GREMLIN Database
SYS - Serine--tRNA ligase
UniProt: P37464 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 425 (417)
Sequences: 4327 (2321)
Seq/√Len: 113.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
402_Q408_V4.5691.00
240_H254_Y4.0551.00
184_L309_V3.8481.00
123_E126_K3.7081.00
314_E411_K3.3231.00
291_K294_D3.2731.00
37_R89_E3.1991.00
51_K75_E3.1851.00
296_Y357_E3.1301.00
44_K82_E3.0101.00
408_V414_R2.9691.00
138_K146_E2.8021.00
294_D297_E2.7881.00
180_F312_L2.7461.00
165_F239_M2.7251.00
332_A357_E2.6081.00
370_R377_E2.5891.00
143_I407_V2.5761.00
148_G167_K2.5361.00
102_L206_T2.5311.00
114_V324_T2.4551.00
308_R312_L2.4501.00
20_H114_V2.4341.00
125_R307_E2.4021.00
134_A403_E2.4021.00
184_L312_L2.3991.00
30_K96_E2.3711.00
253_N301_K2.3591.00
15_K29_D2.3291.00
125_R319_V2.2971.00
63_K73_I2.2341.00
411_K414_R2.2081.00
62_L67_K2.2081.00
397_L407_V2.2031.00
183_D416_Y2.1621.00
10_N13_E2.1561.00
307_E311_Q2.0941.00
402_Q406_S2.0831.00
298_E301_K2.0601.00
92_T96_E2.0471.00
154_R243_E2.0441.00
109_H296_Y2.0171.00
189_Y308_R1.9651.00
369_R376_P1.9471.00
158_V165_F1.9371.00
288_K298_E1.8951.00
188_E312_L1.8911.00
315_L339_V1.8881.00
202_R227_F1.8841.00
127_W311_Q1.8771.00
230_P234_V1.8761.00
16_A20_H1.8721.00
199_M221_I1.8571.00
204_S241_R1.8351.00
149_I170_G1.8301.00
316_P399_N1.8281.00
194_V239_M1.8161.00
322_M334_K1.8081.00
111_S333_K1.7951.00
58_Q61_V1.7521.00
109_H357_E1.7351.00
33_A37_R1.7281.00
50_G54_E1.7231.00
321_S333_K1.7211.00
198_Y261_F1.7211.00
8_R35_D1.6981.00
16_A19_V1.6971.00
144_A150_L1.6861.00
95_A99_T1.6651.00
17_K110_E1.6641.00
108_P327_L1.6601.00
129_E132_S1.6531.00
246_S249_S1.6451.00
70_D74_K1.6351.00
196_P235_P1.6321.00
331_A334_K1.6211.00
370_R373_K1.6201.00
94_E98_D1.6131.00
30_K33_A1.6121.00
78_E82_E1.5931.00
308_R311_Q1.5831.00
329_F359_F1.5751.00
157_K243_E1.5671.00
48_L79_V1.5661.00
247_G291_K1.5521.00
108_P324_T1.5441.00
295_S380_H1.5401.00
54_E58_Q1.5261.00
253_N288_K1.5231.00
6_M10_N1.5191.00
203_A241_R1.5061.00
42_I46_E1.5051.00
387_L392_T1.4911.00
199_M226_Y1.4791.00
164_V278_Q1.4741.00
17_K20_H1.4711.00
224_E263_S1.4631.00
139_P142_D1.4631.00
174_E282_N1.4571.00
40_E44_K1.4481.00
82_E85_K1.4471.00
49_K87_D1.4341.00
36_D40_E1.4311.00
41_L90_L1.4241.00
202_R225_D1.4231.00
291_K368_F1.4211.00
145_D153_E1.4201.00
154_R239_M1.4131.00
44_K47_E1.3951.00
70_D73_I1.3891.00
236_I256_A1.3831.00
155_A164_V1.3831.00
51_K54_E1.3801.00
202_R215_E1.3771.00
253_N298_E1.3751.00
116_E120_D1.3521.00
11_F32_E1.3521.00
88_E92_T1.3471.00
6_M13_E1.3451.00
289_F379_V1.3401.00
55_V76_M1.3391.00
20_H324_T1.3361.00
