EXOA - BACSU - GREMLIN Contacts

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EXOA - Exodeoxyribonuclease

UniProt:	P37454	Sequences: MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQVDLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFVMTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKANRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDYFVVSESLKEQIEDASISADVMGSDHCPVELIINI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	252 (245)
Sequences:	5757 (3472)
Seq/√Len:	221.8

ECOLI - EX3
BACSU - EXOA
SULSO - Q97WD6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
68_V	95_L	3.829	1.00
2_K	249_I	3.422	1.00
206_G	209_D	3.278	1.00
33_C	143_C	3.249	1.00
233_S	247_E	2.991	1.00
186_S	221_V	2.776	1.00
125_E	174_A	2.683	1.00
4_I	247_E	2.461	1.00
52_H	73_E	2.330	1.00
169_D	173_E	2.243	1.00
235_S	247_E	2.236	1.00
186_S	229_I	2.156	1.00
139_P	224_S	2.131	1.00
128_L	177_R	2.086	1.00
162_R	169_D	2.077	1.00
5_S	246_V	2.066	1.00
59_V	88_Q	2.025	1.00
150_H	176_T	1.992	1.00
135_D	224_S	1.984	1.00
231_D	249_I	1.977	1.00
179_L	220_V	1.955	1.00
199_S	246_V	1.933	1.00
33_C	102_V	1.926	1.00
23_Y	27_E	1.917	1.00
189_H	226_K	1.916	1.00
85_E	122_Q	1.903	1.00
223_E	226_K	1.887	1.00
96_E	138_K	1.869	1.00
140_V	183_F	1.865	1.00
184_V	223_E	1.862	1.00
75_L	98_E	1.859	1.00
197_A	236_A	1.857	1.00
11_L	39_I	1.853	1.00
34_L	37_T	1.838	1.00
175_F	220_V	1.786	1.00
219_F	248_L	1.740	1.00
159_K	162_R	1.716	1.00
190_V	229_I	1.702	1.00
187_F	197_A	1.701	1.00
230_E	249_I	1.685	1.00
122_Q	126_A	1.676	1.00
173_E	177_R	1.589	1.00
221_V	229_I	1.535	1.00
184_V	189_H	1.516	1.00
143_C	219_F	1.513	1.00
29_A	32_I	1.498	1.00
229_I	248_L	1.489	1.00
40_Q	43_Q	1.477	1.00
76_Q	96_E	1.471	1.00
139_P	228_Q	1.453	1.00
184_V	226_K	1.446	1.00
157_N	160_A	1.443	1.00
22_S	25_K	1.436	1.00
130_Y	134_L	1.426	1.00
96_E	101_F	1.425	1.00
8_V	34_L	1.419	1.00
81_I	92_V	1.417	1.00
40_Q	61_K	1.415	1.00
112_R	204_R	1.414	1.00
74_P	97_F	1.393	1.00
52_H	72_Q	1.392	1.00
31_I	102_V	1.380	1.00
132_L	181_A	1.378	1.00
175_F	218_Y	1.377	1.00
150_H	218_Y	1.369	1.00
191_Y	197_A	1.367	1.00
46_L	51_Y	1.365	1.00
46_L	50_D	1.363	1.00
152_E	162_R	1.357	1.00
128_L	132_L	1.355	1.00
206_G	210_R	1.352	1.00
131_I	142_L	1.340	1.00
24_L	32_I	1.333	1.00
222_S	225_L	1.311	1.00
39_I	44_V	1.309	1.00
21_L	25_K	1.300	1.00
103_M	131_I	1.300	1.00
