GREMLIN Database
ARGJ - Arginine biosynthesis bifunctional protein ArgJ
UniProt: P36843 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 406 (386)
Sequences: 2839 (1758)
Seq/√Len: 89.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
305_I377_I4.3731.00
395_Y399_K3.5521.00
97_D127_H3.5271.00
59_Q67_Q3.0171.00
43_S241_N3.0131.00
100_T134_H2.9651.00
167_E176_T2.7481.00
295_N384_G2.7441.00
215_E260_K2.6761.00
304_K331_H2.6521.00
23_Q44_E2.5991.00
210_Q214_R2.5561.00
269_D273_E2.3501.00
167_E174_T2.3471.00
51_A237_L2.3451.00
223_Q299_N2.3031.00
327_G331_H2.3031.00
396_D399_K2.3001.00
104_S134_H2.2411.00
292_A298_A2.2341.00
93_Q97_D2.1731.00
36_K152_E2.1411.00
119_S197_F2.0961.00
93_Q127_H2.0911.00
92_E96_K2.0881.00
316_Y395_Y2.0861.00
80_I101_M2.0811.00
97_D130_M2.0711.00
39_G153_A2.0661.00
290_Q376_V2.0251.00
349_C352_K2.0091.00
164_T266_T1.9941.00
150_F180_A1.9821.00
77_K115_L1.9661.00
220_S268_E1.9371.00
344_Y349_C1.9171.00
68_D99_Y1.9091.00
301_I329_I1.8871.00
23_Q42_I1.8821.00
223_Q386_G1.8721.00
212_A263_L1.8691.00
177_I266_T1.8541.00
48_V206_E1.8381.00
166_Y265_L1.8311.00
39_G150_F1.8201.00
342_E380_A1.8141.00
216_I264_L1.7651.00
60_A88_A1.7641.00
164_T269_D1.7611.00
348_Q367_Y1.7321.00
198_V267_C1.7241.00
259_F263_L1.7081.00
224_I275_A1.6961.00
325_I345_L1.6961.00
290_Q378_K1.6811.00
361_E405_R1.6691.00
45_T243_C1.6541.00
40_V105_F1.6531.00
188_H307_G1.6481.00
155_L161_I1.6481.00
272_K284_L1.6481.00
216_I220_S1.6461.00
346_G367_Y1.6321.00
329_I377_I1.6051.00
286_E374_T1.5981.00
60_A233_N1.5971.00
311_V375_I1.5881.00
285_I315_V1.5761.00
166_Y269_D1.5751.00
66_T235_M1.5661.00
288_Q374_T1.5641.00
103_E107_S1.5601.00
293_K297_D1.5601.00
59_Q64_K1.5561.00
288_Q387_R1.5381.00
212_A260_K1.5351.00
291_G378_K1.5271.00
294_N297_D1.5241.00
216_I267_C1.5221.00
203_A246_N1.5071.00
315_V375_I1.5071.00
177_I263_L1.5061.00
65_V102_R1.5031.00
78_A116_V1.4961.00
165_C178_G1.4891.00
221_F267_C1.4821.00
78_A109_L1.4781.00
337_T340_E1.4751.00
219_V264_L1.4690.99
320_A405_R1.4490.99
297_D334_A1.4390.99
179_G270_L1.4370.99
399_K403_S1.4170.99
26_G36_K1.4120.99
65_V98_A1.4100.99
143_T146_G1.4080.99
104_S138_E1.4070.99
49_S239_M1.3970.99
69_S102_R1.3930.99
76_L117_A1.3890.99
301_I379_M1.3880.99
403_S406_T1.3850.99
100_T104_S1.3760.99
316_Y394_T1.3740.99
53_Y70_L1.3740.99
103_E113_P1.3680.99
272_K389_W1.3600.99
81_V197_F1.3590.99
213_L236_V1.3450.99
104_S107_S1.3430.99
326_I343_V1.3420.99
