GREMLIN Database
RESC - Cytochrome c biogenesis protein ResC
UniProt: P35162 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (389)
Sequences: 207 (153)
Seq/√Len: 7.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_A313_A8.1571.00
274_I281_L5.9441.00
8_F57_G5.3451.00
172_K360_E4.3630.98
195_A199_A3.8620.96
60_I64_A3.6440.95
270_L274_I3.1450.89
282_L286_V3.1340.89
180_M279_S3.1060.89
162_K291_L2.9990.87
163_H291_L2.9280.85
81_F152_S2.9260.85
146_Q379_F2.8630.84
323_L326_T2.8390.83
292_D358_H2.8090.83
153_F227_P2.7900.82
45_I94_F2.7710.82
202_E218_V2.7040.80
105_T154_V2.6020.77
2_A123_I2.5950.77
166_Q277_R2.5760.77
80_A153_F2.5670.76
227_P254_N2.5420.76
145_G308_I2.5280.75
225_V257_I2.4700.73
153_F254_N2.4680.73
166_Q173_T2.3820.71
22_I43_I2.3780.70
270_L278_I2.3270.69
14_L264_L2.3010.68
223_A277_R2.2990.68
140_T292_D2.2690.67
14_L18_I2.1900.64
121_T129_S2.1630.63
277_R280_A2.1040.60
355_R378_I2.0700.59
92_L372_I2.0620.59
262_A308_I2.0260.57
142_A318_M1.9930.56
327_R330_G1.9670.55
104_F158_I1.9380.54
39_R127_I1.9360.54
149_L373_I1.9090.53
58_Y65_A1.8680.51
225_V253_V1.8500.50
379_F383_V1.8470.50
83_M140_T1.8310.50
306_F341_T1.8220.49
192_I221_M1.8150.49
49_I90_I1.8030.48
248_F253_V1.7600.47
142_A145_G1.7560.47
87_L348_Y1.7540.46
173_T277_R1.7530.46
270_L281_L1.7470.46
87_L144_L1.7100.45
186_T378_I1.7030.44
91_I109_A1.7020.44
310_T342_F1.6910.44
152_S302_V1.6810.44
80_A298_G1.6690.43
86_V109_A1.6670.43
144_L348_Y1.6630.43
181_F264_L1.6570.43
11_A54_C1.6520.42
12_A255_T1.6480.42
78_T378_I1.6340.42
10_Y133_N1.6260.41
44_G301_A1.6240.41
80_A227_P1.6210.41
22_I47_L1.6140.41
194_S198_L1.5860.40
318_M343_L1.5700.39
121_T127_I1.5670.39
180_M184_V1.5490.38
82_G113_I1.5470.38
206_N231_E1.5240.37
46_T167_T1.5040.37
116_A286_V1.4690.35
29_G348_Y1.4630.35
273_I282_L1.4620.35
80_A254_N1.4580.35
47_L260_F1.4450.34
111_L323_L1.4300.34
74_M140_T1.4300.34
195_A198_L1.4270.34
313_A318_M1.4240.34
224_L242_V1.4040.33
367_V374_M1.3730.32
44_G50_V1.3710.32
25_G28_R1.3670.32
26_A342_F1.3670.32
151_I234_T1.3600.31
358_H374_M1.3570.31
120_P310_T1.3510.31
191_A199_A1.3510.31
79_T82_G1.3260.30
132_S297_V1.3250.30
215_S221_M1.3150.30
71_V103_L1.3020.29
244_L248_F1.3000.29
183_L264_L1.2950.29
23_F75_F1.2930.29
19_A276_K1.2920.29
55_H252_K1.2910.29
34_K257_I1.2820.29
223_A237_R1.2810.29
192_I262_A1.2800.29
244_L249_S1.2620.28
27_I30_N1.2590.28
242_V253_V1.2580.28
148_I373_I1.2500.28
172_K179_I1.2490.28
