GREMLIN Database
RBSB - D-ribose-binding protein
UniProt: P36949 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (278)
Sequences: 38741 (28944)
Seq/√Len: 1735.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_V183_N3.4171.00
159_G219_Q3.1661.00
96_A282_A2.8271.00
178_G182_H2.6901.00
148_A246_I2.6401.00
159_G244_L2.5771.00
250_G268_A2.5721.00
135_T285_I2.4601.00
146_E187_Q2.3491.00
209_E239_S2.3141.00
62_E65_K2.2871.00
205_L238_S2.2721.00
150_A184_I2.2511.00
209_E235_A2.1731.00
146_E184_I2.1691.00
62_E280_E2.1671.00
146_E183_N2.1651.00
143_K147_M2.1471.00
277_L280_E2.0701.00
152_I220_A2.0521.00
142_V179_S2.0221.00
62_E276_K2.0211.00
63_A279_T2.0081.00
16_L20_S1.9891.00
144_G248_F1.9751.00
145_G149_A1.9491.00
284_D289_K1.8881.00
58_G275_G1.8681.00
151_F155_K1.8681.00
149_A181_F1.8381.00
41_G94_V1.8291.00
163_A218_I1.8291.00
204_G231_G1.8181.00
145_G222_F1.7991.00
223_A232_A1.7821.00
61_K272_E1.7611.00
164_E224_H1.7581.00
268_A300_K1.7511.00
213_Q239_S1.7421.00
146_E150_A1.7291.00
150_A154_D1.7271.00
208_M232_A1.7211.00
205_L235_A1.7191.00
236_I243_I1.7101.00
270_Q273_L1.6921.00
235_A239_S1.6731.00
62_E66_R1.6671.00
124_I278_A1.6601.00
151_F154_D1.6481.00
143_K146_E1.6421.00
237_N260_D1.6361.00
58_G272_E1.6251.00
179_S183_N1.6101.00
161_K217_D1.5721.00
147_M299_L1.5401.00
153_A184_I1.5331.00
66_R283_D1.5301.00
38_F95_D1.5201.00
283_D287_H1.5191.00
182_H186_D1.5141.00
235_A238_S1.5121.00
205_L234_E1.5101.00
184_I187_Q1.5051.00
176_E179_S1.4961.00
273_L277_L1.4771.00
277_L295_I1.4611.00
198_D203_K1.4331.00
161_K219_Q1.4181.00
273_L276_K1.4081.00
62_E279_T1.3971.00
140_D143_K1.3941.00
205_L209_E1.3771.00
161_K190_Q1.3631.00
195_Q210_N1.3631.00
163_A211_L1.3591.00
145_G180_G1.3591.00
161_K192_V1.3571.00
149_A153_A1.3551.00
142_V146_E1.3451.00
208_M236_I1.3371.00
149_A184_I1.3231.00
209_E213_Q1.3181.00
147_M150_A1.3181.00
98_L278_A1.3051.00
209_E238_S1.3031.00
180_G184_I1.2981.00
149_A180_G1.2901.00
41_G89_L1.2881.00
237_N262_K1.2841.00
160_A219_Q1.2821.00
73_V85_D1.2791.00
38_F68_M1.2751.00
280_E284_D1.2741.00
63_A70_V1.2691.00
16_L19_C1.2691.00
39_T69_K1.2681.00
112_E116_A1.2681.00
144_G299_L1.2641.00
87_E113_S1.2541.00
73_V89_L1.2511.00
272_E276_K1.2361.00
39_T71_I1.2341.00
59_I279_T1.2291.00
159_G220_A1.2101.00
66_R280_E1.2031.00
17_T21_L1.1891.00
215_H218_I1.1861.00
42_L59_I1.1841.00
208_M221_V1.1741.00
40_I63_A1.1731.00
142_V180_G1.1651.00
164_E178_G1.1591.00
60_E64_K1.1591.00
202_T206_T1.1581.00
231_G235_A1.1471.00
200_D203_K1.1451.00
210_N214_G1.1451.00
142_V176_E1.1431.00
233_L245_V1.1421.00
150_A187_Q1.1381.00
207_V210_N1.1351.00
182_H191_V1.1241.00
181_F185_A1.1231.00
175_R179_S1.1231.00
153_A189_L1.1191.00
246_I264_S1.1021.00
56_K60_E1.1011.00
181_F222_F1.0991.00
42_L70_V1.0891.00
203_K206_T1.0811.00
148_A222_F1.0811.00
226_D266_T1.0791.00
179_S182_H1.0781.00
183_N187_Q1.0781.00
201_R234_E1.0771.00
64_K81_K1.0761.00
221_V232_A1.0741.00
277_L281_A1.0721.00
18_A21_L1.0681.00