204_I259_F1.3420.99
171_G255_D1.3360.99
36_K149_D1.3300.99
306_V390_G1.3300.99
169_A174_T1.3290.99
52_V217_T1.3290.99
168_L262_A1.3270.99
260_K264_L1.3250.99
316_Y396_D1.3230.99
95_L99_Y1.3210.99
344_Y376_V1.3210.99
105_F116_V1.3190.99
22_F241_N1.3120.99
65_V69_S1.3110.99
41_I199_T1.3030.99
363_I366_E1.2910.99
288_Q385_N1.2870.99
287_A306_V1.2820.99
196_G221_F1.2810.99
169_A172_G1.2800.99
123_V405_R1.2750.99
318_T369_E1.2550.98
353_N380_A1.2420.98
24_A41_I1.2400.98
347_G376_V1.2380.98
177_I262_A1.2380.98
108_Q137_I1.2360.98
40_V141_K1.2230.98
108_Q138_E1.2210.98
283_K318_T1.2200.98
238_V263_L1.2200.98
219_V295_N1.2200.98
216_I260_K1.2200.98
205_E208_A1.1990.98
101_M118_V1.1970.98
286_E389_W1.1960.98
300_V333_A1.1930.98
184_S226_V1.1910.98
79_V239_M1.1880.98
160_V273_E1.1860.98
294_N384_G1.1770.98
220_S264_L1.1760.98
55_Q190_N1.1740.98
27_V140_L1.1730.98
119_S235_M1.1710.97
367_Y370_G1.1700.97
100_T103_E1.1670.97
112_E115_L1.1630.97
28_H36_K1.1580.97
101_M133_I1.1520.97
19_P22_F1.1490.97
129_D132_K1.1480.97
268_E272_K1.1410.97
329_I336_V1.1380.97
268_E389_W1.1340.97
177_I259_F1.1330.97
196_G236_V1.1300.97
108_Q141_K1.1300.97
53_Y63_I1.1250.97
117_A237_L1.1240.97
365_K369_E1.1240.97
218_D299_N1.1160.97
204_I238_V1.1080.96
214_R218_D1.1080.96
50_A210_Q1.1020.96
57_H335_Q1.0970.96
178_G199_T1.0930.96
349_C357_Q1.0920.96
342_E352_K1.0910.96
31_L84_A1.0910.96
105_F137_I1.0820.96
152_E155_L1.0810.96
275_A284_L1.0810.96
305_I329_I1.0800.96
173_K246_N1.0780.96
347_G367_Y1.0770.96
224_I271_A1.0760.96
41_I180_A1.0750.96
225_T307_G1.0710.96
48_V209_L1.0640.96
198_V236_V1.0630.96
55_Q192_A1.0630.96
148_G163_Q1.0620.96
213_L238_V1.0580.95
283_K315_V1.0570.95
209_L238_V1.0530.95
288_Q376_V1.0410.95
16_V178_G1.0410.95
290_Q385_N1.0380.95
72_H115_L1.0380.95
101_M105_F1.0350.95
211_K252_D1.0320.95
98_A118_V1.0310.95
299_N386_G1.0290.95
25_K40_V1.0260.95
53_Y66_T1.0250.95
96_K100_T1.0200.94
170_I173_K1.0190.94
299_N303_K1.0170.94
293_K335_Q1.0150.94
32_R84_A1.0110.94
253_H256_W1.0100.94
131_E135_A1.0050.94
208_A256_W1.0050.94
302_A388_A1.0030.94
16_V199_T1.0010.94
22_F43_S0.9970.94
31_L133_I0.9950.94
225_T306_V0.9840.93
194_M274_I0.9810.93
166_Y262_A0.9810.93
109_L141_K0.9810.93
65_V95_L0.9800.93
147_S180_A0.9800.93
316_Y399_K0.9800.93
272_K286_E0.9770.93
89_C326_I0.9750.93
346_G370_G0.9730.93
212_A256_W0.9720.93
272_K372_E0.9720.93
58_F89_C0.9710.93
148_G152_E0.9700.93
63_I235_M0.9640.93
