GREMLIN Database
EXOA - Exodeoxyribonuclease
UniProt: P37454 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 252 (245)
Sequences: 5757 (3472)
Seq/√Len: 221.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_V95_L3.8291.00
2_K249_I3.4221.00
206_G209_D3.2781.00
33_C143_C3.2491.00
233_S247_E2.9911.00
186_S221_V2.7761.00
125_E174_A2.6831.00
4_I247_E2.4611.00
52_H73_E2.3301.00
169_D173_E2.2431.00
235_S247_E2.2361.00
186_S229_I2.1561.00
139_P224_S2.1311.00
128_L177_R2.0861.00
162_R169_D2.0771.00
5_S246_V2.0661.00
59_V88_Q2.0251.00
150_H176_T1.9921.00
135_D224_S1.9841.00
231_D249_I1.9771.00
179_L220_V1.9551.00
199_S246_V1.9331.00
33_C102_V1.9261.00
23_Y27_E1.9171.00
189_H226_K1.9161.00
85_E122_Q1.9031.00
223_E226_K1.8871.00
96_E138_K1.8691.00
140_V183_F1.8651.00
184_V223_E1.8621.00
75_L98_E1.8591.00
197_A236_A1.8571.00
11_L39_I1.8531.00
34_L37_T1.8381.00
175_F220_V1.7861.00
219_F248_L1.7401.00
159_K162_R1.7161.00
190_V229_I1.7021.00
187_F197_A1.7011.00
230_E249_I1.6851.00
122_Q126_A1.6761.00
173_E177_R1.5891.00
221_V229_I1.5351.00
184_V189_H1.5161.00
143_C219_F1.5131.00
29_A32_I1.4981.00
229_I248_L1.4891.00
40_Q43_Q1.4771.00
76_Q96_E1.4711.00
139_P228_Q1.4531.00
184_V226_K1.4461.00
157_N160_A1.4431.00
22_S25_K1.4361.00
130_Y134_L1.4261.00
96_E101_F1.4251.00
8_V34_L1.4191.00
81_I92_V1.4171.00
40_Q61_K1.4151.00
112_R204_R1.4141.00
74_P97_F1.3931.00
52_H72_Q1.3921.00
31_I102_V1.3801.00
132_L181_A1.3781.00
175_F218_Y1.3771.00
150_H218_Y1.3691.00
191_Y197_A1.3671.00
46_L51_Y1.3651.00
46_L50_D1.3631.00
152_E162_R1.3571.00
128_L132_L1.3551.00
206_G210_R1.3521.00
131_I142_L1.3401.00
24_L32_I1.3331.00
222_S225_L1.3111.00
39_I44_V1.3091.00
21_L25_K1.3001.00
103_M131_I1.3001.00
12_R43_Q1.2831.00
156_K212_I1.2701.00
33_C104_T1.2691.00
189_H229_I1.2631.00
151_Q176_T1.2571.00
27_E235_S1.2551.00
33_C68_V1.2471.00
112_R115_E1.2451.00
48_P53_V1.2451.00
68_V104_T1.2441.00
127_L142_L1.2421.00
125_E177_R1.2401.00
221_V250_I1.2371.00
105_V142_L1.2191.00
3_L102_V1.2181.00
3_L141_I1.2081.00
37_T41_D1.1841.00
111_R115_E1.1811.00
128_L181_A1.1791.00
205_A212_I1.1701.00
25_K49_E1.1681.00
176_T180_E1.1621.00
149_A155_L1.1601.00
28_D71_K1.1561.00
124_E148_V1.1551.00
174_A177_R1.1541.00
121_M170_Q1.1341.00
149_A167_F1.1281.00
131_I183_F1.1251.00
207_A212_I1.1191.00
3_L31_I1.1111.00
141_I219_F1.1051.00
190_V231_D1.0871.00
221_V226_K1.0861.00
101_F138_K1.0861.00
152_E167_F1.0811.00
47_Q52_H1.0731.00
83_V126_A1.0661.00
211_N236_A1.0591.00
30_D71_K1.0531.00
39_I43_Q1.0521.00
176_T179_L1.0441.00
232_A248_L1.0411.00
186_S232_A1.0401.00
125_E129_S1.0381.00
82_G87_D1.0351.00
15_M21_L1.0301.00
