ILVC - BACSU - GREMLIN Contacts

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ILVC - Ketol-acid reductoisomerase

UniProt:	P37253	Sequences: MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVIVGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKSLVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEARDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGYQPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKEVLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKEAVVSVAQN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	342 (326)
Sequences:	1931 (661)
Seq/√Len:	36.6

ECOLI - ILVC
BACSU - ILVC
SULSO - ILVC1 ILVC3 ILVC2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
20_V	41_V	4.619	1.00
98_T	101_K	4.162	1.00
148_A	173_G	3.961	1.00
206_V	238_M	3.208	1.00
19_T	42_D	2.985	1.00
99_A	121_D	2.912	1.00
247_R	258_D	2.890	1.00
80_L	88_V	2.859	1.00
102_S	125_F	2.849	1.00
150_F	161_R	2.776	1.00
32_H	106_A	2.773	1.00
174_A	178_V	2.679	1.00
306_A	310_E	2.567	1.00
119_P	122_V	2.551	1.00
206_V	231_L	2.533	1.00
255_Q	305_N	2.501	1.00
202_L	231_L	2.478	1.00
185_E	219_Q	2.460	1.00
139_T	142_Q	2.436	1.00
54_T	57_Q	2.416	1.00
87_K	91_A	2.389	1.00
90_E	94_K	2.356	1.00
273_S	276_E	2.304	0.99
83_E	252_D	2.232	0.99
267_D	270_V	2.205	0.99
138_R	240_E	2.178	0.99
10_I	174_A	2.173	0.99
241_E	245_G	2.149	0.99
261_S	277_V	2.094	0.99
37_K	61_H	2.074	0.99
264_R	280_D	2.042	0.99
78_V	93_I	2.018	0.99
104_V	125_F	2.003	0.99
87_K	295_Q	1.993	0.98
270_V	273_S	1.990	0.98
207_K	308_E	1.927	0.98
45_V	61_H	1.924	0.98
102_S	163_K	1.920	0.98
169_K	174_A	1.908	0.98
49_Q	65_S	1.903	0.98
53_F	57_Q	1.889	0.98
102_S	123_D	1.880	0.98
261_S	280_D	1.870	0.98
261_S	289_E	1.839	0.97
155_D	162_D	1.812	0.97
36_L	170_G	1.810	0.97
296_V	299_P	1.798	0.97
15_L	166_A	1.776	0.97
25_Y	59_D	1.772	0.97
66_V	92_E	1.758	0.97
267_D	273_S	1.746	0.96
67_K	92_E	1.737	0.96
123_D	160_A	1.704	0.96
161_R	180_E	1.680	0.95
13_N	16_A	1.643	0.95
23_I	78_V	1.639	0.95
219_Q	222_L	1.626	0.95
64_F	72_Q	1.625	0.95
269_K	272_E	1.620	0.94
77_M	106_A	1.615	0.94
21_A	69_A	1.615	0.94
131_G	173_G	1.599	0.94
294_N	298_R	1.599	0.94
109_F	287_A	1.598	0.94
206_V	228_L	1.591	0.94
76_I	101_K	1.577	0.94
32_H	77_M	1.546	0.93
62_K	72_Q	1.533	0.93
135_L	138_R	1.530	0.93
57_Q	62_K	1.521	0.92
44_I	72_Q	1.521	0.92
53_F	65_S	1.515	0.92
44_I	64_F	1.506	0.92
121_D	156_V	1.498	0.92
47_V	51_K	1.494	0.92
123_D	159_E	1.475	0.91
23_I	46_G	1.475	0.91
203_S	258_D	1.468	0.91
