GREMLIN Database
SRP54 - Signal recognition particle protein
UniProt: P37105 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 446 (434)
Sequences: 2872 (1350)
Seq/√Len: 64.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_G160_V5.0771.00
106_M118_S4.1121.00
316_K336_E4.0331.00
207_T240_Q3.9041.00
235_K239_E3.7801.00
332_D389_E3.6851.00
147_K150_E3.6501.00
339_G377_E3.5111.00
179_K183_E3.3101.00
197_H229_D3.3061.00
29_K57_S3.2241.00
204_D208_N3.0841.00
238_N269_T3.0201.00
163_L175_Q2.9731.00
119_G280_L2.9301.00
400_K404_K2.8911.00
342_R377_E2.8671.00
277_G282_A2.7231.00
118_S189_I2.6591.00
335_L381_K2.6531.00
178_E182_E2.6481.00
190_L213_A2.5761.00
51_D265_A2.5191.00
119_G152_L2.4651.00
409_S412_E2.4271.00
159_P185_Y2.4211.00
394_I417_L2.4121.00
69_L305_I2.3651.00
52_F56_V2.3331.00
173_A213_A2.3311.00
136_V176_A2.3221.00
161_F175_Q2.3201.00
82_E85_E2.3121.00
118_S135_L2.2911.00
171_E175_Q2.2891.00
334_F420_F2.2521.00
168_S208_N2.2361.00
150_E154_K2.2281.00
168_S171_E2.2001.00
386_L393_I2.1951.00
316_K319_E2.1941.00
403_A413_V2.1471.00
123_N127_K2.1441.00
135_L153_G2.0821.00
321_E325_R2.0661.00
170_V212_I2.0311.00
85_E89_G2.0281.00
138_A173_A2.0271.00
314_E318_K2.0181.00
302_L305_I2.0181.00
126_R157_D2.0121.00
331_L417_L2.0021.00
379_I413_V1.9941.00
125_L187_Y1.9621.00
77_K81_E1.8971.00
217_E272_K1.8721.00
126_R158_M1.8671.00
59_R82_E1.8611.00
122_A158_M1.8481.00
219_F247_V1.8341.00
131_R187_Y1.8121.00
394_I402_I1.8081.00
377_E381_K1.8031.00
59_R81_E1.8001.00
251_L274_A1.7871.00
20_K27_D1.7661.00
94_I125_L1.7531.00
134_M179_K1.7431.00
67_K315_D1.7421.00
135_L189_I1.7351.00
132_K185_Y1.7270.99
375_H412_E1.7220.99
243_L269_T1.7060.99
170_V208_N1.6980.99
54_K58_E1.6950.99
51_D55_K1.6950.99
204_D207_T1.6470.99
55_K85_E1.6450.99
80_Q84_T1.6370.99
318_K321_E1.6350.99
218_I241_L1.6300.99
140_I172_I1.6170.99
150_E162_S1.6130.99
251_L291_M1.6120.99
375_H408_T1.6070.99
91_E285_P1.6030.99
177_I188_V1.5880.99
420_F424_K1.5810.99
371_K374_N1.5780.99
210_K242_G1.5660.99
219_F245_G1.5570.99
59_R85_E1.5540.99
386_L390_Q1.5530.99
136_V188_V1.5510.99
133_P185_Y1.5420.99
96_V187_Y1.5400.99
332_D385_V1.5290.99
98_K102_T1.5190.99
330_T389_E1.4990.99
152_L156_L1.4790.98
28_V61_V1.4790.98
141_Y172_I1.4650.98
140_I169_P1.4590.98
54_K57_S1.4570.98
315_D319_E1.4470.98
210_K218_I1.4410.98
121_L247_V1.4400.98
123_N281_D1.4400.98
124_L129_H1.4390.98
103_V190_L1.4300.98
209_V213_A1.4290.98
156_L280_L1.4140.98
408_T412_E1.4120.98
290_R306_E1.4090.98
127_K310_A1.4050.98
124_L273_F1.4010.98
80_Q293_S1.3990.98
154_K157_D1.3920.98
17_I31_M1.3890.98
178_E181_K1.3780.97
32_M57_S1.3590.97
222_V263_I1.3580.97
152_L280_L1.3530.97
248_L260_A1.3500.97
307_K353_M1.3490.97
