GREMLIN Database
ILVC - Ketol-acid reductoisomerase
UniProt: P37253 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 342 (326)
Sequences: 1931 (661)
Seq/√Len: 36.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_V41_V4.6191.00
98_T101_K4.1621.00
148_A173_G3.9611.00
206_V238_M3.2081.00
19_T42_D2.9851.00
99_A121_D2.9121.00
247_R258_D2.8901.00
80_L88_V2.8591.00
102_S125_F2.8491.00
150_F161_R2.7761.00
32_H106_A2.7731.00
174_A178_V2.6791.00
306_A310_E2.5671.00
119_P122_V2.5511.00
206_V231_L2.5331.00
255_Q305_N2.5011.00
202_L231_L2.4781.00
185_E219_Q2.4601.00
139_T142_Q2.4361.00
54_T57_Q2.4161.00
87_K91_A2.3891.00
90_E94_K2.3561.00
273_S276_E2.3040.99
83_E252_D2.2320.99
267_D270_V2.2050.99
138_R240_E2.1780.99
10_I174_A2.1730.99
241_E245_G2.1490.99
261_S277_V2.0940.99
37_K61_H2.0740.99
264_R280_D2.0420.99
78_V93_I2.0180.99
104_V125_F2.0030.99
87_K295_Q1.9930.98
270_V273_S1.9900.98
207_K308_E1.9270.98
45_V61_H1.9240.98
102_S163_K1.9200.98
169_K174_A1.9080.98
49_Q65_S1.9030.98
53_F57_Q1.8890.98
102_S123_D1.8800.98
261_S280_D1.8700.98
261_S289_E1.8390.97
155_D162_D1.8120.97
36_L170_G1.8100.97
296_V299_P1.7980.97
15_L166_A1.7760.97
25_Y59_D1.7720.97
66_V92_E1.7580.97
267_D273_S1.7460.96
67_K92_E1.7370.96
123_D160_A1.7040.96
161_R180_E1.6800.95
13_N16_A1.6430.95
23_I78_V1.6390.95
219_Q222_L1.6260.95
64_F72_Q1.6250.95
269_K272_E1.6200.94
77_M106_A1.6150.94
21_A69_A1.6150.94
131_G173_G1.5990.94
294_N298_R1.5990.94
109_F287_A1.5980.94
206_V228_L1.5910.94
76_I101_K1.5770.94
32_H77_M1.5460.93
62_K72_Q1.5330.93
135_L138_R1.5300.93
57_Q62_K1.5210.92
44_I72_Q1.5210.92
53_F65_S1.5150.92
44_I64_F1.5060.92
121_D156_V1.4980.92
47_V51_K1.4940.92
123_D159_E1.4750.91
23_I46_G1.4750.91
203_S258_D1.4680.91
7_N174_A1.4560.91
289_E300_R1.4520.90
202_L206_V1.4420.90
77_M104_V1.4390.90
315_V319_K1.4260.90
179_L222_L1.4210.90
279_K283_N1.4170.89
19_T44_I1.4140.89
203_S243_L1.4110.89
139_T144_A1.4060.89
292_V295_Q1.4010.89
49_Q53_F1.3930.89
260_V289_E1.3820.88
70_A101_K1.3800.88
252_D298_R1.3740.88
261_S265_V1.3570.87
292_V296_V1.3460.87
264_R273_S1.3440.87
255_Q259_F1.3420.87
204_A271_K1.3350.86
259_F305_N1.3290.86
19_T72_Q1.3290.86
290_W293_E1.3270.86
276_E280_D1.3200.86
290_W298_R1.3180.86
134_H249_S1.3170.86
70_A96_E1.3040.85
228_L238_M1.3010.85
71_A96_E1.3000.85
203_S247_R1.2940.85
206_V313_I1.2910.84
204_A207_K1.2870.84
54_T58_E1.2830.84
260_V280_D1.2780.84
85_Q110_N1.2680.83
204_A208_A1.2610.83
112_H184_K1.2540.83
215_E275_K1.2520.83
5_Y161_R1.2500.82
34_L61_H1.2440.82
10_I178_V1.2310.81
211_E271_K1.2240.81
