GREMLIN Database
FLHB - Flagellar biosynthetic protein FlhB
UniProt: P35538 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 360 (347)
Sequences: 2432 (1879)
Seq/√Len: 100.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_K124_E6.4061.00
21_K25_D5.2661.00
230_Q234_D4.4781.00
25_D28_K4.4711.00
271_I310_A4.2611.00
134_D137_K4.0641.00
223_K226_K4.0481.00
20_P24_K3.7411.00
221_Y225_I3.6951.00
18_A222_E3.4071.00
23_R222_E3.2681.00
264_E267_K3.1531.00
19_T232_I3.0001.00
305_K308_K2.9811.00
264_E334_D2.9451.00
25_D29_K2.9071.00
26_T225_I2.8611.00
122_S125_V2.8241.00
46_V108_A2.6891.00
248_K251_Q2.6431.00
285_D288_K2.5581.00
249_I253_Q2.5461.00
228_S231_D2.5001.00
220_D224_N2.4781.00
24_K28_K2.4271.00
323_L348_I2.3631.00
271_I306_I2.3571.00
304_L307_R2.3281.00
16_E229_K2.3271.00
31_Q221_Y2.2851.00
23_R225_I2.1571.00
150_E153_K2.1541.00
228_S232_I2.1391.00
124_E127_Q2.1081.00
278_Y299_V2.0851.00
146_R220_D2.0561.00
149_V216_Y2.0411.00
166_F170_W2.0041.00
28_K124_E1.9661.00
137_K140_K1.9591.00
267_K283_K1.9021.00
265_V315_V1.8981.00
248_K252_R1.8501.00
50_S104_V1.8431.00
216_Y220_D1.8301.00
309_I313_H1.8241.00
172_H175_E1.8191.00
307_R311_K1.8161.00
31_Q224_N1.8001.00
145_M223_K1.7751.00
131_E137_K1.7571.00
42_V112_S1.7271.00
219_F223_K1.7231.00
252_R256_M1.7211.00
295_V315_V1.6551.00
164_A205_A1.6541.00
267_K295_V1.6471.00
290_D336_A1.6421.00
289_M293_Y1.6331.00
168_V201_S1.6281.00
278_Y321_R1.5831.00
278_Y300_D1.5811.00
144_S147_A1.5751.00
294_I331_V1.5441.00
34_K113_N1.5301.00
351_Y355_T1.5301.00
163_F167_A1.5231.00
236_Y240_E1.5061.00
21_K239_S1.5051.00
17_K222_E1.5031.00
47_I105_A1.4891.00
41_A210_A1.4801.00
129_K132_K1.4701.00
214_Y218_R1.4641.00
38_V210_A1.4581.00
48_F199_G1.4431.00
279_A304_L1.4431.00
170_W173_Y1.4171.00
251_Q255_E1.4071.00
106_L109_G1.3820.99
280_I294_I1.3770.99
307_R319_E1.3750.99
279_A307_R1.3740.99
61_R96_M1.3540.99
293_Y336_A1.3450.99
325_R329_D1.3360.99
110_V114_Y1.3290.99
304_L319_E1.3280.99
320_N347_E1.3200.99
142_I151_L1.3000.99
172_H197_W1.2960.99
26_T31_Q1.2910.99
61_R93_D1.2910.99
127_Q131_E1.2890.99
38_V214_Y1.2870.99
38_V112_S1.2870.99
309_I312_E1.2850.99
283_K289_M1.2780.99
182_L190_F1.2760.99
257_A260_R1.2660.99
182_L186_E1.2650.99
331_V335_Q1.2610.99
264_E295_V1.2520.99
197_W201_S1.2350.99
254_R258_M1.2280.99
311_K317_M1.2280.99
138_G141_R1.2230.99
34_K117_V1.2150.99
146_R150_E1.2130.99
222_E226_K1.2050.99
318_V351_Y1.2020.99
222_E225_I1.2000.99
234_D238_K1.1980.99
266_P309_I1.1900.98
272_I324_A1.1870.98
23_R221_Y1.1750.98
45_L203_A1.1670.98
298_G306_I1.1660.98
273_T319_E1.1660.98
17_K20_P1.1610.98
27_R120_L1.1580.98
229_K233_K1.1520.98
304_L317_M1.1520.98
23_R26_T1.1510.98
280_I327_L1.1460.98
33_A221_Y1.1440.98
280_I329_D1.1350.98