190_V232_A1.0251.00
219_F250_I1.0221.00
187_F232_A1.0211.00
134_L140_V1.0201.00
142_L146_L1.0201.00
23_Y235_S1.0161.00
46_L53_V1.0161.00
105_V146_L1.0161.00
121_M174_A1.0071.00
117_I168_S1.0021.00
101_F137_K0.9981.00
46_L49_E0.9971.00
122_Q125_E0.9971.00
199_S234_I0.9961.00
70_S95_L0.9931.00
118_D122_Q0.9901.00
86_H126_A0.9821.00
89_E116_R0.9721.00
142_L220_V0.9681.00
107_T124_E0.9681.00
22_S26_E0.9661.00
177_R180_E0.9531.00
94_T101_F0.9481.00
31_I97_F0.9441.00
113_G118_D0.9361.00
74_P77_V0.9351.00
24_L29_A0.9331.00
48_P52_H0.9331.00
132_L135_D0.9331.00
208_R239_M0.9321.00
152_E158_P0.9321.00
124_E174_A0.9321.00
105_V127_L0.9291.00
141_I221_V0.9180.99
128_L178_F0.9180.99
76_Q101_F0.9170.99
114_L118_D0.9160.99
238_V244_C0.9140.99
1_M249_I0.9060.99
4_I27_E0.9040.99
31_I100_V0.9040.99
70_S74_P0.8990.99
199_S232_A0.8940.99
132_L183_F0.8920.99
197_A234_I0.8860.99
99_N228_Q0.8720.99
79_Y93_I0.8650.99
155_L161_N0.8600.99
6_W20_F0.8580.99
153_I195_E0.8580.99
54_Y77_V0.8560.99
129_S133_E0.8540.99
163_N169_D0.8500.99
10_G13_A0.8480.99
158_P167_F0.8480.99
201_W244_C0.8470.99
139_P222_S0.8460.99
102_V219_F0.8360.99
235_S239_M0.8350.99
20_F32_I0.8340.99
70_S97_F0.8320.99
34_L69_F0.8310.99
5_S232_A0.8310.99
37_T67_A0.8290.99
236_A239_M0.8260.99
99_N139_P0.8230.99
20_F46_L0.8220.99
234_I244_C0.8200.99
155_L214_W0.8170.99
54_Y70_S0.8170.99
70_S73_E0.8170.99
48_P51_Y0.8160.99
226_K229_I0.8110.99
4_I29_A0.8080.99
130_Y133_E0.8060.99
92_V103_M0.8050.99
104_T143_C0.8020.99
107_T123_W0.7970.99
191_Y195_E0.7920.98
129_S132_L0.7910.98
94_T103_M0.7900.98
21_L49_E0.7880.98
139_P225_L0.7870.98
173_E176_T0.7860.98
84_E88_Q0.7840.98
157_N212_I0.7840.98
72_Q98_E0.7840.98
49_E53_V0.7720.98
75_L96_E0.7720.98
26_E237_D0.7700.98
133_E136_Q0.7670.98
2_K27_E0.7650.98
5_S35_Q0.7620.98
41_D55_W0.7610.98
128_L174_A0.7580.98
191_Y231_D0.7540.98
187_F199_S0.7530.98
81_I130_Y0.7530.98
161_N214_W0.7530.98
208_R240_G0.7500.98
4_I235_S0.7480.98
74_P95_L0.7380.98
121_M125_E0.7350.97
60_K64_S0.7330.97
10_G62_G0.7310.97
60_K63_Y0.7280.97
68_V93_I0.7250.97
187_F234_I0.7240.97
219_F246_V0.7230.97
191_Y233_S0.7180.97
221_V225_L0.7150.97
161_N164_N0.7130.97
54_Y79_Y0.7100.97
107_T146_L0.7100.97
235_S238_V0.7090.97
3_L33_C0.7060.97
68_V102_V0.7050.97
31_I72_Q0.7040.97
193_D197_A0.7020.97
149_A214_W0.7010.97
92_V130_Y0.7000.97
103_M140_V0.6960.97
111_R164_N0.6960.97
78_I130_Y0.6960.97
197_A233_S0.6960.97
168_S171_E0.6940.96
76_Q79_Y0.6880.96
35_Q104_T0.6840.96
110_S117_I0.6830.96
53_V69_F0.6820.96
201_W211_N0.6760.96
166_G214_W0.6730.96
12_R39_I0.6720.96
207_A210_R0.6720.96
156_K160_A0.6690.96
