1.00
28_T	302_H	1.160	1.00
49_L	250_A	1.157	1.00
202_N	207_N	1.157	1.00
474_L	478_L	1.156	1.00
144_D	157_K	1.153	1.00
35_M	39_K	1.152	1.00
94_D	102_R	1.152	1.00
483_E	487_E	1.145	1.00
517_E	527_E	1.136	1.00
456_L	460_M	1.135	1.00
101_K	104_K	1.124	1.00
403_V	433_R	1.119	1.00
76_R	80_D	1.111	1.00
465_E	469_I	1.110	1.00
533_K	537_Q	1.099	1.00
527_E	532_I	1.094	1.00
395_E	398_H	1.086	1.00
76_R	79_A	1.080	1.00
410_A	414_A	1.080	1.00
107_I	237_V	1.075	1.00
458_S	462_H	1.071	1.00
393_V	401_T	1.064	1.00
7_T	263_K	1.064	1.00
8_F	269_V	1.062	1.00
441_T	459_V	1.057	1.00
42_K	499_W	1.054	1.00
8_F	35_M	1.054	1.00
475_Q	482_P	1.053	1.00
121_Y	176_R	1.052	1.00
227_V	242_D	1.052	1.00
131_I	166_E	1.051	1.00
407_T	411_Y	1.049	1.00
175_F	218_V	1.049	1.00
35_M	269_V	1.046	1.00
218_V	237_V	1.042	1.00
147_R	157_K	1.036	1.00
30_V	34_A	1.033	1.00
132_P	158_S	1.028	1.00
394_T	455_E	1.028	1.00
269_V	298_Q	1.026	1.00
294_P	297_K	1.025	1.00
309_D	349_V	1.025	1.00
427_L	474_L	1.023	1.00
336_Y	478_L	1.022	1.00
71_Q	75_D	1.020	1.00
247_Y	288_L	1.020	1.00
62_K	66_E	1.019	1.00
73_Y	77_A	1.018	1.00
78_A	82_Q	1.016	1.00
398_H	402_S	1.010	1.00
370_L	434_T	1.008	1.00
337_Y	360_N	1.008	1.00
133_D	163_H	1.006	1.00
524_E	528_E	1.006	1.00
537_Q	541_P	1.004	1.00
414_A	417_N	1.001	1.00
106_V	109_K	0.998	1.00
26_A	88_L	0.993	1.00
144_D	154_I	0.992	1.00
533_K	536_M	0.990	1.00
200_R	301_A	0.989	1.00
260_L	263_K	0.987	1.00
128_W	142_L	0.986	1.00
367_L	471_A	0.984	1.00
407_T	473_L	0.984	1.00
34_A	415_M	0.983	1.00
42_K	501_S	0.983	1.00
12_T	48_Y	0.981	1.00
21_L	25_H	0.978	1.00
182_D	185_L	0.977	1.00
175_F	241_I	0.976	1.00
221_T	235_H	0.976	1.00
107_I	227_V	0.974	1.00
85_W	90_I	0.974	1.00
393_V	458_S	0.973	1.00
533_K	538_G	0.971	1.00
190_E	293_L	0.970	1.00
535_K	540_A	0.962	1.00
524_E	527_E	0.962	1.00
144_D	156_G	0.956	1.00
521_P	524_E	0.956	1.00
157_K	162_G	0.955	1.00
425_S	429_Q	0.953	1.00
455_E	458_S	0.953	1.00
400_L	433_R	0.951	1.00
448_K	455_E	0.951	1.00
411_Y	427_L	0.949	1.00
478_L	481_T	0.949	1.00
305_L	348_G	0.948	1.00
103_H	246_N	0.946	1.00
247_Y	265_W	0.944	1.00
511_T	514_Q	0.942	1.00
535_K	538_G	0.942	1.00
269_V	300_F	0.938	1.00
519_L	522_R	0.937	1.00
244_L	287_M	0.937	1.00
275_E	304_W	0.935	1.00
8_F	39_K	0.934	1.00
401_T	462_H	0.934	1.00
201_K	206_N	0.934	1.00
405_E	409_K	0.932	1.00
309_D	316_K	0.931	1.00
340_R	424_L	0.930	1.00
439_D	442_A	0.928	1.00
