GREMLIN Database
FLIP - Flagellar biosynthetic protein FliP
UniProt: P35528 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 221 (208)
Sequences: 1866 (996)
Seq/√Len: 69.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_I112_I5.5791.00
85_E89_E5.0231.00
87_N92_T3.8321.00
100_S103_E3.5181.00
109_E145_L3.0861.00
46_V67_L2.8191.00
45_I78_I2.7001.00
86_I90_A2.6941.00
45_I49_L2.5461.00
143_I148_M2.5271.00
99_I107_K2.5211.00
63_P66_V2.5151.00
126_A130_N2.3471.00
128_F154_I2.3281.00
92_T96_D2.3181.00
55_S168_F2.3071.00
41_C78_I2.2681.00
131_Y218_L2.2661.00
121_R124_D2.2411.00
47_I157_L2.2061.00
48_V217_L2.1981.00
113_K145_L2.1801.00
80_A83_F2.1391.00
145_L149_V2.1121.00
67_L71_A2.0321.00
117_S140_L2.0151.00
28_V35_I1.9191.00
117_S145_L1.8791.00
117_S148_M1.8741.00
91_L95_M1.8621.00
53_R64_N1.8581.00
89_E107_K1.8031.00
123_K211_Y1.7531.00
87_N91_L1.7261.00
134_M144_P1.7221.00
215_K219_Q1.7121.00
107_K110_E1.7001.00
38_L153_A1.6700.99
31_V35_I1.6510.99
113_K148_M1.6420.99
69_G153_A1.6160.99
103_E106_T1.6010.99
82_T85_E1.5980.99
185_M194_M1.5790.99
103_E107_K1.5510.99
85_E114_E1.5440.99
115_F152_F1.5410.99
24_L28_V1.5330.99
90_A108_A1.4940.99
39_M112_I1.4600.99
53_R62_P1.4040.98
130_N136_K1.3750.98
114_E118_K1.3690.98
92_T95_M1.3640.98
129_M137_P1.3620.98
113_K117_S1.3400.98
44_R221_F1.3070.97
39_M43_T1.3030.97
173_I177_V1.3010.97
168_F172_L1.3000.97
109_E113_K1.2990.97
155_S159_T1.2980.97
154_I211_Y1.2950.97
132_A146_T1.2690.97
51_F58_T1.2080.95
134_M147_T1.2080.95
129_M132_A1.2010.95
46_V71_A1.2010.95
208_D211_Y1.1990.95
177_V201_I1.1930.95
38_L69_G1.1700.95
51_F201_I1.1670.94
163_I217_L1.1650.94
50_S60_S1.1570.94
88_K92_T1.1490.94
84_S88_K1.1260.93
52_V215_K1.1170.93
18_S21_K1.1150.93
105_Y108_A1.1120.93
127_L130_N1.1080.93
120_T125_L1.0940.92
20_V24_L1.0920.92
149_V153_A1.0870.92
106_T109_E1.0850.92
169_I173_I1.0750.92
110_E113_K1.0710.91
137_P144_P1.0700.91
158_K162_Q1.0630.91
22_L167_I1.0590.91
154_I214_V1.0540.91
84_S146_T1.0480.91
108_A111_P1.0270.90
80_A84_S1.0240.90
119_H221_F1.0160.89
159_T162_Q1.0130.89
45_I74_L1.0110.89
49_L52_V1.0100.89
101_L105_Y1.0080.89
127_L154_I0.9980.88
58_T62_P0.9960.88
121_R159_T0.9950.88
48_V160_A0.9910.88
46_V50_S0.9760.87
46_V68_I0.9720.87
38_L70_L0.9630.86
139_S142_D0.9620.86
16_V24_L0.9530.86
49_L213_I0.9530.86
47_I163_I0.9460.85
38_L185_M0.9460.85
43_T66_V0.9420.85
41_C45_I0.9390.85
122_Q126_A0.9370.85
55_S201_I0.9230.84
48_V163_I0.9150.84
54_T61_M0.9090.83
52_V213_I0.9030.83
16_V19_T0.9030.83
28_V31_V0.8920.82
207_V216_S0.8910.82
147_T151_A0.8800.81
45_I221_F0.8780.81
189_M197_L0.8730.81
58_T169_I0.8650.80
29_F151_A0.8650.80
31_V34_G0.8610.80
79_M115_F0.8610.80
211_Y214_V0.8610.80
117_S143_I0.8600.80
19_T22_L0.8580.79
65_Q68_I0.8520.79
88_K98_K0.8480.79
82_T162_Q0.8410.78
49_L78_I0.8400.78
60_S182_L0.8330.77
49_L67_L0.8280.77
127_L211_Y0.8250.77
54_T194_M0.8210.76
162_Q166_M0.8100.75
105_Y145_L0.8090.75
128_F147_T0.8070.75
214_V220_S0.8060.75
88_K96_D0.8050.75
72_L76_F0.8000.74
52_V57_A0.8000.74
105_Y109_E0.7960.74
26_L39_M0.7940.74
138_E142_D0.7930.74
60_S193_V0.7910.74
51_F194_M0.7910.74
73_F150_P0.7860.73
24_L101_L0.7830.73
89_E110_E0.7820.73
47_I167_I0.7760.72
72_L77_F0.7750.72
189_M196_S0.7720.72
52_V167_I0.7720.72
63_P182_L0.7720.72
94_L104_A0.7720.72
154_I218_L0.7710.72
107_K118_K0.7690.71
215_K220_S0.7650.71
74_L131_Y0.7630.71