187_V193_T1.2460.28
17_L373_I1.2420.27
204_E278_I1.2400.27
179_I193_T1.2310.27
203_A239_E1.2270.27
65_A123_I1.2250.27
81_F118_M1.2130.27
10_Y124_S1.2090.26
88_A240_P1.2000.26
81_F302_V1.1950.26
58_Y103_L1.1920.26
111_L118_M1.1860.26
87_L379_F1.1820.26
173_T280_A1.1780.25
166_Q280_A1.1770.25
59_F79_T1.1770.25
159_F363_A1.1610.25
81_F348_Y1.1610.25
225_V244_L1.1590.25
178_A182_I1.1550.25
22_I161_L1.1540.25
184_V224_L1.1540.25
105_T140_T1.1500.25
144_L303_S1.1480.25
239_E289_V1.1430.24
48_S86_V1.1430.24
6_G129_S1.1420.24
7_N44_G1.1410.24
298_G301_A1.1390.24
6_G280_A1.1370.24
48_S106_L1.1370.24
344_F351_L1.1360.24
59_F83_M1.1340.24
55_H150_A1.1320.24
108_I346_A1.1310.24
318_M384_L1.1190.24
348_Y379_F1.1180.24
147_A170_S1.1180.24
150_A342_F1.1170.24
84_M144_L1.1130.24
162_K249_S1.1070.23
197_R200_G1.1060.23
110_L147_A1.1010.23
140_T252_K1.1000.23
147_A348_Y1.0940.23
180_M294_V1.0860.23
237_R278_I1.0820.23
8_F75_F1.0800.23
30_N161_L1.0770.22
87_L279_S1.0750.22
112_L146_Q1.0710.22
152_S193_T1.0690.22
58_Y71_V1.0660.22
157_V161_L1.0640.22
226_G240_P1.0640.22
8_F250_G1.0620.22
151_I168_K1.0610.22
85_L187_V1.0580.22
75_F238_M1.0570.22
202_E253_V1.0540.22
78_T116_A1.0530.22
134_W139_V1.0530.22
48_S147_A1.0460.22
108_I197_R1.0380.21
181_F204_E1.0370.21
2_A326_T1.0340.21
10_Y136_Y1.0200.21
176_L358_H1.0200.21
210_K249_S1.0190.21
158_I293_L1.0150.21
289_V371_A1.0120.21
376_N379_F1.0100.21
136_Y140_T1.0070.21
185_T221_M1.0060.21
162_K298_G0.9950.20
129_S146_Q0.9870.20
169_P195_A0.9870.20
164_V182_I0.9840.20
7_N11_A0.9840.20
170_S361_K0.9720.20
33_K290_N0.9700.20
6_G117_S0.9700.20
17_L81_F0.9680.20
223_A361_K0.9570.19
74_M118_M0.9530.19
373_I376_N0.9500.19
109_A379_F0.9500.19
203_A232_L0.9490.19
175_W293_L0.9480.19
197_R241_L0.9450.19
112_L181_F0.9440.19
85_L108_I0.9440.19
4_L383_V0.9420.19
129_S326_T0.9380.19
4_L261_G0.9360.19
223_A232_L0.9330.19
7_N168_K0.9320.19
111_L187_V0.9300.19
83_M106_L0.9260.19
97_R151_I0.9260.19
163_H298_G0.9260.19
260_F264_L0.9250.19
87_L249_S0.9230.18
173_T223_A0.9220.18
223_A235_E0.9210.18
44_G355_R0.9190.18
6_G82_G0.9180.18
199_A262_A0.9150.18
71_V322_Q0.9150.18
336_V339_L0.9140.18
257_I353_L0.9080.18
261_G355_R0.9080.18
93_Y281_L0.9070.18
51_G361_K0.9070.18
148_I308_I0.9060.18
124_S133_N0.9000.18
122_D278_I0.8990.18
253_V368_I0.8960.18
132_S139_V0.8960.18
165_D385_A0.8930.18
187_V190_I0.8900.18
40_W318_M0.8840.18
4_L57_G0.8840.18
243_D342_F0.8830.18