92_K96_M1.1310.98
264_E333_I1.1100.98
140_K223_K1.1100.98
250_K254_R1.1090.98
281_A296_A1.1030.98
272_I316_M1.0980.97
341_F348_I1.0810.97
93_D96_M1.0760.97
142_I147_A1.0760.97
255_E259_R1.0730.97
146_R224_N1.0680.97
218_R222_E1.0630.97
245_I248_K1.0620.97
44_L203_A1.0600.97
277_H300_D1.0590.97
155_I159_V1.0490.97
297_K331_V1.0420.96
98_L102_L1.0370.96
216_Y219_F1.0350.96
352_V355_T1.0320.96
33_A218_R1.0320.96
54_I104_V1.0270.96
273_T317_M1.0240.96
244_I247_S1.0220.96
50_S54_I1.0190.96
136_I140_K1.0120.96
221_Y224_N1.0110.96
36_S150_E1.0100.96
148_I152_I1.0090.96
25_D124_E1.0060.96
274_N277_H1.0030.96
16_E232_I1.0010.96
323_L345_L1.0000.96
15_T229_K0.9950.95
212_L215_L0.9940.95
163_F166_F0.9910.95
145_M148_I0.9910.95
269_D285_D0.9910.95
299_V328_Y0.9890.95
265_V306_I0.9880.95
184_P187_A0.9850.95
289_M336_A0.9840.95
294_I327_L0.9830.95
21_K24_K0.9740.95
42_V108_A0.9720.95
308_K311_K0.9710.95
12_G230_Q0.9690.95
22_K238_K0.9680.95
283_K288_K0.9640.95
336_A342_F0.9630.95
63_L67_E0.9610.94
57_Y61_R0.9570.94
123_A126_I0.9550.94
69_F90_L0.9510.94
21_K238_K0.9480.94
229_K232_I0.9420.94
10_F13_E0.9370.94
159_V163_F0.9330.94
17_K226_K0.9290.93
295_V333_I0.9290.93
251_Q258_M0.9260.93
18_A37_D0.9240.93
278_Y329_D0.9230.93
268_A295_V0.9140.93
133_L136_I0.9120.93
22_K25_D0.9040.92
253_Q257_A0.9030.92
14_K18_A0.9010.92
47_I199_G0.9010.92
326_A341_F0.8970.92
260_R263_Q0.8900.92
116_Q320_N0.8880.92
19_T23_R0.8870.92
41_A203_A0.8870.92
330_Q340_E0.8860.92
43_S47_I0.8790.91
99_A103_L0.8770.91
253_Q256_M0.8750.91
273_T311_K0.8730.91
273_T307_R0.8720.91
242_D245_I0.8710.91
305_K309_I0.8680.91
33_A132_K0.8610.91
114_Y119_F0.8580.90
156_L209_L0.8560.90
18_A23_R0.8480.90
291_A336_A0.8440.90
341_F349_L0.8410.89
42_V115_M0.8390.89
27_R118_G0.8360.89
102_L106_L0.8360.89
117_V120_L0.8340.89
204_G208_I0.8290.89
57_Y96_M0.8270.89
339_E342_F0.8250.89
145_M226_K0.8250.89
265_V313_H0.8240.89
193_K197_W0.8150.88
122_S126_I0.8140.88
105_A263_Q0.8140.88
59_R192_S0.8130.88
94_M98_L0.8120.88
97_I100_P0.8110.88
109_G113_N0.8100.88
136_I139_F0.8070.87
332_E335_Q0.8060.87
37_D68_T0.8010.87
249_I259_R0.8000.87
36_S238_K0.7980.87
36_S113_N0.7980.87
56_P60_D0.7970.87
295_V306_I0.7970.87
261_M305_K0.7960.87
251_Q254_R0.7920.86
150_E157_K0.7880.86
266_P313_H0.7870.86
101_I105_A0.7870.86
264_E283_K0.7860.86
88_V92_K0.7830.86
14_K228_S0.7820.86
45_L49_L0.7820.86
27_R221_Y0.7810.86
244_I249_I0.7800.86
32_V117_V0.7780.85
22_K230_Q0.7740.85
170_W174_G0.7730.85
145_M220_D0.7710.85
138_G142_I0.7700.85
145_M219_F0.7700.85
131_E134_D0.7670.85
33_A214_Y0.7660.85
108_A112_S0.7660.85
269_D283_K0.7640.84
239_S242_D0.7640.84
104_V142_I0.7620.84
31_Q225_I0.7610.84
84_H88_V0.7590.84
266_P306_I0.7590.84
302_L333_I0.7530.84
19_T22_K0.7470.83