167_K192_T1.3241.00
37_R40_E1.3171.00
159_T226_Y1.3151.00
69_A73_I1.3091.00
247_G371_E1.3041.00
74_K78_E1.3011.00
41_L93_V1.2880.99
290_V298_E1.2870.99
240_H289_F1.2850.99
300_E335_Y1.2720.99
215_E227_F1.2640.99
344_Q348_R1.2540.99
35_D39_R1.2540.99
81_E85_K1.2500.99
120_D323_C1.2420.99
314_E400_Y1.2420.99
12_Q16_A1.2410.99
184_L188_E1.2410.99
38_R42_I1.2350.99
295_S355_N1.2310.99
117_T120_D1.2260.99
125_R303_T1.2240.99
304_N311_Q1.2200.99
80_G84_K1.2170.99
296_Y332_A1.2140.99
130_K316_P1.2110.99
400_Y409_I1.2110.99
85_K89_E1.2100.99
139_P343_S1.1860.99
88_E91_R1.1860.99
319_V337_I1.1860.99
61_V65_E1.1850.99
292_P368_F1.1850.99
17_K108_P1.1830.99
47_E51_K1.1810.99
311_Q317_Y1.1790.99
276_I394_A1.1780.99
169_L420_R1.1760.99
184_L308_R1.1730.99
27_D30_K1.1660.99
201_N204_S1.1630.99
6_M14_I1.1570.99
178_Y257_F1.1570.99
366_I379_V1.1490.99
302_L353_C1.1440.99
75_E78_E1.1440.99
126_K130_K1.1420.99
77_R80_G1.1410.99
236_I356_F1.1410.99
311_Q319_V1.1400.99
58_Q62_L1.1400.99
302_L356_F1.1310.99
41_L86_L1.1300.99
89_E92_T1.1230.99
125_R311_Q1.1210.98
288_K301_K1.1210.98
353_C384_G1.1180.98
409_I414_R1.1140.98
184_L189_Y1.1140.98
111_S296_Y1.1120.98
99_T103_S1.1060.98
61_V64_R1.0970.98
68_D71_H1.0910.98
84_K87_D1.0890.98
331_A356_F1.0850.98
15_K28_F1.0850.98
8_R39_R1.0780.98
71_H75_E1.0660.98
207_G364_A1.0620.98
62_L72_I1.0610.98
249_S252_I1.0570.98
181_M309_V1.0530.98
321_S327_L1.0500.98
91_R95_A1.0490.98
34_L93_V1.0470.98
244_I367_R1.0420.98
142_D145_D1.0410.98
220_K227_F1.0380.98
194_V236_I1.0380.98
417_M420_R1.0360.97
361_A381_T1.0350.97
133_F137_P1.0330.97
172_R183_D1.0270.97
303_T319_V1.0220.97
109_H112_V1.0210.97
2_L7_L1.0210.97
7_L10_N1.0190.97
296_Y300_E1.0180.97
300_E303_T1.0090.97
365_N378_H1.0080.97
78_E81_E1.0060.97
5_K9_A1.0060.97
341_I394_A1.0060.97
180_F412_V1.0030.97
71_H74_K1.0010.97
30_K100_I0.9990.97
396_I400_Y0.9990.97
288_K305_Q0.9990.97
341_I348_R0.9970.97
84_K88_E0.9930.97
31_F100_I0.9930.97
205_M218_A0.9890.97
13_E16_A0.9810.97
211_L218_A0.9810.97
368_F377_E0.9770.96
45_V83_I0.9740.96
56_S76_M0.9710.96
303_T337_I0.9700.96
237_T287_V0.9680.96
138_K142_D0.9670.96
93_V97_L0.9660.96
195_I282_N0.9640.96
43_G47_E0.9590.96
182_L186_V0.9590.96
244_I376_P0.9580.96
13_E17_K0.9570.96
312_L412_V0.9550.96
55_V58_Q0.9540.96
48_L82_E0.9510.96
135_Y403_E0.9470.96
370_R374_G0.9470.96
7_L31_F0.9470.96
37_R96_E0.9440.96
17_K107_I0.9440.96
242_D365_N0.9400.96
37_R93_V0.9390.96
33_A36_D0.9330.95
220_K225_D0.9300.95
314_E408_V0.9290.95
297_E301_K0.9280.95
57_Q60_A0.9230.95
31_F104_I0.9210.95
198_Y259_A0.9190.95
