GREMLIN Database
SYL - Leucine--tRNA ligase
UniProt: P36430 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 804 (795)
Sequences: 3600 (1907)
Seq/√Len: 67.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_K144_E5.3631.00
765_T768_Q4.8231.00
235_D317_K4.4621.00
17_L112_Q4.0691.00
766_K770_E4.0541.00
199_D203_E3.9631.00
14_T18_E3.7871.00
316_E357_K3.6321.00
434_D481_K3.6241.00
231_H242_T3.6091.00
229_H242_T3.5251.00
699_E722_H3.4711.00
304_F308_Y3.3781.00
15_Y19_N3.2881.00
756_A776_D3.2561.00
386_H389_E3.2201.00
505_D508_N3.1331.00
385_L393_K3.0861.00
515_P519_E3.0381.00
743_E759_Q2.9801.00
20_K121_D2.8811.00
174_K181_P2.7381.00
206_E219_R2.6801.00
143_Y429_V2.6601.00
231_H240_S2.5801.00
207_E557_K2.5761.00
199_D224_R2.5591.00
4_Q7_E2.5581.00
152_E186_P2.5351.00
766_K795_P2.5251.00
65_K70_Y2.4861.00
511_Q514_S2.4791.00
668_Y708_V2.4671.00
23_A121_D2.4531.00
204_D546_K2.4451.00
311_N314_N2.4421.00
20_K23_A2.4271.00
80_A127_T2.4211.00
241_F259_L2.4041.00
239_D268_N2.3691.00
770_E791_I2.3651.00
771_Q775_A2.3561.00
141_K442_E2.3551.00
519_E555_P2.3431.00
397_W401_T2.3321.00
98_V102_Q2.3211.00
399_E405_E2.3011.00
264_A328_A2.2991.00
475_T482_K2.2921.00
252_F381_F2.2751.00
106_N109_R2.2671.00
514_S517_K2.2241.00
747_V798_L2.1871.00
105_D108_R2.1801.00
254_A318_L2.1711.00
175_S178_G2.1531.00
760_V769_L2.1521.00
793_A799_V2.1521.00
71_D520_K2.1431.00
78_W108_R2.1391.00
203_E224_R2.1351.00
769_L793_A2.1341.00
473_E484_R2.1201.00
108_R123_E2.1151.00
269_I307_A2.1131.00
140_L439_A2.1131.00
78_W123_E2.1051.00
659_E741_D2.0911.00
369_A372_G2.0801.00
197_Y550_D2.0791.00
358_E377_V2.0721.00
508_N511_Q2.0711.00
229_H405_E2.0561.00
440_V444_E2.0541.00
308_Y317_K2.0491.00
393_K396_A2.0481.00
702_V726_I2.0281.00
441_P444_E2.0201.00
309_A320_I2.0191.00
745_E759_Q2.0171.00
654_E696_E2.0171.00
430_I474_V2.0141.00
429_V437_S1.9911.00
160_A180_H1.9871.00
381_F397_W1.9781.00
756_A778_K1.9741.00
476_D479_T1.9741.00
574_N582_G1.9691.00
158_C178_G1.9681.00
343_E347_E1.9651.00
31_Q70_Y1.9621.00
767_E770_E1.9611.00
663_K679_Q1.9551.00
67_M703_K1.9471.00
341_H359_V1.9411.00
233_A240_S1.9381.00
763_D796_G1.9311.00
657_Y697_Y1.9291.00
656_V660_T1.9291.00
662_M734_Y1.9131.00
504_I522_L1.9091.00
350_K356_V1.9051.00
68_Q665_T1.8941.00
627_L709_A1.8841.00
627_L712_L1.8821.00
774_Q791_I1.8711.00
267_E282_I1.8711.00
387_K391_I1.8711.00
392_E406_K1.8701.00
284_E301_T1.8631.00
399_E406_K1.8531.00
152_E188_K1.8361.00
783_L788_I1.8351.00
200_R549_Y1.8341.00
158_C175_S1.8241.00
755_K782_Q1.8231.00
230_V251_L1.8211.00
768_Q771_Q1.8191.00
764_A769_L1.8191.00
396_A400_E1.8191.00
