CARX - BACSU - GREMLIN Contacts

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CARX - Carbamoyl-phosphate synthase arginine-specific small chain

UniProt:	P36838	Sequences: MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPSYKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKWNIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDGNKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGIVLSNGPGDPKAIQPYLGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQNHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIFDDYLKNVIPARREIAHA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	353 (342)
Sequences:	4036 (1920)
Seq/√Len:	103.8

ECOLI - CARA
BACSU - CARX CARA
HALSA - CARA
SULSO - CARA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
163_H	185_K	4.103	1.00
224_I	242_L	4.070	1.00
93_Y	101_K	4.070	1.00
182_R	337_D	4.048	1.00
165_A	189_V	3.532	1.00
27_A	127_A	3.460	1.00
49_I	78_V	3.119	1.00
52_F	77_A	3.040	1.00
295_T	310_A	2.989	1.00
215_K	250_N	2.914	1.00
164_I	343_V	2.800	1.00
150_S	191_Y	2.717	1.00
251_T	284_V	2.694	1.00
244_A	284_V	2.669	1.00
20_H	103_N	2.539	1.00
163_H	187_T	2.498	1.00
8_E	126_G	2.418	1.00
295_T	312_K	2.390	1.00
193_Q	196_A	2.385	1.00
86_F	91_A	2.330	1.00
9_D	118_K	2.298	1.00
30_F	45_Y	2.298	1.00
286_E	299_H	2.256	1.00
252_F	283_V	2.217	1.00
155_S	188_V	2.195	1.00
252_F	285_D	2.141	1.00
259_R	281_S	2.119	1.00
96_K	100_Q	2.112	1.00
32_G	261_A	2.110	1.00
234_L	335_I	2.108	1.00
166_L	206_V	2.080	1.00
174_S	177_S	2.061	1.00
156_T	185_K	2.045	1.00
244_A	309_L	2.000	1.00
151_A	155_S	1.990	1.00
243_I	318_S	1.987	1.00
184_C	340_L	1.955	1.00
18_D	106_L	1.929	1.00
296_I	306_V	1.917	1.00
83_C	86_F	1.900	1.00
293_E	312_K	1.894	1.00
121_A	256_F	1.891	1.00
293_E	313_K	1.879	1.00
167_I	189_V	1.876	1.00
64_E	92_V	1.871	1.00
243_I	316_V	1.833	1.00
39_V	50_I	1.831	1.00
309_L	318_S	1.809	1.00
195_E	226_S	1.789	1.00
166_L	171_Y	1.778	1.00
169_F	220_Y	1.757	1.00
228_I	316_V	1.737	1.00
250_N	285_D	1.718	1.00
13_F	118_K	1.715	1.00
162_K	344_I	1.712	1.00
165_A	200_I	1.701	1.00
67_F	98_Y	1.697	1.00
205_I	231_F	1.688	1.00
144_N	147_E	1.683	1.00
167_I	223_K	1.675	1.00
198_Y	231_F	1.672	1.00
11_T	118_K	1.670	1.00
266_I	271_K	1.666	1.00
78_V	107_L	1.658	1.00
16_E	109_H	1.651	1.00
162_K	343_V	1.644	1.00
311_H	315_P	1.629	1.00
72_P	102_W	1.626	1.00
310_A	338_D	1.616	1.00
110_V	115_V	1.587	1.00
189_V	200_I	1.569	1.00
222_G	225_K	1.567	1.00
53_T	116_V	1.561	1.00
294_L	311_H	1.561	1.00
50_I	74_V	1.552	1.00
49_I	76_A	1.545	1.00
311_H	314_L	1.543	1.00
178_S	333_E	1.540	1.00
230_R	314_L	1.528	1.00
49_I	127_A	1.516	1.00