131_Q363_A0.8810.17
39_R46_T0.8800.17
42_N103_L0.8790.17
50_V180_M0.8780.17
378_I384_L0.8770.17
84_M147_A0.8760.17
53_F220_E0.8750.17
162_K210_K0.8740.17
247_L378_I0.8740.17
55_H322_Q0.8730.17
265_V269_A0.8720.17
143_A313_A0.8720.17
113_I346_A0.8700.17
223_A383_V0.8700.17
52_F90_I0.8690.17
39_R129_S0.8600.17
82_G315_I0.8580.17
179_I371_A0.8570.17
106_L383_V0.8510.17
234_T238_M0.8490.17
180_M225_V0.8480.17
146_Q371_A0.8440.17
122_D190_I0.8380.16
178_A361_K0.8360.16
257_I383_V0.8360.16
124_S355_R0.8350.16
169_P225_V0.8300.16
148_I173_T0.8260.16
54_C147_A0.8250.16
145_G310_T0.8190.16
85_L110_L0.8180.16
122_D216_V0.8170.16
180_M283_H0.8160.16
190_I342_F0.8150.16
101_L120_P0.8100.16
121_T289_V0.8090.16
86_V118_M0.8080.16
242_V286_V0.8080.16
207_W326_T0.8070.16
185_T260_F0.8070.16
18_I64_A0.8060.16
14_L121_T0.8050.16
193_T371_A0.8030.16
64_A109_A0.8000.16
39_R326_T0.7980.16
24_G48_S0.7970.16
162_K303_S0.7970.16
343_L384_L0.7960.16
21_P29_G0.7890.15
244_L250_G0.7890.15
98_L129_S0.7880.15
210_K250_G0.7880.15
45_I123_I0.7870.15
207_W238_M0.7870.15
137_I322_Q0.7770.15
261_G265_V0.7760.15
92_L213_E0.7760.15
100_S268_G0.7760.15
78_T186_T0.7750.15
313_A342_F0.7750.15
113_I141_T0.7680.15
195_A368_I0.7650.15
49_I144_L0.7640.15
255_T378_I0.7630.15
55_H74_M0.7600.15
23_F171_K0.7600.15
8_F363_A0.7600.15
103_L355_R0.7590.15
184_V253_V0.7550.15
154_V178_A0.7550.15
148_I170_S0.7540.15
249_S379_F0.7540.15
315_I362_S0.7530.15
32_D92_L0.7520.15
88_A145_G0.7520.15
144_L225_V0.7520.15
81_F293_L0.7500.15
38_N229_Q0.7490.15
131_Q323_L0.7490.15
14_L348_Y0.7480.15
78_T174_F0.7470.15
24_G162_K0.7450.15
121_T343_L0.7450.15
69_A278_I0.7440.14
80_A143_A0.7430.14
118_M302_V0.7430.14
248_F323_L0.7420.14
110_L124_S0.7420.14
74_M83_M0.7400.14
127_I291_L0.7390.14
217_M225_V0.7370.14
122_D209_D0.7350.14
193_T197_R0.7350.14
74_M81_F0.7350.14
39_R121_T0.7340.14
124_S293_L0.7310.14
302_V379_F0.7270.14
83_M310_T0.7250.14
41_A233_L0.7250.14
42_N50_V0.7240.14
223_A238_M0.7230.14
223_A379_F0.7210.14
165_D280_A0.7190.14
142_A207_W0.7190.14
161_L204_E0.7160.14
53_F199_A0.7150.14
55_H80_A0.7140.14
123_I273_I0.7130.14
220_E279_S0.7130.14
185_T264_L0.7100.14
71_V306_F0.7090.14
7_N171_K0.7080.14
43_I114_A0.7060.14
34_K187_V0.7060.14
149_L305_G0.7050.14
91_I280_A0.7050.14
174_F225_V0.7050.14
103_L179_I0.7040.14
66_S129_S0.7020.14
253_V257_I0.7010.14
77_F342_F0.7000.14
45_I48_S0.6990.14
60_I294_V0.6960.14
140_T144_L0.6940.14