20_V170_G1.2240.81
210_F312_Q1.2210.81
259_F304_I1.2130.80
123_D156_V1.2010.80
214_T312_Q1.2010.80
101_K122_V1.1980.80
70_A76_I1.1950.79
301_F305_N1.1940.79
51_K61_H1.1880.79
303_A307_S1.1850.79
288_K292_V1.1850.79
39_S140_Y1.1850.79
215_E271_K1.1840.79
42_D62_K1.1760.78
290_W294_N1.1670.78
136_V146_V1.1600.77
102_S157_T1.1540.77
125_F160_A1.1520.77
285_T289_E1.1510.77
265_V277_V1.1480.77
253_T286_F1.1460.76
65_S68_E1.1370.76
159_E162_D1.1370.76
115_Q291_I1.1280.75
228_L313_I1.1240.75
123_D157_T1.1240.75
168_A178_V1.1160.75
10_I169_K1.1100.74
11_K14_V1.1100.74
86_Q90_E1.0970.73
30_H249_S1.0920.73
211_E311_H1.0880.73
208_A212_T1.0780.72
185_E222_L1.0710.71
110_N116_I1.0700.71
273_S280_D1.0650.71
250_I258_D1.0610.71
97_L122_V1.0600.71
196_A209_G1.0590.71
23_I80_L1.0500.70
280_D285_T1.0400.69
292_V303_A1.0390.69
66_V70_A1.0350.69
96_E101_K1.0320.69
12_E169_K1.0270.68
291_I296_V1.0270.68
240_E245_G1.0250.68
268_A272_E1.0250.68
265_V270_V1.0240.68
121_D154_Q1.0230.68
7_N169_K1.0100.67
156_V160_A1.0080.67
42_D72_Q1.0020.66
47_V52_S1.0000.66
306_A309_N0.9970.66
67_K96_E0.9940.66
304_I308_E0.9920.65
109_F115_Q0.9890.65
131_G146_V0.9830.65
202_L238_M0.9820.65
197_V209_G0.9780.64
101_K119_P0.9760.64
61_H64_F0.9730.64
298_R302_N0.9610.63
3_K180_E0.9590.63
11_K162_D0.9570.63
76_I119_P0.9480.62
30_H134_H0.9470.62
118_P121_D0.9410.61
303_A306_A0.9390.61
102_S160_A0.9300.60
52_S63_V0.9260.60
65_S70_A0.9160.59
272_E275_K0.9110.59
245_G248_Y0.9110.59
268_A271_K0.8960.57
322_E325_P0.8890.57
204_A263_P0.8880.57
44_I76_I0.8820.56
260_V304_I0.8810.56
244_A309_N0.8810.56
14_V166_A0.8790.56
290_W301_F0.8780.56
127_V168_A0.8720.55
22_V167_Y0.8710.55
74_E101_K0.8690.55
55_Q59_D0.8690.55
131_G148_A0.8680.55
104_V167_Y0.8600.54
298_R301_F0.8600.54
23_I66_V0.8580.54
111_V126_L0.8450.53
34_L59_D0.8420.53
114_H117_V0.8420.53
48_R53_F0.8410.53
97_L119_P0.8370.52
212_T271_K0.8350.52
135_L239_Y0.8340.52
22_V33_A0.8330.52
22_V36_L0.8330.52
252_D290_W0.8290.52
196_A265_V0.8260.51
247_R308_E0.8250.51
23_I70_A0.8250.51
86_Q295_Q0.8210.51
15_L170_G0.8200.51
41_V170_G0.8180.51
47_V63_V0.8160.51
84_Q88_V0.8160.51
85_Q116_I0.8150.50
144_A326_F0.8130.50
161_R165_L0.8090.50
277_V280_D0.8090.50
37_K51_K0.8090.50
144_A327_V0.8010.49
109_F187_T0.7970.49
46_G52_S0.7940.49
265_V273_S0.7940.49
324_M327_V0.7850.48
300_R304_I0.7850.48
300_R303_A0.7850.48
21_A44_I0.7850.48
89_Y103_L0.7810.47
125_F150_F0.7800.47
292_V307_S0.7790.47
3_K8_G0.7770.47
64_F68_E0.7760.47
244_A314_E0.7760.47
139_T239_Y0.7730.47
269_K273_S0.7690.46
228_L243_L0.7660.46
37_K59_D0.7620.46