269_K	295_T	1.509	1.00
194_M	198_Y	1.494	1.00
135_G	138_I	1.491	1.00
76_A	129_V	1.484	1.00
30_F	39_V	1.459	1.00
247_F	311_H	1.447	1.00
169_F	207_L	1.439	1.00
240_H	318_S	1.438	1.00
165_A	202_P	1.433	1.00
86_F	94_S	1.432	1.00
274_F	334_W	1.430	1.00
94_S	97_E	1.428	1.00
79_V	82_A	1.428	1.00
16_E	108_T	1.421	1.00
223_K	226_S	1.416	1.00
192_Q	219_P	1.407	1.00
46_K	73_Q	1.405	1.00
268_R	299_H	1.402	1.00
205_I	227_I	1.400	1.00
247_F	294_L	1.394	1.00
3_G	107_L	1.374	1.00
167_I	197_V	1.355	0.99
166_L	186_V	1.355	0.99
194_M	226_S	1.351	0.99
267_D	338_D	1.338	0.99
93_Y	97_E	1.335	0.99
166_L	176_A	1.326	0.99
221_L	245_L	1.321	0.99
184_C	343_V	1.315	0.99
40_L	74_V	1.290	0.99
11_T	114_A	1.282	0.99
249_G	288_S	1.280	0.99
269_K	310_A	1.278	0.99
274_F	332_S	1.268	0.99
146_A	238_L	1.244	0.99
161_N	344_I	1.241	0.99
171_Y	176_A	1.224	0.99
66_D	90_E	1.224	0.99
6_V	12_S	1.223	0.99
46_K	148_Q	1.221	0.99
206_V	234_L	1.220	0.99
252_F	305_S	1.217	0.99
164_I	184_C	1.216	0.99
228_I	247_F	1.209	0.99
269_K	338_D	1.208	0.99
196_A	199_N	1.191	0.99
63_N	66_D	1.190	0.99
298_F	321_F	1.186	0.99
215_K	251_T	1.185	0.99
8_E	125_M	1.179	0.99
266_I	299_H	1.178	0.99
150_S	192_Q	1.174	0.98
341_K	344_I	1.171	0.98
294_L	309_L	1.170	0.98
70_K	73_Q	1.167	0.98
40_L	77_A	1.159	0.98
163_H	200_I	1.152	0.98
267_D	274_F	1.147	0.98
204_G	343_V	1.141	0.98
180_V	186_V	1.138	0.98
215_K	245_L	1.136	0.98
3_G	17_L	1.134	0.98
286_E	296_I	1.127	0.98
227_I	233_T	1.127	0.98
167_I	193_Q	1.124	0.98
198_Y	230_R	1.111	0.98
222_G	226_S	1.109	0.98
290_N	293_E	1.106	0.98
72_P	104_I	1.104	0.98
21_E	100_Q	1.101	0.98
207_L	224_I	1.100	0.98
64_E	93_Y	1.098	0.98
32_G	39_V	1.083	0.97
341_K	345_P	1.079	0.97
27_A	119_I	1.079	0.97
151_A	154_I	1.073	0.97
285_D	288_S	1.072	0.97
146_A	217_I	1.069	0.97
234_L	317_M	1.064	0.97
82_A	96_K	1.062	0.97
266_I	301_V	1.055	0.97
5_L	107_L	1.051	0.97
3_G	131_A	1.047	0.97
160_G	185_K	1.038	0.97
68_E	177_S	1.032	0.97
62_I	93_Y	1.029	0.97
249_G	289_I	1.017	0.96
243_I	309_L	1.016	0.96
226_S	229_S	1.012	0.96
164_I	340_L	1.011	0.96
233_T	243_I	1.009	0.96
23_C	76_A	0.994	0.96
223_K	227_I	0.993	0.96
293_E	311_H	0.984	0.96
22_N	132_S	0.981	0.95
317_M	335_I	0.978	0.95
261_A	277_S	0.978	0.95
201_K	231_F	0.976	0.95
39_V	52_F	0.975	0.95
224_I	233_T	0.972	0.95
178_S	181_K	0.968	0.95
23_C	129_V	0.966	0.95
187_T	200_I	0.966	0.95
194_M	223_K	0.959	0.95
114_A	118_K	0.956	0.95
140_L	143_E	0.951	0.95
237_C	322_H	0.942	0.94
179_L	184_C	0.932	0.94
217_I	220_Y	0.928	0.94
4_Y	14_S	0.923	0.94
19_G	106_L	0.919	0.94
126_G	140_L	0.914	0.93
162_K	184_C	0.907	0.93
143_E	148_Q	0.904	0.93