12_R	43_Q	1.283	1.00
156_K	212_I	1.270	1.00
33_C	104_T	1.269	1.00
189_H	229_I	1.263	1.00
151_Q	176_T	1.257	1.00
27_E	235_S	1.255	1.00
33_C	68_V	1.247	1.00
112_R	115_E	1.245	1.00
48_P	53_V	1.245	1.00
68_V	104_T	1.244	1.00
127_L	142_L	1.242	1.00
125_E	177_R	1.240	1.00
221_V	250_I	1.237	1.00
105_V	142_L	1.219	1.00
3_L	102_V	1.218	1.00
3_L	141_I	1.208	1.00
37_T	41_D	1.184	1.00
111_R	115_E	1.181	1.00
128_L	181_A	1.179	1.00
205_A	212_I	1.170	1.00
25_K	49_E	1.168	1.00
176_T	180_E	1.162	1.00
149_A	155_L	1.160	1.00
28_D	71_K	1.156	1.00
124_E	148_V	1.155	1.00
174_A	177_R	1.154	1.00
121_M	170_Q	1.134	1.00
149_A	167_F	1.128	1.00
131_I	183_F	1.125	1.00
207_A	212_I	1.119	1.00
3_L	31_I	1.111	1.00
141_I	219_F	1.105	1.00
190_V	231_D	1.087	1.00
221_V	226_K	1.086	1.00
101_F	138_K	1.086	1.00
152_E	167_F	1.081	1.00
47_Q	52_H	1.073	1.00
83_V	126_A	1.066	1.00
211_N	236_A	1.059	1.00
30_D	71_K	1.053	1.00
39_I	43_Q	1.052	1.00
176_T	179_L	1.044	1.00
232_A	248_L	1.041	1.00
186_S	232_A	1.040	1.00
125_E	129_S	1.038	1.00
82_G	87_D	1.035	1.00
15_M	21_L	1.030	1.00
190_V	232_A	1.025	1.00
219_F	250_I	1.022	1.00
187_F	232_A	1.021	1.00
134_L	140_V	1.020	1.00
142_L	146_L	1.020	1.00
23_Y	235_S	1.016	1.00
46_L	53_V	1.016	1.00
105_V	146_L	1.016	1.00
121_M	174_A	1.007	1.00
117_I	168_S	1.002	1.00
101_F	137_K	0.998	1.00
46_L	49_E	0.997	1.00
122_Q	125_E	0.997	1.00
199_S	234_I	0.996	1.00
70_S	95_L	0.993	1.00
118_D	122_Q	0.990	1.00
86_H	126_A	0.982	1.00
89_E	116_R	0.972	1.00
142_L	220_V	0.968	1.00
107_T	124_E	0.968	1.00
22_S	26_E	0.966	1.00
177_R	180_E	0.953	1.00
94_T	101_F	0.948	1.00
31_I	97_F	0.944	1.00
113_G	118_D	0.936	1.00
74_P	77_V	0.935	1.00
24_L	29_A	0.933	1.00
48_P	52_H	0.933	1.00
132_L	135_D	0.933	1.00
208_R	239_M	0.932	1.00
152_E	158_P	0.932	1.00
124_E	174_A	0.932	1.00
105_V	127_L	0.929	1.00
141_I	221_V	0.918	0.99
128_L	178_F	0.918	0.99
76_Q	101_F	0.917	0.99
114_L	118_D	0.916	0.99
238_V	244_C	0.914	0.99
1_M	249_I	0.906	0.99
4_I	27_E	0.904	0.99
31_I	100_V	0.904	0.99
70_S	74_P	0.899	0.99
199_S	232_A	0.894	0.99
132_L	183_F	0.892	0.99
197_A	234_I	0.886	0.99
99_N	228_Q	0.872	0.99
79_Y	93_I	0.865	0.99
155_L	161_N	0.860	0.99
6_W	20_F	0.858	0.99
153_I	195_E	0.858	0.99
54_Y	77_V	0.856	0.99
129_S	133_E	0.854	0.99
163_N	169_D	0.850	0.99
10_G	13_A	0.848	0.99
158_P	167_F	0.848	0.99
201_W	244_C	0.847	0.99
139_P	222_S	0.846	0.99