97_A102_T1.3480.97
117_T275_G1.3360.97
103_V177_I1.3330.97
354_M357_A1.3310.97
399_R417_L1.3250.97
136_V173_A1.3200.97
236_S240_Q1.3180.97
134_M185_Y1.3170.97
133_P159_P1.3100.97
51_D54_K1.3050.96
207_T211_E1.2930.96
309_Q314_E1.2900.96
55_K82_E1.2840.96
135_L160_V1.2830.96
102_T216_E1.2780.96
379_I416_L1.2720.96
229_D232_N1.2540.96
179_K185_Y1.2530.96
274_A291_M1.2520.95
339_G381_K1.2490.95
97_A100_P1.2490.95
14_I17_I1.2390.95
197_H236_S1.2320.95
369_D374_N1.2290.95
176_A188_V1.2250.95
15_S19_G1.2180.95
349_E352_Q1.2170.95
347_L351_L1.2100.95
170_V209_V1.2090.95
276_L283_L1.2080.95
346_P349_E1.2060.94
392_D421_D1.2060.94
117_T247_V1.2000.94
342_R374_N1.1970.94
173_A212_I1.1860.94
26_Q30_E1.1810.94
103_V188_V1.1760.94
166_Q171_E1.1720.94
96_V131_R1.1660.93
287_H303_T1.1620.93
123_N126_R1.1620.93
10_L13_T1.1490.93
59_R64_D1.1460.93
175_Q178_E1.1460.93
153_G159_P1.1430.93
335_L377_E1.1410.93
334_F338_L1.1330.92
174_K212_I1.1320.92
358_G362_G1.1300.92
104_I189_I1.1290.92
179_K182_E1.1270.92
32_M53_V1.1240.92
174_K178_E1.1210.92
396_A399_R1.1160.92
335_L339_G1.1150.92
32_M56_V1.1130.92
313_D316_K1.1130.92
105_M206_L1.1060.91
69_L302_L1.1060.91
200_H204_D1.1030.91
318_K322_Q1.1030.91
171_E174_K1.1020.91
9_R41_E1.1010.91
134_M159_P1.1000.91
153_G156_L1.0780.90
197_H233_V1.0750.90
217_E244_T1.0680.90
123_N280_L1.0630.90
123_N283_L1.0630.90
396_A410_V1.0590.90
229_D233_V1.0450.89
208_N212_I1.0430.89
27_D75_V1.0430.89
12_Q16_K1.0410.89
433_M436_G1.0390.89
360_M363_L1.0340.88
105_M190_L1.0340.88
339_G342_R1.0320.88
177_I213_A1.0300.88
94_I219_F1.0280.88
93_K129_H1.0260.88
319_E322_Q1.0210.88
406_S409_S1.0150.87
151_T154_K1.0080.87
159_P179_K1.0070.87
224_S251_L1.0000.87
379_I408_T1.0000.87
200_H240_Q1.0000.87
167_V171_E0.9990.87
15_S20_K0.9970.87
25_E61_V0.9970.87
325_R431_T0.9900.86
112_A118_S0.9900.86
215_P218_I0.9890.86
385_V389_E0.9870.86
63_Q67_K0.9790.86
289_E302_L0.9750.85
346_P350_L0.9740.85
260_A271_I0.9710.85
16_K30_E0.9660.85
137_A163_L0.9660.85
96_V102_T0.9630.85
371_K375_H0.9610.84
392_D424_K0.9590.84
141_Y205_E0.9580.84
95_A216_E0.9540.84
287_H290_R0.9540.84
32_M75_V0.9530.84
117_T283_L0.9530.84
331_L393_I0.9490.84
98_K216_E0.9480.84
106_M247_V0.9460.84
123_N156_L0.9410.83
55_K265_A0.9400.83
33_R37_L0.9390.83
242_G269_T0.9390.83
372_Q419_Q0.9330.83
163_L167_V0.9330.83
202_L206_L0.9290.82
94_I104_I0.9240.82
177_I181_K0.9210.82
379_I403_A0.9200.82
26_Q29_K0.9200.82
137_A146_I0.9170.82
22_K64_D0.9150.81
173_A177_I0.9120.81
233_V236_S0.9100.81
164_G167_V0.9070.81
136_V190_L0.8980.80
422_E425_K0.8940.80
312_V317_A0.8920.80
104_I187_Y0.8890.80
235_K238_N0.8880.79
210_K243_L0.8880.79
357_A360_M0.8840.79
338_L423_M0.8820.79
103_V216_E0.8810.79
60_A78_V0.8800.79