9_D	122_N	0.903	0.93
18_D	79_V	0.903	0.93
338_D	341_K	0.902	0.93
47_G	75_K	0.901	0.93
130_T	135_G	0.898	0.93
119_I	127_A	0.895	0.93
37_Q	63_N	0.895	0.93
156_T	187_T	0.894	0.93
174_S	178_S	0.892	0.93
144_N	220_Y	0.889	0.92
56_L	81_E	0.886	0.92
62_I	67_F	0.886	0.92
265_V	307_E	0.884	0.92
171_Y	206_V	0.883	0.92
267_D	272_R	0.881	0.92
297_R	310_A	0.879	0.92
97_E	100_Q	0.874	0.92
197_V	202_P	0.871	0.92
147_E	192_Q	0.868	0.91
71_K	102_W	0.865	0.91
151_A	188_V	0.863	0.91
65_K	90_E	0.863	0.91
299_H	304_T	0.862	0.91
195_E	199_N	0.859	0.91
79_V	108_T	0.859	0.91
78_V	110_V	0.858	0.91
158_G	161_N	0.856	0.91
321_F	332_S	0.856	0.91
229_S	314_L	0.855	0.91
44_S	237_C	0.851	0.91
23_C	75_K	0.848	0.91
70_K	173_K	0.847	0.90
4_Y	133_K	0.847	0.90
84_D	108_T	0.846	0.90
25_G	49_I	0.844	0.90
162_K	340_L	0.842	0.90
13_F	114_A	0.837	0.90
186_V	206_V	0.835	0.90
218_Q	222_G	0.834	0.90
340_L	343_V	0.832	0.90
159_D	185_K	0.829	0.90
182_R	340_L	0.826	0.89
169_F	242_L	0.825	0.89
228_I	243_I	0.821	0.89
157_F	180_V	0.820	0.89
27_A	51_V	0.816	0.89
140_L	145_V	0.814	0.89
4_Y	12_S	0.811	0.88
166_L	208_S	0.811	0.88
144_N	219_P	0.810	0.88
178_S	182_R	0.804	0.88
6_V	130_T	0.804	0.88
133_K	138_I	0.801	0.88
140_L	282_Y	0.800	0.88
40_L	95_L	0.798	0.88
267_D	270_T	0.796	0.88
209_N	237_C	0.795	0.87
17_L	131_A	0.794	0.87
247_F	316_V	0.791	0.87
91_A	94_S	0.789	0.87
207_L	233_T	0.788	0.87
311_H	316_V	0.786	0.87
197_V	223_K	0.779	0.86
263_H	302_N	0.779	0.86
142_P	145_V	0.777	0.86
47_G	148_Q	0.774	0.86
41_T	67_F	0.774	0.86
142_P	216_A	0.768	0.86
298_F	334_W	0.767	0.86
249_G	294_L	0.767	0.86
99_L	104_I	0.765	0.85
130_T	134_E	0.759	0.85
97_E	101_K	0.757	0.85
259_R	263_H	0.751	0.84
193_Q	223_K	0.750	0.84
99_L	106_L	0.750	0.84
191_Y	219_P	0.745	0.84
126_G	141_Q	0.745	0.84
238_L	245_L	0.745	0.84
7_L	115_V	0.743	0.84
337_D	340_L	0.743	0.84
155_S	176_A	0.743	0.84
22_N	130_T	0.741	0.84
40_L	99_L	0.740	0.83
118_K	122_N	0.740	0.83
78_V	127_A	0.739	0.83
225_K	229_S	0.736	0.83
19_G	96_K	0.735	0.83
173_K	177_S	0.735	0.83
321_F	334_W	0.734	0.83
24_T	128_T	0.731	0.83
205_I	233_T	0.730	0.83
98_Y	102_W	0.729	0.83
154_I	189_V	0.728	0.82
181_K	333_E	0.723	0.82
247_F	314_L	0.723	0.82
105_P	129_V	0.719	0.82
51_V	116_V	0.716	0.81
132_S	135_G	0.714	0.81
74_V	77_A	0.714	0.81
46_K	75_K	0.712	0.81
261_A	300_H	0.710	0.81
222_G	229_S	0.710	0.81
286_E	306_V	0.709	0.81
145_V	282_Y	0.709	0.81
164_I	204_G	0.707	0.81
96_K	106_L	0.706	0.80
161_N	185_K	0.706	0.80
197_V	205_I	0.704	0.80
134_E	138_I	0.702	0.80
184_C	204_G	0.699	0.80
197_V	227_I	0.697	0.80
141_Q	215_K	0.695	0.79
142_P	282_Y	0.694	0.79