185_L	189_E	0.927	1.00
540_A	543_K	0.925	1.00
105_V	108_E	0.921	1.00
414_A	423_A	0.921	1.00
532_I	535_K	0.921	1.00
336_Y	424_L	0.918	1.00
35_M	420_F	0.913	1.00
272_V	281_T	0.912	1.00
36_A	40_R	0.910	1.00
94_D	97_R	0.910	1.00
185_L	209_I	0.909	1.00
517_E	524_E	0.909	1.00
447_A	456_L	0.905	1.00
367_L	485_M	0.904	1.00
397_D	458_S	0.903	1.00
306_L	349_V	0.900	1.00
121_Y	215_D	0.895	1.00
195_I	277_V	0.894	1.00
510_D	514_Q	0.889	1.00
259_E	263_K	0.888	1.00
506_G	510_D	0.887	1.00
4_E	45_D	0.883	1.00
309_D	317_G	0.882	1.00
516_G	520_F	0.882	1.00
527_E	531_Y	0.880	1.00
111_F	237_V	0.876	1.00
514_Q	517_E	0.876	1.00
183_R	187_Y	0.875	1.00
75_D	99_T	0.870	1.00
403_V	514_Q	0.870	1.00
464_A	468_R	0.869	1.00
68_I	71_Q	0.868	1.00
307_M	310_G	0.865	1.00
529_I	538_G	0.864	1.00
142_L	165_V	0.863	1.00
87_Q	326_I	0.862	1.00
269_V	418_M	0.861	1.00
207_N	210_K	0.860	1.00
447_A	450_P	0.860	1.00
462_H	466_S	0.860	1.00
312_M	319_V	0.856	1.00
400_L	430_L	0.856	1.00
471_A	486_F	0.856	1.00
12_T	32_G	0.856	1.00
307_M	319_V	0.855	1.00
524_E	532_I	0.854	1.00
326_I	331_L	0.853	1.00
150_K	154_I	0.851	1.00
528_E	531_Y	0.848	1.00
366_D	431_I	0.847	1.00
209_I	282_I	0.846	1.00
195_I	205_I	0.844	1.00
519_L	524_E	0.844	1.00
172_S	217_A	0.843	1.00
12_T	92_N	0.842	1.00
411_Y	426_T	0.842	1.00
110_V	245_F	0.841	1.00
484_K	487_E	0.838	1.00
525_A	528_E	0.838	1.00
408_V	500_D	0.837	1.00
77_A	80_D	0.837	1.00
367_L	470_S	0.836	1.00
258_D	261_Y	0.836	1.00
178_G	215_D	0.835	1.00
525_A	529_I	0.835	1.00
23_I	319_V	0.835	1.00
197_P	200_R	0.834	1.00
38_Y	415_M	0.833	1.00
508_L	511_T	0.831	1.00
20_K	84_L	0.831	1.00
83_K	323_V	0.830	1.00
528_E	532_I	0.828	1.00
23_I	305_L	0.828	1.00
52_T	97_R	0.827	1.00
85_W	92_N	0.825	1.00
35_M	418_M	0.823	1.00
48_Y	92_N	0.821	1.00
40_R	46_V	0.810	1.00
118_G	176_R	0.810	1.00
111_F	120_I	0.808	1.00
162_G	315_S	0.806	1.00
69_T	72_E	0.804	1.00
162_G	316_K	0.804	1.00
307_M	317_G	0.803	1.00
12_T	29_T	0.803	1.00
127_G	136_F	0.802	1.00
30_V	339_L	0.801	1.00
538_G	542_A	0.801	1.00
455_E	459_V	0.800	1.00
518_P	522_R	0.799	0.99
410_A	422_V	0.799	0.99
436_K	440_E	0.798	0.99
3_Q	6_N	0.797	0.99
361_Y	365_N	0.797	0.99
108_E	112_Q	0.794	0.99
399_T	403_V	0.793	0.99
405_E	503_T	0.791	0.99
521_P	527_E	0.790	0.99
545_E	548_E	0.789	0.99
406_E	507_Q	0.789	0.99
454_E	458_S	0.786	0.99
41_L	498_A	0.786	0.99
14_I	103_H	0.783	0.99
373_R	441_T	0.782	0.99
187_Y	191_N	0.781	0.99
