GREMLIN Database
ARGD - Acetylornithine aminotransferase
UniProt: P36839 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 385 (369)
Sequences: 20698 (12382)
Seq/√Len: 644.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_K59_D4.3051.00
195_Q199_K3.8401.00
341_L375_Q3.7611.00
22_Y30_T3.4541.00
299_F367_A3.1711.00
17_K24_E3.0071.00
79_K282_Q2.9821.00
299_F363_K2.7901.00
219_K225_H2.7831.00
288_D291_Q2.7641.00
292_E296_K2.6301.00
362_T365_E2.5791.00
49_A286_Q2.5641.00
309_K374_K2.5031.00
52_E56_K2.4951.00
34_F369_A2.3441.00
79_K285_F2.3401.00
157_P193_A2.3061.00
193_A196_S2.2921.00
279_A282_Q2.2891.00
49_A283_I2.2641.00
303_Q370_V2.2261.00
22_Y365_E2.2201.00
153_P159_A2.2051.00
341_L379_H2.2021.00
16_K26_Q2.1841.00
337_E379_H2.1641.00
196_S200_E2.1561.00
47_H283_I2.1341.00
337_E340_T2.0981.00
24_E30_T2.0901.00
49_A279_A2.0691.00
295_D363_K2.0601.00
303_Q367_A2.0491.00
79_K278_N2.0211.00
161_K200_E1.9661.00
114_K168_D1.9521.00
76_A277_V1.9291.00
310_S374_K1.9091.00
368_E372_K1.8951.00
51_T55_K1.8911.00
114_K150_H1.8911.00
301_K305_E1.8481.00
88_L252_K1.8351.00
337_E341_L1.8321.00
29_K342_G1.8051.00
25_D29_K1.8011.00
252_K256_E1.7961.00
343_L372_K1.7831.00
87_D252_K1.7801.00
298_A302_E1.7731.00
283_I287_P1.7521.00
71_S75_Q1.7331.00
119_L153_P1.7321.00
173_M206_I1.7281.00
22_Y368_E1.7181.00
303_Q306_A1.7041.00
301_K318_G1.6861.00
16_K60_S1.6851.00
161_K165_E1.6501.00
310_S378_A1.6451.00
160_F194_V1.6351.00
78_Q82_A1.6211.00
92_C246_G1.6201.00
54_V276_A1.6021.00
99_N234_T1.5901.00
155_N187_S1.5781.00
54_V58_L1.5641.00
219_K294_A1.5581.00
75_Q278_N1.5501.00
19_K48_E1.5381.00
337_E376_A1.5251.00
83_H285_F1.5151.00
172_V198_C1.5111.00
79_K82_A1.5041.00
21_T365_E1.5011.00
164_G203_A1.5001.00
296_K299_F1.4971.00
235_V247_A1.4931.00
174_L194_V1.4871.00
301_K323_L1.4821.00
240_G245_V1.4611.00
56_K60_S1.4601.00
207_I223_Y1.4551.00
296_K366_I1.4531.00
189_E192_S1.4501.00
158_S162_A1.4461.00
116_I169_I1.4381.00
30_T368_E1.4181.00
161_K193_A1.4121.00
374_K378_A1.4121.00
21_T360_T1.4041.00
84_S249_I1.3981.00
152_L163_L1.3971.00
101_G248_V1.3971.00
235_V249_I1.3891.00
195_Q198_C1.3831.00
115_I171_A1.3811.00
338_L345_V1.3771.00
195_Q205_L1.3761.00
89_V249_I1.3701.00
292_E295_D1.3571.00
48_E52_E1.3391.00
81_A89_V1.3301.00
117_T151_Y1.3271.00
103_I115_I1.3271.00
220_G224_E1.3271.00
278_N282_Q1.3251.00
77_A91_F1.3201.00
296_K363_K1.3181.00
279_A283_I1.3111.00
341_L376_A1.3111.00
303_Q371_S1.2981.00
225_H319_K1.2971.00
299_F303_Q1.2951.00
118_F190_F1.2921.00
291_Q295_D1.2921.00
219_K224_E1.2901.00
245_V274_M1.2841.00
52_E55_K1.2761.00
165_E201_K1.2751.00
102_A234_T1.2671.00
82_A285_F1.2671.00
25_D31_Y1.2641.00
174_L191_L1.2631.00
303_Q374_K1.2591.00
361_V366_I1.2561.00
19_K46_C1.2521.00
99_N173_M1.2451.00
229_S251_K1.2431.00
15_I23_V1.2411.00
223_Y233_I1.2341.00
172_V194_V1.2331.00
232_I250_G1.2321.00
17_K60_S1.2281.00
106_A206_I1.2241.00
