FLHB - BACSU - GREMLIN Contacts

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FLHB - Flagellar biosynthetic protein FlhB

UniProt:	P35538	Sequences: MKLRVDLQFFAGEKTEKATPKKRKDTRKKGQVAKSSDVNTAVSLLVIFLSLIAIGPYMRDRLLSFIETFYTESLTMKLSESNVHTLFVSLLKDMGMILAPILLVALVAGVVSNYMQVGFLFSAEVIQPKLEKLDPIKGFKRIYSMRAIVELIKSILKIVVVGFAAFAVLWLHYGEILRLPLLTPEEALSFVSKLTLWMGLSGAGALLILAGLDYLYQRFDYEKNIKMSKQDIKDEYKKSEGDPIIKSKIKQRQREMAMRRMMQEVPKADVIITNPTHYAIALKYDEEKMDAPYIVAKGVDHLALKIRKIAKEHDVMMVENRPLARALYDQVEIDQAVPEEFFKVLAEILAYVYKTKQKVY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	360 (347)
Sequences:	2432 (1879)
Seq/√Len:	100.8

ECOLI - FLHB
BACSU - FLHB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
29_K	124_E	6.406	1.00
21_K	25_D	5.266	1.00
230_Q	234_D	4.478	1.00
25_D	28_K	4.471	1.00
271_I	310_A	4.261	1.00
134_D	137_K	4.064	1.00
223_K	226_K	4.048	1.00
20_P	24_K	3.741	1.00
221_Y	225_I	3.695	1.00
18_A	222_E	3.407	1.00
23_R	222_E	3.268	1.00
264_E	267_K	3.153	1.00
19_T	232_I	3.000	1.00
305_K	308_K	2.981	1.00
264_E	334_D	2.945	1.00
25_D	29_K	2.907	1.00
26_T	225_I	2.861	1.00
122_S	125_V	2.824	1.00
46_V	108_A	2.689	1.00
248_K	251_Q	2.643	1.00
285_D	288_K	2.558	1.00
249_I	253_Q	2.546	1.00
228_S	231_D	2.500	1.00
220_D	224_N	2.478	1.00
24_K	28_K	2.427	1.00
323_L	348_I	2.363	1.00
271_I	306_I	2.357	1.00
304_L	307_R	2.328	1.00
16_E	229_K	2.327	1.00
31_Q	221_Y	2.285	1.00
23_R	225_I	2.157	1.00
150_E	153_K	2.154	1.00
228_S	232_I	2.139	1.00
124_E	127_Q	2.108	1.00
278_Y	299_V	2.085	1.00
146_R	220_D	2.056	1.00
149_V	216_Y	2.041	1.00
166_F	170_W	2.004	1.00
28_K	124_E	1.966	1.00
137_K	140_K	1.959	1.00
267_K	283_K	1.902	1.00
265_V	315_V	1.898	1.00
248_K	252_R	1.850	1.00
50_S	104_V	1.843	1.00
216_Y	220_D	1.830	1.00
309_I	313_H	1.824	1.00
172_H	175_E	1.819	1.00
307_R	311_K	1.816	1.00
31_Q	224_N	1.800	1.00
145_M	223_K	1.775	1.00
131_E	137_K	1.757	1.00
42_V	112_S	1.727	1.00
219_F	223_K	1.723	1.00
252_R	256_M	1.721	1.00
295_V	315_V	1.655	1.00
164_A	205_A	1.654	1.00
267_K	295_V	1.647	1.00
290_D	336_A	1.642	1.00
289_M	293_Y	1.633	1.00
168_V	201_S	1.628	1.00
278_Y	321_R	1.583	1.00
278_Y	300_D	1.581	1.00
144_S	147_A	1.575	1.00
294_I	331_V	1.544	1.00
34_K	113_N	1.530	1.00
351_Y	355_T	1.530	1.00
163_F	167_A	1.523	1.00
236_Y	240_E	1.506	1.00
21_K	239_S	1.505	1.00
17_K	222_E	1.503	1.00
47_I	105_A	1.489	1.00
41_A	210_A	1.480	1.00
129_K	132_K	1.470	1.00
214_Y	218_R	1.464	1.00
38_V	210_A	1.458	1.00
48_F	199_G	1.443	1.00
279_A	304_L	1.443	1.00
170_W	173_Y	1.417	1.00
251_Q	255_E	1.407	1.00
106_L	109_G	1.382	0.99
280_I	294_I	1.377	0.99
307_R	319_E	1.375	0.99
279_A	307_R	1.374	0.99