412_E	501_S	0.781	0.99
393_V	398_H	0.778	0.99
539_S	543_K	0.777	0.99
401_T	405_E	0.776	0.99
284_W	296_P	0.775	0.99
27_Y	348_G	0.772	0.99
180_Y	292_D	0.770	0.99
368_G	481_T	0.767	0.99
520_F	523_L	0.767	0.99
185_L	206_N	0.766	0.99
532_I	537_Q	0.762	0.99
507_Q	511_T	0.761	0.99
31_A	271_L	0.758	0.99
406_E	409_K	0.758	0.99
308_K	352_P	0.757	0.99
34_A	477_F	0.757	0.99
66_E	70_P	0.757	0.99
480_K	484_K	0.756	0.99
538_G	541_P	0.756	0.99
32_G	48_Y	0.755	0.99
529_I	533_K	0.754	0.99
374_T	463_L	0.753	0.99
310_G	317_G	0.753	0.99
466_S	469_I	0.753	0.99
534_G	538_G	0.752	0.99
408_V	502_I	0.752	0.99
535_K	541_P	0.751	0.99
56_G	60_Q	0.748	0.99
136_F	217_A	0.748	0.99
194_F	198_E	0.747	0.99
500_D	503_T	0.746	0.99
517_E	521_P	0.745	0.99
123_D	174_F	0.745	0.99
7_T	268_D	0.743	0.99
533_K	540_A	0.743	0.99
112_Q	115_L	0.742	0.99
107_I	242_D	0.741	0.99
427_L	470_S	0.741	0.99
13_P	28_T	0.740	0.99
370_L	438_I	0.740	0.99
145_I	162_G	0.739	0.99
125_Y	217_A	0.739	0.99
486_F	497_K	0.737	0.99
396_F	441_T	0.732	0.99
531_Y	534_G	0.731	0.99
475_Q	486_F	0.731	0.99
373_R	377_M	0.731	0.99
544_E	547_K	0.729	0.99
201_K	205_I	0.726	0.99
255_T	258_D	0.726	0.99
194_F	297_K	0.726	0.99
106_V	252_G	0.724	0.99
177_M	286_I	0.724	0.99
413_K	416_E	0.723	0.99
405_E	504_A	0.723	0.99
523_L	526_E	0.722	0.99
447_A	455_E	0.721	0.99
6_N	39_K	0.719	0.99
475_Q	483_E	0.719	0.99
524_E	529_I	0.719	0.99
493_D	496_L	0.718	0.99
523_L	527_E	0.718	0.99
372_N	375_V	0.717	0.99
11_T	246_N	0.715	0.99
209_I	285_P	0.714	0.99
47_R	264_Y	0.714	0.99
184_L	187_Y	0.713	0.99
9_Y	251_L	0.713	0.99
546_T	549_E	0.710	0.99
7_T	264_Y	0.706	0.99
352_P	356_V	0.706	0.99
350_F	355_F	0.705	0.99
401_T	466_S	0.704	0.99
537_Q	542_A	0.699	0.99
337_Y	354_G	0.698	0.99
31_A	420_F	0.696	0.99
446_L	459_V	0.696	0.99
404_A	462_H	0.694	0.99
84_L	321_D	0.694	0.99
184_L	286_I	0.692	0.99
289_M	294_P	0.691	0.99
457_R	460_M	0.690	0.99
467_L	489_L	0.690	0.99
524_E	531_Y	0.689	0.99
228_K	234_K	0.689	0.99
9_Y	268_D	0.688	0.98
115_L	120_I	0.688	0.98
484_K	488_Q	0.687	0.98
381_Y	385_Q	0.687	0.98
94_D	100_E	0.687	0.98
534_G	540_A	0.686	0.98
518_P	521_P	0.685	0.98
31_A	339_L	0.685	0.98
497_K	500_D	0.684	0.98
508_L	512_K	0.684	0.98
237_V	241_I	0.683	0.98
252_G	256_E	0.682	0.98
531_Y	535_K	0.682	0.98
539_S	542_A	0.681	0.98
187_Y	294_P	0.679	0.98
133_D	162_G	0.679	0.98
492_T	495_S	0.679	0.98
61_Q	166_E	0.679	0.98