435_G479_T1.8131.00
770_E774_Q1.8121.00
545_H556_T1.8031.00
153_V191_M1.8021.00
361_K375_E1.7811.00
380_D383_N1.7691.00
135_T425_E1.7671.00
549_Y557_K1.7631.00
275_K279_E1.7631.00
432_W435_G1.7621.00
259_L266_V1.7571.00
13_Q711_H1.7561.00
699_E703_K1.7561.00
230_V398_L1.7481.00
26_D517_K1.7471.00
778_K781_E1.7451.00
226_E406_K1.7431.00
662_M666_D1.7361.00
417_F490_M1.7341.00
432_W479_T1.7221.00
745_E757_K1.7191.00
754_V757_K1.7121.00
192_L494_A1.6991.00
64_M68_Q1.6961.00
224_R408_V1.6860.99
662_M736_E1.6580.99
589_E592_A1.6560.99
654_E738_K1.6470.99
155_V164_V1.6460.99
573_N582_G1.6460.99
228_A395_I1.6440.99
251_L398_L1.6420.99
665_T731_W1.6400.99
299_T351_T1.6390.99
278_V322_I1.6370.99
283_K286_Q1.6270.99
204_D207_E1.6210.99
241_F257_T1.6150.99
473_E482_K1.6120.99
432_W476_D1.6100.99
160_A178_G1.6090.99
440_V447_L1.6060.99
364_N367_E1.6050.99
278_V303_V1.6030.99
500_F545_H1.5980.99
214_I565_N1.5840.99
452_T468_I1.5790.99
398_L403_N1.5780.99
58_T528_I1.5780.99
277_A280_A1.5660.99
199_D410_Y1.5640.99
382_L397_W1.5610.99
541_A560_F1.5460.99
746_I769_L1.5440.99
737_T740_V1.5430.99
661_V704_L1.5380.99
313_V397_W1.5260.99
158_C180_H1.5260.99
378_N383_N1.5220.99
575_E581_K1.5190.99
150_V188_K1.5190.99
435_G476_D1.5160.99
254_A335_V1.5140.99
395_I406_K1.5130.99
786_K803_A1.5030.99
513_A518_L1.5030.99
432_W436_T1.5010.99
469_K473_E1.4970.99
789_R803_A1.4920.99
346_F356_V1.4910.99
160_A175_S1.4850.99
774_Q801_I1.4850.99
547_F551_I1.4830.99
200_R204_D1.4800.99
193_K196_A1.4790.99
695_K699_E1.4790.99
135_T495_G1.4730.99
700_G704_L1.4710.99
280_A284_E1.4690.99
310_I317_K1.4680.99
702_V716_L1.4620.98
703_K729_E1.4600.98
655_R741_D1.4590.98
226_E408_V1.4550.98
656_V659_E1.4500.98
175_S180_H1.4450.98
633_L684_I1.4430.98
472_V484_R1.4420.98
10_K14_T1.4390.98
101_K128_D1.4260.98
511_Q515_P1.4250.98
763_D768_Q1.4220.98
346_F350_K1.4200.98
452_T455_I1.4180.98
429_V439_A1.4130.98
358_E361_K1.4020.98
747_V757_K1.3960.98
397_W400_E1.3940.98
436_T479_T1.3920.98
316_E355_P1.3920.98
571_G582_G1.3900.98
230_V243_V1.3870.98
229_H407_K1.3860.98
257_T318_L1.3840.98
11_K715_E1.3780.98
150_V431_H1.3750.98
305_T322_I1.3600.98
281_Y301_T1.3600.98
657_Y700_G1.3580.98
512_L553_V1.3560.98
388_Q391_I1.3550.98
778_K782_Q1.3540.98
433_E484_R1.3530.97
433_E482_K1.3530.97
661_V700_G1.3530.97
432_W438_T1.3440.97
343_E369_A1.3430.97
124_I503_Y1.3370.97
276_E280_A1.3370.97
779_V782_Q1.3300.97
203_E206_E1.3280.97
601_L709_A1.3250.97
382_L394_V1.3240.97
145_K551_I1.3070.97
631_W712_L1.3050.97
516_E519_E1.3040.97
747_V754_V1.3040.97
22_F727_A1.3040.97
144_E442_E1.3020.97
656_V686_E1.2970.97
