GREMLIN Database
ILVH - Acetolactate synthase small subunit
UniProt: P37252 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (158)
Sequences: 2382 (1218)
Seq/√Len: 96.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_V44_S3.8291.00
112_S124_Q3.8191.00
106_I123_V3.4491.00
135_L139_L3.2491.00
11_N42_G3.2211.00
88_A132_I2.7331.00
125_V135_L2.5351.00
90_I136_I2.4251.00
31_E51_H2.4171.00
110_R131_K2.2161.00
103_N113_V2.1471.00
59_E63_K2.1061.00
43_V72_L2.1001.00
92_V139_L2.0641.00
33_I44_S2.0541.00
148_A155_F1.9631.00
16_L35_V1.9191.00
88_A125_V1.9101.00
9_V15_V1.9011.00
11_N44_S1.8851.00
16_L33_I1.8781.00
86_E149_R1.8531.00
104_G107_E1.8281.00
10_V70_D1.7751.00
110_R134_A1.7431.00
100_T104_G1.7131.00
34_T153_T1.7091.00
52_V57_D1.7061.00
93_V145_K1.6691.00
20_T46_I1.6291.00
137_E140_K1.6081.00
10_V72_L1.5991.00
87_L150_T1.5961.00
90_I135_L1.5421.00
131_K134_A1.5231.00
11_N37_H1.5031.00
12_R70_D1.4451.00
32_S49_V1.4331.00
108_P116_V1.4000.99
94_S102_I1.3980.99
3_R76_D1.3950.99
35_V46_I1.3800.99
87_L153_T1.3630.99
110_R127_G1.3280.99
64_Q67_K1.2900.99
18_R68_Q1.2880.99
95_A98_T1.2880.99
17_N24_T1.2800.99
91_K158_G1.2650.99
125_V132_I1.2440.99
106_I111_A1.2380.99
15_V46_I1.2360.99
110_R157_R1.2340.99
21_G26_R1.1990.98
103_N107_E1.1940.98
9_V46_I1.1880.98
150_T153_T1.1640.98
90_I139_L1.1610.98
120_S158_G1.1540.98
29_N35_V1.1500.98
9_V35_V1.1480.98
85_R124_Q1.1470.98
50_V61_L1.1420.98
25_K50_V1.1400.98
59_E73_K1.1370.98
17_N20_T1.1360.98
134_A157_R1.1350.98
34_T46_I1.1340.98
5_I13_S1.1240.97
19_I46_I1.1110.97
109_F134_A1.0980.97
26_R67_K1.0980.97
6_T155_F1.0770.97
129_S133_E1.0770.97
11_N40_T1.0710.97
88_A147_I1.0590.96
2_K84_Q1.0320.96
63_K66_N1.0280.96
66_N73_K1.0080.95
111_A135_L0.9920.95
101_E104_G0.9870.95
50_V142_Y0.9850.95
104_G121_I0.9680.94
2_K91_K0.9640.94
9_V19_I0.9560.94
98_T102_I0.9420.93
25_K67_K0.9390.93
113_V123_V0.9350.93
7_L48_F0.9260.93
127_G131_K0.9250.93
133_E137_E0.9220.92
5_I62_T0.9220.92
15_V20_T0.9180.92
77_I156_A0.9140.92
88_A144_I0.9130.92
28_Y60_Q0.9080.92
126_T153_T0.9050.92
108_P113_V0.9010.92
122_V155_F0.8990.91
85_R110_R0.8980.91
21_G24_T0.8910.91
105_I135_L0.8710.90
102_I142_Y0.8650.90
22_L28_Y0.8620.90
30_I150_T0.8550.89
110_R126_T0.8470.89
60_Q64_Q0.8400.88
115_D120_S0.8360.88
103_N108_P0.8310.88
39_E45_R0.8120.87
11_N38_T0.8110.87
89_L127_G0.8100.87
16_L30_I0.8080.86
85_R89_L0.8070.86
115_D158_G0.8040.86
118_R137_E0.7950.86
133_E149_R0.7920.85
6_T77_I0.7860.85
103_N138_L0.7850.85
109_F131_K0.7780.84
75_T156_A0.7780.84
2_K31_E0.7750.84
131_K157_R0.7660.83
59_E75_T0.7600.83
7_L65_L0.7580.83
143_G154_A0.7570.83