251_L276_L0.8770.79
290_R303_T0.8750.78
369_D372_Q0.8700.78
292_A295_I0.8690.78
162_S165_D0.8640.78
31_M75_V0.8640.78
131_R186_D0.8630.77
126_R154_K0.8630.77
170_V177_I0.8630.77
91_E287_H0.8620.77
320_L327_M0.8610.77
126_R156_L0.8520.77
106_M275_G0.8500.76
236_S239_E0.8480.76
55_K58_E0.8470.76
23_V28_V0.8470.76
99_R102_T0.8450.76
334_F376_V0.8410.76
141_Y169_P0.8390.75
24_S27_D0.8390.75
23_V75_V0.8360.75
81_E302_L0.8360.75
106_M117_T0.8350.75
307_K310_A0.8340.75
231_V266_V0.8290.75
219_F272_K0.8290.75
347_L350_L0.8260.74
328_S424_K0.8240.74
408_T411_Q0.8230.74
289_E293_S0.8230.74
150_E164_G0.8190.74
122_A156_L0.8190.74
150_E160_V0.8090.73
124_L285_P0.8040.72
386_L389_E0.8030.72
35_V75_V0.8020.72
70_T73_Q0.8020.72
305_I309_Q0.8000.72
399_R414_N0.8000.72
167_V175_Q0.7990.72
177_I212_I0.7990.72
134_M188_V0.7940.71
372_Q375_H0.7930.71
315_D318_K0.7920.71
133_P216_E0.7920.71
146_I164_G0.7880.71
348_D363_L0.7830.70
134_M183_E0.7800.70
321_E324_M0.7800.70
105_M218_I0.7790.70
208_N211_E0.7770.70
89_G264_R0.7760.70
433_M437_K0.7760.70
368_V374_N0.7750.70
320_L324_M0.7740.69
88_G288_P0.7720.69
147_K165_D0.7720.69
147_K164_G0.7700.69
137_A162_S0.7690.69
222_V248_L0.7680.69
238_N243_L0.7680.69
119_G156_L0.7660.69
14_I23_V0.7650.69
28_V75_V0.7640.68
374_N381_K0.7590.68
211_E214_N0.7560.68
246_V263_I0.7560.68
301_V305_I0.7550.67
374_N377_E0.7550.67
73_Q301_V0.7550.67
271_I274_A0.7540.67
322_Q326_T0.7540.67
119_G155_Q0.7530.67
138_A190_L0.7510.67
112_A224_S0.7500.67
170_V213_A0.7500.67
27_D30_E0.7460.67
425_K429_Q0.7450.66
369_D375_H0.7440.66
36_R49_V0.7440.66
412_E415_R0.7380.66
334_F426_M0.7380.66
77_K309_Q0.7370.66
152_L155_Q0.7370.66
170_V173_A0.7360.66
66_M305_I0.7330.65
12_Q15_S0.7310.65
35_V76_I0.7310.65
390_Q393_I0.7290.65
62_G65_V0.7290.65
137_A160_V0.7280.65
331_L420_F0.7280.65
351_L354_M0.7280.65
328_S392_D0.7250.64
348_D367_Q0.7240.64
424_K428_K0.7230.64
146_I163_L0.7230.64
155_Q282_A0.7200.64
32_M35_V0.7200.64
42_A256_R0.7180.64
419_Q423_M0.7160.63
342_R370_E0.7150.63
316_K343_N0.7140.63
415_R419_Q0.7120.63
421_D424_K0.7090.63
359_K362_G0.7090.63
323_K330_T0.7040.62
15_S18_R0.7030.62
147_K151_T0.7020.62
220_L246_V0.7000.62
50_K54_K0.6980.61
434_S437_K0.6970.61
406_S411_Q0.6920.61
23_V31_M0.6920.61
396_A400_K0.6890.60
173_A190_L0.6860.60
206_L218_I0.6840.60
307_K311_S0.6840.60
189_I283_L0.6840.60
66_M81_E0.6830.60
163_L171_E0.6810.60
72_G76_I0.6810.60
319_E330_T0.6800.59
140_I205_E0.6790.59
380_I388_K0.6750.59
220_L233_V0.6750.59
110_Q196_L0.6740.59
362_G365_N0.6720.58
360_M366_I0.6720.58
161_F179_K0.6700.58
322_Q325_R0.6670.58
73_Q298_M0.6650.58
203_M229_D0.6640.58
243_L275_G0.6630.57
365_N369_D0.6630.57
153_G158_M0.6600.57
244_T269_T0.6590.57
