GREMLIN Database
RBSK - Ribokinase
UniProt: P36945 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 293 (270)
Sequences: 22426 (16671)
Seq/√Len: 1014.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_A250_V3.1741.00
135_L160_I2.7931.00
71_L86_P2.6611.00
211_E217_R2.5471.00
56_F80_R2.5341.00
218_Y262_L2.4881.00
257_D260_A2.4231.00
251_A256_K2.3531.00
216_V244_F2.3111.00
5_C131_V2.2921.00
48_A53_A2.1861.00
150_K176_H2.1801.00
68_T86_P2.1781.00
50_R77_N2.0721.00
60_K87_V2.0551.00
6_V45_A2.0371.00
184_E211_E2.0061.00
160_I249_A2.0011.00
152_C157_I1.9651.00
251_A264_F1.9491.00
243_T268_A1.9441.00
46_V77_N1.8661.00
225_V259_E1.8471.00
178_T205_A1.8401.00
149_C159_I1.8301.00
133_M158_P1.8271.00
181_T245_N1.8241.00
158_P178_T1.8041.00
60_K120_Y1.7741.00
218_Y225_V1.7711.00
47_A246_A1.7631.00
216_V266_N1.7561.00
256_K260_A1.7501.00
240_A273_V1.7481.00
72_N76_A1.7351.00
75_K81_T1.7261.00
200_L219_S1.7161.00
73_N76_A1.6981.00
133_M160_I1.6931.00
211_E226_L1.6861.00
71_L75_K1.6751.00
230_F267_R1.6751.00
269_A273_V1.6691.00
217_R226_L1.6651.00
259_E263_R1.6651.00
247_A268_A1.6641.00
248_F261_A1.6531.00
195_T198_E1.6321.00
179_Y206_K1.6321.00
146_D172_E1.6161.00
48_A250_V1.6001.00
208_F248_F1.5541.00
236_D277_G1.5451.00
68_T72_N1.5411.00
10_C59_G1.5341.00
147_E150_K1.5261.00
188_S194_L1.5241.00
162_N210_T1.5221.00
206_K220_A1.5081.00
133_M249_A1.5081.00
218_Y258_I1.5021.00
220_A223_K1.5011.00
63_D68_T1.4941.00
4_I48_A1.4791.00
227_I262_L1.4721.00
247_A264_F1.4681.00
146_D150_K1.4631.00
35_T69_A1.4551.00
163_P182_P1.4501.00
37_P70_I1.4471.00
151_Y155_H1.4391.00
153_H178_T1.4351.00
147_E151_Y1.4241.00
211_E214_Q1.4201.00
90_T115_D1.4161.00
158_P179_Y1.3891.00
177_A180_L1.3681.00
151_Y154_S1.3601.00
129_E155_H1.3551.00
42_A74_L1.3531.00
17_T32_S1.3431.00
12_M69_A1.3421.00
230_F263_R1.3361.00
153_H176_H1.3351.00
232_V274_C1.3321.00
250_V254_E1.3311.00
54_Q80_R1.3241.00
63_D86_P1.3241.00
227_I266_N1.3231.00
67_G92_S1.3111.00
71_L84_M1.2971.00
14_L33_F1.2701.00
219_S224_E1.2681.00
248_F252_L1.2601.00
216_V262_L1.2591.00
206_K252_L1.2411.00
210_T244_F1.2361.00
211_E215_G1.2281.00
230_F266_N1.2251.00
37_P73_N1.2221.00
206_K248_F1.2201.00
260_A263_R1.2131.00
181_T210_T1.2131.00
73_N77_N1.2121.00
49_A79_V1.2081.00
251_A261_A1.2051.00
206_K258_I1.2051.00
232_V273_V1.2011.00
248_F265_A1.1981.00
271_L275_S1.1921.00
247_A265_A1.1901.00
72_N75_K1.1891.00
87_V90_T1.1891.00
158_P205_A1.1881.00
107_V111_G1.1861.00
234_P273_V1.1831.00
51_L247_A1.1721.00
68_T71_L1.1671.00
69_A72_N1.1641.00
14_L35_T1.1631.00
193_E198_E1.1581.00
187_A209_I1.1451.00
271_L274_C1.1421.00
48_A55_V1.1421.00
117_T120_Y1.1401.00
230_F270_S1.1351.00
118_P147_E1.1271.00
44_Q135_L1.1171.00
179_Y248_F1.1171.00
45_A55_V1.1151.00
136_I159_I1.1031.00
134_V152_C1.1021.00
53_A253_A1.0961.00
234_P237_T1.0871.00
184_E214_Q1.0791.00
150_K154_S1.0761.00
