GREMLIN Database
CARX - Carbamoyl-phosphate synthase arginine-specific small chain
UniProt: P36838 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 353 (342)
Sequences: 4036 (1920)
Seq/√Len: 103.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
163_H185_K4.1031.00
224_I242_L4.0701.00
93_Y101_K4.0701.00
182_R337_D4.0481.00
165_A189_V3.5321.00
27_A127_A3.4601.00
49_I78_V3.1191.00
52_F77_A3.0401.00
295_T310_A2.9891.00
215_K250_N2.9141.00
164_I343_V2.8001.00
150_S191_Y2.7171.00
251_T284_V2.6941.00
244_A284_V2.6691.00
20_H103_N2.5391.00
163_H187_T2.4981.00
8_E126_G2.4181.00
295_T312_K2.3901.00
193_Q196_A2.3851.00
86_F91_A2.3301.00
9_D118_K2.2981.00
30_F45_Y2.2981.00
286_E299_H2.2561.00
252_F283_V2.2171.00
155_S188_V2.1951.00
252_F285_D2.1411.00
259_R281_S2.1191.00
96_K100_Q2.1121.00
32_G261_A2.1101.00
234_L335_I2.1081.00
166_L206_V2.0801.00
174_S177_S2.0611.00
156_T185_K2.0451.00
244_A309_L2.0001.00
151_A155_S1.9901.00
243_I318_S1.9871.00
184_C340_L1.9551.00
18_D106_L1.9291.00
296_I306_V1.9171.00
83_C86_F1.9001.00
293_E312_K1.8941.00
121_A256_F1.8911.00
293_E313_K1.8791.00
167_I189_V1.8761.00
64_E92_V1.8711.00
243_I316_V1.8331.00
39_V50_I1.8311.00
309_L318_S1.8091.00
195_E226_S1.7891.00
166_L171_Y1.7781.00
169_F220_Y1.7571.00
228_I316_V1.7371.00
250_N285_D1.7181.00
13_F118_K1.7151.00
162_K344_I1.7121.00
165_A200_I1.7011.00
67_F98_Y1.6971.00
205_I231_F1.6881.00
144_N147_E1.6831.00
167_I223_K1.6751.00
198_Y231_F1.6721.00
11_T118_K1.6701.00
266_I271_K1.6661.00
78_V107_L1.6581.00
16_E109_H1.6511.00
162_K343_V1.6441.00
311_H315_P1.6291.00
72_P102_W1.6261.00
310_A338_D1.6161.00
110_V115_V1.5871.00
189_V200_I1.5691.00
222_G225_K1.5671.00
53_T116_V1.5611.00
294_L311_H1.5611.00
50_I74_V1.5521.00
49_I76_A1.5451.00
311_H314_L1.5431.00
178_S333_E1.5401.00
230_R314_L1.5281.00
49_I127_A1.5161.00
269_K295_T1.5091.00
194_M198_Y1.4941.00
135_G138_I1.4911.00
76_A129_V1.4841.00
30_F39_V1.4591.00
247_F311_H1.4471.00
169_F207_L1.4391.00
240_H318_S1.4381.00
165_A202_P1.4331.00
86_F94_S1.4321.00
274_F334_W1.4301.00
94_S97_E1.4281.00
79_V82_A1.4281.00
16_E108_T1.4211.00
223_K226_S1.4161.00
192_Q219_P1.4071.00
46_K73_Q1.4051.00
268_R299_H1.4021.00
205_I227_I1.4001.00
247_F294_L1.3941.00
3_G107_L1.3741.00
167_I197_V1.3550.99
166_L186_V1.3550.99
194_M226_S1.3510.99
267_D338_D1.3380.99
93_Y97_E1.3350.99
166_L176_A1.3260.99
221_L245_L1.3210.99
184_C343_V1.3150.99
40_L74_V1.2900.99
11_T114_A1.2820.99
249_G288_S1.2800.99
269_K310_A1.2780.99
274_F332_S1.2680.99
146_A238_L1.2440.99
161_N344_I1.2410.99
171_Y176_A1.2240.99
66_D90_E1.2240.99
6_V12_S1.2230.99
46_K148_Q1.2210.99
206_V234_L1.2200.99
252_F305_S1.2170.99
164_I184_C1.2160.99
228_I247_F1.2090.99
269_K338_D1.2080.99
