GREMLIN Database
FLIR - Flagellar biosynthetic protein FliR
UniProt: P35537 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 259 (240)
Sequences: 2421 (1881)
Seq/√Len: 121.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
196_D219_K5.4431.00
16_I69_A5.4241.00
147_Y150_Q5.3911.00
20_A73_A5.1871.00
90_V128_A4.2691.00
35_A38_R3.5041.00
101_M223_S3.3311.00
136_N139_H3.1781.00
92_I181_A3.1591.00
110_D113_T3.1331.00
49_C146_Y3.0651.00
132_M137_A2.8671.00
120_I227_L2.8231.00
143_D147_Y2.7921.00
124_I227_L2.4771.00
195_V222_V2.3381.00
19_S42_A2.3051.00
11_F50_F2.2491.00
16_I73_A2.1751.00
22_F45_L2.1581.00
72_E149_F2.1551.00
98_D219_K2.1101.00
13_L68_L2.0681.00
171_A174_F2.0381.00
18_I45_L1.8571.00
98_D120_I1.8571.00
203_A211_V1.8571.00
87_I132_M1.8521.00
168_Y172_K1.8381.00
24_T77_L1.8261.00
244_L247_E1.8251.00
20_A23_V1.8071.00
19_S23_V1.7621.00
136_N143_D1.7481.00
20_A80_G1.7031.00
16_I20_A1.6631.00
188_V226_M1.6601.00
172_K176_A1.6541.00
72_E155_D1.6201.00
98_D103_F1.5971.00
26_P187_P1.5891.00
221_A225_I1.5791.00
243_S247_E1.5781.00
98_D196_D1.5741.00
106_A212_F1.5681.00
81_L85_M1.5591.00
175_N179_I1.5231.00
209_L214_V1.4961.00
68_L71_K1.4631.00
103_F220_I1.4491.00
101_M130_L1.4481.00
217_P220_I1.4261.00
191_S195_V1.4101.00
15_F42_A1.4051.00
71_K155_D1.3881.00
131_F235_F1.3661.00
70_F74_L1.3441.00
132_M141_L1.3431.00
21_F79_L1.3081.00
141_L249_M1.2991.00
14_V18_I1.2941.00
186_A215_G1.2911.00
210_N213_V1.2871.00
195_V199_L1.2841.00
199_L215_G1.2801.00
84_Y88_A1.2661.00
18_I49_C1.2651.00
120_I204_R1.2560.99
23_V77_L1.2400.99
87_I128_A1.2140.99
97_I120_I1.2090.99
126_T130_L1.1890.99
24_T80_G1.1850.99
92_I177_M1.1750.99
79_L249_M1.1720.99
240_N244_L1.1620.99
34_P37_H1.1590.99
129_L133_L1.1570.99
196_D201_I1.1540.99
95_S132_M1.1530.99
101_M192_L1.1360.99
43_F47_V1.1320.99
125_Y129_L1.1140.99
186_A190_A1.1130.99
210_N216_L1.1110.99
99_F128_A1.1090.99
202_V213_V1.1040.99
105_I109_I1.0990.99
15_F46_A1.0880.99
203_A210_N1.0860.99
185_S189_V1.0840.99
83_A144_G1.0840.99
44_F47_V1.0740.98
191_S226_M1.0670.98
18_I42_A1.0630.98
120_I124_I1.0590.98
15_F43_F1.0540.98
72_E156_Q1.0500.98
14_V149_F1.0410.98
56_P154_V1.0320.98
146_Y150_Q1.0240.98
169_F173_S1.0170.98
83_A98_D1.0100.98
19_S39_I1.0080.98
72_E75_V1.0030.98
22_F38_R0.9970.97
131_F191_S0.9940.97
45_L142_L0.9890.97
136_N228_I0.9880.97
96_F142_L0.9810.97
22_F42_A0.9800.97
244_L248_T0.9790.97
79_L148_S0.9780.97
94_G124_I0.9770.97
105_I219_K0.9680.97
164_E167_A0.9640.97
113_T194_L0.9630.97
44_F48_I0.9560.97
37_H232_S0.9540.97
14_V46_A0.9470.96
20_A24_T0.9420.96