138_T	141_Q	0.678	0.98
274_K	304_W	0.677	0.98
20_K	321_D	0.677	0.98
114_L	117_N	0.676	0.98
510_D	513_V	0.676	0.98
324_T	352_P	0.676	0.98
422_V	425_S	0.676	0.98
411_Y	415_M	0.675	0.98
372_N	488_Q	0.674	0.98
543_K	546_T	0.673	0.98
106_V	253_Y	0.672	0.98
370_L	431_I	0.671	0.98
254_D	258_D	0.669	0.98
375_V	379_N	0.668	0.98
400_L	462_H	0.667	0.98
490_G	493_D	0.667	0.98
110_V	241_I	0.665	0.98
493_D	497_K	0.662	0.98
383_D	386_I	0.661	0.98
481_T	484_K	0.661	0.98
312_M	318_N	0.661	0.98
123_D	215_D	0.661	0.98
400_L	437_Y	0.661	0.98
61_Q	65_Q	0.660	0.98
12_T	85_W	0.659	0.98
526_E	530_A	0.659	0.98
414_A	419_E	0.658	0.98
454_E	457_R	0.658	0.98
405_E	502_I	0.657	0.98
29_T	92_N	0.656	0.98
239_V	242_D	0.656	0.98
475_Q	495_S	0.656	0.98
105_V	109_K	0.655	0.98
357_E	360_N	0.654	0.98
245_F	287_M	0.654	0.98
394_T	458_S	0.653	0.98
402_S	405_E	0.653	0.98
37_R	91_S	0.652	0.98
449_D	455_E	0.652	0.98
527_E	538_G	0.651	0.98
198_E	202_N	0.651	0.98
3_Q	263_K	0.651	0.98
534_G	539_S	0.650	0.98
251_L	264_Y	0.649	0.98
407_T	410_A	0.649	0.98
444_W	455_E	0.648	0.98
316_K	319_V	0.648	0.98
115_L	231_E	0.648	0.98
195_I	301_A	0.647	0.98
401_T	507_Q	0.643	0.98
342_V	348_G	0.643	0.98
65_Q	317_G	0.643	0.98
427_L	473_L	0.641	0.98
293_L	297_K	0.639	0.98
371_L	375_V	0.639	0.98
513_V	521_P	0.637	0.98
397_D	462_H	0.636	0.97
510_D	516_G	0.635	0.97
517_E	520_F	0.635	0.97
137_Y	158_S	0.634	0.97
503_T	506_G	0.633	0.97
380_K	460_M	0.633	0.97
21_L	81_I	0.633	0.97
180_Y	290_A	0.632	0.97
289_M	292_D	0.632	0.97
370_L	467_L	0.632	0.97
542_A	545_E	0.631	0.97
339_L	477_F	0.631	0.97
129_Y	134_E	0.630	0.97
223_F	236_V	0.629	0.97
515_K	519_L	0.628	0.97
369_N	373_R	0.628	0.97
145_I	157_K	0.626	0.97
104_K	228_K	0.625	0.97
381_Y	460_M	0.623	0.97
541_P	545_E	0.623	0.97
354_G	357_E	0.622	0.97
241_I	287_M	0.621	0.97
441_T	444_W	0.621	0.97
512_K	516_G	0.621	0.97
248_L	265_W	0.621	0.97
484_K	517_E	0.620	0.97
66_E	73_Y	0.620	0.97
310_G	316_K	0.619	0.97
60_Q	224_D	0.618	0.97
62_K	73_Y	0.617	0.97
195_I	299_V	0.617	0.97
5_N	44_F	0.616	0.97
39_K	46_V	0.616	0.97
9_Y	264_Y	0.614	0.97
524_E	535_K	0.614	0.97
486_F	493_D	0.613	0.97
93_D	96_I	0.612	0.97
459_V	462_H	0.611	0.97
509_K	512_K	0.610	0.97
106_V	249_T	0.609	0.97
513_V	517_E	0.609	0.97
325_L	350_F	0.608	0.97
446_L	456_L	0.608	0.97
499_W	502_I	0.608	0.97
387_G	457_R	0.607	0.97
371_L	374_T	0.607	0.97
542_A	546_T	0.606	0.97
135_T	161_S	0.606	0.97
