GREMLIN Database
RBSR - Ribose operon repressor
UniProt: P36944 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 326 (318)
Sequences: 37161 (26838)
Seq/√Len: 1505.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_Y195_E3.3541.00
171_S232_D3.1791.00
10_A42_K3.1111.00
255_N258_E3.0371.00
162_A263_I2.5831.00
190_F194_L2.5591.00
118_G296_L2.5501.00
171_S261_Q2.4561.00
267_D282_K2.4481.00
149_P299_I2.3331.00
160_K199_Q2.2711.00
30_E34_T2.2291.00
218_Q251_R2.2231.00
84_E87_R2.2001.00
38_A42_K2.1861.00
34_T38_A2.1571.00
84_E294_K2.1391.00
169_G322_T2.1381.00
222_K252_R2.1131.00
160_K195_E2.0711.00
291_E294_K2.0561.00
160_K196_I2.0201.00
164_Q196_I2.0181.00
157_T161_L2.0151.00
167_I200_A2.0141.00
222_K248_E1.9521.00
85_L293_A1.9401.00
21_N36_V1.9311.00
158_G265_Y1.8951.00
156_Y191_N1.8831.00
33_R37_I1.8731.00
80_G289_G1.8661.00
159_V163_A1.8651.00
22_L40_M1.8551.00
164_Q168_H1.8301.00
226_A252_R1.8211.00
84_E290_K1.8181.00
5_K15_V1.8161.00
298_G303_Q1.8151.00
249_A260_I1.7971.00
166_I233_G1.7921.00
217_A244_A1.7851.00
282_K315_T1.7681.00
83_D286_Y1.7521.00
159_V235_I1.7421.00
163_A193_A1.7281.00
164_Q200_A1.6801.00
160_K164_Q1.6721.00
11_A39_A1.6591.00
218_Q248_E1.6541.00
10_A39_A1.6451.00
254_K259_D1.6441.00
221_A245_V1.6291.00
175_T231_T1.6251.00
63_G116_V1.6231.00
284_P287_D1.6171.00
291_E310_I1.6161.00
176_L237_S1.6071.00
80_G286_Y1.6031.00
236_A245_V1.5981.00
161_L314_V1.5861.00
84_E88_E1.5511.00
255_N259_D1.5481.00
277_P320_K1.5471.00
248_E252_R1.5361.00
37_I41_A1.5161.00
157_T160_K1.5131.00
141_L292_A1.5051.00
173_R230_A1.5001.00
191_N195_E1.4911.00
165_A168_H1.4721.00
154_D157_T1.4681.00
167_I196_I1.4681.00
88_E297_L1.4591.00
250_L275_F1.4581.00
287_D291_E1.4511.00
21_N40_M1.4461.00
248_E251_R1.4401.00
7_V39_A1.4231.00
263_I279_S1.4041.00
37_I40_M1.4041.00
173_R205_Q1.4001.00
267_D319_R1.3981.00
188_D191_N1.3911.00
194_L198_K1.3881.00
165_A318_G1.3721.00
287_D290_K1.3661.00
218_Q247_H1.3581.00
84_E293_A1.3541.00
60_R117_A1.3481.00
158_G314_V1.3401.00
211_S216_D1.3371.00
297_L301_K1.3341.00
222_K251_R1.3341.00
163_A167_I1.3271.00
175_T224_L1.3191.00
249_A254_K1.3161.00
221_A234_V1.3041.00
173_R232_D1.2981.00
159_V192_G1.2941.00
218_Q222_K1.2901.00
163_A192_G1.2761.00
196_I199_Q1.2761.00
10_A43_L1.2751.00
163_A196_I1.2691.00
208_E223_E1.2621.00
5_K9_G1.2601.00
294_K298_G1.2511.00
221_A249_A1.2431.00
63_G111_F1.2411.00
156_Y160_K1.2401.00
60_R90_Y1.2391.00
62_I85_L1.2351.00
6_D9_G1.2341.00
30_E33_R1.2331.00
165_A322_T1.2291.00
171_S233_G1.2281.00