196_A199_N1.1910.99
63_N66_D1.1900.99
298_F321_F1.1860.99
215_K251_T1.1850.99
8_E125_M1.1790.99
266_I299_H1.1780.99
150_S192_Q1.1740.98
341_K344_I1.1710.98
294_L309_L1.1700.98
70_K73_Q1.1670.98
40_L77_A1.1590.98
163_H200_I1.1520.98
267_D274_F1.1470.98
204_G343_V1.1410.98
180_V186_V1.1380.98
215_K245_L1.1360.98
3_G17_L1.1340.98
286_E296_I1.1270.98
227_I233_T1.1270.98
167_I193_Q1.1240.98
198_Y230_R1.1110.98
222_G226_S1.1090.98
290_N293_E1.1060.98
72_P104_I1.1040.98
21_E100_Q1.1010.98
207_L224_I1.1000.98
64_E93_Y1.0980.98
32_G39_V1.0830.97
341_K345_P1.0790.97
27_A119_I1.0790.97
151_A154_I1.0730.97
285_D288_S1.0720.97
146_A217_I1.0690.97
234_L317_M1.0640.97
82_A96_K1.0620.97
266_I301_V1.0550.97
5_L107_L1.0510.97
3_G131_A1.0470.97
160_G185_K1.0380.97
68_E177_S1.0320.97
62_I93_Y1.0290.97
249_G289_I1.0170.96
243_I309_L1.0160.96
226_S229_S1.0120.96
164_I340_L1.0110.96
233_T243_I1.0090.96
23_C76_A0.9940.96
223_K227_I0.9930.96
293_E311_H0.9840.96
22_N132_S0.9810.95
317_M335_I0.9780.95
261_A277_S0.9780.95
201_K231_F0.9760.95
39_V52_F0.9750.95
224_I233_T0.9720.95
178_S181_K0.9680.95
23_C129_V0.9660.95
187_T200_I0.9660.95
194_M223_K0.9590.95
114_A118_K0.9560.95
140_L143_E0.9510.95
237_C322_H0.9420.94
179_L184_C0.9320.94
217_I220_Y0.9280.94
4_Y14_S0.9230.94
19_G106_L0.9190.94
126_G140_L0.9140.93
162_K184_C0.9070.93
143_E148_Q0.9040.93
9_D122_N0.9030.93
18_D79_V0.9030.93
338_D341_K0.9020.93
47_G75_K0.9010.93
130_T135_G0.8980.93
119_I127_A0.8950.93
37_Q63_N0.8950.93
156_T187_T0.8940.93
174_S178_S0.8920.93
144_N220_Y0.8890.92
56_L81_E0.8860.92
62_I67_F0.8860.92
265_V307_E0.8840.92
171_Y206_V0.8830.92
267_D272_R0.8810.92
297_R310_A0.8790.92
97_E100_Q0.8740.92
197_V202_P0.8710.92
147_E192_Q0.8680.91
71_K102_W0.8650.91
151_A188_V0.8630.91
65_K90_E0.8630.91
299_H304_T0.8620.91
195_E199_N0.8590.91
79_V108_T0.8590.91
78_V110_V0.8580.91
158_G161_N0.8560.91
321_F332_S0.8560.91
229_S314_L0.8550.91
44_S237_C0.8510.91
23_C75_K0.8480.91
70_K173_K0.8470.90
4_Y133_K0.8470.90
84_D108_T0.8460.90
25_G49_I0.8440.90
162_K340_L0.8420.90
13_F114_A0.8370.90
186_V206_V0.8350.90
218_Q222_G0.8340.90
340_L343_V0.8320.90
159_D185_K0.8290.90
182_R340_L0.8260.89
169_F242_L0.8250.89
228_I243_I0.8210.89
157_F180_V0.8200.89
27_A51_V0.8160.89
140_L145_V0.8140.89
4_Y12_S0.8110.88
166_L208_S0.8110.88
144_N219_P0.8100.88
178_S182_R0.8040.88
6_V130_T0.8040.88
133_K138_I0.8010.88
140_L282_Y0.8000.88
40_L95_L0.7980.88
267_D270_T0.7960.88
209_N237_C0.7950.87
17_L131_A0.7940.87
247_F316_V0.7910.87
91_A94_S0.7890.87
207_L233_T0.7880.87
311_H316_V0.7860.87
197_V223_K0.7790.86
263_H302_N0.7790.86
142_P145_V0.7770.86
47_G148_Q0.7740.86
41_T67_F0.7740.86
142_P216_A0.7680.86
298_F334_W0.7670.86