282_I	286_I	0.605	0.97
191_N	294_P	0.604	0.97
251_L	265_W	0.602	0.97
312_M	320_V	0.601	0.96
41_L	476_P	0.601	0.96
535_K	542_A	0.601	0.96
468_R	486_F	0.601	0.96
536_M	541_P	0.600	0.96
19_G	25_H	0.599	0.96
130_S	137_Y	0.599	0.96
441_T	455_E	0.598	0.96
516_G	524_E	0.598	0.96
120_I	175_F	0.598	0.96
128_W	165_V	0.597	0.96
185_L	204_M	0.597	0.96
75_D	100_E	0.597	0.96
148_N	151_G	0.597	0.96
422_V	426_T	0.597	0.96
28_T	32_G	0.596	0.96
3_Q	45_D	0.596	0.96
74_V	78_A	0.596	0.96
534_G	544_E	0.596	0.96
177_M	180_Y	0.596	0.96
202_N	206_N	0.595	0.96
306_L	347_D	0.595	0.96
248_L	288_L	0.594	0.96
532_I	536_M	0.594	0.96
433_R	436_K	0.594	0.96
203_E	206_N	0.593	0.96
255_T	259_E	0.591	0.96
461_Y	465_E	0.590	0.96
184_L	285_P	0.589	0.96
256_E	261_Y	0.588	0.96
114_L	175_F	0.588	0.96
263_K	266_P	0.588	0.96
521_P	528_E	0.587	0.96
514_Q	518_P	0.587	0.96
11_T	267_A	0.586	0.96
96_I	260_L	0.586	0.96
265_W	293_L	0.586	0.96
491_I	494_E	0.586	0.96
394_T	444_W	0.585	0.96
8_F	418_M	0.585	0.96
367_L	481_T	0.584	0.96
529_I	532_I	0.584	0.96
466_S	470_S	0.582	0.96
527_E	530_A	0.581	0.96
438_I	463_L	0.581	0.96
154_I	157_K	0.580	0.96
535_K	544_E	0.579	0.96
534_G	541_P	0.577	0.96
137_Y	165_V	0.576	0.96
396_F	399_T	0.576	0.96
47_R	260_L	0.575	0.96
519_L	527_E	0.574	0.95
390_K	393_V	0.574	0.95
399_T	433_R	0.574	0.95
377_M	460_M	0.573	0.95
516_G	526_E	0.569	0.95
397_D	444_W	0.568	0.95
457_R	461_Y	0.567	0.95
519_L	523_L	0.567	0.95
400_L	434_T	0.565	0.95
516_G	521_P	0.565	0.95
173_Y	232_N	0.565	0.95
203_E	207_N	0.564	0.95
62_K	315_S	0.564	0.95
200_R	203_E	0.563	0.95
513_V	522_R	0.563	0.95
515_K	520_F	0.563	0.95
52_T	78_A	0.563	0.95
507_Q	510_D	0.561	0.95
404_A	407_T	0.561	0.95
261_Y	265_W	0.561	0.95
178_G	181_A	0.561	0.95
530_A	533_K	0.560	0.95
325_L	352_P	0.558	0.95
339_L	424_L	0.558	0.95
399_T	402_S	0.557	0.95
514_Q	526_E	0.557	0.95
390_K	461_Y	0.557	0.95
194_F	417_N	0.557	0.95
486_F	490_G	0.556	0.95
310_G	349_V	0.556	0.95
285_P	294_P	0.556	0.95
522_R	526_E	0.556	0.95
320_V	350_F	0.554	0.95
84_L	323_V	0.554	0.95
300_F	418_M	0.554	0.95
145_I	155_G	0.554	0.95
521_P	525_A	0.553	0.94
383_D	388_S	0.552	0.94
177_M	213_L	0.552	0.94
218_V	229_V	0.551	0.94
541_P	546_T	0.551	0.94
499_W	503_T	0.550	0.94
329_Y	356_V	0.550	0.94
517_E	523_L	0.549	0.94
270_H	284_W	0.549	0.94
388_S	391_G	0.549	0.94
343_P	421_S	0.549	0.94
513_V	528_E	0.548	0.94
271_L	302_H	0.547	0.94
247_Y	287_M	0.546	0.94