158_S161_K1.2161.00
88_L256_E1.2111.00
365_E368_E1.2101.00
43_L283_I1.2101.00
53_A279_A1.2021.00
51_T59_D1.2021.00
75_Q282_Q1.2011.00
46_C51_T1.1981.00
226_F319_K1.1891.00
294_A298_A1.1881.00
239_L245_V1.1851.00
47_H287_P1.1851.00
282_Q286_Q1.1831.00
92_C248_V1.1741.00
189_E226_F1.1721.00
109_A254_L1.1661.00
192_S196_S1.1601.00
204_L254_L1.1571.00
51_T58_L1.1491.00
132_A149_F1.1461.00
245_V277_V1.1451.00
371_S375_Q1.1331.00
91_F274_M1.1291.00
54_V272_L1.1281.00
215_G290_L1.1261.00
161_K197_F1.1231.00
55_K58_L1.1231.00
239_L247_A1.1171.00
192_S227_G1.1161.00
162_A166_E1.1001.00
305_E308_L1.1001.00
338_L372_K1.0881.00
221_F235_V1.0881.00
132_A173_M1.0881.00
338_L376_A1.0751.00
232_I248_V1.0711.00
368_E371_S1.0711.00
341_L372_K1.0671.00
207_I228_L1.0651.00
302_E306_A1.0651.00
22_Y32_L1.0651.00
283_I286_Q1.0531.00
16_K71_S1.0511.00
14_D26_Q1.0491.00
343_L369_A1.0471.00
21_T32_L1.0441.00
363_K367_A1.0331.00
19_K30_T1.0141.00
150_H163_L1.0111.00
159_A162_A1.0061.00
333_D337_E1.0061.00
314_K328_D1.0051.00
367_A371_S1.0051.00
16_K24_E1.0041.00
198_C203_A1.0031.00
153_P156_D1.0021.00
16_K28_G1.0011.00
98_A234_T0.9991.00
307_E313_V0.9941.00
338_L343_L0.9931.00
112_K202_Q0.9921.00
49_A282_Q0.9901.00
76_A278_N0.9871.00
161_K196_S0.9841.00
83_H220_G0.9841.00
19_K24_E0.9831.00
79_K83_H0.9801.00
96_A129_G0.9751.00
314_K326_E0.9751.00
105_L248_V0.9661.00
196_S199_K0.9641.00
188_A192_S0.9641.00
154_Y186_A0.9591.00
336_A340_T0.9591.00
218_G224_E0.9581.00
241_N280_T0.9551.00
113_T168_D0.9511.00
176_T207_I0.9431.00
291_Q294_A0.9381.00
171_A206_I0.9361.00
52_E59_D0.9311.00
290_L293_A0.9281.00
103_I132_A0.9261.00
364_D367_A0.9201.00
326_E351_N0.9181.00
49_A52_E0.9181.00
86_G233_I0.9101.00
117_T173_M0.9101.00
32_L365_E0.9091.00
214_I284_V0.9061.00
118_F154_Y0.9061.00
43_L280_T0.9041.00
161_K201_K0.9011.00
191_L226_F0.9001.00
164_G169_I0.8991.00
14_D74_E0.8991.00
113_T148_G0.8961.00
292_E363_K0.8951.00
105_L250_G0.8921.00
56_K275_A0.8921.00
42_N238_G0.8901.00
102_A206_I0.8881.00
275_A279_A0.8861.00
85_A223_Y0.8861.00
185_P319_K0.8851.00
194_V205_L0.8831.00
189_E193_A0.8821.00
114_K169_I0.8781.00
114_K165_E0.8761.00
324_G352_V0.8731.00
32_L368_E0.8721.00
306_A309_K0.8711.00
83_H281_L0.8701.00
297_G301_K0.8691.00
43_L50_V0.8621.00
284_V290_L0.8611.00
118_F186_A0.8601.00
284_V289_F0.8541.00
34_F361_V0.8531.00
302_E305_E0.8531.00
56_K59_D0.8501.00
109_A112_K0.8501.00
197_F201_K0.8491.00
243_F273_A0.8461.00
21_T362_T0.8451.00
199_K229_S0.8421.00
26_Q71_S0.8391.00
50_V276_A0.8331.00
193_A197_F0.8331.00
225_H294_A0.8321.00
106_A171_A0.8321.00
72_L275_A0.8311.00
289_F293_A0.8241.00
315_Q326_E0.8211.00
114_K148_G0.8201.00
177_V319_K0.8201.00
41_S241_N0.8181.00
131_A146_L0.8161.00
220_G290_L0.8151.00
96_A126_T0.8141.00
332_A336_A0.8121.00
109_A257_A0.8111.00
106_A204_L0.8101.00
361_V369_A0.8091.00
306_A374_K0.8091.00
212_T322_M0.8071.00
49_A53_A0.8051.00
163_L166_E0.8001.00