206_N214_K0.6930.13
77_F297_V0.6910.13
103_L154_V0.6900.13
79_T346_A0.6890.13
133_N136_Y0.6880.13
81_F110_L0.6870.13
52_F84_M0.6850.13
4_L237_R0.6830.13
161_L298_G0.6830.13
35_G288_N0.6820.13
129_S291_L0.6820.13
180_M195_A0.6800.13
39_R94_F0.6800.13
131_Q188_A0.6800.13
202_E306_F0.6790.13
9_L75_F0.6780.13
285_L347_A0.6780.13
54_C279_S0.6750.13
310_T315_I0.6750.13
362_S377_L0.6690.13
362_S367_V0.6670.13
141_T373_I0.6650.13
250_G293_L0.6640.13
136_Y326_T0.6640.13
15_V80_A0.6570.13
273_I361_K0.6560.13
15_V202_E0.6560.13
104_F254_N0.6560.13
11_A19_A0.6530.13
10_Y137_I0.6520.13
54_C391_A0.6480.13
38_N129_S0.6460.13
248_F251_R0.6460.13
18_I264_L0.6420.13
114_A257_I0.6390.13
181_F308_I0.6380.12
87_L303_S0.6360.12
250_G318_M0.6350.12
20_V234_T0.6350.12
15_V122_D0.6340.12
166_Q169_P0.6330.12
38_N261_G0.6320.12
112_L231_E0.6300.12
240_P347_A0.6290.12
22_I205_F0.6290.12
164_V200_G0.6290.12
127_I215_S0.6280.12
79_T385_A0.6270.12
78_T154_V0.6260.12
147_A190_I0.6250.12
131_Q355_R0.6250.12
46_T202_E0.6220.12
367_V377_L0.6220.12
57_G75_F0.6210.12
231_E282_L0.6210.12
28_R371_A0.6190.12
206_N244_L0.6190.12
182_I225_V0.6180.12
180_M241_L0.6170.12
44_G198_L0.6150.12
145_G227_P0.6150.12
336_V374_M0.6140.12
92_L383_V0.6140.12
40_W206_N0.6110.12
17_L69_A0.6090.12
242_V264_L0.6080.12
184_V188_A0.6080.12
48_S77_F0.6060.12
100_S211_S0.6050.12
212_K274_I0.6040.12
291_L298_G0.6030.12
140_T166_Q0.6030.12
190_I250_G0.6020.12
68_H351_L0.6000.12
57_G199_A0.6000.12
43_I243_D0.6000.12
79_T113_I0.5990.12
65_A360_E0.5980.12
78_T97_R0.5960.12
22_I44_G0.5960.12
28_R302_V0.5960.12
247_L250_G0.5930.12
65_A84_M0.5920.12
171_K187_V0.5910.12
59_F375_F0.5900.12
66_S187_V0.5890.12
303_S348_Y0.5890.12
180_M204_E0.5870.12
246_A249_S0.5870.12
8_F228_H0.5870.12
114_A225_V0.5870.12
18_I23_F0.5860.12
181_F199_A0.5860.12
66_S186_T0.5860.12
65_A346_A0.5820.12
187_V383_V0.5810.12
169_P361_K0.5800.12
26_A109_A0.5790.11
255_T259_S0.5790.11
24_G100_S0.5780.11
221_M229_Q0.5770.11
109_A249_S0.5770.11
121_T355_R0.5770.11
41_A99_P0.5760.11
44_G178_A0.5760.11
12_A105_T0.5750.11
20_V148_I0.5740.11
310_T354_S0.5740.11
89_F101_L0.5730.11
156_G298_G0.5710.11
12_A171_K0.5710.11
25_G302_V0.5700.11
118_M152_S0.5690.11
54_C116_A0.5690.11
121_T379_F0.5660.11
87_L233_L0.5660.11
45_I109_A0.5660.11
50_V294_V0.5660.11
238_M372_I0.5660.11
2_A38_N0.5660.11
165_D168_K0.5650.11
45_I86_V0.5650.11
178_A279_S0.5640.11
242_V248_F0.5620.11
199_A287_K0.5620.11
