GREMLIN Database
FLIZ - Flagellar biosynthetic protein FliZ
UniProt: P35536 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 219 (199)
Sequences: 165 (146)
Seq/√Len: 10.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_W44_K3.2590.96
146_K153_E2.9530.93
122_R141_T2.8370.91
110_V116_T2.5690.86
101_N120_Q2.5380.86
81_F191_S2.5350.86
124_I145_L2.4950.85
122_R134_L2.3500.81
196_L199_Q2.1690.75
82_A89_L2.1590.75
71_V75_D2.1590.75
87_I142_I2.1400.74
124_I201_E2.1040.73
113_I154_I2.0950.72
95_K136_V2.0710.71
132_S147_E2.0390.70
125_Q138_V2.0240.70
83_L161_H1.9950.68
119_G125_Q1.9400.66
118_V127_I1.9260.66
115_G139_G1.8880.64
142_I200_L1.8710.63
115_G125_Q1.8710.63
83_L116_T1.8700.63
136_V212_K1.8490.62
115_G123_S1.8260.61
33_T118_V1.8140.61
18_S136_V1.7790.59
102_R141_T1.6430.53
132_S135_V1.6230.52
90_I94_V1.6140.52
16_L27_A1.5940.51
82_A111_E1.5900.50
135_V142_I1.5850.50
90_I135_V1.5750.50
162_E171_W1.5650.49
134_L196_L1.5620.49
29_S36_E1.5580.49
59_T174_F1.5560.49
91_Y147_E1.5420.48
39_Q127_I1.5320.48
34_V119_G1.5280.48
118_V199_Q1.5100.47
75_D79_M1.5060.46
100_R179_K1.4840.45
42_D124_I1.4720.45
116_T128_K1.4600.44
17_F28_D1.4530.44
31_N93_L1.3910.41
29_S83_L1.3880.41
114_G125_Q1.3670.40
15_V197_K1.3620.40
80_I121_N1.3500.39
18_S33_T1.3350.39
124_I211_K1.3250.38
135_V174_F1.3180.38
130_G139_G1.3170.38
122_R178_L1.3100.38
35_N78_K1.3080.38
86_V157_I1.3070.37
114_G139_G1.2950.37
34_V128_K1.2900.37
101_N112_N1.2890.37
208_S212_K1.2710.36
81_F88_V1.2640.36
134_L155_E1.2460.35
127_I136_V1.2320.34
78_K131_K1.2090.33
83_L168_K1.2000.33
76_F211_K1.1970.33
95_K125_Q1.1920.33
203_L206_N1.1670.32
139_G158_L1.1620.31
78_K195_A1.1580.31
91_Y150_D1.1570.31
135_V196_L1.1510.31
82_A85_F1.1500.31
114_G196_L1.1480.31
115_G130_G1.1480.31
117_S120_Q1.1330.30
110_V132_S1.1310.30
89_L123_S1.1240.30
86_V89_L1.1110.29
203_L207_R1.1100.29
17_F20_H1.1080.29
123_S138_V1.1070.29
81_F201_E1.1030.29
99_K104_L1.0930.29
97_M134_L1.0910.29
172_Q177_P1.0890.29
100_R117_S1.0690.28
123_S130_G1.0610.27
13_F118_V1.0480.27
75_D207_R1.0300.26
87_I104_L1.0280.26
30_D141_T1.0250.26
82_A145_L1.0250.26
72_S79_M1.0230.26
76_F206_N1.0220.26
68_A87_I1.0210.26
47_D136_V1.0190.26
135_V161_H1.0090.26
101_N124_I1.0030.25
135_V145_L0.9990.25
81_F124_I0.9980.25
112_N115_G0.9960.25
119_G139_G0.9930.25
111_E203_L0.9900.25
89_L139_G0.9850.25
76_F122_R0.9840.25
74_F122_R0.9810.25
149_E180_S0.9790.25
48_Q124_I0.9750.24
15_V21_P0.9710.24
105_K142_I0.9700.24
37_W41_K0.9690.24
115_G128_K0.9670.24
110_V157_I0.9640.24
129_V134_L0.9610.24
89_L130_G0.9600.24
34_V153_E0.9520.24
77_V126_L0.9430.23
77_V140_E0.9410.23
115_G119_G0.9360.23
89_L138_V0.9260.23
105_K127_I0.9260.23
81_F179_K0.9220.23
40_K187_Q0.9220.23
125_Q196_L0.9170.22
78_K101_N0.9150.22
34_V145_L0.9140.22
90_I133_V0.9100.22
68_A73_A0.9080.22
36_E59_T0.9040.22
78_K130_G0.9030.22
132_S153_E0.8980.22
9_V19_V0.8970.22
89_L115_G0.8970.22
148_I204_K0.8960.22
88_V149_E0.8950.22
119_G148_I0.8890.22
138_V195_A0.8880.22
103_L203_L0.8860.21
115_G121_N0.8850.21
35_N39_Q0.8820.21
42_D46_A0.8790.21
114_G138_V0.8730.21
147_E207_R0.8680.21
79_M88_V0.8660.21
12_C97_M0.8640.21
110_V128_K0.8620.21
79_M96_L0.8570.21
125_Q139_G0.8420.20
124_I131_K0.8410.20
147_E150_D0.8400.20
117_S126_L0.8390.20