196_G211_N0.6670.96
115_E118_D0.6670.96
16_R22_S0.6660.96
92_V127_L0.6640.95
4_I23_Y0.6640.95
49_E52_H0.6610.95
236_A240_G0.6570.95
94_T130_Y0.6570.95
86_H122_Q0.6560.95
13_A16_R0.6550.95
10_G63_Y0.6520.95
92_V105_V0.6520.95
16_R21_L0.6480.95
175_F179_L0.6460.95
77_V93_I0.6430.95
158_P162_R0.6420.95
221_V248_L0.6340.94
128_L180_E0.6300.94
32_I69_F0.6290.94
116_R119_Y0.6280.94
190_V196_G0.6240.94
205_A210_R0.6230.94
171_E200_W0.6210.94
78_I101_F0.6190.93
127_L130_Y0.6110.93
141_I250_I0.6080.93
191_Y232_A0.6060.93
54_Y74_P0.6060.93
192_P197_A0.6030.93
36_E145_D0.6030.93
126_A129_S0.6000.92
192_P195_E0.5970.92
15_M44_V0.5930.92
208_R244_C0.5930.92
146_L220_V0.5910.92
157_N162_R0.5900.92
235_S240_G0.5890.92
86_H119_Y0.5870.92
106_Y145_D0.5860.91
50_D53_V0.5840.91
132_L177_R0.5830.91
153_I193_D0.5810.91
6_W109_N0.5800.91
26_E238_V0.5780.91
208_R236_A0.5770.91
156_K214_W0.5760.91
231_D247_E0.5750.91
25_K28_D0.5750.91
58_A90_G0.5750.91
145_D242_D0.5740.91
117_I170_Q0.5740.91
142_L178_F0.5730.91
170_Q173_E0.5700.90
110_S120_R0.5690.90
66_T93_I0.5630.90
92_V123_W0.5620.90
146_L218_Y0.5610.90
82_G133_E0.5600.90
120_R174_A0.5580.89
223_E227_E0.5570.89
54_Y93_I0.5570.89
131_I178_F0.5560.89
37_T40_Q0.5550.89
120_R124_E0.5540.89
102_V141_I0.5530.89
36_E147_N0.5520.89
156_K161_N0.5510.89
47_Q53_V0.5480.89
2_K28_D0.5480.89
209_D240_G0.5470.88
23_Y238_V0.5470.88
152_E159_K0.5460.88
6_W240_G0.5460.88
186_S248_L0.5460.88
162_R167_F0.5420.88
11_L20_F0.5410.88
36_E106_Y0.5400.88
48_P69_F0.5400.88
9_N12_R0.5380.88
78_I94_T0.5370.88
106_Y147_N0.5370.88
7_N147_N0.5360.87
31_I70_S0.5360.87
112_R164_N0.5360.87
159_K163_N0.5360.87
103_M107_T0.5350.87
82_G130_Y0.5330.87
72_Q97_F0.5320.87
229_I250_I0.5310.87
187_F190_V0.5290.87
186_S226_K0.5230.86
167_F170_Q0.5200.86
75_L100_V0.5200.86
121_M124_E0.5160.85
185_D215_R0.5150.85
110_S124_E0.5140.85
166_G171_E0.5130.85
47_Q50_D0.5110.85
100_V225_L0.5110.85
1_M4_I0.5080.84
120_R123_W0.5060.84
189_H227_E0.5050.84
230_E233_S0.5030.84
58_A79_Y0.5020.84
31_I95_L0.5010.84
201_W213_G0.5000.84
160_A164_N0.5000.84
97_F100_V0.5000.84
107_T127_L0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jc5A 1 0.9921 100 0.358 Contact Map
3g91A 1 0.9921 100 0.358 Contact Map
1hd7A 1 0.9484 100 0.359 Contact Map
2j63A 1 1 100 0.362 Contact Map
4f1rA 1 0.9881 100 0.365 Contact Map
4jg3A 1 0.9921 100 0.369 Contact Map
2voaA 1 0.9762 100 0.375 Contact Map
2jc4A 1 0.9802 100 0.377 Contact Map
4qheA 1 0.996 100 0.406 Contact Map
1akoA 1 0.9841 100 0.412 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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