102_V	219_F	0.836	0.99
235_S	239_M	0.835	0.99
20_F	32_I	0.834	0.99
70_S	97_F	0.832	0.99
34_L	69_F	0.831	0.99
5_S	232_A	0.831	0.99
37_T	67_A	0.829	0.99
236_A	239_M	0.826	0.99
99_N	139_P	0.823	0.99
20_F	46_L	0.822	0.99
234_I	244_C	0.820	0.99
155_L	214_W	0.817	0.99
54_Y	70_S	0.817	0.99
70_S	73_E	0.817	0.99
48_P	51_Y	0.816	0.99
226_K	229_I	0.811	0.99
4_I	29_A	0.808	0.99
130_Y	133_E	0.806	0.99
92_V	103_M	0.805	0.99
104_T	143_C	0.802	0.99
107_T	123_W	0.797	0.99
191_Y	195_E	0.792	0.98
129_S	132_L	0.791	0.98
94_T	103_M	0.790	0.98
21_L	49_E	0.788	0.98
139_P	225_L	0.787	0.98
173_E	176_T	0.786	0.98
84_E	88_Q	0.784	0.98
157_N	212_I	0.784	0.98
72_Q	98_E	0.784	0.98
49_E	53_V	0.772	0.98
75_L	96_E	0.772	0.98
26_E	237_D	0.770	0.98
133_E	136_Q	0.767	0.98
2_K	27_E	0.765	0.98
5_S	35_Q	0.762	0.98
41_D	55_W	0.761	0.98
128_L	174_A	0.758	0.98
191_Y	231_D	0.754	0.98
187_F	199_S	0.753	0.98
81_I	130_Y	0.753	0.98
161_N	214_W	0.753	0.98
208_R	240_G	0.750	0.98
4_I	235_S	0.748	0.98
74_P	95_L	0.738	0.98
121_M	125_E	0.735	0.97
60_K	64_S	0.733	0.97
10_G	62_G	0.731	0.97
60_K	63_Y	0.728	0.97
68_V	93_I	0.725	0.97
187_F	234_I	0.724	0.97
219_F	246_V	0.723	0.97
191_Y	233_S	0.718	0.97
221_V	225_L	0.715	0.97
161_N	164_N	0.713	0.97
54_Y	79_Y	0.710	0.97
107_T	146_L	0.710	0.97
235_S	238_V	0.709	0.97
3_L	33_C	0.706	0.97
68_V	102_V	0.705	0.97
31_I	72_Q	0.704	0.97
193_D	197_A	0.702	0.97
149_A	214_W	0.701	0.97
92_V	130_Y	0.700	0.97
103_M	140_V	0.696	0.97
111_R	164_N	0.696	0.97
78_I	130_Y	0.696	0.97
197_A	233_S	0.696	0.97
168_S	171_E	0.694	0.96
76_Q	79_Y	0.688	0.96
35_Q	104_T	0.684	0.96
110_S	117_I	0.683	0.96
53_V	69_F	0.682	0.96
201_W	211_N	0.676	0.96
166_G	214_W	0.673	0.96
12_R	39_I	0.672	0.96
207_A	210_R	0.672	0.96
156_K	160_A	0.669	0.96
196_G	211_N	0.667	0.96
115_E	118_D	0.667	0.96
16_R	22_S	0.666	0.96
92_V	127_L	0.664	0.95
4_I	23_Y	0.664	0.95
49_E	52_H	0.661	0.95
236_A	240_G	0.657	0.95
94_T	130_Y	0.657	0.95
86_H	122_Q	0.656	0.95
13_A	16_R	0.655	0.95
10_G	63_Y	0.652	0.95
92_V	105_V	0.652	0.95
16_R	21_L	0.648	0.95
175_F	179_L	0.646	0.95
77_V	93_I	0.643	0.95
158_P	162_R	0.642	0.95
221_V	248_L	0.634	0.94
128_L	180_E	0.630	0.94
32_I	69_F	0.629	0.94
116_R	119_Y	0.628	0.94
190_V	196_G	0.624	0.94
205_A	210_R	0.623	0.94
171_E	200_W	0.621	0.94
78_I	101_F	0.619	0.93
127_L	130_Y	0.611	0.93
141_I	250_I	0.608	0.93
191_Y	232_A	0.606	0.93
