GREMLIN Database
RBSC - Ribose transport system permease protein RbsC
UniProt: P36948 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 322 (267)
Sequences: 31284 (19594)
Seq/√Len: 1199.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_C229_L3.8301.00
111_A225_S3.5051.00
111_A229_L3.0001.00
88_L109_I2.9371.00
115_M225_S2.9111.00
206_E220_K2.7881.00
92_M105_L2.7191.00
59_G179_M2.5231.00
66_T278_T2.5171.00
199_T223_I2.5161.00
215_K218_R2.4931.00
123_K217_T2.3861.00
189_L195_F2.3541.00
218_R222_M2.3301.00
187_W191_H2.2921.00
188_V192_K2.2731.00
110_G232_A2.2321.00
115_M221_V2.2001.00
114_G228_G2.1921.00
198_R219_V2.1621.00
117_N135_T2.1451.00
256_D289_N2.1391.00
119_L123_K2.1221.00
98_D101_L2.0731.00
195_F222_M2.0661.00
185_I189_L2.0511.00
89_V106_G1.9581.00
100_V104_I1.9421.00
61_I257_A1.9371.00
83_A143_T1.9201.00
107_C233_L1.9121.00
89_V236_A1.8241.00
110_G228_G1.7721.00
55_V286_G1.7541.00
62_A278_T1.7411.00
103_I236_A1.7301.00
202_I219_V1.7181.00
184_V188_V1.7161.00
137_T140_R1.6981.00
91_G95_S1.6901.00
68_V227_A1.6541.00
201_A209_A1.6451.00
67_F186_L1.6401.00
118_G221_V1.6271.00
194_P198_R1.6111.00
93_I102_A1.5561.00
55_V283_L1.5561.00
59_G282_V1.5531.00
113_L139_F1.5151.00
70_L200_Y1.5111.00
256_D306_K1.4951.00
123_K221_V1.4931.00
84_L113_L1.4821.00
107_C236_A1.4811.00
207_K210_L1.4541.00
222_M225_S1.4521.00
97_V101_L1.4461.00
195_F199_T1.4401.00
80_A140_R1.4311.00
91_G146_Y1.4211.00
206_E210_L1.4101.00
163_M166_R1.4061.00
153_T156_G1.3981.00
61_I82_L1.3961.00
101_L104_I1.3811.00
82_L238_L1.3791.00
198_R214_I1.3761.00
183_F279_L1.3721.00
135_T139_F1.3721.00
274_R277_G1.3611.00
167_G170_L1.3251.00
71_T223_I1.3231.00
60_L234_A1.3211.00
198_R209_A1.3191.00
264_G277_G1.3001.00
64_G230_L1.2781.00
162_Q165_G1.2661.00
209_A214_I1.2651.00
264_G281_G1.2591.00
119_L221_V1.2551.00
67_F223_I1.2531.00
92_M97_V1.2501.00
202_I216_V1.2451.00
221_V225_S1.2331.00
59_G279_L1.2281.00
106_G110_G1.2251.00
102_A106_G1.2231.00
104_I108_I1.2201.00
47_N290_N1.2201.00
122_T217_T1.2111.00
73_G220_K1.2011.00
78_V231_S1.1981.00
51_L287_T1.1931.00
60_L237_I1.1891.00
51_L286_G1.1891.00
63_F186_L1.1791.00
191_H200_Y1.1761.00
214_I219_V1.1741.00
202_I209_A1.1691.00
162_Q166_R1.1691.00
73_G128_P1.1591.00
65_M261_V1.1571.00
225_S229_L1.1481.00
91_G147_T1.1471.00
157_T160_G1.1441.00
168_Y171_G1.1411.00
65_M257_A1.1401.00
290_N293_N1.1341.00
161_F164_F1.1311.00
182_A230_L1.1281.00
187_W192_K1.1241.00
88_L92_M1.1241.00
108_I111_A1.1181.00
80_A139_F1.1041.00
150_N153_T1.1041.00
90_A94_V1.1011.00
62_A260_A1.0961.00
112_V115_M1.0911.00
55_V282_V1.0821.00
73_G224_Y1.0741.00
81_I113_L1.0741.00
64_G78_V1.0711.00
210_L216_V1.0691.00
210_L217_T1.0611.00
120_L131_A1.0611.00
140_R144_L1.0551.00
219_V222_M1.0541.00
222_M226_L1.0481.00
253_Y256_D1.0481.00
186_L226_L1.0461.00
183_F230_L1.0421.00
228_G232_A1.0371.00
301_Y304_V1.0351.00