7_N	174_A	1.456	0.91
289_E	300_R	1.452	0.90
202_L	206_V	1.442	0.90
77_M	104_V	1.439	0.90
315_V	319_K	1.426	0.90
179_L	222_L	1.421	0.90
279_K	283_N	1.417	0.89
19_T	44_I	1.414	0.89
203_S	243_L	1.411	0.89
139_T	144_A	1.406	0.89
292_V	295_Q	1.401	0.89
49_Q	53_F	1.393	0.89
260_V	289_E	1.382	0.88
70_A	101_K	1.380	0.88
252_D	298_R	1.374	0.88
261_S	265_V	1.357	0.87
292_V	296_V	1.346	0.87
264_R	273_S	1.344	0.87
255_Q	259_F	1.342	0.87
204_A	271_K	1.335	0.86
259_F	305_N	1.329	0.86
19_T	72_Q	1.329	0.86
290_W	293_E	1.327	0.86
276_E	280_D	1.320	0.86
290_W	298_R	1.318	0.86
134_H	249_S	1.317	0.86
70_A	96_E	1.304	0.85
228_L	238_M	1.301	0.85
71_A	96_E	1.300	0.85
203_S	247_R	1.294	0.85
206_V	313_I	1.291	0.84
204_A	207_K	1.287	0.84
54_T	58_E	1.283	0.84
260_V	280_D	1.278	0.84
85_Q	110_N	1.268	0.83
204_A	208_A	1.261	0.83
112_H	184_K	1.254	0.83
215_E	275_K	1.252	0.83
5_Y	161_R	1.250	0.82
34_L	61_H	1.244	0.82
10_I	178_V	1.231	0.81
211_E	271_K	1.224	0.81
20_V	170_G	1.224	0.81
210_F	312_Q	1.221	0.81
259_F	304_I	1.213	0.80
123_D	156_V	1.201	0.80
214_T	312_Q	1.201	0.80
101_K	122_V	1.198	0.80
70_A	76_I	1.195	0.79
301_F	305_N	1.194	0.79
51_K	61_H	1.188	0.79
303_A	307_S	1.185	0.79
288_K	292_V	1.185	0.79
39_S	140_Y	1.185	0.79
215_E	271_K	1.184	0.79
42_D	62_K	1.176	0.78
290_W	294_N	1.167	0.78
136_V	146_V	1.160	0.77
102_S	157_T	1.154	0.77
125_F	160_A	1.152	0.77
285_T	289_E	1.151	0.77
265_V	277_V	1.148	0.77
253_T	286_F	1.146	0.76
65_S	68_E	1.137	0.76
159_E	162_D	1.137	0.76
115_Q	291_I	1.128	0.75
228_L	313_I	1.124	0.75
123_D	157_T	1.124	0.75
168_A	178_V	1.116	0.75
10_I	169_K	1.110	0.74
11_K	14_V	1.110	0.74
86_Q	90_E	1.097	0.73
30_H	249_S	1.092	0.73
211_E	311_H	1.088	0.73
208_A	212_T	1.078	0.72
185_E	222_L	1.071	0.71
110_N	116_I	1.070	0.71
273_S	280_D	1.065	0.71
250_I	258_D	1.061	0.71
97_L	122_V	1.060	0.71
196_A	209_G	1.059	0.71
23_I	80_L	1.050	0.70
280_D	285_T	1.040	0.69
292_V	303_A	1.039	0.69
66_V	70_A	1.035	0.69
96_E	101_K	1.032	0.69
12_E	169_K	1.027	0.68
291_I	296_V	1.027	0.68
240_E	245_G	1.025	0.68
268_A	272_E	1.025	0.68
265_V	270_V	1.024	0.68
121_D	154_Q	1.023	0.68
7_N	169_K	1.010	0.67
156_V	160_A	1.008	0.67
42_D	72_Q	1.002	0.66
47_V	52_S	1.000	0.66
306_A	309_N	0.997	0.66
67_K	96_E	0.994	0.66
304_I	308_E	0.992	0.65
109_F	115_Q	0.989	0.65
131_G	146_V	0.983	0.65
202_L	238_M	0.982	0.65
197_V	209_G	0.978	0.64
101_K	119_P	0.976	0.64
61_H	64_F	0.973	0.64
298_R	302_N	0.961	0.63
3_K	180_E	0.959	0.63
11_K	162_D	0.957	0.63