177_V322_M0.7991.00
75_Q79_K0.7961.00
290_L294_A0.7961.00
321_L361_V0.7921.00
62_W243_F0.7911.00
152_L159_A0.7851.00
111_G168_D0.7831.00
152_L160_F0.7801.00
108_K262_S0.7801.00
299_F302_E0.7791.00
309_K378_A0.7781.00
167_G201_K0.7771.00
80_L249_I0.7741.00
375_Q379_H0.7711.00
317_R326_E0.7701.00
202_Q253_Q0.7681.00
223_Y228_L0.7651.00
303_Q366_I0.7641.00
32_L369_A0.7641.00
198_C205_L0.7611.00
295_D299_F0.7611.00
214_I281_L0.7591.00
20_G360_T0.7561.00
89_V247_A0.7551.00
316_I323_L0.7551.00
164_G197_F0.7531.00
72_L278_N0.7531.00
176_T191_L0.7511.00
355_L373_L0.7501.00
322_M356_L0.7471.00
76_A274_M0.7461.00
259_T262_S0.7461.00
335_I347_P0.7401.00
221_F233_I0.7401.00
86_G229_S0.7401.00
195_Q228_L0.7371.00
72_L75_Q0.7351.00
159_A163_L0.7311.00
179_G211_Q0.7311.00
174_L205_L0.7291.00
92_C98_A0.7251.00
214_I235_V0.7251.00
220_G285_F0.7241.00
109_A202_Q0.7231.00
334_I373_L0.7221.00
69_Q74_E0.7211.00
39_A356_L0.7211.00
333_D336_A0.7211.00
318_G323_L0.7201.00
57_Q60_S0.7191.00
169_I203_A0.7191.00
106_A232_I0.7181.00
119_L151_Y0.7181.00
295_D298_A0.7151.00
103_I173_M0.7151.00
253_Q256_E0.7131.00
214_I220_G0.7131.00
296_K321_L0.7111.00
265_T268_G0.7111.00
72_L274_M0.7081.00
334_I376_A0.7061.00
192_S226_F0.7051.00
102_A232_I0.7021.00
172_V203_A0.7001.00
70_N73_Q0.6981.00
118_F152_L0.6961.00
53_A276_A0.6961.00
177_V217_T0.6951.00
21_T358_P0.6941.00
164_G201_K0.6931.00
217_T225_H0.6891.00
293_A297_G0.6891.00
61_V64_V0.6881.00
105_L258_F0.6881.00
32_L343_L0.6881.00
73_Q77_A0.6841.00
364_D368_E0.6831.00
251_K254_L0.6831.00
58_L272_L0.6821.00
215_G284_V0.6821.00
34_F343_L0.6801.00
307_E310_S0.6781.00
60_S71_S0.6731.00
128_A146_L0.6721.00
35_I346_L0.6701.00
74_E78_Q0.6701.00
160_F172_V0.6691.00
310_S377_I0.6681.00
50_V241_N0.6671.00
99_N129_G0.6671.00
327_C334_I0.6641.00
104_K263_H0.6621.00
254_L257_A0.6621.00
297_G318_G0.6611.00
94_S97_E0.6581.00
86_G223_Y0.6571.00
214_I239_L0.6571.00
338_L373_L0.6561.00
235_V239_L0.6551.00
186_A189_E0.6541.00
93_N97_E0.6541.00
370_V374_K0.6541.00
14_D69_Q0.6531.00
369_A372_K0.6531.00
205_L228_L0.6511.00
178_Q184_N0.6511.00
326_E352_V0.6471.00
327_C377_I0.6471.00
185_P318_G0.6461.00
299_F366_I0.6441.00
79_K281_L0.6431.00
292_E362_T0.6431.00
72_L76_A0.6431.00
223_Y230_P0.6431.00
334_I338_L0.6421.00
206_I232_I0.6411.00
21_T361_V0.6411.00
83_H221_F0.6391.00
15_I18_A0.6381.00
343_L368_E0.6381.00
84_S233_I0.6371.00
81_A87_D0.6371.00
60_S72_L0.6371.00
376_A379_H0.6361.00
30_T372_K0.6331.00
156_D159_A0.6331.00
361_V365_E0.6331.00
107_R144_P0.6331.00
85_A229_S0.6331.00
210_I234_T0.6311.00
188_A226_F0.6311.00
298_A301_K0.6301.00
316_I325_I0.6301.00
57_Q72_L0.6281.00
95_G210_I0.6281.00
29_K340_T0.6261.00
53_A56_K0.6241.00
199_K205_L0.6241.00
188_A319_K0.6231.00
197_F200_E0.6221.00
105_L232_I0.6221.00
191_L207_I0.6221.00
116_I160_F0.6211.00
372_K376_A0.6181.00
162_A165_E0.6181.00
179_G322_M0.6181.00
334_I353_I0.6151.00
250_G255_G0.6151.00