249_G294_L0.7670.86
99_L104_I0.7650.85
130_T134_E0.7590.85
97_E101_K0.7570.85
259_R263_H0.7510.84
193_Q223_K0.7500.84
99_L106_L0.7500.84
191_Y219_P0.7450.84
126_G141_Q0.7450.84
238_L245_L0.7450.84
7_L115_V0.7430.84
337_D340_L0.7430.84
155_S176_A0.7430.84
22_N130_T0.7410.84
40_L99_L0.7400.83
118_K122_N0.7400.83
78_V127_A0.7390.83
225_K229_S0.7360.83
19_G96_K0.7350.83
173_K177_S0.7350.83
321_F334_W0.7340.83
24_T128_T0.7310.83
205_I233_T0.7300.83
98_Y102_W0.7290.83
154_I189_V0.7280.82
181_K333_E0.7230.82
247_F314_L0.7230.82
105_P129_V0.7190.82
51_V116_V0.7160.81
132_S135_G0.7140.81
74_V77_A0.7140.81
46_K75_K0.7120.81
261_A300_H0.7100.81
222_G229_S0.7100.81
286_E306_V0.7090.81
145_V282_Y0.7090.81
164_I204_G0.7070.81
96_K106_L0.7060.80
161_N185_K0.7060.80
197_V205_I0.7040.80
134_E138_I0.7020.80
184_C204_G0.6990.80
197_V227_I0.6970.80
141_Q215_K0.6950.79
142_P282_Y0.6940.79
274_F321_F0.6920.79
164_I179_L0.6900.79
220_Y223_K0.6890.79
30_F52_F0.6880.79
45_Y48_Q0.6880.79
74_V104_I0.6830.78
77_A99_L0.6810.78
4_Y136_A0.6810.78
46_K71_K0.6800.78
189_V193_Q0.6760.78
219_P222_G0.6760.78
204_G339_Y0.6720.77
119_I124_T0.6700.77
126_G139_A0.6690.77
233_T316_V0.6670.77
41_T98_Y0.6670.77
57_I79_V0.6660.77
60_Y302_N0.6640.76
312_K315_P0.6630.76
175_I237_C0.6630.76
5_L110_V0.6620.76
165_A197_V0.6620.76
163_H203_D0.6610.76
250_N288_S0.6610.76
165_A187_T0.6590.76
175_I325_A0.6590.76
175_I236_I0.6570.76
167_I220_Y0.6550.75
32_G277_S0.6520.75
21_E105_P0.6520.75
157_F176_A0.6500.75
69_S73_Q0.6490.75
198_Y226_S0.6470.74
198_Y227_I0.6460.74
154_I200_I0.6430.74
155_S180_V0.6420.74
254_L283_V0.6420.74
259_R321_F0.6390.74
193_Q227_I0.6360.73
60_Y63_N0.6340.73
249_G309_L0.6330.73
167_I207_L0.6330.73
158_G185_K0.6320.73
8_E122_N0.6320.73
43_P324_E0.6320.73
3_G105_P0.6310.73
278_Q307_E0.6300.72
39_V45_Y0.6290.72
244_A249_G0.6290.72
221_L225_K0.6270.72
315_P342_N0.6250.72
18_D82_A0.6240.72
245_L250_N0.6240.72
72_P98_Y0.6230.72
237_C329_P0.6220.72
162_K203_D0.6220.72
218_Q221_L0.6220.72
237_C256_F0.6220.72
68_E174_S0.6210.71
52_F57_I0.6200.71
33_M60_Y0.6200.71
121_A255_P0.6190.71
219_P223_K0.6190.71
30_F263_H0.6150.71
194_M227_I0.6130.70
107_L110_V0.6120.70
247_F290_N0.6110.70
37_Q298_F0.6110.70
82_A108_T0.6080.70
179_L186_V0.6070.70
28_V259_R0.6070.70
17_L21_E0.6040.69
162_K183_G0.6040.69
192_Q196_A0.6030.69
46_K145_V0.6030.69
244_A294_L0.6000.69
176_A206_V0.5990.69
176_A188_V0.5990.69
216_A282_Y0.5980.69
285_D306_V0.5980.69
147_E219_P0.5940.68
116_V300_H0.5930.68
146_A169_F0.5930.68
204_G234_L0.5910.68
20_H100_Q0.5870.67
115_V127_A0.5860.67
144_N216_A0.5830.67
182_R333_E0.5830.67
237_C257_G0.5820.66
44_S322_H0.5810.66
51_V78_V0.5810.66
259_R307_E0.5800.66
174_S333_E0.5790.66