61_R	96_M	1.354	0.99
293_Y	336_A	1.345	0.99
325_R	329_D	1.336	0.99
110_V	114_Y	1.329	0.99
304_L	319_E	1.328	0.99
320_N	347_E	1.320	0.99
142_I	151_L	1.300	0.99
172_H	197_W	1.296	0.99
26_T	31_Q	1.291	0.99
61_R	93_D	1.291	0.99
127_Q	131_E	1.289	0.99
38_V	214_Y	1.287	0.99
38_V	112_S	1.287	0.99
309_I	312_E	1.285	0.99
283_K	289_M	1.278	0.99
182_L	190_F	1.276	0.99
257_A	260_R	1.266	0.99
182_L	186_E	1.265	0.99
331_V	335_Q	1.261	0.99
264_E	295_V	1.252	0.99
197_W	201_S	1.235	0.99
254_R	258_M	1.228	0.99
311_K	317_M	1.228	0.99
138_G	141_R	1.223	0.99
34_K	117_V	1.215	0.99
146_R	150_E	1.213	0.99
222_E	226_K	1.205	0.99
318_V	351_Y	1.202	0.99
222_E	225_I	1.200	0.99
234_D	238_K	1.198	0.99
266_P	309_I	1.190	0.98
272_I	324_A	1.187	0.98
23_R	221_Y	1.175	0.98
45_L	203_A	1.167	0.98
298_G	306_I	1.166	0.98
273_T	319_E	1.166	0.98
17_K	20_P	1.161	0.98
27_R	120_L	1.158	0.98
229_K	233_K	1.152	0.98
304_L	317_M	1.152	0.98
23_R	26_T	1.151	0.98
280_I	327_L	1.146	0.98
33_A	221_Y	1.144	0.98
280_I	329_D	1.135	0.98
92_K	96_M	1.131	0.98
264_E	333_I	1.110	0.98
140_K	223_K	1.110	0.98
250_K	254_R	1.109	0.98
281_A	296_A	1.103	0.98
272_I	316_M	1.098	0.97
341_F	348_I	1.081	0.97
93_D	96_M	1.076	0.97
142_I	147_A	1.076	0.97
255_E	259_R	1.073	0.97
146_R	224_N	1.068	0.97
218_R	222_E	1.063	0.97
245_I	248_K	1.062	0.97
44_L	203_A	1.060	0.97
277_H	300_D	1.059	0.97
155_I	159_V	1.049	0.97
297_K	331_V	1.042	0.96
98_L	102_L	1.037	0.96
216_Y	219_F	1.035	0.96
352_V	355_T	1.032	0.96
33_A	218_R	1.032	0.96
54_I	104_V	1.027	0.96
273_T	317_M	1.024	0.96
244_I	247_S	1.022	0.96
50_S	54_I	1.019	0.96
136_I	140_K	1.012	0.96
221_Y	224_N	1.011	0.96
36_S	150_E	1.010	0.96
148_I	152_I	1.009	0.96
25_D	124_E	1.006	0.96
274_N	277_H	1.003	0.96
16_E	232_I	1.001	0.96
323_L	345_L	1.000	0.96
15_T	229_K	0.995	0.95
212_L	215_L	0.994	0.95
163_F	166_F	0.991	0.95
145_M	148_I	0.991	0.95
269_D	285_D	0.991	0.95
299_V	328_Y	0.989	0.95
265_V	306_I	0.988	0.95
184_P	187_A	0.985	0.95
289_M	336_A	0.984	0.95
294_I	327_L	0.983	0.95
21_K	24_K	0.974	0.95
42_V	108_A	0.972	0.95
308_K	311_K	0.971	0.95
12_G	230_Q	0.969	0.95
22_K	238_K	0.968	0.95
283_K	288_K	0.964	0.95
336_A	342_F	0.963	0.95
63_L	67_E	0.961	0.94
57_Y	61_R	0.957	0.94
123_A	126_I	0.955	0.94
69_F	90_L	0.951	0.94
21_K	238_K	0.948	0.94
229_K	232_I	0.942	0.94
10_F	13_E	0.937	0.94
159_V	163_F	0.933	0.94
17_K	226_K	0.929	0.93
295_V	333_I	0.929	0.93
251_Q	258_M	0.926	0.93
18_A	37_D	0.924	0.93
278_Y	329_D	0.923	0.93
268_A	295_V	0.914	0.93
133_L	136_I	0.912	0.93
22_K	25_D	0.904	0.92
253_Q	257_A	0.903	0.92
14_K	18_A	0.901	0.92
47_I	199_G	0.901	0.92
326_A	341_F	0.897	0.92
260_R	263_Q	0.890	0.92
