GREMLIN Database
RSIX - Sigma-X negative effector
UniProt: P35166 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 368 (363)
Sequences: 108 (96)
Seq/√Len: 5.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_R30_I7.1891.00
330_K358_V4.3860.94
25_R31_Y3.5920.84
327_L362_P3.3780.80
8_E11_I3.3670.80
268_V302_L3.2790.78
326_L337_V3.1250.74
6_W146_L2.9170.68
331_E362_P2.8680.67
359_P363_N2.7380.63
286_L324_G2.7150.63
15_L23_D2.6970.62
31_Y238_I2.6540.61
19_P23_D2.6190.60
30_I179_L2.6170.60
265_F274_E2.5120.56
8_E52_C2.4570.54
133_I325_L2.4290.54
205_S211_Y2.4270.53
321_M355_A2.3580.51
122_D326_L2.3400.51
15_L19_P2.2830.49
330_K337_V2.2660.48
8_E212_E2.2550.48
130_P271_A2.2480.48
200_K339_F2.2040.46
56_I286_L2.1990.46
164_F341_E2.1050.43
121_A161_I2.0830.42
323_E359_P2.0760.42
122_D330_K2.0560.41
245_S271_A2.0430.41
132_S330_K2.0300.41
8_E43_P2.0250.40
19_P50_P2.0200.40
34_L304_I1.9690.39
128_I321_M1.9690.39
106_V166_D1.9680.39
57_A191_S1.9640.39
58_V267_T1.9580.38
53_A68_F1.9290.38
31_Y359_P1.8920.36
117_T132_S1.8790.36
323_E363_N1.8720.36
192_I281_E1.8630.36
164_F345_K1.8550.35
329_A337_V1.8420.35
11_I35_T1.8260.34
69_F131_V1.8110.34
20_A352_I1.7870.33
130_P363_N1.7800.33
224_G330_K1.7700.33
30_I34_L1.7540.32
245_S265_F1.7440.32
155_L302_L1.7440.32
34_L37_A1.7390.32
332_F359_P1.7250.32
11_I27_P1.6910.31
109_E353_S1.6880.31
106_V110_K1.6680.30
28_Q321_M1.6660.30
298_K317_A1.6640.30
13_E171_K1.6620.30
11_I58_V1.6290.29
30_I362_P1.6220.29
121_A218_S1.5910.28
15_L25_R1.5860.28
172_E211_Y1.5820.28
66_P228_G1.5780.28
265_F347_I1.5680.27
302_L326_L1.5650.27
115_Y132_S1.5480.27
109_E166_D1.5380.27
11_I159_I1.5290.26
198_L246_Y1.5120.26
133_I316_I1.5070.26
19_P130_P1.4680.25
203_K356_I1.4650.25
258_L333_G1.4620.25
23_D31_Y1.4400.24
30_I275_M1.4360.24
240_K304_I1.4320.24
244_R362_P1.4270.24
246_Y275_M1.4140.24
3_K331_E1.4030.23
55_A238_I1.4010.23
342_T352_I1.3910.23
332_F358_V1.3750.23
25_R362_P1.3730.23
130_P323_E1.3640.22
11_I46_R1.3640.22
290_G352_I1.3610.22
224_G348_G1.3420.22
122_D218_S1.3410.22
56_I160_T1.3310.22
271_A337_V1.3220.21
227_I349_K1.3210.21
204_E207_K1.3210.21
48_I334_F1.3060.21
323_E332_F1.3000.21
131_V304_I1.2830.21
154_I185_Q1.2720.20
119_A201_L1.2680.20
181_I227_I1.2570.20
25_R34_L1.2550.20
93_S253_Q1.2510.20
130_P260_P1.2490.20
309_E322_I1.2480.20
43_P76_Q1.2460.20
87_K171_K1.2220.19
120_V327_L1.2200.19
1_M6_W1.2200.19
87_K109_E1.2140.19
31_Y358_V1.2080.19
246_Y258_L1.2080.19
44_A69_F1.2040.19
185_Q192_I1.2030.19
11_I30_I1.2020.19
104_S111_E1.1990.19
18_L323_E1.1960.19
224_G244_R1.1940.19
67_H120_V1.1920.19
3_K224_G1.1840.19
122_D126_S1.1830.19
115_Y182_R1.1800.18
30_I62_F1.1770.18
334_F356_I1.1680.18
54_A57_A1.1630.18
53_A66_P1.1590.18
272_I287_I1.1400.18
10_Q252_K1.1360.18
8_E211_Y1.1350.18
184_H191_S1.1340.18
104_S148_E1.1270.17
50_P57_A1.1220.17