15_Y718_E1.2910.97
140_L442_E1.2910.97
448_I451_K1.2890.97
102_Q105_D1.2840.97
783_L801_I1.2840.97
108_R112_Q1.2680.96
33_F65_K1.2660.96
757_K798_L1.2660.96
770_E801_I1.2630.96
134_W137_W1.2620.96
791_I801_I1.2610.96
702_V720_L1.2520.96
774_Q788_I1.2510.96
361_K377_V1.2420.96
678_S682_V1.2380.96
605_F681_M1.2320.96
365_V368_A1.2270.96
435_G438_T1.2260.96
590_I599_L1.2250.95
700_G703_K1.2210.95
706_S713_A1.2190.95
248_P395_I1.2190.95
52_P114_L1.2180.95
392_E396_A1.2180.95
252_F397_W1.2170.95
687_A697_Y1.2170.95
346_F365_V1.2140.95
762_A796_G1.2120.95
734_Y739_L1.2110.95
199_D226_E1.2100.95
396_A406_K1.2080.95
781_E784_E1.2070.95
64_M665_T1.2060.95
630_V705_L1.2050.95
304_F307_A1.2030.95
571_G584_V1.2010.95
760_V764_A1.1980.95
37_D74_H1.1940.95
515_P555_P1.1930.95
233_A403_N1.1910.95
468_I472_V1.1900.95
32_K520_K1.1890.95
6_K592_A1.1830.95
598_T620_L1.1800.94
425_E495_G1.1780.94
724_G729_E1.1770.94
775_A780_K1.1770.94
651_E742_D1.1710.94
740_V762_A1.1710.94
436_T476_D1.1700.94
767_E771_Q1.1690.94
299_T302_G1.1650.94
251_L313_V1.1650.94
679_Q682_V1.1630.94
660_T664_V1.1610.94
159_P183_E1.1590.94
657_Y661_V1.1590.94
432_W477_P1.1560.94
284_E287_S1.1540.94
97_A101_K1.1520.94
705_L713_A1.1480.94
501_L522_L1.1410.93
130_E509_P1.1390.93
634_F698_M1.1360.93
735_D738_K1.1320.93
255_T357_K1.1320.93
432_W483_G1.1300.93
148_A192_L1.1270.93
570_L574_N1.1270.93
750_L782_Q1.1260.93
141_K551_I1.1230.93
283_K287_S1.1220.93
98_V451_K1.1190.93
474_V483_G1.1170.93
624_R628_D1.1170.93
140_L429_V1.1120.93
266_V322_I1.1120.93
143_Y437_S1.1030.92
230_V248_P1.1020.92
181_P287_S1.1010.92
653_L687_A1.1010.92
760_V772_L1.0990.92
684_I688_Y1.0990.92
472_V487_T1.0960.92
159_P180_H1.0920.92
161_L175_S1.0890.92
11_K718_E1.0870.92
687_A701_F1.0870.92
633_L698_M1.0850.92
5_H624_R1.0850.92
65_K68_Q1.0780.91
748_V758_L1.0780.91
97_A451_K1.0750.91
433_E481_K1.0740.91
214_I531_A1.0740.91
477_P483_G1.0740.91
377_V383_N1.0730.91
27_N30_K1.0640.91
248_P391_I1.0630.91
714_E725_T1.0610.91
766_K793_A1.0600.91
278_V282_I1.0600.91
144_E478_E1.0600.91
343_E346_F1.0590.91
213_S531_A1.0570.90
142_L544_W1.0570.90
630_V701_F1.0550.90
777_E780_K1.0530.90
438_T483_G1.0460.90
751_N803_A1.0440.90
663_K667_H1.0420.90
373_D388_Q1.0420.90
266_V270_T1.0390.90
215_K219_R1.0380.90
161_L178_G1.0380.90
717_W721_G1.0370.90
438_T479_T1.0370.90
200_R546_K1.0360.90
571_G575_E1.0340.89
684_I701_F1.0320.89
706_S726_I1.0310.89
372_G387_K1.0300.89
360_V376_H1.0260.89
12_W715_E1.0250.89
430_I483_G1.0250.89
141_K553_V1.0220.89
375_E386_H1.0200.89
113_A592_A1.0190.89
161_L180_H1.0160.89
518_L555_P1.0160.89
313_V398_L1.0150.89