274_F	321_F	0.692	0.79
164_I	179_L	0.690	0.79
220_Y	223_K	0.689	0.79
30_F	52_F	0.688	0.79
45_Y	48_Q	0.688	0.79
74_V	104_I	0.683	0.78
77_A	99_L	0.681	0.78
4_Y	136_A	0.681	0.78
46_K	71_K	0.680	0.78
189_V	193_Q	0.676	0.78
219_P	222_G	0.676	0.78
204_G	339_Y	0.672	0.77
119_I	124_T	0.670	0.77
126_G	139_A	0.669	0.77
233_T	316_V	0.667	0.77
41_T	98_Y	0.667	0.77
57_I	79_V	0.666	0.77
60_Y	302_N	0.664	0.76
312_K	315_P	0.663	0.76
175_I	237_C	0.663	0.76
5_L	110_V	0.662	0.76
165_A	197_V	0.662	0.76
163_H	203_D	0.661	0.76
250_N	288_S	0.661	0.76
165_A	187_T	0.659	0.76
175_I	325_A	0.659	0.76
175_I	236_I	0.657	0.76
167_I	220_Y	0.655	0.75
32_G	277_S	0.652	0.75
21_E	105_P	0.652	0.75
157_F	176_A	0.650	0.75
69_S	73_Q	0.649	0.75
198_Y	226_S	0.647	0.74
198_Y	227_I	0.646	0.74
154_I	200_I	0.643	0.74
155_S	180_V	0.642	0.74
254_L	283_V	0.642	0.74
259_R	321_F	0.639	0.74
193_Q	227_I	0.636	0.73
60_Y	63_N	0.634	0.73
249_G	309_L	0.633	0.73
167_I	207_L	0.633	0.73
158_G	185_K	0.632	0.73
8_E	122_N	0.632	0.73
43_P	324_E	0.632	0.73
3_G	105_P	0.631	0.73
278_Q	307_E	0.630	0.72
39_V	45_Y	0.629	0.72
244_A	249_G	0.629	0.72
221_L	225_K	0.627	0.72
315_P	342_N	0.625	0.72
18_D	82_A	0.624	0.72
245_L	250_N	0.624	0.72
72_P	98_Y	0.623	0.72
237_C	329_P	0.622	0.72
162_K	203_D	0.622	0.72
218_Q	221_L	0.622	0.72
237_C	256_F	0.622	0.72
68_E	174_S	0.621	0.71
52_F	57_I	0.620	0.71
33_M	60_Y	0.620	0.71
121_A	255_P	0.619	0.71
219_P	223_K	0.619	0.71
30_F	263_H	0.615	0.71
194_M	227_I	0.613	0.70
107_L	110_V	0.612	0.70
247_F	290_N	0.611	0.70
37_Q	298_F	0.611	0.70
82_A	108_T	0.608	0.70
179_L	186_V	0.607	0.70
28_V	259_R	0.607	0.70
17_L	21_E	0.604	0.69
162_K	183_G	0.604	0.69
192_Q	196_A	0.603	0.69
46_K	145_V	0.603	0.69
244_A	294_L	0.600	0.69
176_A	206_V	0.599	0.69
176_A	188_V	0.599	0.69
216_A	282_Y	0.598	0.69
285_D	306_V	0.598	0.69
147_E	219_P	0.594	0.68
116_V	300_H	0.593	0.68
146_A	169_F	0.593	0.68
204_G	234_L	0.591	0.68
20_H	100_Q	0.587	0.67
115_V	127_A	0.586	0.67
144_N	216_A	0.583	0.67
182_R	333_E	0.583	0.67
237_C	257_G	0.582	0.66
44_S	322_H	0.581	0.66
51_V	78_V	0.581	0.66
259_R	307_E	0.580	0.66
174_S	333_E	0.579	0.66
326_H	330_A	0.578	0.66
322_H	329_P	0.578	0.66
300_H	307_E	0.577	0.66
75_K	148_Q	0.577	0.66
56_L	60_Y	0.576	0.66
124_T	282_Y	0.575	0.66
27_A	78_V	0.575	0.66
5_L	27_A	0.574	0.65
267_D	334_W	0.574	0.65
19_G	105_P	0.573	0.65
206_V	318_S	0.570	0.65
30_F	51_V	0.570	0.65
238_L	242_L	0.569	0.65
51_V	119_I	0.569	0.65
79_V	106_L	0.568	0.65
283_V	306_V	0.568	0.65
261_A	326_H	0.567	0.64
221_L	246_A	0.567	0.64
254_L	281_S	0.566	0.64
65_K	92_V	0.566	0.64
274_F	298_F	0.566	0.64