116_Q	320_N	0.888	0.92
19_T	23_R	0.887	0.92
41_A	203_A	0.887	0.92
330_Q	340_E	0.886	0.92
43_S	47_I	0.879	0.91
99_A	103_L	0.877	0.91
253_Q	256_M	0.875	0.91
273_T	311_K	0.873	0.91
273_T	307_R	0.872	0.91
242_D	245_I	0.871	0.91
305_K	309_I	0.868	0.91
33_A	132_K	0.861	0.91
114_Y	119_F	0.858	0.90
156_L	209_L	0.856	0.90
18_A	23_R	0.848	0.90
291_A	336_A	0.844	0.90
341_F	349_L	0.841	0.89
42_V	115_M	0.839	0.89
27_R	118_G	0.836	0.89
102_L	106_L	0.836	0.89
117_V	120_L	0.834	0.89
204_G	208_I	0.829	0.89
57_Y	96_M	0.827	0.89
339_E	342_F	0.825	0.89
145_M	226_K	0.825	0.89
265_V	313_H	0.824	0.89
193_K	197_W	0.815	0.88
122_S	126_I	0.814	0.88
105_A	263_Q	0.814	0.88
59_R	192_S	0.813	0.88
94_M	98_L	0.812	0.88
97_I	100_P	0.811	0.88
109_G	113_N	0.810	0.88
136_I	139_F	0.807	0.87
332_E	335_Q	0.806	0.87
37_D	68_T	0.801	0.87
249_I	259_R	0.800	0.87
36_S	238_K	0.798	0.87
36_S	113_N	0.798	0.87
56_P	60_D	0.797	0.87
295_V	306_I	0.797	0.87
261_M	305_K	0.796	0.87
251_Q	254_R	0.792	0.86
150_E	157_K	0.788	0.86
266_P	313_H	0.787	0.86
101_I	105_A	0.787	0.86
264_E	283_K	0.786	0.86
88_V	92_K	0.783	0.86
14_K	228_S	0.782	0.86
45_L	49_L	0.782	0.86
27_R	221_Y	0.781	0.86
244_I	249_I	0.780	0.86
32_V	117_V	0.778	0.85
22_K	230_Q	0.774	0.85
170_W	174_G	0.773	0.85
145_M	220_D	0.771	0.85
138_G	142_I	0.770	0.85
145_M	219_F	0.770	0.85
131_E	134_D	0.767	0.85
33_A	214_Y	0.766	0.85
108_A	112_S	0.766	0.85
269_D	283_K	0.764	0.84
239_S	242_D	0.764	0.84
104_V	142_I	0.762	0.84
31_Q	225_I	0.761	0.84
84_H	88_V	0.759	0.84
266_P	306_I	0.759	0.84
302_L	333_I	0.753	0.84
19_T	22_K	0.747	0.83
337_V	345_L	0.746	0.83
89_S	93_D	0.742	0.83
128_P	131_E	0.742	0.83
304_L	311_K	0.741	0.83
41_A	207_L	0.734	0.82
175_E	190_F	0.734	0.82
296_A	306_I	0.732	0.82
301_H	304_L	0.732	0.82
113_N	117_V	0.731	0.82
151_L	154_S	0.730	0.82
249_I	255_E	0.728	0.81
62_L	94_M	0.727	0.81
220_D	223_K	0.724	0.81
238_K	242_D	0.722	0.81
126_I	133_L	0.718	0.81
344_V	348_I	0.716	0.80
78_L	83_V	0.713	0.80
265_V	333_I	0.712	0.80
137_K	141_R	0.709	0.80
151_L	155_I	0.709	0.80
111_V	115_M	0.708	0.80
103_L	107_V	0.708	0.80
231_D	234_D	0.708	0.80
29_K	121_F	0.708	0.80
183_T	186_E	0.707	0.80
338_P	341_F	0.705	0.79
127_Q	143_Y	0.704	0.79
269_D	349_L	0.702	0.79
321_R	325_R	0.700	0.79
77_K	83_V	0.699	0.79
275_P	325_R	0.697	0.79
253_Q	353_Y	0.695	0.78
106_L	110_V	0.695	0.78
39_N	117_V	0.694	0.78
270_V	348_I	0.693	0.78
261_M	333_I	0.690	0.78
322_P	326_A	0.688	0.78
32_V	221_Y	0.686	0.78
46_V	104_V	0.685	0.77
127_Q	140_K	0.685	0.77
274_N	325_R	0.684	0.77
41_A	206_L	0.683	0.77
276_T	325_R	0.683	0.77
350_A	353_Y	0.678	0.77
50_S	101_I	0.674	0.76
149_V	152_I	0.674	0.76