222_K226_A1.2261.00
29_H32_T1.2251.00
20_R25_N1.2121.00
7_V11_A1.2101.00
192_G196_I1.2091.00
129_E133_G1.2081.00
120_I292_A1.2031.00
35_R39_A1.2021.00
95_G107_Y1.2001.00
161_L164_Q1.1971.00
246_L262_I1.1951.00
95_G111_F1.1911.00
39_A42_K1.1861.00
39_A43_L1.1851.00
85_L92_L1.1761.00
165_A169_G1.1711.00
172_Q232_D1.1621.00
164_Q199_Q1.1591.00
7_V43_L1.1451.00
81_A293_A1.1441.00
223_E227_S1.1421.00
156_Y188_D1.1391.00
228_Y231_T1.1371.00
286_Y290_K1.1361.00
64_L81_A1.1321.00
32_T35_R1.1311.00
193_A197_L1.1251.00
109_Q130_E1.1251.00
4_I15_V1.1221.00
81_A120_I1.1141.00
215_K219_S1.1041.00
244_A248_E1.1041.00
61_L91_R1.1001.00
64_L92_L1.0961.00
156_Y192_G1.0921.00
261_Q322_T1.0901.00
177_L245_V1.0891.00
88_E294_K1.0891.00
176_L190_F1.0811.00
196_I200_A1.0811.00
167_I202_V1.0761.00
174_I197_L1.0751.00
162_A235_I1.0751.00
82_E86_N1.0691.00
289_G293_A1.0671.00
4_I18_V1.0651.00
38_A41_A1.0631.00
234_V245_V1.0591.00
61_L93_I1.0581.00
195_E199_Q1.0571.00
295_L310_I1.0561.00
213_S216_D1.0541.00
239_D280_T1.0541.00
34_T37_I1.0521.00
21_N28_V1.0471.00
220_M223_E1.0431.00
168_H200_A1.0361.00
291_E295_L1.0311.00
173_R229_P1.0211.00
191_N194_L1.0201.00
239_D264_G1.0151.00
105_L109_Q1.0151.00
48_N54_L1.0151.00
50_V53_S1.0121.00
193_A235_I1.0111.00
24_D33_R1.0061.00
88_E301_K0.9981.00
194_L204_F0.9971.00
236_A242_A0.9941.00
217_A221_A0.9911.00
86_N103_K0.9871.00
290_K294_K0.9831.00
236_A241_Q0.9791.00
219_S223_E0.9741.00
216_D219_S0.9721.00
90_Y297_L0.9701.00
40_M43_L0.9691.00
291_E312_M0.9651.00
187_Q191_N0.9621.00
169_G318_G0.9581.00
173_R203_D0.9511.00
296_L300_I0.9491.00
157_T313_P0.9381.00
174_I233_G0.9331.00
165_A279_S0.9331.00
184_P188_D0.9291.00
103_K106_E0.9291.00
51_A54_L0.9251.00
214_I247_H0.9251.00
11_A18_V0.9241.00
87_R290_K0.9221.00
250_L277_P0.9201.00
48_N51_A0.9191.00
246_L256_V0.9181.00
162_A281_I0.9161.00
221_A225_F0.9161.00
109_Q113_Q0.9141.00
120_I296_L0.9111.00
79_R83_D0.9041.00
282_K317_I0.9031.00
208_E220_M0.8981.00
169_G261_Q0.8941.00
163_A197_L0.8931.00
83_D290_K0.8901.00
197_L202_V0.8821.00
149_P295_L0.8821.00
246_L274_L0.8761.00
167_I172_Q0.8751.00
315_T318_G0.8731.00
172_Q202_V0.8691.00
47_P52_R0.8681.00
24_D37_I0.8641.00
182_H187_Q0.8631.00
154_D311_Q0.8601.00
62_I120_I0.8591.00
284_P312_M0.8581.00
181_A209_T0.8581.00
284_P315_T0.8571.00
150_S309_A0.8571.00
78_A82_E0.8561.00
81_A289_G0.8541.00
179_G212_F0.8501.00
234_V260_I0.8461.00
151_V295_L0.8461.00
73_F285_A0.8451.00
153_S284_P0.8421.00
254_K260_I0.8411.00
219_S222_K0.8401.00
197_L204_F0.8351.00