111_A232_A1.0331.00
89_V240_S1.0251.00
87_A143_T1.0211.00
97_V105_L1.0171.00
136_M140_R1.0141.00
303_L306_K1.0101.00
289_N306_K1.0071.00
66_T261_V1.0071.00
117_N131_A1.0061.00
104_I107_C1.0061.00
199_T219_V1.0031.00
70_L273_G0.9991.00
106_G236_A0.9981.00
62_A261_V0.9961.00
226_L230_L0.9941.00
181_L185_I0.9911.00
177_I181_L0.9911.00
92_M95_S0.9881.00
119_L124_G0.9861.00
184_V187_W0.9841.00
49_L53_R0.9771.00
61_I234_A0.9701.00
122_T132_T0.9661.00
260_A282_V0.9651.00
160_G163_M0.9641.00
92_M102_A0.9481.00
291_G295_L0.9461.00
87_A247_P0.9441.00
80_A136_M0.9421.00
195_F219_V0.9411.00
260_A281_G0.9351.00
170_L177_I0.9311.00
87_A147_T0.9271.00
84_L88_L0.9251.00
46_L49_L0.9231.00
218_R221_V0.9201.00
187_W276_V0.9161.00
85_S106_G0.9131.00
69_I261_V0.9121.00
121_I131_A0.9111.00
235_G239_T0.9111.00
276_V280_I0.9101.00
66_T273_G0.9071.00
227_A231_S0.9051.00
120_L124_G0.9031.00
54_Q58_N0.9031.00
174_V177_I0.9011.00
180_V184_V0.9001.00
197_R200_Y0.8961.00
85_S110_G0.8951.00
48_I291_G0.8931.00
125_K206_E0.8921.00
208_A212_S0.8881.00
108_I112_V0.8871.00
82_L253_Y0.8861.00
89_V93_I0.8861.00
62_A282_V0.8801.00
252_S256_D0.8781.00
142_L146_Y0.8771.00
70_L191_H0.8711.00
154_G157_T0.8701.00
292_L305_V0.8631.00
159_Y162_Q0.8611.00
57_I234_A0.8611.00
190_L199_T0.8601.00
56_A176_A0.8551.00
71_T199_T0.8521.00
81_I231_S0.8501.00
86_S249_A0.8501.00
60_L179_M0.8481.00
202_I223_I0.8471.00
285_I306_K0.8461.00
65_M78_V0.8441.00
116_I120_L0.8441.00
59_G183_F0.8431.00
145_V301_Y0.8421.00
63_F182_A0.8401.00
217_T220_K0.8401.00
79_G254_E0.8371.00
75_D78_V0.8311.00
101_L105_L0.8301.00
173_P177_I0.8281.00
86_S239_T0.8281.00
179_M183_F0.8231.00
115_M119_L0.8231.00
205_N208_A0.8201.00
274_R278_T0.8181.00
88_L91_G0.8161.00
68_V75_D0.8091.00
166_R169_F0.8031.00
141_G144_L0.8031.00
63_F278_T0.8021.00
216_V220_K0.8021.00
118_G122_T0.8021.00
155_L158_N0.8011.00
81_I110_G0.8011.00
176_A180_V0.8011.00
175_P237_I0.8011.00
272_R276_V0.7991.00
231_S235_G0.7971.00
312_I316_L0.7931.00
229_L232_A0.7911.00
67_F226_L0.7811.00
82_L250_G0.7781.00
67_F190_L0.7771.00
107_C232_A0.7761.00
112_V116_I0.7741.00
202_I220_K0.7731.00
86_S245_A0.7701.00
85_S235_G0.7671.00
278_T282_V0.7601.00
79_G252_S0.7601.00
217_T221_V0.7591.00
174_V178_T0.7591.00
61_I78_V0.7541.00
90_A245_A0.7531.00
238_L242_L0.7491.00
50_N54_Q0.7491.00
118_G123_K0.7481.00
169_F173_P0.7471.00
290_N294_L0.7461.00
152_I155_L0.7411.00
89_V102_A0.7401.00
206_E216_V0.7291.00
229_L233_L0.7221.00
64_G231_S0.7141.00
82_L234_A0.7021.00
85_S109_I0.6991.00
68_V224_Y0.6951.00
107_C111_A0.6941.00
189_L192_K0.6941.00
169_F177_I0.6931.00
198_R215_K0.6911.00
167_G171_G0.6901.00
185_I188_V0.6871.00
283_L287_T0.6871.00
282_V286_G0.6841.00
61_I64_G0.6821.00
76_L258_I0.6761.00
308_I312_I0.6731.00
60_L182_A0.6711.00
97_V100_V0.6711.00
84_L110_G0.6701.00
183_F187_W0.6631.00
128_P224_Y0.6631.00
103_I107_C0.6601.00