54_Y	74_P	0.606	0.93
192_P	197_A	0.603	0.93
36_E	145_D	0.603	0.93
126_A	129_S	0.600	0.92
192_P	195_E	0.597	0.92
15_M	44_V	0.593	0.92
208_R	244_C	0.593	0.92
146_L	220_V	0.591	0.92
157_N	162_R	0.590	0.92
235_S	240_G	0.589	0.92
86_H	119_Y	0.587	0.92
106_Y	145_D	0.586	0.91
50_D	53_V	0.584	0.91
132_L	177_R	0.583	0.91
153_I	193_D	0.581	0.91
6_W	109_N	0.580	0.91
26_E	238_V	0.578	0.91
208_R	236_A	0.577	0.91
156_K	214_W	0.576	0.91
231_D	247_E	0.575	0.91
25_K	28_D	0.575	0.91
58_A	90_G	0.575	0.91
145_D	242_D	0.574	0.91
117_I	170_Q	0.574	0.91
142_L	178_F	0.573	0.91
170_Q	173_E	0.570	0.90
110_S	120_R	0.569	0.90
66_T	93_I	0.563	0.90
92_V	123_W	0.562	0.90
146_L	218_Y	0.561	0.90
82_G	133_E	0.560	0.90
120_R	174_A	0.558	0.89
223_E	227_E	0.557	0.89
54_Y	93_I	0.557	0.89
131_I	178_F	0.556	0.89
37_T	40_Q	0.555	0.89
120_R	124_E	0.554	0.89
102_V	141_I	0.553	0.89
36_E	147_N	0.552	0.89
156_K	161_N	0.551	0.89
47_Q	53_V	0.548	0.89
2_K	28_D	0.548	0.89
209_D	240_G	0.547	0.88
23_Y	238_V	0.547	0.88
152_E	159_K	0.546	0.88
6_W	240_G	0.546	0.88
186_S	248_L	0.546	0.88
162_R	167_F	0.542	0.88
11_L	20_F	0.541	0.88
36_E	106_Y	0.540	0.88
48_P	69_F	0.540	0.88
9_N	12_R	0.538	0.88
78_I	94_T	0.537	0.88
106_Y	147_N	0.537	0.88
7_N	147_N	0.536	0.87
31_I	70_S	0.536	0.87
112_R	164_N	0.536	0.87
159_K	163_N	0.536	0.87
103_M	107_T	0.535	0.87
82_G	130_Y	0.533	0.87
72_Q	97_F	0.532	0.87
229_I	250_I	0.531	0.87
187_F	190_V	0.529	0.87
186_S	226_K	0.523	0.86
167_F	170_Q	0.520	0.86
75_L	100_V	0.520	0.86
121_M	124_E	0.516	0.85
185_D	215_R	0.515	0.85
110_S	124_E	0.514	0.85
166_G	171_E	0.513	0.85
47_Q	50_D	0.511	0.85
100_V	225_L	0.511	0.85
1_M	4_I	0.508	0.84
120_R	123_W	0.506	0.84
189_H	227_E	0.505	0.84
230_E	233_S	0.503	0.84
58_A	79_Y	0.502	0.84
31_I	95_L	0.501	0.84
201_W	213_G	0.500	0.84
160_A	164_N	0.500	0.84
97_F	100_V	0.500	0.84
107_T	127_L	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2jc5A	1	0.9921	100	0.358	Contact Map
3g91A	1	0.9921	100	0.358	Contact Map
1hd7A	1	0.9484	100	0.359	Contact Map
2j63A	1	1	100	0.362	Contact Map
4f1rA	1	0.9881	100	0.365	Contact Map
4jg3A	1	0.9921	100	0.369	Contact Map
2voaA	1	0.9762	100	0.375	Contact Map
2jc4A	1	0.9802	100	0.377	Contact Map
4qheA	1	0.996	100	0.406	Contact Map
1akoA	1	0.9841	100	0.412	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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