175_T234_V0.8341.00
239_D267_D0.8331.00
249_A262_I0.8321.00
225_F248_E0.8311.00
21_N37_I0.8241.00
64_L78_A0.8231.00
264_G280_T0.8211.00
157_T314_V0.8211.00
210_A241_Q0.8191.00
202_V205_Q0.8151.00
195_E198_K0.8141.00
178_R190_F0.8091.00
100_E103_K0.8051.00
31_E34_T0.8041.00
295_L298_G0.7991.00
152_S311_Q0.7981.00
153_S283_Q0.7921.00
76_Q286_Y0.7891.00
318_G322_T0.7891.00
267_D317_I0.7871.00
81_A92_L0.7841.00
216_D220_M0.7831.00
59_S117_A0.7801.00
155_G189_R0.7801.00
83_D87_R0.7791.00
166_I263_I0.7781.00
118_G300_I0.7781.00
153_S314_V0.7761.00
49_E52_R0.7741.00
80_G290_K0.7731.00
77_L141_L0.7721.00
152_S309_A0.7711.00
230_A254_K0.7681.00
154_D313_P0.7671.00
61_L114_N0.7671.00
177_L236_A0.7661.00
106_E109_Q0.7641.00
165_A316_Y0.7631.00
13_V36_V0.7631.00
293_A297_L0.7601.00
130_E133_G0.7561.00
17_T20_R0.7561.00
188_D192_G0.7551.00
221_A224_L0.7521.00
176_L235_I0.7491.00
31_E35_R0.7461.00
112_K134_M0.7441.00
78_A94_F0.7421.00
16_A20_R0.7381.00
131_Y138_V0.7361.00
225_F252_R0.7361.00
93_I116_V0.7341.00
267_D271_S0.7331.00
221_A248_E0.7321.00
80_G84_E0.7301.00
144_T309_A0.7301.00
46_Y113_Q0.7271.00
67_P74_F0.7251.00
247_H250_L0.7251.00
20_R26_G0.7221.00
266_D283_Q0.7201.00
242_A264_G0.7181.00
161_L281_I0.7141.00
279_S316_Y0.7061.00
79_R82_E0.7051.00
20_R27_Y0.7051.00
103_K107_Y0.7051.00
58_E117_A0.7041.00
63_G119_I0.7021.00
98_D103_K0.6991.00
120_I141_L0.6981.00
279_S322_T0.6971.00
298_G302_K0.6951.00
160_K192_G0.6941.00
102_K106_E0.6931.00
62_I293_A0.6911.00
206_V227_S0.6911.00
58_E301_K0.6901.00
82_E92_L0.6871.00
243_A274_L0.6861.00
227_S230_A0.6861.00
65_L107_Y0.6851.00
235_I263_I0.6841.00
193_A204_F0.6841.00
210_A216_D0.6761.00
249_A256_V0.6751.00
223_E226_A0.6741.00
190_F207_I0.6731.00
239_D242_A0.6731.00
140_F145_L0.6671.00
132_S138_V0.6661.00
227_S231_T0.6641.00
167_I197_L0.6621.00
82_E96_N0.6621.00
118_G139_V0.6611.00
247_H251_R0.6571.00
34_T41_A0.6571.00
232_D261_Q0.6511.00
46_Y109_Q0.6511.00
138_V148_A0.6491.00
217_A220_M0.6471.00
21_N33_R0.6461.00
129_E132_S0.6441.00
174_I232_D0.6421.00
186_A212_F0.6421.00
247_H277_P0.6411.00
93_I114_N0.6401.00
112_K136_Y0.6391.00
5_K55_Y0.6381.00
176_L193_A0.6371.00
118_G292_A0.6341.00
27_Y32_T0.6331.00
302_K305_L0.6291.00
221_A244_A0.6271.00
166_I235_I0.6271.00
71_N240_I0.6261.00
179_G186_A0.6241.00
108_L119_I0.6241.00
243_A270_Q0.6211.00
212_F237_S0.6191.00
139_V151_V0.6121.00
35_R38_A0.6101.00
214_I270_Q0.6091.00
142_D185_T0.6071.00
238_N266_D0.6071.00
41_A44_N0.6061.00
206_V209_T0.6041.00
162_A233_G0.6041.00