76_I	119_P	0.948	0.62
30_H	134_H	0.947	0.62
118_P	121_D	0.941	0.61
303_A	306_A	0.939	0.61
102_S	160_A	0.930	0.60
52_S	63_V	0.926	0.60
65_S	70_A	0.916	0.59
272_E	275_K	0.911	0.59
245_G	248_Y	0.911	0.59
268_A	271_K	0.896	0.57
322_E	325_P	0.889	0.57
204_A	263_P	0.888	0.57
44_I	76_I	0.882	0.56
260_V	304_I	0.881	0.56
244_A	309_N	0.881	0.56
14_V	166_A	0.879	0.56
290_W	301_F	0.878	0.56
127_V	168_A	0.872	0.55
22_V	167_Y	0.871	0.55
74_E	101_K	0.869	0.55
55_Q	59_D	0.869	0.55
131_G	148_A	0.868	0.55
104_V	167_Y	0.860	0.54
298_R	301_F	0.860	0.54
23_I	66_V	0.858	0.54
111_V	126_L	0.845	0.53
34_L	59_D	0.842	0.53
114_H	117_V	0.842	0.53
48_R	53_F	0.841	0.53
97_L	119_P	0.837	0.52
212_T	271_K	0.835	0.52
135_L	239_Y	0.834	0.52
22_V	33_A	0.833	0.52
22_V	36_L	0.833	0.52
252_D	290_W	0.829	0.52
196_A	265_V	0.826	0.51
247_R	308_E	0.825	0.51
23_I	70_A	0.825	0.51
86_Q	295_Q	0.821	0.51
15_L	170_G	0.820	0.51
41_V	170_G	0.818	0.51
47_V	63_V	0.816	0.51
84_Q	88_V	0.816	0.51
85_Q	116_I	0.815	0.50
144_A	326_F	0.813	0.50
161_R	165_L	0.809	0.50
277_V	280_D	0.809	0.50
37_K	51_K	0.809	0.50
144_A	327_V	0.801	0.49
109_F	187_T	0.797	0.49
46_G	52_S	0.794	0.49
265_V	273_S	0.794	0.49
324_M	327_V	0.785	0.48
300_R	304_I	0.785	0.48
300_R	303_A	0.785	0.48
21_A	44_I	0.785	0.48
89_Y	103_L	0.781	0.47
125_F	150_F	0.780	0.47
292_V	307_S	0.779	0.47
3_K	8_G	0.777	0.47
64_F	68_E	0.776	0.47
244_A	314_E	0.776	0.47
139_T	239_Y	0.773	0.47
269_K	273_S	0.769	0.46
228_L	243_L	0.766	0.46
37_K	59_D	0.762	0.46
261_S	273_S	0.761	0.46
55_Q	58_E	0.759	0.46
78_V	88_V	0.758	0.45
115_Q	292_V	0.758	0.45
204_A	247_R	0.757	0.45
148_A	178_V	0.756	0.45
75_I	125_F	0.752	0.45
280_D	289_E	0.752	0.45
101_K	121_D	0.752	0.45
148_A	171_I	0.751	0.45
85_Q	105_F	0.744	0.44
74_E	98_T	0.736	0.44
52_S	55_Q	0.728	0.43
320_L	324_M	0.728	0.43
206_V	235_V	0.726	0.43
163_K	166_A	0.723	0.42
256_W	289_E	0.715	0.42
238_M	243_L	0.714	0.42
266_V	270_V	0.712	0.41
99_A	156_V	0.712	0.41
6_Y	323_M	0.711	0.41
27_S	134_H	0.705	0.41
138_R	141_E	0.702	0.41
150_F	164_A	0.701	0.41
14_V	163_K	0.701	0.41
56_A	61_H	0.701	0.41
243_L	308_E	0.699	0.40
292_V	300_R	0.699	0.40
43_V	46_G	0.698	0.40
216_A	278_L	0.698	0.40
34_L	52_S	0.698	0.40
71_A	98_T	0.696	0.40
68_E	72_Q	0.694	0.40
47_V	53_F	0.694	0.40
131_G	138_R	0.693	0.40
259_F	289_E	0.693	0.40
75_I	166_A	0.692	0.40
292_V	306_A	0.686	0.39
80_L	84_Q	0.684	0.39
231_L	238_M	0.683	0.39
126_L	148_A	0.682	0.39
309_N	312_Q	0.681	0.39
115_Q	294_N	0.679	0.39
