GREMLIN Database
SSBA - Single-stranded DNA-binding protein A
UniProt: P37455 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (131)
Sequences: 3342 (2236)
Seq/√Len: 195.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_E89_R3.4581.00
19_Y25_A3.1581.00
84_N88_Q2.9901.00
70_L104_E2.9431.00
51_C97_A2.6221.00
80_R94_E2.5511.00
81_N89_R2.5011.00
80_R92_V2.3451.00
12_T48_F2.2711.00
53_T61_V2.2531.00
13_K30_T2.2421.00
2_L6_V2.2011.00
30_T50_N2.1611.00
10_R70_L2.1471.00
84_N90_V2.1151.00
29_F53_T2.1011.00
11_L65_L2.0821.00
24_A55_R2.0591.00
76_R98_E1.9571.00
17_L27_A1.9511.00
4_R74_D1.9481.00
20_T54_W1.9461.00
20_T26_V1.9311.00
65_L71_A1.9241.00
61_V65_L1.8971.00
29_F51_C1.8751.00
45_E78_Q1.7911.00
82_Y92_V1.7651.00
56_R59_E1.6161.00
20_T24_A1.6111.00
2_L8_V1.5531.00
78_Q96_Q1.5041.00
7_L31_L1.5011.00
25_A59_E1.4761.00
31_L73_V1.4551.00
33_V49_I1.4291.00
8_V103_L1.4281.00
79_T93_T1.4031.00
53_T97_A1.3891.00
17_L62_A1.3561.00
28_T80_R1.3371.00
52_V94_E1.3141.00
12_T30_T1.3081.00
35_R45_E1.2981.00
53_T57_Q1.2731.00
26_V54_W1.2381.00
77_L95_V1.2301.00
53_T73_V1.2231.00
60_N102_F1.1901.00
97_A100_V1.1481.00
13_K50_N1.1391.00
59_E63_N1.1291.00
53_T100_V1.1141.00
2_L72_G1.0851.00
5_V77_L1.0851.00
61_V71_A1.0801.00
79_T91_F1.0661.00
15_P27_A1.0391.00
13_K16_E1.0031.00
52_V80_R0.9971.00
38_T42_G0.9891.00
11_L15_P0.9860.99
10_R34_N0.9660.99
50_N92_V0.9600.99
7_L95_V0.9590.99
49_I93_T0.9570.99
21_P24_A0.9310.99
54_W96_Q0.9180.99
69_S104_E0.9170.99
66_K69_S0.9070.99
14_D66_K0.8870.99
8_V72_G0.8840.99
49_I95_V0.8780.99
81_N92_V0.8780.99
34_N46_A0.8730.99
118_E121_S0.8520.99
19_Y59_E0.8480.98
28_T52_V0.8390.98
25_A62_A0.8380.98
2_L101_Q0.8370.98
34_N44_R0.8370.98
60_N100_V0.8310.98
70_L101_Q0.8290.98
31_L71_A0.8220.98
82_Y94_E0.8190.98
39_N42_G0.8180.98
78_Q98_E0.8180.98
47_D79_T0.7970.98
69_S102_F0.7870.98
76_R96_Q0.7860.98
18_R26_V0.7790.97
57_Q60_N0.7730.97
35_R76_R0.7730.97
110_G113_S0.7660.97
55_R98_E0.7630.97
5_V95_V0.7450.97
57_Q97_A0.7280.96
61_V100_V0.7280.96
37_F42_G0.7280.96
19_Y63_N0.7240.96
85_Q88_Q0.7230.96
82_Y88_Q0.7230.96
49_I79_T0.7170.96
17_L25_A0.7130.96
7_L49_I0.7130.96
38_T44_R0.7110.96
47_D95_V0.7100.95
65_L102_F0.7080.95
25_A58_A0.7070.95
29_F97_A0.7030.95
108_G112_G0.7020.95
60_N64_F0.7020.95
73_V100_V0.6960.95
27_A61_V0.6930.95
24_A54_W0.6880.95
69_S107_N0.6820.94
6_V74_D0.6820.94
35_R98_E0.6780.94
118_E122_G0.6750.94
27_A53_T0.6750.94
57_Q100_V0.6740.94
83_E92_V0.6650.94
50_N91_F0.6630.94
38_T41_S0.6530.93
123_G126_Y0.6490.93
109_G112_G0.6480.93
39_N43_E0.6450.93
35_R47_D0.6450.93
15_P61_V0.6440.93
60_N63_N0.6440.93
28_T50_N0.6420.92
25_A63_N0.6410.92
27_A58_A0.6410.92
39_N45_E0.6400.92
39_N44_R0.6380.92
127_F131_Q0.6360.92
47_D82_Y0.6360.92
118_E124_G0.6340.92
69_S106_K0.6330.92
83_E88_Q0.6240.91
125_Q130_G0.6230.91
117_N122_G0.6210.91
40_Q43_E0.6200.91
104_E107_N0.6110.90
33_V47_D0.6110.90
36_T44_R0.6110.90
70_L103_L0.6090.90
53_T60_N0.6080.90
121_S124_G0.6010.90
116_Y130_G0.5960.89
113_S116_Y0.5950.89
124_G127_F0.5930.89
47_D93_T0.5910.89
119_G122_G0.5890.89
82_Y85_Q0.5860.89
56_R60_N0.5790.88
74_D99_S0.5760.88
17_L58_A0.5700.87
37_F40_Q0.5700.87
107_N111_S0.5670.87
106_K110_G0.5630.87
8_V101_Q0.5630.87
127_F130_G0.5600.86
126_Y131_Q0.5600.86
6_V72_G0.5590.86
121_S125_Q0.5570.86
119_G128_G0.5570.86
110_G114_G0.5550.86
113_S117_N0.5500.85
82_Y89_R0.5490.85
119_G127_F0.5480.85
77_L92_V0.5470.85
112_G115_G0.5470.85
119_G132_N0.5460.85
107_N112_G0.5460.85
60_N103_L0.5460.85
108_G111_S0.5450.85
117_N121_S0.5450.85
125_Q128_G0.5390.84
114_G117_N0.5370.84
52_V96_Q0.5310.83
76_R97_A0.5280.83
129_G132_N0.5200.82
119_G130_G0.5200.82
11_L71_A0.5170.82
116_Y119_G0.5150.81
37_F44_R0.5140.81
28_T92_V0.5120.81
55_R58_A0.5120.81
55_R70_L0.5100.81
50_N79_T0.5100.81
65_L100_V0.5060.80
55_R59_E0.5050.80
20_T52_V0.5040.80
113_S123_G0.5030.80
122_G126_Y0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mz9A 4 0.6105 100 0.214 Contact Map
1se8A 2 0.5698 100 0.25 Contact Map
1z9fA 4 0.5 100 0.251 Contact Map
3pgzA 2 0.6047 100 0.262 Contact Map
3lgjA 2 0.5233 100 0.263 Contact Map
3afpA 3 0.6221 100 0.292 Contact Map
2vw9A 3 0.6163 100 0.294 Contact Map
3eivA 3 0.6395 100 0.296 Contact Map
2fxqA 2 0.5581 100 0.301 Contact Map
3tqyA 4 0.6047 100 0.301 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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