337_V345_L0.7460.83
89_S93_D0.7420.83
128_P131_E0.7420.83
304_L311_K0.7410.83
41_A207_L0.7340.82
175_E190_F0.7340.82
296_A306_I0.7320.82
301_H304_L0.7320.82
113_N117_V0.7310.82
151_L154_S0.7300.82
249_I255_E0.7280.81
62_L94_M0.7270.81
220_D223_K0.7240.81
238_K242_D0.7220.81
126_I133_L0.7180.81
344_V348_I0.7160.80
78_L83_V0.7130.80
265_V333_I0.7120.80
137_K141_R0.7090.80
151_L155_I0.7090.80
111_V115_M0.7080.80
103_L107_V0.7080.80
231_D234_D0.7080.80
29_K121_F0.7080.80
183_T186_E0.7070.80
338_P341_F0.7050.79
127_Q143_Y0.7040.79
269_D349_L0.7020.79
321_R325_R0.7000.79
77_K83_V0.6990.79
275_P325_R0.6970.79
253_Q353_Y0.6950.78
106_L110_V0.6950.78
39_N117_V0.6940.78
270_V348_I0.6930.78
261_M333_I0.6900.78
322_P326_A0.6880.78
32_V221_Y0.6860.78
46_V104_V0.6850.77
127_Q140_K0.6850.77
274_N325_R0.6840.77
41_A206_L0.6830.77
276_T325_R0.6830.77
350_A353_Y0.6780.77
50_S101_I0.6740.76
149_V152_I0.6740.76
12_G15_T0.6710.76
106_L207_L0.6710.76
52_I196_L0.6690.76
326_A330_Q0.6690.76
263_Q302_L0.6680.76
308_K312_E0.6670.76
261_M306_I0.6650.75
68_T89_S0.6640.75
137_K224_N0.6620.75
297_K332_E0.6620.75
268_A281_A0.6610.75
262_M266_P0.6610.75
12_G17_K0.6600.75
300_D304_L0.6600.75
291_A342_F0.6570.74
49_L311_K0.6560.74
167_A171_L0.6540.74
281_A298_G0.6530.74
283_K293_Y0.6520.74
117_V214_Y0.6520.74
223_K236_Y0.6510.74
116_Q214_Y0.6490.74
269_D291_A0.6460.73
294_I349_L0.6430.73
189_S193_K0.6420.73
61_R64_S0.6420.73
130_L134_D0.6410.73
64_S93_D0.6410.73
32_V108_A0.6410.73
160_V205_A0.6400.73
165_A202_G0.6370.72
39_N43_S0.6370.72
156_L160_V0.6370.72
186_E190_F0.6360.72
265_V309_I0.6360.72
166_F171_L0.6360.72
19_T236_Y0.6360.72
320_N348_I0.6340.72
252_R255_E0.6330.72
156_L214_Y0.6320.72
318_V348_I0.6290.71
129_K329_D0.6280.71
150_E257_A0.6270.71
300_D351_Y0.6250.71
247_S257_A0.6250.71
271_I281_A0.6230.70
236_Y242_D0.6230.70
154_S158_I0.6230.70
69_F73_S0.6210.70
205_A209_L0.6210.70
124_E129_K0.6200.70
179_L289_M0.6200.70
37_D210_A0.6170.70
302_L328_Y0.6170.70
164_A202_G0.6170.70
150_E217_Q0.6170.70
144_S148_I0.6140.69
36_S259_R0.6120.69
346_A350_A0.6110.69
147_A151_L0.6110.69
254_R257_A0.6090.69
18_A158_I0.6090.69
47_I51_L0.6080.69
57_Y60_D0.6070.69
211_G215_L0.6060.68
280_I321_R0.6050.68
251_Q299_V0.6040.68
14_K237_K0.6040.68
172_H194_L0.6030.68
279_A311_K0.6020.68
43_S105_A0.6020.68
327_L331_V0.6000.68
18_A226_K0.6000.68
48_F203_A0.5990.68
58_M61_R0.5990.68
316_M355_T0.5990.68
334_D350_A0.5980.67
22_K218_R0.5970.67
168_V197_W0.5970.67
140_K145_M0.5950.67
269_D353_Y0.5930.67
171_L201_S0.5930.67
134_D140_K0.5910.66
229_K237_K0.5910.66
51_L54_I0.5900.66
278_Y304_L0.5890.66
270_V273_T0.5890.66
179_L182_L0.5880.66
123_A318_V0.5870.66
52_I65_F0.5870.66
139_F142_I0.5870.66
133_L137_K0.5870.66
282_L337_V0.5860.66