118_V205_S1.1210.17
47_W194_D1.1200.17
321_M333_G1.1190.17
89_E92_D1.1180.17
142_I350_Y1.1100.17
31_Y117_T1.1050.17
34_L146_L1.1020.17
65_S184_H1.1020.17
22_K146_L1.0980.17
163_T201_L1.0940.17
56_I201_L1.0890.17
118_V165_I1.0850.17
106_V109_E1.0810.17
23_D30_I1.0760.17
323_E330_K1.0750.17
333_G350_Y1.0720.16
205_S247_Y1.0700.16
7_N339_F1.0650.16
275_M324_G1.0640.16
198_L288_Q1.0630.16
156_D160_T1.0470.16
167_E171_K1.0440.16
245_S331_E1.0430.16
18_L245_S1.0410.16
27_P30_I1.0380.16
246_Y329_A1.0340.16
19_P25_R1.0310.16
43_P211_Y1.0140.15
151_E165_I1.0120.15
164_F359_P1.0080.15
30_I63_I1.0080.15
351_D354_D1.0060.15
57_A124_D1.0060.15
18_L31_Y1.0050.15
122_D179_L1.0000.15
302_L337_V0.9960.15
223_T247_Y0.9950.15
132_S157_H0.9940.15
323_E326_L0.9910.15
79_A85_V0.9880.15
170_I279_S0.9860.15
118_V302_L0.9820.15
181_I185_Q0.9810.15
129_I240_K0.9770.15
145_M148_E0.9760.15
42_K108_P0.9750.15
5_E11_I0.9610.15
25_R348_G0.9600.15
132_S320_L0.9580.15
316_I354_D0.9580.15
43_P253_Q0.9520.14
33_R188_T0.9500.14
216_F224_G0.9470.14
331_E347_I0.9470.14
132_S334_F0.9460.14
193_K294_S0.9450.14
1_M216_F0.9440.14
78_E99_S0.9440.14
120_V228_G0.9440.14
100_L298_K0.9440.14
327_L359_P0.9370.14
285_P294_S0.9360.14
52_C360_A0.9350.14
61_A83_N0.9330.14
311_E357_P0.9310.14
268_V351_D0.9300.14
48_I235_E0.9270.14
80_S277_S0.9210.14
329_A348_G0.9200.14
20_A341_E0.9160.14
272_I325_L0.9160.14
76_Q79_A0.9140.14
57_A104_S0.9100.14
128_I195_D0.9090.14
98_S102_Q0.9070.14
55_A292_V0.9060.14
260_P271_A0.9020.14
25_R64_I0.9020.14
350_Y356_I0.9020.14
55_A175_K0.8980.14
295_V315_S0.8970.14
136_T164_F0.8930.14
216_F248_L0.8900.13
57_A331_E0.8890.13
104_S134_Q0.8830.13
131_V327_L0.8820.13
271_A330_K0.8820.13
18_L59_Y0.8810.13
43_P95_K0.8810.13
53_A228_G0.8800.13
129_I249_Y0.8800.13
6_W283_T0.8740.13
34_L334_F0.8740.13
245_S261_S0.8730.13
96_A162_P0.8700.13
34_L128_I0.8690.13
116_I365_I0.8690.13
267_T296_T0.8680.13
243_K299_Q0.8670.13
290_G308_K0.8590.13
1_M23_D0.8590.13
95_K243_K0.8570.13
140_Q354_D0.8560.13
314_D330_K0.8550.13
281_E347_I0.8540.13
8_E205_S0.8530.13
151_E160_T0.8530.13
75_Q267_T0.8500.13
89_E95_K0.8450.13
132_S298_K0.8440.13
122_D358_V0.8440.13
2_M109_E0.8430.13
250_Q255_Q0.8430.13
37_A286_L0.8420.13
45_V336_E0.8420.13
321_M365_I0.8420.13
63_I164_F0.8410.13
16_S304_I0.8390.13
136_T206_L0.8380.13
24_H46_R0.8380.13
258_L336_E0.8380.13
55_A291_A0.8340.13
231_G359_P0.8330.13
337_V348_G0.8320.13
157_H160_T0.8320.13
48_I131_V0.8290.13
122_D198_L0.8290.13
272_I288_Q0.8280.13
204_E362_P0.8250.13
11_I365_I0.8230.12
63_I123_A0.8200.12
88_T91_E0.8190.12
48_I83_N0.8180.12
260_P359_P0.8170.12
179_L217_L0.8160.12
11_I55_A0.8160.12
246_Y347_I0.8140.12
240_K266_D0.8140.12
120_V131_V0.8120.12
29_D155_L0.8110.12
102_Q198_L0.8080.12
11_I25_R0.8050.12
21_V31_Y0.8020.12
135_K195_D0.8020.12
333_G359_P0.8000.12
