GREMLIN Database
YLXM - UPF0122 protein YlxM
UniProt: P37104 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 110 (100)
Sequences: 960 (777)
Seq/√Len: 77.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_R64_E3.7501.00
15_F76_F3.6431.00
30_L34_D3.0521.00
71_L74_K2.8181.00
39_G49_R2.4511.00
29_S33_L2.4451.00
18_S25_K2.3771.00
9_M28_M2.2861.00
13_F28_M2.1751.00
19_L66_Y2.1621.00
74_K78_E2.1131.00
30_L45_Y2.0581.00
15_F72_L2.0561.00
35_D58_R1.9521.00
28_M59_T1.8781.00
22_S26_S1.8641.00
27_Y55_N1.8471.00
47_V52_V1.6561.00
13_F29_S1.6121.00
21_T24_Q1.5780.99
65_Q68_E1.5510.99
27_Y47_V1.5490.99
30_L44_E1.5140.99
15_F73_L1.5100.99
10_N33_L1.5030.99
5_K60_E1.4880.99
31_Y41_I1.4090.99
50_Q58_R1.4020.99
7_T10_N1.3870.99
11_Y73_L1.3800.99
65_Q69_K1.3730.99
27_Y45_Y1.3610.98
47_V51_A1.3260.98
98_E101_A1.2710.98
11_Y76_F1.2310.97
3_L6_T1.2260.97
54_D58_R1.2200.97
27_Y59_T1.2010.97
55_N58_R1.1750.96
21_T62_M1.1700.96
9_M60_E1.1560.96
88_E92_G1.1390.95
14_D33_L1.0640.93
22_S25_K1.0430.93
36_F44_E1.0240.92
55_N59_T1.0190.92
97_E101_A0.9950.91
19_L48_S0.9840.90
86_L90_A0.9830.90
13_F33_L0.9740.90
97_E100_T0.9600.89
99_I102_L0.9560.89
26_S29_S0.9450.89
23_K55_N0.9090.87
26_S45_Y0.8940.86
9_M32_Y0.8930.86
79_R82_M0.8810.85
34_D102_L0.8790.85
3_L7_T0.8780.85
23_K52_V0.8660.84
68_E71_L0.8590.83
5_K63_L0.8500.83
42_A45_Y0.8460.82
71_L75_K0.8460.82
32_Y56_I0.8180.80
95_E102_L0.8150.80
51_A79_R0.8150.80
37_S58_R0.8100.80
93_S96_E0.8050.79
94_K100_T0.8040.79
11_Y15_F0.8010.79
85_K98_E0.7920.78
6_T9_M0.7800.77
6_T10_N0.7750.77
5_K8_R0.7650.76
57_K66_Y0.7560.75
73_L77_Q0.7560.75
11_Y14_D0.7520.74
86_L93_S0.7510.74
42_A52_V0.7340.73
95_E98_E0.7200.71
78_E82_M0.7150.71
49_R53_Y0.7120.70
78_E81_E0.7090.70
31_Y63_L0.6960.69
96_E99_I0.6890.68
96_E101_A0.6860.67
95_E101_A0.6810.67
48_S73_L0.6710.66
30_L43_E0.6670.65
64_E68_E0.6640.65
39_G53_Y0.6580.64
87_K91_S0.6570.64
7_T11_Y0.6540.64
81_E101_A0.6540.64
53_Y57_K0.6520.64
95_E100_T0.6480.63
15_F50_Q0.6440.63
57_K60_E0.6430.62
3_L21_T0.6380.62
29_S47_V0.6370.62
39_G62_M0.6330.61
85_K88_E0.6280.61
84_N89_L0.6230.60
32_Y44_E0.6230.60
72_L75_K0.6220.60
50_Q90_A0.6190.60
94_K98_E0.6150.59
46_E91_S0.6050.58
3_L25_K0.6030.58
6_T31_Y0.5970.57
91_S100_T0.5970.57
28_M32_Y0.5960.57
32_Y60_E0.5890.56
81_E84_N0.5870.56
42_A76_F0.5850.55
34_D44_E0.5810.55
17_Q25_K0.5780.54
11_Y26_S0.5760.54
77_Q82_M0.5750.54
9_M52_V0.5740.54
31_Y57_K0.5710.53
8_R55_N0.5690.53
76_F80_K0.5680.53
15_F67_E0.5630.52
92_G96_E0.5620.52
5_K21_T0.5600.52
35_D54_D0.5570.52
17_Q33_L0.5530.51
91_S96_E0.5500.51
56_I81_E0.5460.50
93_S99_I0.5410.50
60_E83_F0.5410.50
89_L92_G0.5340.49
24_Q58_R0.5340.49
38_L53_Y0.5330.49
17_Q75_K0.5320.49
9_M15_F0.5290.48
95_E99_I0.5280.48
8_R73_L0.5240.47
91_S97_E0.5150.46
86_L102_L0.5150.46
81_E92_G0.5140.46
22_S98_E0.5140.46
81_E100_T0.5140.46
85_K92_G0.5130.46
84_N91_S0.5130.46
25_K29_S0.5110.46
9_M23_K0.5070.45
46_E86_L0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s7oA 3 0.9636 99.3 0.622 Contact Map
1xsvA 2 0.9636 99.3 0.63 Contact Map
1l0oC 1 0 98.1 0.759 Contact Map
1rp3A 1 0.6273 98 0.761 Contact Map
1ku3A 1 0.5182 98 0.764 Contact Map
1l9zH 1 0.7 98 0.765 Contact Map
3hugA 3 0.6636 98 0.766 Contact Map
2a6hF 1 0.6545 98 0.766 Contact Map
3mzyA 1 0.6455 97.9 0.769 Contact Map
2o8xA 7 0.5545 97.9 0.771 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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