77_F313_A0.5600.11
189_F366_A0.5590.11
373_I379_F0.5590.11
81_F194_S0.5590.11
16_Y145_G0.5590.11
115_Y266_L0.5580.11
133_N235_E0.5570.11
39_R45_I0.5570.11
18_I348_Y0.5570.11
235_E371_A0.5560.11
242_V257_I0.5560.11
213_E342_F0.5550.11
168_K210_K0.5540.11
365_L378_I0.5540.11
224_L253_V0.5530.11
26_A182_I0.5530.11
35_G178_A0.5520.11
67_G144_L0.5510.11
210_K291_L0.5510.11
14_L162_K0.5500.11
209_D248_F0.5480.11
18_I136_Y0.5470.11
20_V286_V0.5470.11
61_T104_F0.5470.11
74_M80_A0.5460.11
124_S290_N0.5440.11
27_I232_L0.5440.11
94_F178_A0.5440.11
182_I198_L0.5430.11
56_L129_S0.5430.11
244_L247_L0.5410.11
169_P192_I0.5410.11
129_S356_G0.5410.11
185_T188_A0.5400.11
124_S178_A0.5400.11
204_E216_V0.5400.11
213_E257_I0.5400.11
240_P377_L0.5400.11
161_L261_G0.5390.11
55_H301_A0.5380.11
272_L361_K0.5370.11
10_Y81_F0.5340.11
200_G220_E0.5330.11
192_I268_G0.5330.11
101_L310_T0.5330.11
167_T187_V0.5310.11
123_I173_T0.5300.11
54_C74_M0.5290.11
211_S308_I0.5290.11
232_L287_K0.5290.11
112_L378_I0.5280.11
149_L194_S0.5270.11
146_Q154_V0.5260.11
28_R81_F0.5260.11
77_F252_K0.5250.11
87_L326_T0.5250.11
52_F86_V0.5250.11
318_M339_L0.5240.11
168_K231_E0.5240.11
17_L20_V0.5240.11
257_I265_V0.5220.11
71_V105_T0.5220.11
83_M147_A0.5220.11
66_S166_Q0.5220.11
97_R368_I0.5210.11
85_L190_I0.5210.11
14_L212_K0.5200.11
3_E211_S0.5200.11
24_G194_S0.5200.11
204_E218_V0.5180.11
356_G363_A0.5180.11
158_I302_V0.5180.11
223_A266_L0.5170.11
23_F200_G0.5170.11
12_A93_Y0.5140.10
92_L179_I0.5140.10
124_S264_L0.5130.10
42_N97_R0.5130.10
144_L294_V0.5130.10
83_M175_W0.5130.10
216_V224_L0.5110.10
183_L371_A0.5110.10
132_S144_L0.5110.10
161_L250_G0.5100.10
342_F360_E0.5090.10
289_V383_V0.5090.10
36_R270_L0.5080.10
54_C163_H0.5080.10
87_L121_T0.5080.10
210_K301_A0.5070.10
140_T227_P0.5060.10
43_I56_L0.5050.10
140_T153_F0.5030.10
117_S280_A0.5010.10
249_S291_L0.5010.10
54_C140_T0.5010.10
245_P367_V0.5000.10
97_R326_T0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jq6A 3 0.4604 28.1 0.983 Contact Map
1zcdA 1 0.2327 12.1 0.985 Contact Map
4hyjA 2 0.509 11.6 0.986 Contact Map
2jafA 3 0.5192 11.2 0.986 Contact Map
3qapA 1 0.4936 10.7 0.986 Contact Map
4fbzA 3 0.5473 9.1 0.986 Contact Map
1b9uA 1 0.087 8.1 0.987 Contact Map
3wxwA 1 0.1816 6.9 0.987 Contact Map
1xioA 2 0.509 6.5 0.987 Contact Map
4knfA 3 0.4962 6.4 0.987 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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