47_N294_L0.6581.00
73_G206_E0.6581.00
300_F303_L0.6571.00
122_T221_V0.6551.00
51_L55_V0.6551.00
69_I258_I0.6551.00
259_A310_I0.6521.00
81_I117_N0.6511.00
45_P48_I0.6511.00
55_V59_G0.6511.00
93_I240_S0.6501.00
138_V142_L0.6501.00
299_S302_Q0.6501.00
58_N256_D0.6491.00
81_I85_S0.6481.00
151_P154_G0.6481.00
52_L56_A0.6301.00
81_I228_G0.6281.00
216_V219_V0.6271.00
66_T70_L0.6241.00
238_L253_Y0.6241.00
84_L139_F0.6221.00
56_A179_M0.6211.00
66_T275_I0.6161.00
114_G225_S0.6151.00
58_N260_A0.6151.00
92_M109_I0.6141.00
306_K310_I0.6121.00
50_N290_N0.6111.00
51_L290_N0.6111.00
53_R241_R0.6101.00
289_N302_Q0.6081.00
159_Y163_M0.6071.00
263_L281_G0.6041.00
172_I177_I0.6011.00
186_L230_L0.6001.00
64_G68_V0.5991.00
85_S231_S0.5981.00
226_L229_L0.5961.00
195_F226_L0.5961.00
292_L297_V0.5911.00
232_A236_A0.5871.00
182_A233_L0.5861.00
81_I139_F0.5851.00
57_I238_L0.5851.00
111_A114_G0.5841.00
71_T220_K0.5811.00
189_L222_M0.5801.00
45_P49_L0.5751.00
71_T202_I0.5751.00
57_I241_R0.5751.00
110_G114_G0.5741.00
186_L190_L0.5731.00
121_I128_P0.5731.00
58_N253_Y0.5721.00
160_G164_F0.5701.00
156_G159_Y0.5691.00
161_F165_G0.5691.00
140_R254_E0.5691.00
125_K217_T0.5681.00
89_V235_G0.5671.00
88_L105_L0.5671.00
168_Y172_I0.5671.00
188_V191_H0.5661.00
58_N282_V0.5651.00
107_C110_G0.5641.00
121_I224_Y0.5641.00
67_F189_L0.5611.00
54_Q290_N0.5611.00
81_I114_G0.5591.00
207_K211_I0.5571.00
63_F183_F0.5541.00
260_A278_T0.5501.00
63_F187_W0.5491.00
53_R176_A0.5481.00
256_D303_L0.5471.00
92_M96_G0.5471.00
52_L55_V0.5451.00
261_V278_T0.5451.00
159_Y165_G0.5441.00
263_L313_A0.5441.00
189_L193_T0.5441.00
187_W274_R0.5441.00
264_G278_T0.5431.00
181_L184_V0.5401.00
91_G94_V0.5401.00
137_T141_G0.5391.00
63_F184_V0.5371.00
133_L137_T0.5331.00
277_G281_G0.5311.00
178_T182_A0.5311.00
132_T136_M0.5311.00
160_G166_R0.5301.00
84_L109_I0.5301.00
169_F174_V0.5301.00
209_A216_V0.5261.00
220_K223_I0.5251.00
77_S117_N0.5241.00
228_G231_S0.5241.00
139_F143_T0.5231.00
191_H194_P0.5201.00
182_A186_L0.5191.00
276_V279_L0.5191.00
136_M254_E0.5191.00
172_I175_P0.5171.00
225_S228_G0.5131.00
88_L106_G0.5121.00
111_A228_G0.5111.00
99_P240_S0.5081.00
58_N62_A0.5081.00
79_G250_G0.5061.00
68_V73_G0.5061.00
47_N50_N0.5051.00
83_A249_A0.5051.00
59_G63_F0.5041.00
302_Q306_K0.5031.00
251_E254_E0.5021.00
48_I52_L0.5011.00
133_L136_M0.5011.00
248_T251_E0.5011.00
163_M168_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g1uA 2 0.823 97.1 0.879 Contact Map
2nq2A 2 0.8571 96.3 0.89 Contact Map
2qi9A 2 0.9006 96 0.893 Contact Map
3d31C 2 0.736 22.9 0.95 Contact Map
1pw4A 1 0.587 22.4 0.95 Contact Map
2onkC 2 0.7422 20.9 0.951 Contact Map
2m8rA 1 0.1366 20 0.951 Contact Map
3o7qA 1 0.5497 18.3 0.952 Contact Map
1u7gA 3 0.5745 18 0.952 Contact Map
2gfpA 2 0.5559 11.1 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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