342_E349_C0.9630.93
44_E243_C0.9610.92
297_D335_Q0.9600.92
336_V381_E0.9580.92
360_S363_I0.9570.92
68_D71_K0.9540.92
19_P176_T0.9530.92
101_M137_I0.9500.92
39_G81_V0.9440.92
78_A111_I0.9360.91
166_Y266_T0.9310.91
289_V302_A0.9290.91
351_F356_P0.9280.91
228_G331_H0.9210.91
216_I263_L0.9210.91
80_I105_F0.9210.91
204_I208_A0.9200.91
96_K99_Y0.9170.91
191_M196_G0.9140.90
217_T222_N0.9130.90
264_L268_E0.9130.90
18_S176_T0.9080.90
27_V38_L0.9050.90
399_K402_A0.9020.90
104_S108_Q0.9020.90
343_V377_I0.9020.90
342_E353_N0.9010.90
28_H33_Y0.9000.90
395_Y403_S0.8990.90
320_A368_L0.8940.89
149_D152_E0.8930.89
217_T236_V0.8890.89
40_V140_L0.8870.89
297_D300_V0.8850.89
261_K265_L0.8850.89
281_A391_C0.8780.89
303_K388_A0.8770.89
31_L129_D0.8750.88
146_G149_D0.8730.88
170_I175_V0.8680.88
43_S239_M0.8670.88
52_V213_L0.8580.87
291_G380_A0.8570.87
181_A274_I0.8560.87
340_E353_N0.8520.87
64_K95_L0.8520.87
29_C38_L0.8500.87
283_K373_I0.8470.87
181_A196_G0.8440.87
320_A403_S0.8430.86
93_Q96_K0.8420.86
286_E387_R0.8420.86
344_Y347_G0.8400.86
19_P199_T0.8380.86
282_T394_T0.8380.86
60_A86_A0.8330.86
27_V36_K0.8310.86
155_L184_S0.8300.86
77_K111_I0.8300.86
296_L300_V0.8280.86
204_I209_L0.8280.86
287_A390_G0.8260.85
136_G140_L0.8250.85
212_A259_F0.8240.85
66_T117_A0.8190.85
49_S76_L0.8180.85
168_L175_V0.8160.85
184_S400_I0.8150.85
88_A233_N0.8130.84
38_L136_G0.8130.84
102_R118_V0.8120.84
311_V315_V0.8110.84
65_V118_V0.8110.84
256_W260_K0.8110.84
130_M136_G0.8110.84
352_K358_P0.8080.84
64_K339_E0.8070.84
132_K135_A0.8060.84
164_T273_E0.8030.84
255_D258_V0.8020.84
346_G373_I0.8020.84
320_A365_K0.8020.84
42_I109_L0.8020.84
336_V341_V0.8000.83
125_G322_W0.7970.83
285_I390_G0.7960.83
98_A101_M0.7950.83
253_H257_P0.7910.83
24_A147_S0.7850.82
152_E161_I0.7820.82
230_T331_H0.7820.82
28_H34_S0.7760.82
55_Q191_M0.7760.82
68_D95_L0.7760.82
291_G384_G0.7750.82
85_I127_H0.7750.82
104_S130_M0.7740.81
303_K306_V0.7700.81
75_T115_L0.7690.81
284_L389_W0.7660.81
66_T237_L0.7650.81
24_A199_T0.7630.81
360_S364_A0.7580.80
60_A90_T0.7570.80
72_H114_E0.7510.79
148_G161_I0.7500.79
223_Q295_N0.7500.79
22_F47_A0.7440.79
78_A105_F0.7440.79
159_T184_S0.7430.79
215_E264_L0.7410.79
301_I304_K0.7400.78
49_S70_L0.7320.78
51_A63_I0.7320.78
100_T130_M0.7310.78
276_R371_D0.7300.78
16_V19_P0.7290.77
22_F199_T0.7270.77
18_S178_G0.7270.77
224_I274_I0.7240.77
20_K243_C0.7240.77
28_H406_T0.7210.77
136_G139_L0.7190.76
41_I197_F0.7180.76