161_L165_A0.6041.00
18_V40_M0.6011.00
80_G285_A0.6001.00
79_R286_Y0.6001.00
174_I193_A0.5991.00
13_V32_T0.5981.00
142_D155_G0.5981.00
139_V299_I0.5961.00
76_Q285_A0.5961.00
215_K218_Q0.5881.00
139_V296_L0.5881.00
246_L250_L0.5871.00
238_N241_Q0.5871.00
250_L276_P0.5871.00
77_L285_A0.5861.00
249_A252_R0.5851.00
18_V21_N0.5851.00
155_G188_D0.5831.00
271_S280_T0.5821.00
20_R28_V0.5811.00
160_K163_A0.5811.00
243_A268_I0.5801.00
247_H275_F0.5781.00
7_V18_V0.5771.00
90_Y300_I0.5761.00
59_S91_R0.5761.00
214_I244_A0.5761.00
271_S278_L0.5751.00
277_P319_R0.5731.00
208_E227_S0.5731.00
140_F148_A0.5711.00
250_L255_N0.5681.00
169_G232_D0.5661.00
235_I265_Y0.5651.00
73_F77_L0.5621.00
46_Y50_V0.5621.00
62_I300_I0.5611.00
208_E224_L0.5601.00
286_Y289_G0.5601.00
144_T150_S0.5591.00
62_I118_G0.5591.00
173_R206_V0.5551.00
119_I136_Y0.5541.00
173_R231_T0.5521.00
52_R56_K0.5521.00
265_Y283_Q0.5501.00
25_N28_V0.5471.00
132_S148_A0.5471.00
95_G110_T0.5461.00
263_I322_T0.5451.00
165_A263_I0.5441.00
295_L299_I0.5431.00
220_M224_L0.5401.00
90_Y117_A0.5391.00
62_I90_Y0.5381.00
97_S104_E0.5381.00
85_L90_Y0.5371.00
18_V36_V0.5371.00
140_F150_S0.5361.00
101_L105_L0.5351.00
186_A237_S0.5341.00
139_V295_L0.5331.00
72_P240_I0.5321.00
85_L297_L0.5321.00
279_S318_G0.5311.00
288_M312_M0.5311.00
281_I314_V0.5281.00
212_F241_Q0.5281.00
236_A264_G0.5261.00
111_F116_V0.5261.00
299_I305_L0.5261.00
206_V210_A0.5251.00
116_V119_I0.5251.00
61_L117_A0.5251.00
13_V18_V0.5251.00
139_V292_A0.5241.00
210_A217_A0.5221.00
16_A25_N0.5201.00
124_N127_D0.5191.00
274_L277_P0.5191.00
79_R98_D0.5181.00
272_G277_P0.5171.00
218_Q221_A0.5161.00
225_F249_A0.5161.00
299_I302_K0.5151.00
276_P321_T0.5141.00
173_R228_Y0.5141.00
109_Q112_K0.5141.00
256_V259_D0.5121.00
11_A21_N0.5121.00
251_R275_F0.5111.00
81_A85_L0.5081.00
151_V291_E0.5061.00
130_E134_M0.5051.00
177_L220_M0.5041.00
74_F122_A0.5041.00
11_A36_V0.5041.00
239_D268_I0.5041.00
28_V33_R0.5031.00
218_Q244_A0.5021.00
153_S158_G0.5021.00
231_T234_V0.5011.00
231_T254_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hsgA 1 0.9816 100 0.085 Contact Map
3ctpA 2 0.8067 100 0.087 Contact Map
3dbiA 2 0.8252 100 0.087 Contact Map
3bilA 2 0.7699 100 0.088 Contact Map
2o20A 2 0.8221 100 0.093 Contact Map
1qpzA 2 0.9969 100 0.093 Contact Map
4o5aA 2 0.8098 100 0.094 Contact Map
3jvdA 2 0.7945 100 0.099 Contact Map
3h5oA 2 0.8098 100 0.102 Contact Map
3e3mA 2 0.8006 100 0.104 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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