155_A159_T0.9140.95
253_N305_Q0.9130.95
304_N307_E0.9080.95
52_R80_G0.9050.95
169_L419_N0.9040.94
213_K217_D0.8990.94
128_G131_P0.8930.94
409_I417_M0.8910.94
96_E99_T0.8890.94
189_Y305_Q0.8880.94
159_T201_N0.8880.94
118_E320_M0.8800.94
185_H386_G0.8800.94
202_R206_T0.8770.94
117_T325_G0.8770.94
314_E412_V0.8690.93
2_L14_I0.8680.93
221_I226_Y0.8670.93
131_P408_V0.8670.93
240_H252_I0.8660.93
11_F28_F0.8660.93
307_E317_Y0.8630.93
46_E49_K0.8600.93
123_E318_R0.8470.92
112_V321_S0.8440.92
76_M79_V0.8420.92
373_K377_E0.8410.92
2_L6_M0.8410.92
41_L89_E0.8390.92
45_V87_D0.8380.92
304_N308_R0.8370.92
247_G250_L0.8370.92
244_I369_R0.8370.92
291_K370_R0.8330.92
100_I103_S0.8310.92
247_G370_R0.8290.92
87_D91_R0.8290.92
191_Y288_K0.8280.91
169_L417_M0.8260.91
183_D415_P0.8220.91
299_L335_Y0.8160.91
63_K69_A0.8140.91
236_I254_Y0.8130.91
198_Y282_N0.8130.91
124_V335_Y0.8070.90
343_S394_A0.8060.90
46_E90_L0.8060.90
34_L96_E0.8040.90
56_S60_A0.8030.90
188_E308_R0.8010.90
209_G330_T0.8000.90
121_N323_C0.7980.90
400_Y412_V0.7980.90
22_G116_E0.7970.90
178_Y389_V0.7950.90
240_H245_L0.7900.89
21_K328_G0.7890.89
355_N380_H0.7890.89
414_R420_R0.7880.89
343_S346_T0.7880.89
57_Q61_V0.7860.89
174_E195_I0.7840.89
159_T204_S0.7820.89
198_Y280_Q0.7820.89
124_V321_S0.7750.89
60_A73_I0.7740.88
62_L65_E0.7720.88
154_R165_F0.7720.88
309_V387_L0.7720.88
116_E323_C0.7700.88
259_A282_N0.7690.88
246_S369_R0.7680.88
98_D102_L0.7620.88
219_F263_S0.7610.88
45_V49_K0.7580.87
131_P316_P0.7530.87
31_F97_L0.7530.87
204_S238_N0.7510.87
76_M80_G0.7510.87
46_E50_G0.7490.87
36_D39_R0.7450.87
44_K86_L0.7400.86
276_I348_R0.7400.86
191_Y305_Q0.7340.86
139_P394_A0.7330.86
239_M254_Y0.7330.86
45_V90_L0.7320.86
176_A417_M0.7290.85
160_G226_Y0.7290.85
149_I397_L0.7290.85
4_T101_L0.7280.85
162_R350_I0.7260.85
198_Y229_I0.7250.85
286_L302_L0.7240.85
41_L44_K0.7230.85
122_V321_S0.7200.85
185_H255_A0.7200.85
292_P377_E0.7190.85
244_I365_N0.7180.84
148_G168_G0.7180.84
150_L164_V0.7170.84
166_Y393_V0.7170.84
30_K34_L0.7140.84
155_A165_F0.7120.84
27_D100_I0.7120.84
371_E374_G0.7110.84
147_L407_V0.7110.84
19_V25_L0.7100.84
167_K194_V0.7100.84
296_Y355_N0.7080.84
42_I94_E0.7060.83
55_V72_I0.7060.83
172_R418_G0.7030.83
144_A147_L0.7030.83
93_V96_E0.7010.83
143_I401_Q0.6960.83
149_I167_K0.6960.83
303_T353_C0.6950.82
210_Q238_N0.6940.82
60_A77_R0.6930.82
49_K83_I0.6930.82
95_A98_D0.6930.82
112_V327_L0.6930.82
144_A397_L0.6910.82
162_R271_D0.6880.82
322_M331_A0.6880.82
55_V75_E0.6840.81
73_I77_R0.6820.81
215_E220_K0.6810.81
77_R81_E0.6810.81
29_D33_A0.6810.81
7_L14_I0.6800.81
149_I169_L0.6790.81