163_Q180_A0.7170.76
284_L372_E0.7170.76
139_L142_E0.7160.76
170_I255_D0.7130.76
262_A266_T0.7080.75
63_I66_T0.7080.75
99_Y113_P0.7070.75
43_S47_A0.7070.75
175_V262_A0.7060.75
276_R372_E0.7060.75
187_I274_I0.7040.75
50_A209_L0.7010.75
38_L140_L0.7000.75
229_E327_G0.6980.74
99_Y103_E0.6970.74
203_A245_E0.6910.74
26_G140_L0.6910.74
147_S199_T0.6900.73
284_L391_C0.6880.73
17_S147_S0.6880.73
208_A211_K0.6850.73
265_L269_D0.6840.73
168_L177_I0.6840.73
106_A116_V0.6820.73
173_K244_A0.6800.72
315_V373_I0.6770.72
90_T356_P0.6770.72
352_K357_Q0.6750.72
300_V334_A0.6750.72
208_A253_H0.6730.72
229_E331_H0.6710.71
309_N313_T0.6710.71
348_Q364_A0.6700.71
204_I263_L0.6660.71
126_E356_P0.6660.71
42_I111_I0.6620.70
79_V237_L0.6620.70
130_M134_H0.6610.70
198_V238_V0.6610.70
105_F141_K0.6600.70
200_T240_A0.6590.70
326_I341_V0.6580.70
309_N393_L0.6570.70
135_A139_L0.6570.70
48_V75_T0.6570.70
34_S406_T0.6550.70
226_V391_C0.6530.69
361_E364_A0.6530.69
332_S335_Q0.6530.69
342_E351_F0.6500.69
38_L138_E0.6500.69
215_E219_V0.6470.69
258_V261_K0.6460.68
287_A302_A0.6460.68
344_Y378_K0.6440.68
17_S178_G0.6430.68
165_C176_T0.6420.68
80_I118_V0.6400.68
340_E354_N0.6390.68
390_G393_L0.6390.68
47_A241_N0.6390.68
285_I375_I0.6370.67
211_K256_W0.6370.67
243_C246_N0.6360.67
50_A213_L0.6350.67
22_F239_M0.6330.67
213_L217_T0.6330.67
66_T118_V0.6270.66
18_S24_A0.6250.66
64_K67_Q0.6250.66
41_I239_M0.6240.66
285_I373_I0.6240.66
168_L202_A0.6210.65
169_A173_K0.6200.65
92_E95_L0.6190.65
290_Q344_Y0.6190.65
198_V266_T0.6180.65
268_E387_R0.6170.65
304_K332_S0.6160.65
188_H303_K0.6150.65
51_A70_L0.6150.65
297_D381_E0.6150.65
184_S396_D0.6150.65
24_A178_G0.6140.65
361_E365_K0.6120.64
208_A251_E0.6120.64
18_S199_T0.6120.64
304_K327_G0.6110.64
133_I136_G0.6110.64
61_A88_A0.6100.64
200_T259_F0.6090.64
85_I123_V0.6080.64
36_K83_S0.6060.64
315_V394_T0.6050.63
171_G246_N0.6050.63
306_V388_A0.6020.63
320_A361_E0.6020.63
177_I198_V0.6010.63
147_S178_G0.6000.63
179_G198_V0.6000.63
93_Q355_E0.5990.63
257_P261_K0.5990.63
106_A112_E0.5980.63
211_K251_E0.5980.63
46_P77_K0.5980.63
194_M236_V0.5970.62
191_M222_N0.5960.62
19_P241_N0.5950.62
320_A402_A0.5940.62
26_G152_E0.5940.62
89_C341_V0.5940.62
80_I140_L0.5900.62
44_E47_A0.5900.62
190_N331_H0.5900.62
203_A242_G0.5890.61
92_E355_E0.5880.61
194_M221_F0.5880.61
58_F336_V0.5870.61
204_I256_W0.5860.61
61_A90_T0.5860.61
104_S137_I0.5850.61
67_Q71_K0.5820.60
56_S327_G0.5810.60