76_R	83_K	0.546	0.94
161_S	164_P	0.544	0.94
177_M	181_A	0.544	0.94
273_G	304_W	0.544	0.94
184_L	282_I	0.543	0.94
405_E	469_I	0.543	0.94
68_I	72_E	0.542	0.94
536_M	540_A	0.542	0.94
518_P	524_E	0.542	0.94
408_V	411_Y	0.541	0.94
502_I	508_L	0.540	0.94
397_D	459_V	0.540	0.94
382_F	386_I	0.538	0.94
540_A	545_E	0.537	0.94
58_K	160_D	0.537	0.94
430_L	473_L	0.536	0.94
59_I	73_Y	0.536	0.94
224_D	228_K	0.535	0.93
545_E	549_E	0.534	0.93
199_S	274_K	0.532	0.93
544_E	549_E	0.531	0.93
486_F	491_I	0.530	0.93
530_A	534_G	0.529	0.93
119_D	176_R	0.527	0.93
28_T	271_L	0.526	0.93
371_L	488_Q	0.526	0.93
27_Y	305_L	0.526	0.93
50_T	92_N	0.525	0.93
515_K	518_P	0.525	0.93
15_Y	29_T	0.525	0.93
127_G	137_Y	0.524	0.93
319_V	322_P	0.523	0.93
403_V	510_D	0.523	0.93
490_G	495_S	0.523	0.93
273_G	302_H	0.523	0.93
393_V	397_D	0.522	0.93
515_K	527_E	0.521	0.93
41_L	499_W	0.521	0.93
31_A	344_F	0.520	0.92
470_S	474_L	0.520	0.92
278_R	282_I	0.520	0.92
125_Y	170_E	0.519	0.92
149_E	153_V	0.519	0.92
201_K	204_M	0.519	0.92
144_D	153_V	0.519	0.92
147_R	150_K	0.517	0.92
436_K	439_D	0.517	0.92
89_E	331_L	0.516	0.92
375_V	488_Q	0.516	0.92
189_E	202_N	0.515	0.92
525_A	547_K	0.514	0.92
448_K	456_L	0.513	0.92
110_V	248_L	0.512	0.92
143_V	162_G	0.512	0.92
20_K	76_R	0.511	0.92
486_F	494_E	0.511	0.92
104_K	108_E	0.511	0.92
289_M	295_L	0.511	0.92
393_V	461_Y	0.510	0.92
351_T	354_G	0.510	0.92
542_A	547_K	0.510	0.92
516_G	523_L	0.510	0.92
312_M	317_G	0.510	0.92
158_S	162_G	0.509	0.92
191_N	201_K	0.509	0.92
516_G	527_E	0.508	0.92
174_F	217_A	0.508	0.92
532_I	538_G	0.508	0.92
320_V	325_L	0.506	0.91
533_K	543_K	0.506	0.91
509_K	531_Y	0.504	0.91
304_W	311_K	0.504	0.91
511_T	515_K	0.503	0.91
188_Y	209_I	0.503	0.91
398_H	401_T	0.503	0.91
172_S	221_T	0.502	0.91
196_Q	200_R	0.502	0.91
390_K	458_S	0.501	0.91
44_F	268_D	0.500	0.91
512_K	515_K	0.500	0.91
135_T	160_D	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1rqgA	2	0.7997	100	0.195	Contact Map
1gaxA	1	0.9383	100	0.279	Contact Map
1ffyA	1	0.9066	100	0.306	Contact Map
1ileA	1	0.7892	100	0.332	Contact Map
3kflA	1	0.7771	100	0.356	Contact Map
4qreA	1	0.7771	100	0.373	Contact Map
1wz2A	1	0.9172	100	0.377	Contact Map
3ziuA	1	0.7681	100	0.381	Contact Map
3h99A	1	0.7771	100	0.385	Contact Map
2x1lA	1	0.7666	100	0.387	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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