12_G	15_T	0.671	0.76
106_L	207_L	0.671	0.76
52_I	196_L	0.669	0.76
326_A	330_Q	0.669	0.76
263_Q	302_L	0.668	0.76
308_K	312_E	0.667	0.76
261_M	306_I	0.665	0.75
68_T	89_S	0.664	0.75
137_K	224_N	0.662	0.75
297_K	332_E	0.662	0.75
268_A	281_A	0.661	0.75
262_M	266_P	0.661	0.75
12_G	17_K	0.660	0.75
300_D	304_L	0.660	0.75
291_A	342_F	0.657	0.74
49_L	311_K	0.656	0.74
167_A	171_L	0.654	0.74
281_A	298_G	0.653	0.74
283_K	293_Y	0.652	0.74
117_V	214_Y	0.652	0.74
223_K	236_Y	0.651	0.74
116_Q	214_Y	0.649	0.74
269_D	291_A	0.646	0.73
294_I	349_L	0.643	0.73
189_S	193_K	0.642	0.73
61_R	64_S	0.642	0.73
130_L	134_D	0.641	0.73
64_S	93_D	0.641	0.73
32_V	108_A	0.641	0.73
160_V	205_A	0.640	0.73
165_A	202_G	0.637	0.72
39_N	43_S	0.637	0.72
156_L	160_V	0.637	0.72
186_E	190_F	0.636	0.72
265_V	309_I	0.636	0.72
166_F	171_L	0.636	0.72
19_T	236_Y	0.636	0.72
320_N	348_I	0.634	0.72
252_R	255_E	0.633	0.72
156_L	214_Y	0.632	0.72
318_V	348_I	0.629	0.71
129_K	329_D	0.628	0.71
150_E	257_A	0.627	0.71
300_D	351_Y	0.625	0.71
247_S	257_A	0.625	0.71
271_I	281_A	0.623	0.70
236_Y	242_D	0.623	0.70
154_S	158_I	0.623	0.70
69_F	73_S	0.621	0.70
205_A	209_L	0.621	0.70
124_E	129_K	0.620	0.70
179_L	289_M	0.620	0.70
37_D	210_A	0.617	0.70
302_L	328_Y	0.617	0.70
164_A	202_G	0.617	0.70
150_E	217_Q	0.617	0.70
144_S	148_I	0.614	0.69
36_S	259_R	0.612	0.69
346_A	350_A	0.611	0.69
147_A	151_L	0.611	0.69
254_R	257_A	0.609	0.69
18_A	158_I	0.609	0.69
47_I	51_L	0.608	0.69
57_Y	60_D	0.607	0.69
211_G	215_L	0.606	0.68
280_I	321_R	0.605	0.68
251_Q	299_V	0.604	0.68
14_K	237_K	0.604	0.68
172_H	194_L	0.603	0.68
279_A	311_K	0.602	0.68
43_S	105_A	0.602	0.68
327_L	331_V	0.600	0.68
18_A	226_K	0.600	0.68
48_F	203_A	0.599	0.68
58_M	61_R	0.599	0.68
316_M	355_T	0.599	0.68
334_D	350_A	0.598	0.67
22_K	218_R	0.597	0.67
168_V	197_W	0.597	0.67
140_K	145_M	0.595	0.67
269_D	353_Y	0.593	0.67
171_L	201_S	0.593	0.67
134_D	140_K	0.591	0.66
229_K	237_K	0.591	0.66
51_L	54_I	0.590	0.66
278_Y	304_L	0.589	0.66
270_V	273_T	0.589	0.66
179_L	182_L	0.588	0.66
123_A	318_V	0.587	0.66
52_I	65_F	0.587	0.66
139_F	142_I	0.587	0.66
133_L	137_K	0.587	0.66
282_L	337_V	0.586	0.66
130_L	133_L	0.586	0.66
288_K	293_Y	0.586	0.66
277_H	325_R	0.585	0.66
261_M	271_I	0.583	0.65
14_K	293_Y	0.582	0.65
19_T	176_I	0.582	0.65
47_I	192_S	0.581	0.65
252_R	282_L	0.579	0.65
224_N	349_L	0.579	0.65
261_M	296_A	0.579	0.65
78_L	82_N	0.577	0.65
307_R	317_M	0.576	0.65
168_V	337_V	0.576	0.65
60_D	64_S	0.575	0.64
164_A	201_S	0.574	0.64
159_V	162_G	0.574	0.64
79_S	82_N	0.573	0.64
14_K	29_K	0.573	0.64
276_T	300_D	0.572	0.64
286_E	353_Y	0.572	0.64
294_I	337_V	0.571	0.64
271_I	279_A	0.570	0.64