278_Q	300_H	0.566	0.64
67_F	173_K	0.564	0.64
146_A	216_A	0.564	0.64
46_K	149_A	0.564	0.64
338_D	342_N	0.563	0.64
237_C	241_Q	0.561	0.64
97_E	103_N	0.558	0.63
45_Y	237_C	0.558	0.63
62_I	91_A	0.557	0.63
195_E	198_Y	0.556	0.63
152_Q	225_K	0.556	0.63
240_H	284_V	0.556	0.63
47_G	143_E	0.553	0.63
230_R	315_P	0.553	0.63
154_I	196_A	0.551	0.62
32_G	259_R	0.549	0.62
267_D	298_F	0.548	0.62
28_V	255_P	0.547	0.62
39_V	263_H	0.546	0.62
157_F	188_V	0.546	0.62
30_F	175_I	0.545	0.61
40_L	52_F	0.544	0.61
267_D	297_R	0.544	0.61
4_Y	130_T	0.542	0.61
217_I	238_L	0.542	0.61
178_S	259_R	0.542	0.61
209_N	322_H	0.541	0.61
317_M	342_N	0.540	0.61
60_Y	237_C	0.540	0.61
209_N	319_V	0.539	0.61
307_E	321_F	0.539	0.61
119_I	125_M	0.538	0.60
44_S	209_N	0.538	0.60
146_A	149_A	0.537	0.60
241_Q	322_H	0.536	0.60
174_S	326_H	0.536	0.60
289_I	293_E	0.536	0.60
17_L	106_L	0.535	0.60
266_I	304_T	0.533	0.60
213_D	251_T	0.532	0.60
18_D	105_P	0.532	0.60
67_F	102_W	0.532	0.60
17_L	82_A	0.532	0.60
140_L	216_A	0.529	0.59
121_A	289_I	0.528	0.59
25_G	50_I	0.528	0.59
317_M	338_D	0.526	0.59
284_V	309_L	0.526	0.59
191_Y	220_Y	0.525	0.59
18_D	108_T	0.524	0.58
263_H	282_Y	0.523	0.58
140_L	281_S	0.523	0.58
193_Q	197_V	0.523	0.58
4_Y	134_E	0.522	0.58
173_K	176_A	0.521	0.58
58_G	61_G	0.520	0.58
177_S	207_L	0.518	0.58
13_F	110_V	0.518	0.58
118_K	125_M	0.518	0.58
259_R	302_N	0.518	0.58
39_V	240_H	0.518	0.58
63_N	298_F	0.518	0.58
289_I	296_I	0.517	0.57
28_V	256_F	0.516	0.57
220_Y	242_L	0.516	0.57
141_Q	145_V	0.516	0.57
81_E	84_D	0.514	0.57
206_V	317_M	0.514	0.57
129_V	293_E	0.514	0.57
139_A	142_P	0.513	0.57
18_D	254_L	0.511	0.57
141_Q	216_A	0.510	0.56
49_I	74_V	0.510	0.56
54_Y	60_Y	0.509	0.56
192_Q	220_Y	0.509	0.56
7_L	127_A	0.508	0.56
337_D	341_K	0.507	0.56
56_L	307_E	0.506	0.56
172_K	328_G	0.505	0.56
150_S	155_S	0.505	0.56
209_N	241_Q	0.504	0.56
7_L	118_K	0.504	0.56
240_H	309_L	0.504	0.56
228_I	233_T	0.503	0.55
319_V	335_I	0.502	0.55
51_V	54_Y	0.502	0.55
298_F	335_I	0.501	0.55
252_F	286_E	0.501	0.55
20_H	105_P	0.501	0.55
322_H	328_G	0.500	0.55
81_E	109_H	0.500	0.55

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1a9xB	1	0.9858	100	0.209	Contact Map
1vcoA	4	0.9235	100	0.65	Contact Map
1s1mA	4	0.949	100	0.66	Contact Map
3nvaA	2	0.9575	100	0.687	Contact Map
4zdjA	4	0.949	100	0.703	Contact Map
2vxoA	2	0.5212	100	0.782	Contact Map
1qdlB	2	0.5042	100	0.79	Contact Map
1i1qB	1	0.4901	100	0.791	Contact Map
2h2wA	2	0.6771	100	0.792	Contact Map
3tqiA	3	0.4958	100	0.792	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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