409_I420_R0.6780.81
211_L215_E0.6780.81
237_T356_F0.6740.81
327_L334_K0.6740.81
12_Q15_K0.6730.80
245_L249_S0.6720.80
166_Y282_N0.6720.80
185_H286_L0.6710.80
159_T221_I0.6710.80
34_L97_L0.6660.80
243_E249_S0.6660.80
13_E110_E0.6640.80
324_T327_L0.6630.79
159_T200_V0.6630.79
51_K55_V0.6620.79
240_H366_I0.6620.79
218_A230_P0.6590.79
293_E370_R0.6590.79
232_A235_P0.6570.79
124_V303_T0.6570.79
89_E93_V0.6530.78
191_Y286_L0.6520.78
90_L93_V0.6520.78
19_V24_D0.6500.78
58_Q72_I0.6490.78
408_V411_K0.6480.78
60_A69_A0.6450.78
52_R83_I0.6450.78
158_V204_S0.6440.77
66_K69_A0.6430.77
38_R97_L0.6420.77
245_L379_V0.6420.77
409_I419_N0.6410.77
200_V235_P0.6400.77
137_P343_S0.6400.77
150_L166_Y0.6390.77
37_R41_L0.6380.77
232_A256_A0.6370.77
75_E82_E0.6360.77
400_Y411_K0.6350.76
175_R193_E0.6350.76
218_A234_V0.6340.76
232_A255_A0.6340.76
96_E100_I0.6300.76
257_F282_N0.6300.76
38_R93_V0.6300.76
208_T237_T0.6260.75
86_L89_E0.6260.75
289_F366_I0.6260.75
74_K77_R0.6260.75
69_A72_I0.6260.75
168_G192_T0.6260.75
208_T287_V0.6250.75
38_R94_E0.6240.75
199_M228_L0.6230.75
28_F31_F0.6230.75
339_V395_A0.6230.75
45_V86_L0.6220.75
58_Q68_D0.6200.75
194_V254_Y0.6200.75
147_L170_G0.6190.75
302_L382_L0.6190.75
296_Y299_L0.6180.75
180_F184_L0.6180.75
115_G325_G0.6180.75
275_L394_A0.6180.75
252_I255_A0.6150.74
370_R375_K0.6150.74
134_A137_P0.6140.74
299_L353_C0.6140.74
15_K19_V0.6140.74
7_L32_E0.6140.74
195_I259_A0.6130.74
48_L83_I0.6130.74
169_L172_R0.6130.74
299_L303_T0.6120.74
52_R79_V0.6120.74
182_L255_A0.6110.74
127_W317_Y0.6100.74
81_E84_K0.6080.73
300_E333_K0.6060.73
287_V356_F0.6050.73
59_V76_M0.6040.73
195_I198_Y0.6030.73
137_P401_Q0.6030.73
141_W273_R0.6010.72
358_A380_H0.6000.72
72_I75_E0.5990.72
62_L68_D0.5990.72
278_Q393_V0.5980.72
85_K88_E0.5960.72
63_K70_D0.5960.72
221_I224_E0.5950.72
396_I412_V0.5950.72
6_M11_F0.5950.72
91_R94_E0.5940.72
401_Q405_G0.5940.72
179_N257_F0.5940.72
116_E119_D0.5930.71
347_Y392_T0.5920.71
271_D348_R0.5920.71
309_V312_L0.5920.71
152_F275_L0.5900.71
66_K70_D0.5890.71
220_K223_E0.5870.71
215_E218_A0.5870.71
174_E389_V0.5860.71
83_I87_D0.5860.71
82_E86_L0.5850.70
138_K143_I0.5850.70
15_K25_L0.5850.70
396_I409_I0.5850.70
368_F379_V0.5840.70
157_K242_D0.5840.70
98_D206_T0.5830.70
35_D101_L0.5810.70
54_E57_Q0.5800.70
201_N226_Y0.5800.70
158_V239_M0.5790.70
330_T334_K0.5780.70
6_M9_A0.5780.70
247_G374_G0.5780.70
164_V275_L0.5780.70
288_K302_L0.5770.69
221_I263_S0.5760.69
21_K108_P0.5760.69
219_F226_Y0.5740.69
263_S267_S0.5740.69
112_V324_T0.5740.69
42_I45_V0.5740.69
215_E222_R0.5730.69
306_A337_I0.5700.69