244_F409_T1.0140.89
680_L701_F1.0130.89
234_I237_H1.0120.88
393_K397_W1.0090.88
593_S621_D1.0090.88
440_V443_E1.0070.88
291_L294_T1.0070.88
137_W141_K1.0040.88
158_C179_G1.0040.88
248_P394_V1.0030.88
199_D408_V1.0030.88
564_Y610_D1.0020.88
137_W442_E1.0010.88
376_H387_K1.0000.88
228_A398_L1.0000.88
196_A199_D1.0000.88
764_A768_Q0.9980.88
505_D517_K0.9970.88
129_P448_I0.9970.88
389_E393_K0.9960.88
62_S117_S0.9950.88
750_L773_A0.9950.88
258_V323_A0.9930.88
657_Y693_L0.9910.87
607_G613_I0.9900.87
85_A99_F0.9870.87
362_G365_V0.9870.87
360_V387_K0.9870.87
653_L690_A0.9850.87
270_T307_A0.9840.87
758_L776_D0.9830.87
66_R117_S0.9830.87
435_G477_P0.9780.87
370_Y373_D0.9730.86
764_A772_L0.9730.86
323_A352_F0.9710.86
376_H382_L0.9670.86
314_N317_K0.9650.86
391_I394_V0.9640.86
61_L526_M0.9630.86
15_Y21_T0.9620.86
634_F702_V0.9600.86
653_L686_E0.9590.86
664_V676_G0.9590.86
667_H675_T0.9580.86
268_N271_T0.9570.85
758_L769_L0.9560.85
773_A791_I0.9520.85
313_V394_V0.9520.85
125_N128_D0.9510.85
267_E279_E0.9500.85
507_H517_K0.9500.85
275_K303_V0.9490.85
231_H405_E0.9480.85
452_T470_E0.9470.85
234_I238_D0.9430.85
67_M730_A0.9420.85
178_G181_P0.9410.85
37_D58_T0.9410.85
639_G642_N0.9390.84
280_A283_K0.9370.84
15_Y725_T0.9360.84
204_D557_K0.9360.84
479_T483_G0.9340.84
396_A399_E0.9320.84
474_V477_P0.9310.84
770_E793_A0.9300.84
142_L547_F0.9290.84
780_K783_L0.9280.84
211_P214_I0.9280.84
45_A106_N0.9250.84
588_D592_A0.9240.83
158_C165_L0.9230.83
635_I719_K0.9200.83
252_F313_V0.9200.83
359_V363_G0.9200.83
101_K105_D0.9190.83
56_T604_M0.9180.83
269_I305_T0.9160.83
660_T704_L0.9160.83
602_Y606_M0.9160.83
21_T727_A0.9130.83
230_V245_T0.9060.82
658_H661_V0.9050.82
259_L269_I0.9040.82
274_Q277_A0.9030.82
772_L776_D0.9030.82
705_L709_A0.9020.82
35_A62_S0.8990.82
242_T405_E0.8980.82
750_L779_V0.8980.82
598_T624_R0.8960.82
637_D641_L0.8950.81
137_W553_V0.8940.81
571_G574_N0.8940.81
376_H390_A0.8920.81
279_E282_I0.8910.81
281_Y324_D0.8900.81
769_L798_L0.8870.81
271_T274_Q0.8870.81
468_I471_W0.8860.81
171_I176_E0.8860.81
570_L582_G0.8860.81
257_T335_V0.8850.81
234_I320_I0.8850.81
88_Y99_F0.8790.80
564_Y613_I0.8790.80
279_E283_K0.8780.80
150_V437_S0.8770.80
68_Q733_V0.8770.80
32_K525_D0.8750.80
61_L671_L0.8730.80
130_E507_H0.8720.80
58_T74_H0.8720.80
53_E613_I0.8710.80
158_C161_L0.8710.80
573_N584_V0.8680.79
570_L575_E0.8670.79
545_H554_V0.8670.79
241_F334_A0.8650.79
12_W714_E0.8650.79
766_K771_Q0.8650.79
768_Q772_L0.8640.79
750_L783_L0.8640.79
788_I801_I0.8630.79
363_G367_E0.8630.79
575_E582_G0.8620.79
438_T476_D0.8620.79
764_A796_G0.8620.79
154_P184_R0.8610.79
395_I399_E0.8600.79