326_H330_A0.5780.66
322_H329_P0.5780.66
300_H307_E0.5770.66
75_K148_Q0.5770.66
56_L60_Y0.5760.66
124_T282_Y0.5750.66
27_A78_V0.5750.66
5_L27_A0.5740.65
267_D334_W0.5740.65
19_G105_P0.5730.65
206_V318_S0.5700.65
30_F51_V0.5700.65
238_L242_L0.5690.65
51_V119_I0.5690.65
79_V106_L0.5680.65
283_V306_V0.5680.65
261_A326_H0.5670.64
221_L246_A0.5670.64
254_L281_S0.5660.64
65_K92_V0.5660.64
274_F298_F0.5660.64
278_Q300_H0.5660.64
67_F173_K0.5640.64
146_A216_A0.5640.64
46_K149_A0.5640.64
338_D342_N0.5630.64
237_C241_Q0.5610.64
97_E103_N0.5580.63
45_Y237_C0.5580.63
62_I91_A0.5570.63
195_E198_Y0.5560.63
152_Q225_K0.5560.63
240_H284_V0.5560.63
47_G143_E0.5530.63
230_R315_P0.5530.63
154_I196_A0.5510.62
32_G259_R0.5490.62
267_D298_F0.5480.62
28_V255_P0.5470.62
39_V263_H0.5460.62
157_F188_V0.5460.62
30_F175_I0.5450.61
40_L52_F0.5440.61
267_D297_R0.5440.61
4_Y130_T0.5420.61
217_I238_L0.5420.61
178_S259_R0.5420.61
209_N322_H0.5410.61
317_M342_N0.5400.61
60_Y237_C0.5400.61
209_N319_V0.5390.61
307_E321_F0.5390.61
119_I125_M0.5380.60
44_S209_N0.5380.60
146_A149_A0.5370.60
241_Q322_H0.5360.60
174_S326_H0.5360.60
289_I293_E0.5360.60
17_L106_L0.5350.60
266_I304_T0.5330.60
213_D251_T0.5320.60
18_D105_P0.5320.60
67_F102_W0.5320.60
17_L82_A0.5320.60
140_L216_A0.5290.59
121_A289_I0.5280.59
25_G50_I0.5280.59
317_M338_D0.5260.59
284_V309_L0.5260.59
191_Y220_Y0.5250.59
18_D108_T0.5240.58
263_H282_Y0.5230.58
140_L281_S0.5230.58
193_Q197_V0.5230.58
4_Y134_E0.5220.58
173_K176_A0.5210.58
58_G61_G0.5200.58
177_S207_L0.5180.58
13_F110_V0.5180.58
118_K125_M0.5180.58
259_R302_N0.5180.58
39_V240_H0.5180.58
63_N298_F0.5180.58
289_I296_I0.5170.57
28_V256_F0.5160.57
220_Y242_L0.5160.57
141_Q145_V0.5160.57
81_E84_D0.5140.57
206_V317_M0.5140.57
129_V293_E0.5140.57
139_A142_P0.5130.57
18_D254_L0.5110.57
141_Q216_A0.5100.56
49_I74_V0.5100.56
54_Y60_Y0.5090.56
192_Q220_Y0.5090.56
7_L127_A0.5080.56
337_D341_K0.5070.56
56_L307_E0.5060.56
172_K328_G0.5050.56
150_S155_S0.5050.56
209_N241_Q0.5040.56
7_L118_K0.5040.56
240_H309_L0.5040.56
228_I233_T0.5030.55
319_V335_I0.5020.55
51_V54_Y0.5020.55
298_F335_I0.5010.55
252_F286_E0.5010.55
20_H105_P0.5010.55
322_H328_G0.5000.55
81_E109_H0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a9xB 1 0.9858 100 0.209 Contact Map
1vcoA 4 0.9235 100 0.65 Contact Map
1s1mA 4 0.949 100 0.66 Contact Map
3nvaA 2 0.9575 100 0.687 Contact Map
4zdjA 4 0.949 100 0.703 Contact Map
2vxoA 2 0.5212 100 0.782 Contact Map
1qdlB 2 0.5042 100 0.79 Contact Map
1i1qB 1 0.4901 100 0.791 Contact Map
2h2wA 2 0.6771 100 0.792 Contact Map
3tqiA 3 0.4958 100 0.792 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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