13_S34_T0.7480.82
117_S120_S0.7460.82
107_E131_K0.7420.81
140_K143_G0.7400.81
62_T66_N0.7390.81
16_L46_I0.7390.81
30_I35_V0.7370.81
17_N21_G0.7290.80
37_H41_A0.7280.80
129_S152_T0.7250.80
39_E148_A0.7240.80
94_S121_I0.7230.80
93_V143_G0.7050.78
62_T145_K0.7040.78
105_I138_L0.7030.78
115_D157_R0.6990.77
119_D159_T0.6970.77
15_V44_S0.6920.77
30_I33_I0.6900.76
112_S138_L0.6860.76
77_I122_V0.6820.76
28_Y61_L0.6810.76
24_T34_T0.6740.75
45_R148_A0.6730.75
31_E37_H0.6720.75
18_R44_S0.6710.74
99_R131_K0.6700.74
54_G57_D0.6680.74
4_I14_G0.6660.74
127_G134_A0.6660.74
115_D131_K0.6650.74
78_T81_S0.6640.74
52_V149_R0.6590.73
101_E105_I0.6580.73
94_S116_V0.6550.73
4_I84_Q0.6510.72
107_E133_E0.6490.72
52_V58_V0.6470.72
14_G23_F0.6450.72
22_L60_Q0.6410.71
10_V155_F0.6400.71
5_I58_V0.6390.71
17_N58_V0.6380.71
7_L28_Y0.6320.70
23_F50_V0.6320.70
38_T41_A0.6310.70
126_T131_K0.6270.69
133_E136_I0.6260.69
91_K122_V0.6250.69
32_S148_A0.6220.69
19_I68_Q0.6190.68
36_G133_E0.6190.68
91_K146_E0.6110.67
4_I152_T0.6090.67
5_I72_L0.6060.67
111_A123_V0.6050.67
79_N93_V0.6040.67
94_S118_R0.6030.66
92_V143_G0.5990.66
21_G30_I0.5970.66
114_V127_G0.5910.65
83_V122_V0.5910.65
84_Q152_T0.5900.65
25_K121_I0.5890.65
16_L44_S0.5870.64
11_N31_E0.5870.64
36_G148_A0.5860.64
28_Y40_T0.5840.64
14_G21_G0.5840.64
29_N44_S0.5780.63
90_I147_I0.5730.62
73_K145_K0.5710.62
81_S130_N0.5710.62
105_I120_S0.5690.62
121_I142_Y0.5670.62
100_T121_I0.5600.61
109_F138_L0.5580.60
63_K73_K0.5580.60
15_V25_K0.5570.60
19_I65_L0.5570.60
37_H122_V0.5550.60
38_T43_V0.5530.60
74_V141_P0.5530.60
142_Y145_K0.5510.59
5_I18_R0.5490.59
128_E137_E0.5420.58
36_G121_I0.5420.58
40_T82_I0.5380.58
47_T67_K0.5380.58
30_I114_V0.5380.58
102_I139_L0.5380.58
22_L147_I0.5340.57
85_R109_F0.5340.57
69_I75_T0.5310.57
39_E73_K0.5280.56
27_H52_V0.5260.56
62_T76_D0.5250.56
56_N155_F0.5230.56
52_V56_N0.5210.55
84_Q130_N0.5200.55
80_Q130_N0.5160.55
26_R123_V0.5130.54
86_E129_S0.5110.54
38_T42_G0.5090.54
37_H61_L0.5090.54
50_V58_V0.5060.53
59_E66_N0.5060.53
17_N25_K0.5060.53
5_I50_V0.5030.53
13_S106_I0.5010.52
11_N70_D0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f1fA 4 0.9419 100 0.237 Contact Map
2pc6A 2 0.9477 100 0.239 Contact Map
2fgcA 2 0.9186 100 0.249 Contact Map
2lvwA 2 0.5233 99.2 0.782 Contact Map
1y7pA 5 0.814 98.7 0.821 Contact Map
1zpvA 3 0.5 98.5 0.833 Contact Map
2ko1A 2 0.4942 98.5 0.833 Contact Map
2f06A 4 0.7791 98.4 0.836 Contact Map
1u8sA 2 0.4767 98.3 0.841 Contact Map
2nyiA 2 0.4651 97.9 0.858 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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