167_I207_V0.7620.71
47_I76_F0.7610.71
160_A182_L0.7600.71
202_L214_V0.7600.71
113_K143_I0.7590.70
37_I65_Q0.7560.70
121_R128_F0.7510.70
20_V94_L0.7510.70
88_K102_D0.7490.69
87_N90_A0.7490.69
132_A147_T0.7450.69
87_N96_D0.7420.69
14_E17_S0.7300.67
74_L160_A0.7300.67
116_M119_H0.7250.67
59_Q167_I0.7250.67
124_D215_K0.7070.65
94_L101_L0.7000.64
94_L99_I0.6900.63
73_F149_V0.6880.63
88_K133_K0.6840.62
70_L154_I0.6810.62
63_P74_L0.6790.62
28_V32_A0.6780.62
110_E179_A0.6780.62
162_Q208_D0.6720.61
76_F80_A0.6690.61
46_V63_P0.6650.60
173_I190_L0.6650.60
115_F119_H0.6590.60
124_D158_K0.6590.60
133_K138_E0.6570.59
34_G38_L0.6530.59
118_K134_M0.6520.59
36_L72_L0.6520.59
158_K208_D0.6510.59
167_I213_I0.6500.59
26_L191_P0.6470.58
53_R188_M0.6460.58
45_I217_L0.6460.58
18_S36_L0.6450.58
169_I203_L0.6430.58
52_V162_Q0.6410.57
168_F201_I0.6400.57
14_E18_S0.6400.57
16_V137_P0.6390.57
32_A154_I0.6370.57
130_N159_T0.6350.57
137_P143_I0.6280.56
32_A191_P0.6260.56
110_E145_L0.6260.56
75_T83_F0.6250.56
85_E135_D0.6240.55
123_K219_Q0.6230.55
48_V168_F0.6230.55
90_A104_A0.6230.55
122_Q139_S0.6220.55
129_M135_D0.6200.55
58_T176_M0.6160.54
137_P147_T0.6160.54
177_V199_F0.6140.54
215_K218_L0.6070.53
52_V169_I0.6060.53
107_K213_I0.6050.53
201_I213_I0.6050.53
99_I104_A0.6040.53
51_F59_Q0.6040.53
48_V62_P0.5980.52
57_A60_S0.5970.52
85_E88_K0.5960.52
16_V191_P0.5950.52
149_V152_F0.5950.52
16_V202_L0.5890.51
63_P82_T0.5880.51
18_S22_L0.5880.51
98_K107_K0.5870.51
99_I103_E0.5870.51
26_L118_K0.5850.51
50_S54_T0.5850.51
18_S205_V0.5830.51
24_L66_V0.5810.50
170_P179_A0.5800.50
36_L83_F0.5800.50
113_K146_T0.5760.50
33_P79_M0.5760.50
110_E114_E0.5760.50
107_K141_K0.5740.49
126_A136_K0.5730.49
26_L32_A0.5730.49
69_G203_L0.5720.49
56_L217_L0.5720.49
16_V159_T0.5720.49
144_P147_T0.5710.49
96_D103_E0.5710.49
36_L49_L0.5670.49
90_A99_I0.5650.48
88_K138_E0.5650.48
65_Q203_L0.5630.48
22_L31_V0.5630.48
58_T201_I0.5580.48
106_T110_E0.5560.47
108_A112_I0.5550.47
21_K215_K0.5540.47
39_M153_A0.5480.46
21_K44_R0.5470.46
187_M196_S0.5440.46
69_G199_F0.5440.46
98_K133_K0.5430.46
26_L30_S0.5380.45
49_L107_K0.5370.45
42_F68_I0.5360.45
172_L195_I0.5350.45
211_Y221_F0.5350.45
37_I43_T0.5340.45
30_S37_I0.5330.45
44_R99_I0.5270.44
96_D122_Q0.5250.44
51_F185_M0.5250.44
58_T61_M0.5240.43
99_I108_A0.5230.43
188_M215_K0.5220.43
30_S144_P0.5210.43
61_M207_V0.5210.43
35_I76_F0.5210.43
109_E148_M0.5200.43
110_E118_K0.5170.43
14_E122_Q0.5160.43
65_Q214_V0.5150.42
19_T25_L0.5140.42
36_L184_S0.5130.42
14_E218_L0.5120.42
16_V32_A0.5110.42
98_K138_E0.5100.42
106_T141_K0.5100.42
147_T173_I0.5100.42
44_R124_D0.5090.42
167_I201_I0.5090.42
17_S21_K0.5090.42
21_K181_V0.5090.42
156_E159_T0.5070.41
17_S201_I0.5070.41
76_F176_M0.5070.41
181_V212_L0.5070.41
36_L169_I0.5050.41
121_R162_Q0.5030.41
135_D190_L0.5030.41
75_T201_I0.5020.41
126_A139_S0.5010.41
87_N172_L0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4w252 1 0.2805 18.4 0.966 Contact Map
1rh5B 1 0.2534 18.1 0.966 Contact Map
2ww9B 1 0.2715 16.6 0.966 Contact Map
2f6mA 1 0.2805 9.2 0.97 Contact Map
3mp7B 1 0.2443 8.6 0.971 Contact Map
1w53A 2 0.3801 4.7 0.974 Contact Map
3hxaA 5 0.1493 2.5 0.977 Contact Map
1co4A 1 0.0814 2.2 0.978 Contact Map
2mk9A 2 0.086 1.8 0.979 Contact Map
1m45B 1 0.1131 1.8 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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