23_V344_L0.6141.00
36_Q356_L0.6091.00
46_C58_L0.6081.00
236_A246_G0.6071.00
85_A224_E0.6051.00
35_I344_L0.6041.00
81_A86_G0.6041.00
336_A339_Q0.6021.00
353_I373_L0.5981.00
36_Q358_P0.5971.00
18_A61_V0.5961.00
296_K361_V0.5961.00
43_L289_F0.5951.00
83_H219_K0.5951.00
160_F197_F0.5951.00
84_S221_F0.5941.00
325_I373_L0.5921.00
53_A282_Q0.5911.00
15_I68_F0.5901.00
355_L369_A0.5891.00
58_L276_A0.5891.00
335_I339_Q0.5871.00
300_L323_L0.5861.00
178_Q181_G0.5861.00
101_G263_H0.5851.00
176_T212_T0.5841.00
293_A359_L0.5831.00
48_E59_D0.5831.00
51_T243_F0.5821.00
300_L370_V0.5821.00
19_K22_Y0.5811.00
199_K253_Q0.5811.00
42_N359_L0.5801.00
112_K203_A0.5801.00
160_F164_G0.5801.00
107_R127_Y0.5771.00
276_A279_A0.5751.00
372_K375_Q0.5741.00
293_A321_L0.5741.00
13_I16_K0.5731.00
296_K362_T0.5731.00
300_L366_I0.5701.00
331_V347_P0.5701.00
122_F125_R0.5681.00
118_F174_L0.5671.00
232_I254_L0.5661.00
18_A23_V0.5651.00
165_E200_E0.5651.00
317_R324_G0.5641.00
58_L62_W0.5641.00
14_D71_S0.5641.00
112_K168_D0.5631.00
116_I152_L0.5631.00
165_E168_D0.5621.00
76_A245_V0.5621.00
307_E374_K0.5601.00
117_T149_F0.5591.00
294_A297_G0.5591.00
116_I163_L0.5581.00
103_I128_A0.5581.00
76_A91_F0.5551.00
313_V377_I0.5521.00
314_K330_P0.5501.00
192_S195_Q0.5471.00
50_V280_T0.5461.00
81_A249_I0.5461.00
373_L377_I0.5461.00
214_I221_F0.5441.00
42_N284_V0.5431.00
75_Q78_Q0.5431.00
150_H169_I0.5431.00
134_G151_Y0.5421.00
32_L361_V0.5411.00
15_I61_V0.5360.99
270_N273_A0.5350.99
299_F370_V0.5350.99
68_F344_L0.5340.99
136_D140_T0.5340.99
56_K279_A0.5330.99
16_K19_K0.5320.99
84_S235_V0.5320.99
366_I370_V0.5290.99
204_L232_I0.5290.99
317_R352_V0.5280.99
233_I249_I0.5270.99
313_V325_I0.5260.99
174_L207_I0.5260.99
256_E260_P0.5230.99
292_E366_I0.5220.99
136_D139_K0.5210.99
369_A373_L0.5200.99
192_S228_L0.5180.99
13_I339_Q0.5170.99
367_A370_V0.5160.99
110_T170_A0.5160.99
366_I369_A0.5150.99
230_P233_I0.5150.99
160_F193_A0.5140.99
325_I355_L0.5140.99
256_E259_T0.5140.99
194_V203_A0.5130.99
343_L376_A0.5120.99
346_L349_G0.5110.99
78_Q81_A0.5100.99
340_T379_H0.5100.99
120_Q181_G0.5090.99
190_F194_V0.5090.99
220_G281_L0.5090.99
185_P226_F0.5080.99
154_Y178_Q0.5080.99
358_P361_V0.5080.99
188_A227_G0.5060.99
81_A84_S0.5060.99
158_S193_A0.5050.99
339_Q344_L0.5040.99
92_C97_E0.5040.99
305_E316_I0.5020.99
50_V279_A0.5020.99
236_A267_F0.5020.99
211_Q322_M0.5010.99
220_G284_V0.5010.99
287_P292_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z7dA 2 0.9273 100 0.343 Contact Map
4uoxA 3 1 100 0.348 Contact Map
4atqA 7 0.9896 100 0.355 Contact Map
3oksA 2 0.9844 100 0.357 Contact Map
4e3qA 3 0.9922 100 0.359 Contact Map
4nogA 2 1 100 0.363 Contact Map
4ffcA 4 0.9922 100 0.367 Contact Map
2epjA 2 0.9688 100 0.367 Contact Map
2oatA 3 0.9844 100 0.37 Contact Map
4a0gA 2 0.987 100 0.372 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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