190_N230_T0.5810.60
151_E161_I0.5810.60
263_L266_T0.5800.60
316_Y398_I0.5790.60
363_I367_Y0.5780.60
215_E218_D0.5780.60
366_E370_G0.5770.60
90_T127_H0.5760.60
96_K103_E0.5760.60
58_F341_V0.5750.60
40_V80_I0.5750.60
82_N120_S0.5750.60
298_A386_G0.5730.59
281_A284_L0.5720.59
163_Q178_G0.5710.59
86_A233_N0.5700.59
229_E308_S0.5680.59
188_H388_A0.5660.58
65_V99_Y0.5650.58
126_E405_R0.5650.58
17_S24_A0.5650.58
192_A224_I0.5630.58
342_E378_K0.5630.58
175_V246_N0.5620.58
101_M130_M0.5620.58
219_V223_Q0.5610.58
133_I138_E0.5610.58
28_H83_S0.5600.58
272_K276_R0.5600.58
275_A391_C0.5570.57
24_A150_F0.5570.57
299_N307_G0.5560.57
18_S165_C0.5560.57
80_I136_G0.5530.57
293_K381_E0.5520.56
290_Q380_A0.5480.56
26_G39_G0.5460.56
51_A66_T0.5460.56
31_L132_K0.5450.56
223_Q388_A0.5430.55
160_V276_R0.5420.55
218_D222_N0.5400.55
303_K307_G0.5400.55
325_I350_L0.5380.55
286_E372_E0.5380.55
318_T365_K0.5370.54
22_F379_M0.5370.54
147_S163_Q0.5360.54
215_E256_W0.5350.54
203_A244_A0.5330.54
107_S113_P0.5330.54
399_K406_T0.5330.54
64_K68_D0.5310.54
56_S59_Q0.5300.53
338_A341_V0.5300.53
105_F108_Q0.5300.53
378_K381_E0.5290.53
254_P257_P0.5280.53
292_A379_M0.5260.53
73_G76_L0.5250.53
400_I403_S0.5250.53
123_V320_A0.5250.53
105_F109_L0.5250.53
179_G224_I0.5250.53
168_L173_K0.5250.53
19_P43_S0.5240.53
45_T241_N0.5230.53
73_G114_E0.5190.52
213_L267_C0.5190.52
362_S365_K0.5190.52
236_V274_I0.5180.52
47_A239_M0.5180.52
173_K245_E0.5180.52
328_A331_H0.5170.52
228_G327_G0.5170.52
168_L258_V0.5160.52
350_L356_P0.5160.52
19_P179_G0.5150.51
56_S331_H0.5150.51
307_G388_A0.5130.51
295_N386_G0.5130.51
53_Y235_M0.5130.51
188_H230_T0.5120.51
65_V68_D0.5120.51
16_V24_A0.5110.51
42_I77_K0.5110.51
320_A360_S0.5110.51
291_G379_M0.5100.51
219_V260_K0.5100.51
264_L267_C0.5070.50
104_S133_I0.5070.50
127_H356_P0.5060.50
109_L116_V0.5050.50
283_K394_T0.5040.50
93_Q130_M0.5030.50
69_S113_P0.5010.50
272_K275_A0.5000.49
200_T209_L0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vz6A 2 0.9064 100 0.067 Contact Map
1vraB 2 0.5222 100 0.47 Contact Map
2v4iB 2 0.4877 100 0.485 Contact Map
3it4B 2 0.4975 100 0.491 Contact Map
1vraA 1 0.4631 100 0.577 Contact Map
3it4A 1 0.4483 100 0.593 Contact Map
2v4iA 1 0.4187 100 0.6 Contact Map
1y2mA 4 0.1601 34.9 0.98 Contact Map
3axgA 4 0.6207 23.7 0.982 Contact Map
4a34A 5 0.2635 20 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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