36_L	167_Y	0.679	0.39
276_E	279_K	0.675	0.38
17_G	166_A	0.675	0.38
315_V	318_R	0.673	0.38
5_Y	180_E	0.673	0.38
109_F	291_I	0.672	0.38
124_V	154_Q	0.672	0.38
169_K	178_V	0.672	0.38
280_D	283_N	0.672	0.38
134_H	248_Y	0.672	0.38
86_Q	291_I	0.669	0.38
201_G	205_L	0.668	0.38
12_E	41_V	0.668	0.38
53_F	63_V	0.664	0.37
113_F	187_T	0.663	0.37
276_E	285_T	0.663	0.37
114_H	153_Y	0.660	0.37
256_W	326_F	0.659	0.37
56_A	63_V	0.659	0.37
51_K	63_V	0.658	0.37
144_A	239_Y	0.658	0.37
149_L	180_E	0.658	0.37
131_G	135_L	0.657	0.37
155_D	158_G	0.653	0.37
30_H	59_D	0.647	0.36
48_R	84_Q	0.644	0.36
196_A	277_V	0.642	0.36
277_V	289_E	0.641	0.36
70_A	78_V	0.639	0.35
112_H	153_Y	0.638	0.35
179_L	219_Q	0.638	0.35
161_R	164_A	0.637	0.35
104_V	163_K	0.636	0.35
139_T	325_P	0.636	0.35
23_I	93_I	0.633	0.35
301_F	304_I	0.630	0.35
76_I	122_V	0.629	0.35
18_K	163_K	0.628	0.35
179_L	326_F	0.628	0.35
187_T	287_A	0.627	0.34
192_F	278_L	0.626	0.34
48_R	66_V	0.625	0.34
138_R	245_G	0.624	0.34
204_A	258_D	0.624	0.34
305_N	309_N	0.623	0.34
32_H	104_V	0.620	0.34
99_A	122_V	0.620	0.34
52_S	56_A	0.618	0.34
83_E	327_V	0.615	0.34
83_E	250_I	0.614	0.33
247_R	250_I	0.613	0.33
77_M	167_Y	0.612	0.33
83_E	255_Q	0.611	0.33
317_G	321_R	0.608	0.33
94_K	119_P	0.607	0.33
21_A	46_G	0.605	0.33
289_E	292_V	0.605	0.33
305_N	308_E	0.604	0.33
7_N	12_E	0.604	0.33
135_L	139_T	0.603	0.33
8_G	169_K	0.602	0.33
319_K	322_E	0.602	0.33
244_A	318_R	0.601	0.32
30_H	34_L	0.599	0.32
68_E	71_A	0.599	0.32
144_A	325_P	0.599	0.32
34_L	38_E	0.598	0.32
243_L	313_I	0.598	0.32
117_V	302_N	0.597	0.32
292_V	299_P	0.597	0.32
131_G	175_R	0.597	0.32
204_A	281_I	0.596	0.32
72_Q	166_A	0.595	0.32
177_G	225_F	0.595	0.32
123_D	163_K	0.593	0.32
150_F	222_L	0.593	0.32
260_V	273_S	0.593	0.32
184_K	222_L	0.591	0.32
285_T	288_K	0.590	0.32
99_A	119_P	0.589	0.32
289_E	304_I	0.589	0.32
188_E	282_Q	0.587	0.31
10_I	14_V	0.586	0.31
21_A	76_I	0.585	0.31
135_L	327_V	0.585	0.31
307_S	310_E	0.584	0.31
252_D	305_N	0.582	0.31
64_F	69_A	0.580	0.31
216_A	282_Q	0.579	0.31
138_R	142_Q	0.577	0.31
17_G	42_D	0.577	0.31
98_T	122_V	0.576	0.31
7_N	38_E	0.576	0.31
310_E	315_V	0.571	0.30
37_K	64_F	0.570	0.30
288_K	300_R	0.570	0.30
163_K	288_K	0.569	0.30
15_L	72_Q	0.568	0.30
304_I	307_S	0.568	0.30
65_S	92_E	0.568	0.30
66_V	80_L	0.567	0.30
299_P	302_N	0.567	0.30
48_R	51_K	0.566	0.30
256_W	261_S	0.565	0.30
204_A	211_E	0.565	0.30
34_L	37_K	0.565	0.30
18_K	74_E	0.563	0.30
116_I	253_T	0.562	0.30
232_K	236_D	0.562	0.30