702_V713_A0.8580.79
355_P358_E0.8580.79
769_L799_V0.8580.79
430_I440_V0.8570.79
783_L803_A0.8570.79
346_F366_E0.8550.78
756_A773_A0.8520.78
184_R289_S0.8510.78
504_I517_K0.8460.78
435_G478_E0.8460.78
237_H268_N0.8460.78
21_T725_T0.8450.78
570_L573_N0.8440.77
316_E380_D0.8440.77
282_I286_Q0.8410.77
783_L786_K0.8400.77
175_S179_G0.8400.77
766_K799_V0.8400.77
497_C500_F0.8380.77
109_R113_A0.8380.77
291_L296_L0.8380.77
746_I760_V0.8350.77
78_W125_N0.8340.77
564_Y671_L0.8310.76
654_E658_H0.8310.76
522_L556_T0.8290.76
143_Y439_A0.8280.76
140_L143_Y0.8270.76
385_L390_A0.8260.76
435_G483_G0.8260.76
161_L179_G0.8240.76
676_G680_L0.8240.76
209_D215_K0.8240.76
39_F560_F0.8220.76
91_D582_G0.8210.76
744_V762_A0.8210.76
265_L268_N0.8200.75
235_D310_I0.8200.75
289_S292_E0.8200.75
212_E216_D0.8200.75
298_K301_T0.8200.75
270_T278_V0.8170.75
505_D514_S0.8170.75
381_F400_E0.8160.75
360_V370_Y0.8160.75
584_V588_D0.8150.75
340_G356_V0.8130.75
761_P764_A0.8120.75
572_E575_E0.8100.75
475_T481_K0.8100.75
228_A248_P0.8100.75
340_G358_E0.8090.74
724_G728_Y0.8090.74
436_T477_P0.8080.74
750_L781_E0.8070.74
340_G346_F0.8040.74
301_T324_D0.8040.74
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253_G338_V0.5100.41
340_G343_E0.5090.41
660_T683_F0.5080.41
651_E738_K0.5080.41
138_I494_A0.5080.41
505_D510_D0.5080.41
602_Y623_A0.5080.41
531_A565_N0.5070.41
87_Q161_L0.5070.41
4_Q624_R0.5060.41
649_A696_E0.5060.41
25_L520_K0.5060.41
233_A310_I0.5060.41
695_K720_L0.5050.41
91_D177_R0.5050.41
159_P173_G0.5050.41
569_I606_M0.5050.41
520_K523_P0.5040.40
417_F493_W0.5040.40
425_E491_P0.5040.40
176_E492_Q0.5040.40
28_N520_K0.5040.40
183_E186_P0.5040.40
135_T416_L0.5040.40
501_L556_T0.5040.40
591_V598_T0.5040.40
633_L701_F0.5040.40
52_P587_P0.5040.40
259_L265_L0.5030.40
234_I241_F0.5030.40
52_P116_F0.5030.40
504_I514_S0.5030.40
758_L764_A0.5030.40
252_F379_S0.5030.40
490_M501_L0.5020.40
243_V251_L0.5020.40
517_K520_K0.5020.40
212_E219_R0.5020.40
773_A799_V0.5020.40
258_V261_P0.5010.40
206_E389_E0.5010.40
508_N513_A0.5010.40
299_T303_V0.5010.40
294_T300_K0.5000.40
39_F541_A0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v0cA 1 0.9142 100 0.204 Contact Map
4arcA 1 0.9316 100 0.216 Contact Map
3ziuA 1 0.7438 100 0.415 Contact Map
1ffyA 1 0.9042 100 0.466 Contact Map
1ileA 1 0.8607 100 0.471 Contact Map
1gaxA 1 0.8445 100 0.483 Contact Map
1wz2A 1 0.8968 100 0.493 Contact Map
1wkbA 1 0.7948 100 0.523 Contact Map
1rqgA 2 0.6119 100 0.692 Contact Map
4qreA 1 0.5871 100 0.692 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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