121_N128_K0.8350.20
97_M206_N0.8320.20
72_S75_D0.8270.20
86_V122_R0.8240.20
18_S40_K0.8230.20
32_S83_L0.8230.20
87_I145_L0.8170.19
73_A95_K0.8050.19
80_I128_K0.8050.19
140_E184_Q0.8020.19
142_I204_K0.8010.19
114_G123_S0.8000.19
85_F164_A0.7980.19
93_L124_I0.7970.19
85_F135_V0.7950.19
13_F18_S0.7940.19
105_K111_E0.7890.19
90_I173_K0.7870.19
80_I167_S0.7860.18
15_V24_A0.7800.18
128_K151_E0.7780.18
121_N161_H0.7760.18
121_N126_L0.7740.18
209_E212_K0.7710.18
114_G119_G0.7710.18
98_N192_F0.7690.18
122_R165_M0.7690.18
76_F107_F0.7610.18
36_E178_L0.7550.18
115_G196_L0.7530.18
193_S198_E0.7530.18
108_Q136_V0.7510.18
34_V115_G0.7480.17
33_T168_K0.7470.17
103_L111_E0.7420.17
83_L110_V0.7420.17
130_G192_F0.7410.17
29_S99_K0.7390.17
15_V113_I0.7380.17
11_I19_V0.7380.17
126_L159_S0.7350.17
82_A128_K0.7310.17
134_L175_V0.7250.17
82_A134_L0.7230.17
154_I157_I0.7200.17
159_S163_E0.7190.17
77_V102_R0.7120.16
17_F35_N0.7090.16
109_Y128_K0.7090.16
210_G213_K0.6980.16
140_E208_S0.6960.16
81_F198_E0.6890.16
32_S79_M0.6880.16
45_T201_E0.6860.16
11_I185_P0.6860.16
110_V161_H0.6830.16
47_D77_V0.6810.16
123_S139_G0.6810.16
89_L192_F0.6780.16
126_L209_E0.6770.16
87_I118_V0.6760.16
207_R211_K0.6710.15
112_N147_E0.6690.15
82_A112_N0.6670.15
60_A184_Q0.6640.15
17_F205_Q0.6600.15
116_T122_R0.6570.15
14_F68_A0.6470.15
158_L174_F0.6450.15
82_A115_G0.6380.15
121_N150_D0.6350.15
17_F201_E0.6340.15
88_V141_T0.6330.15
136_V209_E0.6310.15
61_D177_P0.6310.15
48_Q57_T0.6270.14
13_F39_Q0.6240.14
122_R202_E0.6230.14
192_F195_A0.6220.14
95_K119_G0.6200.14
133_V152_K0.6110.14
66_A171_W0.6100.14
9_V49_S0.6080.14
203_L214_G0.6050.14
90_I213_K0.6050.14
75_D131_K0.6040.14
14_F212_K0.6020.14
133_V213_K0.6010.14
127_I214_G0.5990.14
77_V118_V0.5980.14
134_L214_G0.5960.14
84_L182_E0.5920.14
119_G130_G0.5890.14
129_V139_G0.5830.13
83_L204_K0.5820.13
31_N47_D0.5820.13
125_Q137_G0.5810.13
90_I199_Q0.5790.13
11_I197_K0.5790.13
111_E155_E0.5780.13
61_D176_K0.5760.13
83_L91_Y0.5690.13
62_E212_K0.5670.13
15_V22_I0.5620.13
69_P87_I0.5610.13
136_V200_L0.5600.13
60_A155_E0.5590.13
40_K164_A0.5590.13
35_N110_V0.5580.13
134_L203_L0.5550.13
117_S154_I0.5550.13
134_L141_T0.5520.13
75_D128_K0.5500.13
82_A151_E0.5490.13
62_E136_V0.5490.13
36_E120_Q0.5460.13
112_N207_R0.5440.13
17_F176_K0.5370.12
88_V92_G0.5360.12
10_F61_D0.5350.12
94_V147_E0.5340.12
12_C175_V0.5330.12
81_F178_L0.5330.12
134_L194_K0.5320.12
96_L175_V0.5320.12
37_W40_K0.5310.12
29_S70_S0.5290.12
16_L20_H0.5290.12
73_A116_T0.5260.12
139_G151_E0.5260.12
140_E174_F0.5200.12
129_V157_I0.5180.12
78_K171_W0.5180.12
93_L180_S0.5170.12
13_F201_E0.5100.12
95_K130_G0.5080.12
48_Q194_K0.5050.12
87_I122_R0.5050.12
108_Q118_V0.5030.12
13_F17_F0.5030.12
72_S80_I0.5010.12
92_G203_L0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kncA 1 0.2329 37.6 0.947 Contact Map
4cgkA 3 0.7671 26.1 0.951 Contact Map
2kv5A 1 0.1507 23.1 0.952 Contact Map
2lx0A 1 0.1461 16.3 0.955 Contact Map
4b19A 1 0.137 12.9 0.957 Contact Map
3j9pD 4 0.6895 12 0.958 Contact Map
2m3eA 1 0.2146 11.9 0.958 Contact Map
1pfiA 7 0.21 11.6 0.958 Contact Map
2ks1B 1 0.2009 10.6 0.959 Contact Map
2mfrA 1 0.2603 10.2 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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