182_F185_S0.9410.96
96_F100_Q0.9340.96
51_S54_D0.9330.96
18_I149_F0.9320.96
86_M245_T0.9270.96
95_S122_Q0.9260.96
20_A25_I0.9240.96
206_V213_V0.9110.96
164_E168_Y0.9090.96
101_M220_I0.9070.95
98_D101_M0.9020.95
11_F46_A0.8980.95
88_A91_Q0.8910.95
127_M235_F0.8900.95
27_L133_L0.8870.95
116_Q233_V0.8860.95
109_I114_G0.8790.95
53_I149_F0.8780.95
7_L10_A0.8770.95
108_V111_P0.8770.95
109_I118_P0.8760.95
206_V209_L0.8720.94
91_Q125_Y0.8700.94
134_S224_F0.8690.94
41_F45_L0.8670.94
41_F44_F0.8640.94
196_D211_V0.8630.94
11_F43_F0.8600.94
24_T69_A0.8600.94
104_S118_P0.8560.94
22_F41_F0.8550.94
30_H104_S0.8480.94
155_D158_F0.8460.93
116_Q119_L0.8420.93
165_K168_Y0.8360.93
218_L247_E0.8350.93
218_L229_V0.8350.93
37_H42_A0.8320.93
72_E242_F0.8310.93
98_D174_F0.8300.93
152_I208_Q0.8290.93
32_N37_H0.8270.93
213_V216_L0.8260.93
11_F15_F0.8240.93
110_D116_Q0.8210.92
135_V239_R0.8210.92
191_S205_T0.8180.92
13_L154_V0.8180.92
175_N178_F0.8160.92
48_I52_T0.8130.92
202_V210_N0.8130.92
101_M104_S0.8130.92
131_F135_V0.8030.92
16_I202_V0.8000.91
118_P121_G0.7990.91
117_S204_R0.7960.91
218_L242_F0.7880.91
30_H206_V0.7860.91
27_L231_M0.7840.91
95_S104_S0.7820.91
213_V217_P0.7810.90
169_F172_K0.7800.90
33_V61_I0.7790.90
20_A42_A0.7770.90
58_S67_L0.7750.90
29_G32_N0.7730.90
195_V203_A0.7670.90
56_P59_L0.7670.90
85_M174_F0.7660.90
230_C234_I0.7560.89
228_I232_S0.7550.89
198_A201_I0.7540.89
25_I184_M0.7530.89
139_H142_L0.7510.89
176_A179_I0.7490.89
105_I214_V0.7440.88
95_S118_P0.7430.88
71_K154_V0.7410.88
20_A30_H0.7390.88
226_M230_C0.7390.88
184_M232_S0.7370.88
124_I199_L0.7350.88
100_Q202_V0.7330.87
211_V221_A0.7310.87
43_F77_L0.7250.87
43_F50_F0.7230.87
60_E63_E0.7220.87
172_K175_N0.7200.87
58_S61_I0.7130.86
123_F202_V0.7090.86
59_L68_L0.7080.86
36_V39_I0.7070.86
28_F132_M0.7020.85
30_H210_N0.6990.85
13_L72_E0.6980.85
15_F204_R0.6980.85
9_P65_Y0.6950.85
110_D213_V0.6920.84
13_L149_F0.6890.84
100_Q208_Q0.6860.84
105_I215_G0.6850.84
30_H238_V0.6770.83
180_I241_V0.6760.83
111_P214_V0.6760.83
104_S132_M0.6740.83
56_P60_E0.6720.83
210_N215_G0.6720.83
93_A97_I0.6710.82
21_F24_T0.6700.82
53_I57_P0.6680.82
93_A185_S0.6610.81
211_V214_V0.6580.81
47_V63_E0.6530.81
65_Y69_A0.6490.80
94_G226_M0.6490.80
23_V79_L0.6450.80
199_L208_Q0.6440.80
8_F78_C0.6440.80
25_I83_A0.6410.79
240_N243_S0.6410.79
47_V78_C0.6400.79
205_T210_N0.6390.79
170_I175_N0.6390.79
18_I145_I0.6360.79
45_L53_I0.6330.79
183_Q237_V0.6320.79
86_M144_G0.6300.78
174_F177_M0.6280.78
13_L65_Y0.6260.78
14_V206_V0.6230.78
44_F66_M0.6220.77
193_F223_S0.6150.77
83_A246_I0.6120.76