170_I362_P0.7990.12
53_A307_S0.7990.12
201_L249_Y0.7980.12
145_M184_H0.7960.12
144_D153_G0.7960.12
17_Q332_F0.7960.12
96_A110_K0.7950.12
11_I23_D0.7870.12
161_I283_T0.7840.12
352_I359_P0.7840.12
37_A310_S0.7840.12
120_V361_A0.7830.12
261_S318_G0.7830.12
304_I327_L0.7820.12
218_S326_L0.7800.12
47_W357_P0.7790.12
170_I341_E0.7780.12
310_S344_T0.7750.12
22_K169_E0.7730.12
126_S161_I0.7730.12
31_Y229_S0.7720.12
8_E21_V0.7720.12
222_E314_D0.7700.12
181_I261_S0.7700.12
31_Y37_A0.7660.12
166_D187_A0.7650.12
64_I112_Q0.7650.12
10_Q82_E0.7650.12
21_V48_I0.7630.12
166_D364_P0.7610.12
126_S135_K0.7610.12
221_N247_Y0.7590.12
276_E295_V0.7550.12
21_V222_E0.7540.12
135_K334_F0.7500.11
12_K18_L0.7490.11
12_K324_G0.7460.11
5_E362_P0.7450.11
116_I204_E0.7450.11
47_W231_G0.7440.11
204_E247_Y0.7420.11
58_V200_K0.7410.11
76_Q267_T0.7400.11
9_E42_K0.7400.11
166_D247_Y0.7360.11
86_T93_S0.7360.11
60_I76_Q0.7360.11
96_A302_L0.7350.11
285_P297_K0.7320.11
354_D360_A0.7300.11
154_I233_F0.7300.11
1_M15_L0.7290.11
42_K218_S0.7280.11
224_G322_I0.7260.11
337_V359_P0.7190.11
259_V284_T0.7160.11
106_V163_T0.7140.11
261_S306_F0.7130.11
179_L237_S0.7130.11
248_L302_L0.7110.11
31_Y348_G0.7110.11
60_I171_K0.7080.11
43_P75_Q0.7060.11
64_I364_P0.7030.11
188_T227_I0.6990.11
50_P66_P0.6990.11
88_T132_S0.6980.11
131_V337_V0.6970.11
161_I218_S0.6970.11
214_V257_F0.6960.11
170_I274_E0.6960.11
122_D348_G0.6960.11
193_K238_I0.6950.11
135_K222_E0.6950.11
68_F238_I0.6950.11
22_K102_Q0.6950.11
224_G331_E0.6930.11
18_L168_V0.6910.11
73_Q171_K0.6910.11
66_P230_Y0.6890.11
108_P228_G0.6890.11
121_A126_S0.6870.11
256_D286_L0.6870.11
128_I365_I0.6870.11
258_L275_M0.6870.11
127_A204_E0.6860.11
58_V299_Q0.6840.11
276_E303_Y0.6830.11
96_A339_F0.6790.11
141_T150_S0.6790.11
271_A358_V0.6780.11
64_I131_V0.6770.11
17_Q58_V0.6770.11
114_N229_S0.6770.11
24_H285_P0.6750.11
126_S224_G0.6740.11
352_I363_N0.6740.11
25_R57_A0.6730.11
170_I302_L0.6720.10
176_Q225_V0.6710.10
265_F341_E0.6710.10
100_L271_A0.6670.10
41_N69_F0.6670.10
21_V285_P0.6650.10
23_D363_N0.6630.10
14_L27_P0.6620.10
129_I303_Y0.6610.10
57_A360_A0.6600.10
29_D157_H0.6600.10
147_F166_D0.6530.10
94_P305_R0.6530.10
92_D265_F0.6520.10
238_I241_Q0.6500.10
222_E355_A0.6500.10
68_F131_V0.6500.10
69_F112_Q0.6500.10
64_I160_T0.6490.10
257_F337_V0.6490.10
334_F339_F0.6480.10
120_V281_E0.6470.10
119_A156_D0.6450.10
19_P324_G0.6440.10
144_D170_I0.6440.10
214_V228_G0.6430.10
42_K257_F0.6420.10
48_I132_S0.6420.10
50_P156_D0.6420.10
55_A205_S0.6410.10
202_L250_Q0.6410.10
352_I358_V0.6390.10
270_E332_F0.6380.10
23_D50_P0.6360.10
13_E252_K0.6360.10
124_D316_I0.6350.10
265_F271_A0.6340.10
267_T335_T0.6340.10
128_I204_E0.6320.10
187_A350_Y0.6310.10
17_Q263_H0.6310.10
112_Q304_I0.6300.10
148_E205_S0.6290.10
56_I157_H0.6290.10
52_C160_T0.6260.10
205_S254_G0.6250.10
195_D325_L0.6240.10