46_V50_R1.0731.00
206_K218_Y1.0641.00
47_A243_T1.0641.00
53_A254_E1.0591.00
65_H68_T1.0501.00
229_S266_N1.0411.00
61_V67_G1.0371.00
63_D89_H1.0371.00
251_A254_E1.0351.00
135_L249_A1.0341.00
49_A78_G1.0281.00
266_N269_A1.0231.00
122_L147_E1.0191.00
243_T272_S1.0161.00
161_L177_A1.0161.00
10_C70_I1.0121.00
179_Y252_L1.0111.00
6_V41_G1.0091.00
134_V157_I0.9971.00
261_A265_A0.9911.00
61_V71_L0.9861.00
263_R267_R0.9851.00
181_T248_F0.9831.00
135_L245_N0.9821.00
48_A246_A0.9811.00
56_F83_Y0.9801.00
250_V264_F0.9691.00
17_T34_Q0.9671.00
223_K259_E0.9651.00
7_I134_V0.9641.00
62_G92_S0.9611.00
248_F258_I0.9611.00
51_L268_A0.9581.00
87_V115_D0.9541.00
56_F131_V0.9521.00
143_E147_E0.9501.00
183_N186_E0.9491.00
37_P69_A0.9481.00
234_P274_C0.9431.00
15_V36_V0.9371.00
5_C58_V0.9331.00
49_A54_Q0.9321.00
131_V157_I0.9311.00
61_V84_M0.9241.00
69_A73_N0.9231.00
215_G229_S0.9231.00
126_E129_E0.9221.00
56_F127_Q0.9211.00
71_L81_T0.9171.00
81_T84_M0.9121.00
256_K264_F0.9101.00
16_V96_H0.9081.00
10_C42_A0.9081.00
10_C57_M0.9071.00
64_D92_S0.9061.00
214_Q226_L0.9051.00
184_E188_S0.9011.00
14_L66_Y0.8991.00
107_V110_K0.8971.00
4_I253_A0.8961.00
42_A279_Q0.8911.00
136_I149_C0.8871.00
233_E274_C0.8861.00
252_L261_A0.8811.00
150_K172_E0.8691.00
257_D261_A0.8631.00
182_P187_A0.8601.00
11_S93_G0.8531.00
167_R170_K0.8531.00
197_S224_E0.8501.00
144_T148_V0.8501.00
71_L85_E0.8491.00
136_I145_V0.8461.00
14_L94_T0.8461.00
162_N181_T0.8441.00
225_V262_L0.8381.00
243_T269_A0.8381.00
243_T247_A0.8361.00
244_F266_N0.8331.00
61_V86_P0.8271.00
160_I181_T0.8251.00
13_D38_G0.8241.00
113_N116_I0.8221.00
44_Q245_N0.8221.00
175_D203_Y0.8191.00
227_I263_R0.8191.00
70_I92_S0.8141.00
235_V276_F0.8131.00
60_K85_E0.8121.00
213_K231_P0.8111.00
24_A103_D0.8111.00
172_E175_D0.8101.00
162_N182_P0.8091.00
174_I177_A0.8071.00
232_V270_S0.7941.00
220_A258_I0.7911.00
267_R271_L0.7901.00
247_A251_A0.7901.00
227_I259_E0.7891.00
5_C56_F0.7841.00
12_M66_Y0.7821.00
196_I199_A0.7811.00
45_A57_M0.7761.00
128_I131_V0.7741.00
49_A55_V0.7741.00
127_Q131_V0.7731.00
103_D106_I0.7731.00
128_I157_I0.7651.00
138_Q161_L0.7601.00
7_I148_V0.7591.00
85_E120_Y0.7551.00
266_N270_S0.7471.00
149_C176_H0.7441.00
217_R224_E0.7391.00
12_M35_T0.7381.00
269_A272_S0.7361.00
30_G107_V0.7361.00
116_I120_Y0.7361.00
56_F82_D0.7301.00
105_S108_V0.7291.00
146_D176_H0.7281.00
133_M253_A0.7271.00
46_V279_Q0.7231.00
220_A225_V0.7231.00
215_G226_L0.7231.00
35_T66_Y0.7201.00
116_I121_A0.7181.00
120_Y123_N0.7111.00
208_F218_Y0.7111.00
104_N108_V0.7101.00
51_L250_V0.7101.00
23_K26_E0.7101.00
38_G43_N0.7031.00
54_Q132_D0.7001.00
73_N279_Q0.7001.00
40_K164_A0.6991.00
160_I179_Y0.6971.00
244_F262_L0.6951.00
108_V111_G0.6821.00
244_F265_A0.6811.00
256_K261_A0.6811.00
83_Y127_Q0.6781.00
118_P143_E0.6761.00
97_I106_I0.6761.00
51_L264_F0.6741.00
66_Y94_T0.6731.00
143_E146_D0.6681.00