276_K280_E1.0661.00
162_V185_A1.0611.00
223_A228_M1.0511.00
226_D247_G1.0491.00
172_S176_E1.0471.00
160_A189_L1.0461.00
165_L232_A1.0431.00
59_I98_L1.0391.00
83_T87_E1.0361.00
275_G279_T1.0351.00
81_K84_S1.0331.00
68_M283_D1.0241.00
169_P196_S1.0161.00
66_R287_H1.0151.00
161_K216_P1.0141.00
282_A286_L1.0141.00
28_K31_N1.0101.00
155_K244_L1.0101.00
206_T210_N1.0031.00
108_S112_E1.0001.00
162_V220_A0.9981.00
223_A229_A0.9961.00
135_T281_A0.9951.00
26_W32_S0.9931.00
65_K276_K0.9901.00
29_P32_S0.9881.00
87_E91_Q0.9871.00
149_A185_A0.9851.00
57_K61_K0.9851.00
281_A295_I0.9771.00
195_Q207_V0.9691.00
204_G208_M0.9681.00
148_A267_V0.9621.00
167_G199_F0.9541.00
17_T20_S0.9531.00
208_M212_L0.9501.00
51_F271_P0.9481.00
151_F264_S0.9431.00
143_K298_P0.9411.00
98_L282_A0.9291.00
233_L259_K0.9271.00
221_V243_I0.9201.00
78_D81_K0.9171.00
61_K65_K0.9101.00
206_T209_E0.9001.00
153_A160_A0.8991.00
40_I98_L0.8961.00
55_L124_I0.8931.00
229_A247_G0.8901.00
141_N177_R0.8811.00
277_L297_A0.8801.00
96_A286_L0.8801.00
59_I275_G0.8801.00
155_K159_G0.8791.00
234_E237_N0.8751.00
163_A221_V0.8681.00
166_E178_G0.8671.00
61_K276_K0.8611.00
236_I245_V0.8601.00
203_K207_V0.8591.00
281_A284_D0.8591.00
270_Q300_K0.8571.00
170_G175_R0.8551.00
39_T92_Q0.8531.00
139_S270_Q0.8531.00
226_D250_G0.8521.00
56_K72_I0.8481.00
212_L235_A0.8471.00
71_I92_Q0.8441.00
136_L294_T0.8311.00
71_I94_V0.8301.00
279_T283_D0.8301.00
84_S87_E0.8281.00
152_I246_I0.8281.00
197_A228_M0.8261.00
19_C22_E0.8251.00
139_S269_Q0.8251.00
140_D296_S0.8241.00
183_N186_D0.8221.00
81_K85_D0.8211.00
42_L56_K0.8171.00
25_Q30_S0.8131.00
208_M235_A0.8051.00
115_N132_K0.8051.00
113_S116_A0.7991.00
24_P91_Q0.7981.00
137_V281_A0.7961.00
110_A113_S0.7941.00
57_K60_E0.7921.00
257_S262_K0.7911.00
59_I70_V0.7901.00
212_L239_S0.7881.00
185_A189_L0.7831.00
138_A296_S0.7821.00
76_Q81_K0.7801.00
45_S52_F0.7801.00
185_A191_V0.7781.00
153_A185_A0.7781.00
58_G276_K0.7771.00
139_S299_L0.7691.00
43_S85_D0.7681.00
58_G62_E0.7651.00
143_K299_L0.7631.00
164_E222_F0.7631.00
27_A30_S0.7611.00
127_S294_T0.7541.00
165_L223_A0.7531.00
54_S272_E0.7521.00
96_A122_V0.7511.00
256_A260_D0.7501.00
208_M211_L0.7461.00
98_L124_I0.7461.00
138_A294_T0.7431.00
114_A121_V0.7431.00
146_E180_G0.7411.00
247_G266_T0.7411.00
90_I117_V0.7401.00
176_E180_G0.7381.00
210_N213_Q0.7381.00
256_A259_K0.7381.00
26_W29_P0.7341.00
60_E70_V0.7321.00
123_T133_V0.7281.00
112_E115_N0.7221.00
270_Q297_A0.7201.00
37_E69_K0.7171.00
234_E262_K0.7141.00
123_T128_A0.7121.00
41_G97_L0.7111.00
226_D229_A0.7111.00
284_D288_G0.7071.00
83_T110_A0.7061.00
122_V285_I0.7061.00
80_S84_S0.7031.00
147_M267_V0.7031.00
199_F224_H0.7031.00
140_D298_P0.7021.00
24_P87_E0.7011.00
37_E95_D0.7011.00
151_F301_L0.7001.00
36_K95_D0.6961.00
249_D269_Q0.6921.00
234_E238_S0.6921.00
178_G194_K0.6871.00
40_I279_T0.6861.00
174_T199_F0.6851.00
49_N227_E0.6811.00
214_G217_D0.6781.00
225_N249_D0.6731.00
250_G256_A0.6721.00
181_F191_V0.6711.00
135_T293_K0.6701.00