261_S273_S0.7610.46
55_Q58_E0.7590.46
78_V88_V0.7580.45
115_Q292_V0.7580.45
204_A247_R0.7570.45
148_A178_V0.7560.45
75_I125_F0.7520.45
280_D289_E0.7520.45
101_K121_D0.7520.45
148_A171_I0.7510.45
85_Q105_F0.7440.44
74_E98_T0.7360.44
52_S55_Q0.7280.43
320_L324_M0.7280.43
206_V235_V0.7260.43
163_K166_A0.7230.42
256_W289_E0.7150.42
238_M243_L0.7140.42
266_V270_V0.7120.41
99_A156_V0.7120.41
6_Y323_M0.7110.41
27_S134_H0.7050.41
138_R141_E0.7020.41
150_F164_A0.7010.41
14_V163_K0.7010.41
56_A61_H0.7010.41
243_L308_E0.6990.40
292_V300_R0.6990.40
43_V46_G0.6980.40
216_A278_L0.6980.40
34_L52_S0.6980.40
71_A98_T0.6960.40
68_E72_Q0.6940.40
47_V53_F0.6940.40
131_G138_R0.6930.40
259_F289_E0.6930.40
75_I166_A0.6920.40
292_V306_A0.6860.39
80_L84_Q0.6840.39
231_L238_M0.6830.39
126_L148_A0.6820.39
309_N312_Q0.6810.39
115_Q294_N0.6790.39
36_L167_Y0.6790.39
276_E279_K0.6750.38
17_G166_A0.6750.38
315_V318_R0.6730.38
5_Y180_E0.6730.38
109_F291_I0.6720.38
124_V154_Q0.6720.38
169_K178_V0.6720.38
280_D283_N0.6720.38
134_H248_Y0.6720.38
86_Q291_I0.6690.38
201_G205_L0.6680.38
12_E41_V0.6680.38
53_F63_V0.6640.37
113_F187_T0.6630.37
276_E285_T0.6630.37
114_H153_Y0.6600.37
256_W326_F0.6590.37
56_A63_V0.6590.37
51_K63_V0.6580.37
144_A239_Y0.6580.37
149_L180_E0.6580.37
131_G135_L0.6570.37
155_D158_G0.6530.37
30_H59_D0.6470.36
48_R84_Q0.6440.36
196_A277_V0.6420.36
277_V289_E0.6410.36
70_A78_V0.6390.35
112_H153_Y0.6380.35
179_L219_Q0.6380.35
161_R164_A0.6370.35
104_V163_K0.6360.35
139_T325_P0.6360.35
23_I93_I0.6330.35
301_F304_I0.6300.35
76_I122_V0.6290.35
18_K163_K0.6280.35
179_L326_F0.6280.35
187_T287_A0.6270.34
192_F278_L0.6260.34
48_R66_V0.6250.34
138_R245_G0.6240.34
204_A258_D0.6240.34
305_N309_N0.6230.34
32_H104_V0.6200.34
99_A122_V0.6200.34
52_S56_A0.6180.34
83_E327_V0.6150.34
83_E250_I0.6140.33
247_R250_I0.6130.33
77_M167_Y0.6120.33
83_E255_Q0.6110.33
317_G321_R0.6080.33
94_K119_P0.6070.33
21_A46_G0.6050.33
289_E292_V0.6050.33
305_N308_E0.6040.33
7_N12_E0.6040.33
135_L139_T0.6030.33
8_G169_K0.6020.33
319_K322_E0.6020.33
244_A318_R0.6010.32
30_H34_L0.5990.32
68_E71_A0.5990.32
144_A325_P0.5990.32
34_L38_E0.5980.32
243_L313_I0.5980.32
117_V302_N0.5970.32
292_V299_P0.5970.32
131_G175_R0.5970.32
204_A281_I0.5960.32
72_Q166_A0.5950.32
177_G225_F0.5950.32
123_D163_K0.5930.32
150_F222_L0.5930.32
260_V273_S0.5930.32
184_K222_L0.5910.32
285_T288_K0.5900.32
99_A119_P0.5890.32
289_E304_I0.5890.32
188_E282_Q0.5870.31
10_I14_V0.5860.31
21_A76_I0.5850.31
135_L327_V0.5850.31
307_S310_E0.5840.31
252_D305_N0.5820.31
64_F69_A0.5800.31