130_L133_L0.5860.66
288_K293_Y0.5860.66
277_H325_R0.5850.66
261_M271_I0.5830.65
14_K293_Y0.5820.65
19_T176_I0.5820.65
47_I192_S0.5810.65
252_R282_L0.5790.65
224_N349_L0.5790.65
261_M296_A0.5790.65
78_L82_N0.5770.65
307_R317_M0.5760.65
168_V337_V0.5760.65
60_D64_S0.5750.64
164_A201_S0.5740.64
159_V162_G0.5740.64
79_S82_N0.5730.64
14_K29_K0.5730.64
276_T300_D0.5720.64
286_E353_Y0.5720.64
294_I337_V0.5710.64
271_I279_A0.5700.64
290_D293_Y0.5700.64
19_T127_Q0.5670.63
101_I344_V0.5640.63
17_K232_I0.5630.63
253_Q260_R0.5630.63
133_L139_F0.5620.63
89_S92_K0.5580.62
69_F72_E0.5580.62
262_M333_I0.5560.62
255_E258_M0.5550.62
200_L204_G0.5540.62
13_E40_T0.5510.61
262_M305_K0.5510.61
95_G193_K0.5490.61
319_E347_E0.5490.61
234_D239_S0.5480.61
43_S110_V0.5470.61
58_M91_L0.5460.60
80_E135_P0.5460.60
245_I249_I0.5460.60
39_N102_L0.5450.60
244_I254_R0.5450.60
119_F123_A0.5430.60
22_K231_D0.5430.60
299_V321_R0.5410.60
49_L53_A0.5400.60
95_G99_A0.5400.60
166_F169_L0.5400.60
219_F224_N0.5390.59
65_F93_D0.5390.59
203_A207_L0.5380.59
285_D289_M0.5360.59
341_F350_A0.5340.59
64_S67_E0.5330.59
85_T110_V0.5320.58
60_D63_L0.5320.58
162_G286_E0.5320.58
249_I257_A0.5310.58
190_F194_L0.5300.58
91_L95_G0.5290.58
109_G202_G0.5280.58
138_G260_R0.5280.58
21_K28_K0.5280.58
54_I57_Y0.5270.58
50_S108_A0.5260.58
343_K347_E0.5260.58
270_V282_L0.5240.57
46_V54_I0.5220.57
18_A22_K0.5210.57
210_A352_V0.5210.57
254_R319_E0.5200.57
302_L305_K0.5190.57
236_Y239_S0.5180.56
17_K238_K0.5160.56
19_T222_E0.5160.56
41_A258_M0.5150.56
295_V304_L0.5150.56
107_V111_V0.5140.56
46_V228_S0.5140.56
331_V342_F0.5140.56
114_Y272_I0.5140.56
116_Q218_R0.5130.56
304_L308_K0.5130.56
167_A170_W0.5120.56
117_V225_I0.5120.56
244_I251_Q0.5110.55
20_P232_I0.5100.55
126_I132_K0.5090.55
300_D325_R0.5090.55
307_R325_R0.5090.55
329_D341_F0.5080.55
307_R321_R0.5080.55
129_K174_G0.5080.55
215_L218_R0.5080.55
85_T103_L0.5080.55
49_L310_A0.5070.55
175_E179_L0.5060.55
298_G303_A0.5060.55
131_E140_K0.5060.55
191_V340_E0.5050.55
198_M205_A0.5050.55
212_L276_T0.5040.54
289_M353_Y0.5040.54
44_L206_L0.5040.54
76_M82_N0.5040.54
282_L349_L0.5030.54
223_K228_S0.5030.54
141_R248_K0.5020.54
177_L293_Y0.5020.54
83_V87_F0.5010.54
35_S38_V0.5010.54
27_R218_R0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jljA 2 0.3194 100 0.543 Contact Map
3bzsA 1 0.2611 100 0.549 Contact Map
2jliA 1 0.2778 100 0.589 Contact Map
3t7yA 2 0.2611 100 0.696 Contact Map
3b1sB 1 0.2361 100 0.739 Contact Map
3c01E 2 0.2389 100 0.744 Contact Map
2vt1B 1 0.225 100 0.744 Contact Map
3b0zB 1 0.2333 100 0.744 Contact Map
3bzyB 3 0.2306 100 0.745 Contact Map
2ml9A 1 0.1611 99.9 0.811 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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