146_D149_C0.6681.00
220_A224_E0.6621.00
244_F269_A0.6571.00
16_V30_G0.6551.00
97_I238_T0.6551.00
148_V152_C0.6521.00
152_C155_H0.6521.00
168_P171_Q0.6501.00
34_Q276_F0.6481.00
132_D157_I0.6461.00
112_A115_D0.6451.00
82_D127_Q0.6421.00
98_V105_S0.6411.00
45_A79_V0.6381.00
160_I245_N0.6371.00
118_P144_T0.6361.00
159_I177_A0.6331.00
48_A249_A0.6321.00
180_L207_L0.6311.00
9_S139_E0.6261.00
5_C127_Q0.6261.00
203_Y207_L0.6251.00
59_G84_M0.6221.00
262_L266_N0.6211.00
16_V33_F0.6191.00
188_S193_E0.6141.00
246_A250_V0.6131.00
68_T75_K0.6121.00
95_A98_V0.6101.00
119_A122_L0.6091.00
51_L246_A0.6081.00
93_G98_V0.6071.00
134_V148_V0.6061.00
85_E123_N0.6031.00
167_R171_Q0.6021.00
252_L255_G0.6011.00
152_C159_I0.6011.00
171_Q202_L0.6001.00
105_S109_V0.5961.00
17_T276_F0.5941.00
4_I53_A0.5941.00
40_K139_E0.5931.00
133_M179_Y0.5911.00
64_D67_G0.5901.00
44_Q249_A0.5901.00
42_A57_M0.5901.00
145_V148_V0.5881.00
238_T278_A0.5881.00
204_P207_L0.5861.00
118_P122_L0.5851.00
260_A264_F0.5851.00
27_T40_K0.5841.00
216_V227_I0.5831.00
49_A77_N0.5761.00
91_E94_T0.5761.00
93_G113_N0.5761.00
149_C173_T0.5761.00
37_P279_Q0.5761.00
227_I230_F0.5711.00
208_F244_F0.5701.00
87_V120_Y0.5691.00
98_V107_V0.5671.00
90_T93_G0.5661.00
83_Y86_P0.5631.00
113_N117_T0.5631.00
162_N242_D0.5621.00
132_D158_P0.5611.00
181_T208_F0.5591.00
9_S164_A0.5591.00
122_L126_E0.5571.00
185_H189_I0.5551.00
54_Q253_A0.5551.00
187_A219_S0.5521.00
42_A46_V0.5501.00
182_P210_T0.5481.00
74_L79_V0.5471.00
135_L139_E0.5451.00
127_Q130_K0.5441.00
187_A199_A0.5441.00
258_I261_A0.5421.00
213_K234_P0.5411.00
90_T112_A0.5371.00
123_N126_E0.5371.00
258_I262_L0.5321.00
210_T242_D0.5321.00
197_S226_L0.5311.00
135_L138_Q0.5311.00
41_G45_A0.5301.00
186_E191_F0.5301.00
13_D95_A0.5301.00
17_T99_L0.5301.00
43_N278_A0.5291.00
133_M252_L0.5291.00
152_C156_D0.5261.00
17_T100_A0.5251.00
208_F262_L0.5251.00
166_A189_I0.5211.00
160_I252_L0.5211.00
63_D87_V0.5201.00
10_C74_L0.5201.00
46_V79_V0.5171.00
177_A204_P0.5141.00
12_M70_I0.5141.00
6_V48_A0.5141.00
191_F199_A0.5131.00
212_G237_T0.5121.00
74_L81_T0.5121.00
55_V79_V0.5111.00
255_G261_A0.5101.00
44_Q48_A0.5101.00
95_A139_E0.5091.00
93_G97_I0.5091.00
184_E212_G0.5091.00
148_V151_Y0.5081.00
271_L283_P0.5081.00
187_A207_L0.5081.00
254_E264_F0.5071.00
174_I204_P0.5061.00
13_D278_A0.5021.00
44_Q246_A0.5001.00
153_H156_D0.5001.00
5_C128_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rbcA 2 0.9898 100 0.173 Contact Map
3ry7A 2 0.9932 100 0.177 Contact Map
4xdaA 2 1 100 0.179 Contact Map
3ikhA 2 0.9659 100 0.18 Contact Map
1rkdA 2 1 100 0.184 Contact Map
2fv7A 2 1 100 0.19 Contact Map
3go6A 4 0.9454 100 0.206 Contact Map
1vm7A 2 0.9727 100 0.206 Contact Map
3vasA 1 0.9795 100 0.209 Contact Map
3ljsA 2 0.9659 100 0.214 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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