45_V	64_F	0.561	0.29
34_L	55_Q	0.560	0.29
33_A	291_I	0.560	0.29
139_T	173_G	0.560	0.29
207_K	243_L	0.560	0.29
102_S	159_E	0.559	0.29
318_R	322_E	0.558	0.29
188_E	218_Y	0.556	0.29
322_E	328_K	0.556	0.29
210_F	215_E	0.555	0.29
115_Q	297_N	0.554	0.29
46_G	76_I	0.554	0.29
268_A	275_K	0.553	0.29
261_S	276_E	0.552	0.29
21_A	73_A	0.552	0.29
211_E	263_P	0.550	0.29
125_F	164_A	0.550	0.29
264_R	276_E	0.549	0.29
22_V	106_A	0.548	0.29
199_C	250_I	0.546	0.28
125_F	163_K	0.546	0.28
30_H	248_Y	0.545	0.28
285_T	300_R	0.543	0.28
277_V	285_T	0.542	0.28
106_A	231_L	0.541	0.28
37_K	42_D	0.541	0.28
12_E	37_K	0.541	0.28
4_V	219_Q	0.541	0.28
8_G	16_A	0.540	0.28
113_F	283_N	0.539	0.28
136_V	173_G	0.538	0.28
135_L	324_M	0.537	0.28
141_E	144_A	0.537	0.28
131_G	250_I	0.537	0.28
196_A	231_L	0.536	0.28
115_Q	295_Q	0.536	0.28
210_F	219_Q	0.534	0.28
80_L	92_E	0.534	0.28
4_V	23_I	0.534	0.28
260_V	265_V	0.533	0.27
72_Q	101_K	0.531	0.27
260_V	277_V	0.531	0.27
113_F	253_T	0.529	0.27
252_D	255_Q	0.529	0.27
211_E	214_T	0.528	0.27
165_L	178_V	0.527	0.27
243_L	259_F	0.525	0.27
37_K	49_Q	0.524	0.27
250_I	254_A	0.523	0.27
66_V	88_V	0.522	0.27
315_V	322_E	0.521	0.27
258_D	308_E	0.521	0.27
4_V	222_L	0.520	0.27
4_V	139_T	0.519	0.26
47_V	57_Q	0.518	0.26
38_E	141_E	0.518	0.26
283_N	288_K	0.518	0.26
25_Y	58_E	0.518	0.26
78_V	85_Q	0.517	0.26
230_E	257_G	0.517	0.26
157_T	160_A	0.517	0.26
261_S	304_I	0.516	0.26
252_D	301_F	0.516	0.26
30_H	33_A	0.516	0.26
81_P	88_V	0.516	0.26
115_Q	287_A	0.515	0.26
61_H	72_Q	0.515	0.26
115_Q	293_E	0.514	0.26
275_K	279_K	0.513	0.26
41_V	166_A	0.513	0.26
53_F	66_V	0.513	0.26
261_S	264_R	0.512	0.26
139_T	290_W	0.510	0.26
117_V	162_D	0.510	0.26
114_H	292_V	0.506	0.26
44_I	73_A	0.506	0.26
71_A	265_V	0.505	0.26
55_Q	248_Y	0.505	0.26
126_L	151_A	0.504	0.25
22_V	171_I	0.503	0.25
117_V	120_A	0.502	0.25
44_I	166_A	0.502	0.25
323_M	328_K	0.501	0.25
92_E	95_D	0.501	0.25
267_D	272_E	0.500	0.25

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ulkA	3	0.9444	100	0.494	Contact Map
4xdyA	2	0.9503	100	0.508	Contact Map
4xdzA	2	0.9591	100	0.508	Contact Map
4tskA	3	0.9737	100	0.521	Contact Map
1np3A	4	0.9532	100	0.585	Contact Map
3fr7A	2	0.9678	100	0.586	Contact Map
4kqwA	2	0.9503	100	0.602	Contact Map
4yt2A	2	0.8918	99.9	0.834	Contact Map
3ggoA	2	0.7719	99.7	0.879	Contact Map
3c24A	2	0.7632	99.4	0.898	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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