191_S287_I0.6230.10
86_T299_Q0.6220.10
1_M19_P0.6220.10
5_E14_L0.6210.10
169_E305_R0.6200.10
234_T276_E0.6170.10
29_D331_E0.6160.10
69_F162_P0.6150.10
304_I357_P0.6150.10
221_N224_G0.6140.10
302_L329_A0.6140.10
39_R311_E0.6120.10
37_A334_F0.6120.10
26_S211_Y0.6120.10
119_A281_E0.6100.10
26_S280_Q0.6100.10
13_E355_A0.6100.10
73_Q129_I0.6090.10
1_M328_T0.6040.10
26_S58_V0.6010.10
50_P130_P0.6000.10
50_P324_G0.6000.10
327_L332_F0.5990.10
106_V116_I0.5990.10
54_A105_F0.5980.10
82_E252_K0.5970.10
21_V55_A0.5960.10
42_K298_K0.5960.10
272_I316_I0.5950.10
206_L238_I0.5940.10
304_I364_P0.5920.10
189_A290_G0.5890.10
198_L306_F0.5890.10
63_I166_D0.5880.10
28_Q198_L0.5830.09
198_L351_D0.5810.09
191_S194_D0.5800.09
52_C63_I0.5800.09
288_Q345_K0.5800.09
206_L211_Y0.5790.09
247_Y279_S0.5780.09
56_I275_M0.5780.09
14_L260_P0.5760.09
117_T361_A0.5760.09
71_Q301_H0.5740.09
204_E285_P0.5730.09
147_F331_E0.5720.09
159_I185_Q0.5710.09
147_F328_T0.5700.09
88_T92_D0.5670.09
57_A249_Y0.5670.09
31_Y362_P0.5660.09
98_S267_T0.5660.09
172_E219_D0.5660.09
179_L324_G0.5650.09
107_V305_R0.5630.09
31_Y68_F0.5600.09
11_I66_P0.5590.09
330_K348_G0.5580.09
245_S300_K0.5580.09
272_I319_I0.5570.09
24_H353_S0.5570.09
129_I259_V0.5560.09
120_V128_I0.5560.09
120_V201_L0.5560.09
74_P216_F0.5560.09
21_V28_Q0.5540.09
121_A324_G0.5520.09
50_P337_V0.5490.09
181_I224_G0.5470.09
228_G257_F0.5460.09
130_P337_V0.5450.09
61_A174_P0.5440.09
181_I271_A0.5420.09
238_I274_E0.5400.09
21_V84_A0.5390.09
63_I304_I0.5360.09
100_L307_S0.5360.09
205_S208_W0.5350.09
306_F321_M0.5340.09
110_K303_Y0.5330.09
196_T212_E0.5320.09
22_K112_Q0.5310.09
109_E163_T0.5310.09
10_Q228_G0.5300.09
22_K117_T0.5280.09
16_S26_S0.5280.09
288_Q325_L0.5270.09
52_C270_E0.5270.09
23_D26_S0.5270.09
148_E247_Y0.5270.09
156_D159_I0.5260.09
3_K275_M0.5250.09
68_F83_N0.5250.09
272_I324_G0.5250.09
152_L324_G0.5220.09
109_E272_I0.5200.09
8_E118_V0.5200.09
214_V327_L0.5190.09
163_T166_D0.5180.09
58_V123_A0.5180.09
104_S131_V0.5160.09
1_M363_N0.5150.09
267_T315_S0.5140.09
8_E126_S0.5130.09
1_M25_R0.5130.09
334_F358_V0.5110.09
18_L76_Q0.5100.09
202_L227_I0.5070.09
68_F272_I0.5060.09
178_E290_G0.5050.09
132_S306_F0.5050.09
283_T362_P0.5040.09
22_K37_A0.5030.09
34_L254_G0.5030.09
260_P332_F0.5020.09
69_F98_S0.5020.09
138_A177_K0.5010.09
228_G273_K0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kogA 1 0.1793 41.7 0.969 Contact Map
2kncA 1 0.1467 28.9 0.971 Contact Map
2m8rA 1 0.1821 25.7 0.972 Contact Map
3hd7A 1 0.1793 19.3 0.974 Contact Map
4c3eA 5 0.1087 18.5 0.974 Contact Map
2w3zA 1 0.5408 16 0.975 Contact Map
4myzA 4 0.0734 9.6 0.977 Contact Map
2m3eA 1 0.1359 8 0.978 Contact Map
2wbrA 1 0.2418 7.9 0.978 Contact Map
2yumA 1 0.1467 7.4 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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