200_G203_A0.6120.76
220_I223_S0.6100.76
19_S138_H0.6100.76
92_I95_S0.6080.76
43_F79_L0.6070.76
190_A203_A0.6050.75
137_A204_R0.6030.75
32_N145_I0.6010.75
40_G60_E0.6010.75
112_Q123_F0.6010.75
176_A180_I0.5970.75
179_I183_Q0.5960.74
99_F122_Q0.5950.74
71_K159_P0.5920.74
110_D210_N0.5920.74
87_I125_Y0.5920.74
71_K157_A0.5910.74
43_F46_A0.5860.73
61_I66_M0.5850.73
82_I156_Q0.5840.73
120_I245_T0.5830.73
118_P181_A0.5830.73
37_H46_A0.5830.73
187_P217_P0.5810.73
74_L179_I0.5800.72
55_K58_S0.5800.72
109_I181_A0.5780.72
202_V206_V0.5740.72
156_Q159_P0.5730.71
10_A57_P0.5710.71
176_A244_L0.5710.71
45_L48_I0.5700.71
170_I174_F0.5690.71
14_V50_F0.5680.71
24_T84_Y0.5680.71
70_F222_V0.5670.71
125_Y128_A0.5650.70
51_S90_V0.5650.70
130_L134_S0.5640.70
121_G135_V0.5620.70
41_F78_C0.5610.70
101_M122_Q0.5600.70
103_F196_D0.5600.70
181_A185_S0.5590.70
96_F182_F0.5570.69
149_F216_L0.5550.69
14_V86_M0.5550.69
137_A246_I0.5540.69
116_Q176_A0.5540.69
233_V236_V0.5510.69
110_D118_P0.5510.69
55_K64_H0.5510.69
82_I242_F0.5490.68
132_M135_V0.5490.68
82_I181_A0.5490.68
142_L146_Y0.5470.68
38_R50_F0.5460.68
214_V237_V0.5460.68
14_V49_C0.5440.68
31_R43_F0.5420.67
152_I156_Q0.5410.67
122_Q199_L0.5410.67
8_F244_L0.5400.67
75_V235_F0.5360.66
208_Q219_K0.5350.66
242_F246_I0.5330.66
46_A228_I0.5330.66
97_I102_G0.5320.66
38_R122_Q0.5310.66
25_I28_F0.5300.66
142_L189_V0.5290.65
104_S109_I0.5280.65
78_C166_F0.5260.65
192_L220_I0.5250.65
21_F25_I0.5240.65
59_L73_A0.5230.65
48_I51_S0.5220.64
58_S172_K0.5220.64
83_A180_I0.5210.64
106_A138_H0.5210.64
190_A214_V0.5170.64
182_F189_V0.5150.63
25_I188_V0.5150.63
68_L194_L0.5150.63
34_P120_I0.5140.63
186_A203_A0.5130.63
13_L69_A0.5130.63
49_C145_I0.5120.63
38_R201_I0.5120.63
52_T243_S0.5100.63
123_F154_V0.5100.63
8_F24_T0.5100.63
147_Y238_V0.5100.63
40_G48_I0.5080.62
15_F39_I0.5070.62
45_L146_Y0.5060.62
140_L143_D0.5040.62
82_I173_S0.5030.62
194_L212_F0.5030.62
170_I231_M0.5020.61
105_I223_S0.5020.61
199_L203_A0.5020.61
203_A209_L0.5010.61
177_M198_A0.5010.61
83_A184_M0.5000.61
86_M177_M0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zy9A 2 0.5058 6 0.96 Contact Map
3tuiA 2 0.3629 2.3 0.968 Contact Map
2onkC 2 0.5019 1.7 0.97 Contact Map
1we0A 3 0.2317 1.2 0.972 Contact Map
2m0sA 1 0.1081 1.2 0.973 Contact Map
4u9nA 2 0.3436 1.1 0.974 Contact Map
4ma9A 5 0.2317 1.1 0.974 Contact Map
2mi2A 1 0.1892 0.9 0.975 Contact Map
1zugA 1 0.112 0.9 0.975 Contact Map
1xccA 2 0.2317 0.9 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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