372_Q423_M0.6590.57
222_V391_P0.6580.57
107_V158_M0.6580.57
372_Q412_E0.6570.57
19_G24_S0.6560.57
190_L209_V0.6560.57
382_S405_G0.6560.57
346_P354_M0.6530.56
163_L166_Q0.6530.56
395_N399_R0.6500.56
306_E309_Q0.6480.56
188_V213_A0.6480.56
125_L272_K0.6470.56
14_I21_G0.6460.56
102_T131_R0.6460.56
28_V32_M0.6450.55
133_P186_D0.6450.55
162_S167_V0.6440.55
273_F285_P0.6430.55
419_Q422_E0.6430.55
338_L373_L0.6410.55
332_D381_K0.6400.55
357_A362_G0.6390.55
287_H306_E0.6390.55
86_L244_T0.6360.54
95_A102_T0.6350.54
327_M431_T0.6340.54
117_T276_L0.6340.54
334_F424_K0.6340.54
33_R50_K0.6330.54
135_L159_P0.6330.54
63_Q315_D0.6320.54
147_K154_K0.6320.54
307_K349_E0.6300.54
81_E305_I0.6300.54
350_L354_M0.6280.53
168_S176_A0.6270.53
352_Q361_K0.6240.53
307_K409_S0.6240.53
276_L307_K0.6230.53
344_M350_L0.6220.53
320_L323_K0.6220.53
327_M424_K0.6220.53
141_Y202_L0.6210.53
309_Q312_V0.6190.52
340_Q344_M0.6180.52
323_K333_D0.6170.52
35_V87_M0.6170.52
107_V218_I0.6160.52
137_A335_L0.6160.52
421_D425_K0.6160.52
97_A101_P0.6160.52
275_G400_K0.6090.51
106_M189_I0.6090.51
135_L149_L0.6080.51
14_I31_M0.6060.51
56_V79_V0.6060.51
57_S61_V0.6050.51
66_M74_Q0.6040.51
332_D335_L0.6040.51
378_A408_T0.6030.51
276_L284_E0.6030.51
3_F326_T0.6020.50
15_S27_D0.6020.50
420_F427_M0.6020.50
13_T16_K0.6010.50
238_N241_L0.6000.50
14_I72_G0.5990.50
4_E93_K0.5990.50
150_E165_D0.5990.50
156_L160_V0.5990.50
37_L40_L0.5980.50
334_F349_E0.5980.50
8_D12_Q0.5980.50
334_F377_E0.5980.50
76_I302_L0.5970.50
201_E204_D0.5960.50
2_A164_G0.5950.50
203_M225_M0.5940.49
358_G363_L0.5930.49
417_L420_F0.5930.49
116_T275_G0.5910.49
299_G355_P0.5910.49
40_L56_V0.5900.49
9_R14_I0.5900.49
166_Q175_Q0.5890.49
78_V313_D0.5880.49
284_E291_M0.5880.49
351_L357_A0.5880.49
77_K226_T0.5870.49
214_N244_T0.5850.48
219_F406_S0.5850.48
170_V246_V0.5850.48
200_H386_L0.5840.48
401_R405_G0.5840.48
242_G358_G0.5840.48
365_N368_V0.5830.48
137_A153_G0.5820.48
11_Q359_K0.5820.48
206_L236_S0.5820.48
246_V269_T0.5820.48
348_D352_Q0.5810.48
130_N162_S0.5800.48
169_P209_V0.5790.48
9_R36_R0.5790.48
273_F406_S0.5780.48
150_E153_G0.5750.47
69_L152_L0.5750.47
393_I417_L0.5730.47
197_H206_L0.5730.47
206_L233_V0.5720.47
308_A312_V0.5720.47
66_M69_L0.5710.47
55_K350_L0.5690.47
199_D203_M0.5680.46
178_E211_E0.5670.46
89_G92_S0.5670.46
348_D370_E0.5660.46
27_D35_V0.5660.46
165_D168_S0.5660.46
156_L159_P0.5650.46
256_R292_A0.5650.46
59_R65_V0.5630.46
92_S264_R0.5630.46
87_M291_M0.5600.46
27_D305_I0.5600.46
16_K21_G0.5590.45
274_A303_T0.5580.45
28_V31_M0.5580.45
225_M254_D0.5580.45
410_V414_N0.5570.45
311_S314_E0.5560.45
137_A216_E0.5560.45
326_T428_K0.5560.45
27_D72_G0.5550.45
331_L380_I0.5530.45
249_T253_G0.5520.45
350_L375_H0.5520.45