159_T199_M0.5690.68
118_E348_R0.5690.68
200_V229_I0.5680.68
52_R56_S0.5680.68
176_A419_N0.5670.68
309_V386_G0.5670.68
306_A351_S0.5670.68
333_K355_N0.5660.68
238_N241_R0.5660.68
24_D27_D0.5650.68
29_D32_E0.5640.68
63_K66_K0.5630.68
301_K305_Q0.5620.67
350_I392_T0.5620.67
218_A227_F0.5590.67
341_I346_T0.5590.67
44_K48_L0.5590.67
245_L252_I0.5570.67
141_W152_F0.5560.67
162_R348_R0.5560.67
143_I146_E0.5560.67
267_S270_R0.5560.67
109_H332_A0.5560.67
151_D154_R0.5550.66
14_I107_I0.5540.66
351_S384_G0.5540.66
291_K297_E0.5500.66
343_S348_R0.5490.66
135_Y401_Q0.5490.66
136_E142_D0.5490.66
237_T381_T0.5480.65
370_R376_P0.5460.65
144_A149_I0.5460.65
415_P418_G0.5440.65
236_I255_A0.5430.65
240_H243_E0.5430.65
348_R390_G0.5430.65
7_L11_F0.5420.65
20_H108_P0.5420.65
330_T356_F0.5410.65
185_H189_Y0.5400.64
174_E390_G0.5400.64
60_A64_R0.5380.64
41_L45_V0.5380.64
221_I225_D0.5380.64
47_E50_G0.5380.64
392_T396_I0.5380.64
21_K324_T0.5370.64
268_A272_T0.5370.64
252_I289_F0.5370.64
133_F136_E0.5370.64
248_D371_E0.5360.64
38_R90_L0.5360.64
223_E263_S0.5360.64
131_P314_E0.5340.64
25_L28_F0.5340.64
131_P402_Q0.5330.63
165_F196_P0.5330.63
200_V205_M0.5320.63
218_A258_S0.5310.63
166_Y195_I0.5300.63
92_T95_A0.5300.63
316_P347_Y0.5290.63
44_K89_E0.5280.63
43_G46_E0.5270.63
179_N183_D0.5270.63
182_L193_E0.5260.62
59_V69_A0.5250.62
185_H309_V0.5240.62
121_N325_G0.5230.62
321_S337_I0.5230.62
389_V392_T0.5220.62
90_L94_E0.5220.62
62_L71_H0.5210.62
276_I344_Q0.5200.61
3_D362_R0.5200.61
40_E43_G0.5200.61
25_L104_I0.5190.61
111_S321_S0.5190.61
278_Q394_A0.5180.61
11_F15_K0.5180.61
303_T335_Y0.5180.61
229_I235_P0.5180.61
358_A362_R0.5170.61
111_S300_E0.5160.61
240_H379_V0.5150.61
186_V255_A0.5150.61
270_R320_M0.5130.60
155_A163_F0.5120.60
68_D73_I0.5110.60
208_T234_V0.5100.60
60_A63_K0.5100.60
63_K68_D0.5100.60
230_P385_S0.5080.60
414_R417_M0.5080.60
178_Y282_N0.5070.60
341_I350_I0.5070.60
156_A160_G0.5060.59
126_K347_Y0.5060.59
286_L305_Q0.5050.59
190_N253_N0.5050.59
231_T383_N0.5040.59
181_M385_S0.5030.59
66_K73_I0.5020.59
109_H355_N0.5020.59
238_N287_V0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dq0A 2 0.9976 100 0.231 Contact Map
1sesA 2 0.9812 100 0.234 Contact Map
1wleA 2 0.9882 100 0.247 Contact Map
2dq3A 2 0.9953 100 0.247 Contact Map
3lssA 2 0.9906 100 0.251 Contact Map
3vbbA 2 0.9882 100 0.265 Contact Map
3qneA 2 0.9741 100 0.273 Contact Map
3errA 2 0.9812 100 0.361 Contact Map
2cjaA 2 0.9294 100 0.535 Contact Map
3w3sA 2 0.9035 100 0.597 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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