233_L237_N0.6691.00
79_S83_T0.6671.00
36_K287_H0.6661.00
222_F246_I0.6641.00
230_L259_K0.6601.00
219_Q244_L0.6591.00
125_D173_A0.6561.00
244_L264_S0.6531.00
123_T136_L0.6521.00
164_E181_F0.6501.00
204_G207_V0.6471.00
40_I96_A0.6471.00
63_A68_M0.6411.00
225_N228_M0.6411.00
167_G174_T0.6411.00
90_I119_V0.6401.00
162_V219_Q0.6361.00
96_A278_A0.6361.00
54_S271_P0.6321.00
222_F248_F0.6321.00
122_V282_A0.6321.00
226_D251_N0.6311.00
86_V97_L0.6281.00
115_N121_V0.6281.00
19_C23_P0.6271.00
97_L119_V0.6271.00
40_I286_L0.6261.00
234_E260_D0.6211.00
195_Q214_G0.6201.00
197_A203_K0.6201.00
152_I222_F0.6141.00
236_I239_S0.6141.00
52_F100_N0.6071.00
202_T205_L0.6071.00
151_F246_I0.6061.00
73_V88_D0.6051.00
122_V137_V0.6051.00
125_D141_N0.6041.00
214_G218_I0.6041.00
58_G271_P0.6041.00
223_A247_G0.6011.00
147_M151_F0.6011.00
109_T112_E0.6001.00
138_A141_N0.5981.00
161_K218_I0.5981.00
229_A263_L0.5981.00
127_S136_L0.5961.00
30_S34_N0.5931.00
248_F269_Q0.5921.00
201_R231_G0.5911.00
211_L215_H0.5881.00
57_K272_E0.5871.00
141_N173_A0.5831.00
208_M231_G0.5821.00
84_S88_D0.5811.00
40_I68_M0.5801.00
207_V211_L0.5771.00
39_T95_D0.5751.00
68_M95_D0.5751.00
230_L251_N0.5751.00
162_V181_F0.5741.00
159_G188_K0.5741.00
195_Q211_L0.5731.00
60_E74_D0.5731.00
113_S117_V0.5721.00
161_K215_H0.5681.00
141_N176_E0.5671.00
122_V281_A0.5671.00
174_T224_H0.5641.00
39_T94_V0.5631.00
150_A153_A0.5621.00
232_A236_I0.5621.00
51_F55_L0.5621.00
109_T113_S0.5601.00
83_T113_S0.5591.00
85_D88_D0.5581.00
148_A220_A0.5571.00
38_F286_L0.5561.00
55_L271_P0.5531.00
177_R269_Q0.5521.00
234_E257_S0.5501.00
281_A285_I0.5491.00
88_D91_Q0.5491.00
125_D274_I0.5461.00
24_P28_K0.5441.00
205_L231_G0.5441.00
112_E132_K0.5411.00
38_F287_H0.5391.00
87_E90_I0.5391.00
229_A245_V0.5391.00
259_K262_K0.5381.00
212_L236_I0.5381.00
120_P285_I0.5381.00
146_E149_A0.5381.00
220_A244_L0.5371.00
57_K76_Q0.5361.00
205_L208_M0.5361.00
63_A283_D0.5351.00
68_M286_L0.5341.00
251_N255_L0.5341.00
285_I288_G0.5331.00
122_V278_A0.5331.00
80_S83_T0.5321.00
296_S299_L0.5311.00
199_F228_M0.5311.00
165_L207_V0.5291.00
218_I221_V0.5291.00
277_L284_D0.5261.00
284_D293_K0.5261.00
58_G61_K0.5231.00
272_E275_G0.5211.00
89_L94_V0.5191.00
182_H194_K0.5171.00
238_S260_D0.5161.00
217_D242_D0.5121.00
208_M223_A0.5121.00
160_A220_A0.5081.00
155_K264_S0.5081.00
197_A204_G0.5081.00
55_L275_G0.5071.00
54_S57_K0.5061.00
201_R227_E0.5051.00
139_S144_G0.5041.00
59_I63_A0.5021.00
166_E224_H0.5001.00
90_I113_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iksA 2 0.8656 100 0.204 Contact Map
3huuA 2 0.8328 100 0.207 Contact Map
2hsgA 1 0.9639 100 0.21 Contact Map
4o5aA 2 0.8459 100 0.212 Contact Map
3brqA 2 0.859 100 0.218 Contact Map
3dbiA 2 0.8656 100 0.218 Contact Map
1qpzA 2 0.977 100 0.22 Contact Map
3e3mA 2 0.8393 100 0.224 Contact Map
3bilA 2 0.8066 100 0.225 Contact Map
3kjxA 2 0.9738 100 0.227 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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