357_A361_K0.5520.45
140_I146_I0.5510.44
69_L74_Q0.5510.44
282_A285_P0.5510.44
164_G250_K0.5510.44
106_M121_L0.5510.44
161_F164_G0.5500.44
140_I163_L0.5500.44
223_D250_K0.5490.44
87_M106_M0.5490.44
3_F7_A0.5480.44
343_N348_D0.5470.44
46_F50_K0.5460.44
56_V323_K0.5440.44
56_V60_A0.5430.44
70_T297_G0.5420.43
337_Q341_V0.5420.43
209_V212_I0.5420.43
23_V27_D0.5410.43
83_L301_V0.5410.43
226_T230_A0.5410.43
211_E385_V0.5410.43
204_D239_E0.5400.43
198_I204_D0.5390.43
123_N155_Q0.5390.43
55_K59_R0.5380.43
182_E239_E0.5380.43
346_P352_Q0.5370.43
132_K179_K0.5360.43
30_E63_Q0.5360.43
126_R155_Q0.5360.43
302_L309_Q0.5360.43
69_L73_Q0.5360.43
37_L41_E0.5350.43
198_I203_M0.5350.43
181_K216_E0.5350.43
204_D211_E0.5340.43
12_Q64_D0.5330.42
23_V79_V0.5320.42
103_V181_K0.5310.42
9_R391_P0.5310.42
39_L49_V0.5310.42
319_E323_K0.5310.42
181_K204_D0.5300.42
400_K411_Q0.5300.42
238_N263_I0.5290.42
5_G8_D0.5290.42
168_S212_I0.5280.42
177_I209_V0.5270.42
102_T137_A0.5260.42
135_L213_A0.5260.42
38_A260_A0.5260.42
372_Q415_R0.5260.42
18_R188_V0.5260.42
341_V376_V0.5260.42
220_L243_L0.5250.42
375_H424_K0.5250.42
202_L310_A0.5250.42
341_V354_M0.5240.41
368_V372_Q0.5240.41
68_S267_T0.5240.41
303_T306_E0.5240.41
99_R216_E0.5240.41
181_K348_D0.5240.41
190_L212_I0.5240.41
105_M424_K0.5230.41
196_L229_D0.5230.41
367_Q374_N0.5220.41
146_I250_K0.5220.41
36_R155_Q0.5210.41
188_V268_N0.5200.41
87_M224_S0.5200.41
192_T298_M0.5200.41
409_S415_R0.5190.41
155_Q280_L0.5180.41
432_N437_K0.5170.41
155_Q279_K0.5170.41
29_K238_N0.5160.40
110_Q203_M0.5160.40
392_D395_N0.5150.40
118_S122_A0.5140.40
54_K106_M0.5130.40
368_V373_L0.5120.40
35_V248_L0.5120.40
174_K406_S0.5100.40
197_H232_N0.5100.40
324_M327_M0.5090.40
146_I169_P0.5090.40
138_A176_A0.5090.40
50_K55_K0.5090.40
140_I166_Q0.5090.40
117_T243_L0.5090.40
76_I298_M0.5080.40
386_L413_V0.5060.39
92_S272_K0.5060.39
264_R268_N0.5050.39
312_V349_E0.5050.39
10_L35_V0.5050.39
366_I369_D0.5040.39
153_G163_L0.5040.39
170_V174_K0.5040.39
23_V65_V0.5030.39
225_M295_I0.5030.39
198_I289_E0.5020.39
99_R181_K0.5020.39
2_A7_A0.5020.39
130_N214_N0.5020.39
347_L363_L0.5010.39
2_A5_G0.5010.39
138_A381_K0.5010.39
310_A315_D0.5000.39
144_A155_Q0.5000.39
18_R359_K0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ffhA 4 0.9126 100 0.384 Contact Map
2v3cC 1 0.8991 100 0.393 Contact Map
2xxaA 1 0.9238 100 0.395 Contact Map
2j37W 1 0.9753 100 0.408 Contact Map
3dm5A 4 0.9305 100 0.438 Contact Map
3kl4A 1 0.9126 100 0.444 Contact Map
4c7oA 1 0.6659 100 0.617 Contact Map
1ls1A 1 0.648 100 0.631 Contact Map
2yhsA 1 0.657 100 0.658 Contact Map
2og2A 1 0.6278 100 0.664 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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