216_A282_Q0.5790.31
138_R142_Q0.5770.31
17_G42_D0.5770.31
98_T122_V0.5760.31
7_N38_E0.5760.31
310_E315_V0.5710.30
37_K64_F0.5700.30
288_K300_R0.5700.30
163_K288_K0.5690.30
15_L72_Q0.5680.30
304_I307_S0.5680.30
65_S92_E0.5680.30
66_V80_L0.5670.30
299_P302_N0.5670.30
48_R51_K0.5660.30
256_W261_S0.5650.30
204_A211_E0.5650.30
34_L37_K0.5650.30
18_K74_E0.5630.30
116_I253_T0.5620.30
232_K236_D0.5620.30
45_V64_F0.5610.29
34_L55_Q0.5600.29
33_A291_I0.5600.29
139_T173_G0.5600.29
207_K243_L0.5600.29
102_S159_E0.5590.29
318_R322_E0.5580.29
188_E218_Y0.5560.29
322_E328_K0.5560.29
210_F215_E0.5550.29
115_Q297_N0.5540.29
46_G76_I0.5540.29
268_A275_K0.5530.29
261_S276_E0.5520.29
21_A73_A0.5520.29
211_E263_P0.5500.29
125_F164_A0.5500.29
264_R276_E0.5490.29
22_V106_A0.5480.29
199_C250_I0.5460.28
125_F163_K0.5460.28
30_H248_Y0.5450.28
285_T300_R0.5430.28
277_V285_T0.5420.28
106_A231_L0.5410.28
37_K42_D0.5410.28
12_E37_K0.5410.28
4_V219_Q0.5410.28
8_G16_A0.5400.28
113_F283_N0.5390.28
136_V173_G0.5380.28
135_L324_M0.5370.28
141_E144_A0.5370.28
131_G250_I0.5370.28
196_A231_L0.5360.28
115_Q295_Q0.5360.28
210_F219_Q0.5340.28
80_L92_E0.5340.28
4_V23_I0.5340.28
260_V265_V0.5330.27
72_Q101_K0.5310.27
260_V277_V0.5310.27
113_F253_T0.5290.27
252_D255_Q0.5290.27
211_E214_T0.5280.27
165_L178_V0.5270.27
243_L259_F0.5250.27
37_K49_Q0.5240.27
250_I254_A0.5230.27
66_V88_V0.5220.27
315_V322_E0.5210.27
258_D308_E0.5210.27
4_V222_L0.5200.27
4_V139_T0.5190.26
47_V57_Q0.5180.26
38_E141_E0.5180.26
283_N288_K0.5180.26
25_Y58_E0.5180.26
78_V85_Q0.5170.26
230_E257_G0.5170.26
157_T160_A0.5170.26
261_S304_I0.5160.26
252_D301_F0.5160.26
30_H33_A0.5160.26
81_P88_V0.5160.26
115_Q287_A0.5150.26
61_H72_Q0.5150.26
115_Q293_E0.5140.26
275_K279_K0.5130.26
41_V166_A0.5130.26
53_F66_V0.5130.26
261_S264_R0.5120.26
139_T290_W0.5100.26
117_V162_D0.5100.26
114_H292_V0.5060.26
44_I73_A0.5060.26
71_A265_V0.5050.26
55_Q248_Y0.5050.26
126_L151_A0.5040.25
22_V171_I0.5030.25
117_V120_A0.5020.25
44_I166_A0.5020.25
323_M328_K0.5010.25
92_E95_D0.5010.25
267_D272_E0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ulkA 3 0.9444 100 0.494 Contact Map
4xdyA 2 0.9503 100 0.508 Contact Map
4xdzA 2 0.9591 100 0.508 Contact Map
4tskA 3 0.9737 100 0.521 Contact Map
1np3A 4 0.9532 100 0.585 Contact Map
3fr7A 2 0.9678 100 0.586 Contact Map
4kqwA 2 0.9503 100 0.602 Contact Map
4yt2A 2 0.8918 99.9 0.834 Contact Map
3ggoA 2 0.7719 99.7 0.879 Contact Map
3c24A 2 0.7632 99.4 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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