290_D	293_Y	0.570	0.64
19_T	127_Q	0.567	0.63
101_I	344_V	0.564	0.63
17_K	232_I	0.563	0.63
253_Q	260_R	0.563	0.63
133_L	139_F	0.562	0.63
89_S	92_K	0.558	0.62
69_F	72_E	0.558	0.62
262_M	333_I	0.556	0.62
255_E	258_M	0.555	0.62
200_L	204_G	0.554	0.62
13_E	40_T	0.551	0.61
262_M	305_K	0.551	0.61
95_G	193_K	0.549	0.61
319_E	347_E	0.549	0.61
234_D	239_S	0.548	0.61
43_S	110_V	0.547	0.61
58_M	91_L	0.546	0.60
80_E	135_P	0.546	0.60
245_I	249_I	0.546	0.60
39_N	102_L	0.545	0.60
244_I	254_R	0.545	0.60
119_F	123_A	0.543	0.60
22_K	231_D	0.543	0.60
299_V	321_R	0.541	0.60
49_L	53_A	0.540	0.60
95_G	99_A	0.540	0.60
166_F	169_L	0.540	0.60
219_F	224_N	0.539	0.59
65_F	93_D	0.539	0.59
203_A	207_L	0.538	0.59
285_D	289_M	0.536	0.59
341_F	350_A	0.534	0.59
64_S	67_E	0.533	0.59
85_T	110_V	0.532	0.58
60_D	63_L	0.532	0.58
162_G	286_E	0.532	0.58
249_I	257_A	0.531	0.58
190_F	194_L	0.530	0.58
91_L	95_G	0.529	0.58
109_G	202_G	0.528	0.58
138_G	260_R	0.528	0.58
21_K	28_K	0.528	0.58
54_I	57_Y	0.527	0.58
50_S	108_A	0.526	0.58
343_K	347_E	0.526	0.58
270_V	282_L	0.524	0.57
46_V	54_I	0.522	0.57
18_A	22_K	0.521	0.57
210_A	352_V	0.521	0.57
254_R	319_E	0.520	0.57
302_L	305_K	0.519	0.57
236_Y	239_S	0.518	0.56
17_K	238_K	0.516	0.56
19_T	222_E	0.516	0.56
41_A	258_M	0.515	0.56
295_V	304_L	0.515	0.56
107_V	111_V	0.514	0.56
46_V	228_S	0.514	0.56
331_V	342_F	0.514	0.56
114_Y	272_I	0.514	0.56
116_Q	218_R	0.513	0.56
304_L	308_K	0.513	0.56
167_A	170_W	0.512	0.56
117_V	225_I	0.512	0.56
244_I	251_Q	0.511	0.55
20_P	232_I	0.510	0.55
126_I	132_K	0.509	0.55
300_D	325_R	0.509	0.55
307_R	325_R	0.509	0.55
329_D	341_F	0.508	0.55
307_R	321_R	0.508	0.55
129_K	174_G	0.508	0.55
215_L	218_R	0.508	0.55
85_T	103_L	0.508	0.55
49_L	310_A	0.507	0.55
175_E	179_L	0.506	0.55
298_G	303_A	0.506	0.55
131_E	140_K	0.506	0.55
191_V	340_E	0.505	0.55
198_M	205_A	0.505	0.55
212_L	276_T	0.504	0.54
289_M	353_Y	0.504	0.54
44_L	206_L	0.504	0.54
76_M	82_N	0.504	0.54
282_L	349_L	0.503	0.54
223_K	228_S	0.503	0.54
141_R	248_K	0.502	0.54
177_L	293_Y	0.502	0.54
83_V	87_F	0.501	0.54
35_S	38_V	0.501	0.54
27_R	218_R	0.500	0.54

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2jljA	2	0.3194	100	0.543	Contact Map
3bzsA	1	0.2611	100	0.549	Contact Map
2jliA	1	0.2778	100	0.589	Contact Map
3t7yA	2	0.2611	100	0.696	Contact Map
3b1sB	1	0.2361	100	0.739	Contact Map
3c01E	2	0.2389	100	0.744	Contact Map
2vt1B	1	0.225	100	0.744	Contact Map
3b0zB	1	0.2333	100	0.744	Contact Map
3bzyB	3	0.2306	100	0.745	Contact Map
2ml9A	1	0.1611	99.9	0.811	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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