GREMLIN Database
RESB - Cytochrome c biogenesis protein ResB
UniProt: P35161 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 542 (460)
Sequences: 1297 (909)
Seq/√Len: 42.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
325_R328_Q5.0541.00
222_I474_G5.0491.00
279_F300_V4.7051.00
100_K107_G4.0151.00
110_Y115_F3.8941.00
165_Q505_A3.8701.00
183_I495_L3.7451.00
98_Y102_Q3.6121.00
114_G122_W3.5701.00
212_G481_G3.3741.00
298_D323_D3.3741.00
300_V321_E3.1931.00
139_S221_I3.0931.00
69_L131_I3.0321.00
226_G474_G3.0271.00
184_V196_E2.9811.00
219_G477_I2.9701.00
331_R336_S2.9471.00
348_D414_F2.9341.00
305_E317_E2.8751.00
109_L112_L2.8391.00
340_V459_G2.8361.00
299_A324_I2.7721.00
77_S124_Y2.7711.00
73_T131_I2.7101.00
279_F321_E2.6311.00
318_K321_E2.5401.00
226_G470_V2.5271.00
294_N325_R2.5131.00
476_A480_I2.4961.00
170_E503_M2.4631.00
296_Q325_R2.4591.00
194_I201_I2.4371.00
181_E185_T2.3771.00
298_D321_E2.3401.00
322_E328_Q2.3291.00
351_V450_D2.3271.00
132_G224_L2.2651.00
469_W473_V2.2631.00
99_Y465_D2.2191.00
136_V221_I2.2051.00
132_G220_L2.1851.00
76_A123_W2.1751.00
324_I330_L2.1581.00
441_G444_K2.1270.99
285_R456_N2.1090.99
296_Q323_D2.1080.99
105_T109_L2.1040.99
135_L138_C2.0670.99
139_S218_I2.0380.99
114_G121_S2.0340.99
277_K300_V1.9540.99
84_P87_A1.9440.99
83_F106_F1.9340.99
276_K337_V1.9050.99
196_E199_G1.9030.99
181_E196_E1.8960.99
282_A298_D1.8810.99
349_Q450_D1.8770.99
363_F374_D1.8720.99
138_C162_L1.8510.98
278_V460_L1.8310.98
334_S466_L1.8280.98
506_G515_L1.7720.98
226_G467_T1.7710.98
409_P452_V1.7710.98
86_E117_H1.7500.98
226_G471_L1.7330.98
66_G138_C1.7290.98
245_E455_K1.7140.97
393_D406_T1.6910.97
180_K184_V1.6910.97
281_D285_R1.6840.97
278_V458_T1.6810.97
263_N266_S1.6660.97
234_G465_D1.6650.97
301_L330_L1.6500.97
162_L206_G1.6420.97
299_A330_L1.6350.97
303_K333_D1.6240.96
491_R518_D1.5950.96
187_L203_A1.5900.96
117_H120_G1.5860.96
420_T442_N1.5850.96
177_G181_E1.5810.96
148_R189_K1.5700.96
324_I460_L1.5480.95
221_I527_G1.5480.95
104_G108_Q1.5290.95
165_Q205_K1.5280.95
219_G481_G1.5240.95
262_N265_F1.5220.95
99_Y110_Y1.5160.95
114_G117_H1.5080.95
100_K108_Q1.5060.95
115_F118_L1.4770.94
178_E182_K1.4750.94
351_V446_K1.4530.93
180_K495_L1.4440.93
172_V501_A1.4300.93
178_E181_E1.4270.93
286_V289_G1.4210.93
201_I495_L1.4080.92
434_Q437_I1.4070.92
342_Y456_N1.3950.92
90_P460_L1.3940.92
245_E278_V1.3880.92
277_K302_Y1.3860.92
351_V367_K1.3730.91
143_V218_I1.3730.91
136_V140_L1.3650.91
429_S434_Q1.3580.91
287_G410_N1.3490.91
106_F110_Y1.3430.90
108_Q112_L1.3310.90
63_V141_D1.3300.90
126_L225_I1.3290.90
295_F325_R1.3270.90
99_Y107_G1.3210.90
343_K457_I1.3130.89
280_A298_D1.3120.89
221_I225_I1.3100.89
261_K265_F1.3080.89
260_L263_N1.3050.89
338_Y465_D1.2960.89
400_G411_N1.2940.89
234_G483_I1.2890.88
397_N401_E1.2770.88
404_T412_P1.2720.88
52_I56_I1.2700.88
99_Y338_Y1.2680.88
281_D494_W1.2660.88
263_N300_V1.2650.88
265_F268_E1.2600.87
286_V293_K1.2530.87
96_D104_G1.2500.87
472_A476_A1.2480.87
366_L447_L1.2470.87
420_T423_K1.2270.86
392_P395_Y1.2260.86
390_Y393_D1.2240.86
226_G459_G1.2210.86
524_A528_L1.2190.85
185_T473_V1.2190.85
265_F494_W1.2180.85
276_K460_L1.2120.85
181_E525_D1.2110.85
219_G467_T1.2100.85
238_D461_T1.2100.85
133_I442_N1.2070.85
395_Y413_A1.2060.85
69_L130_S1.2020.85
175_L182_K1.2000.85
172_V218_I1.1950.84
63_V70_I1.1930.84
244_R247_E1.1900.84
134_S213_P1.1840.84
511_N514_G1.1720.83
143_V147_Y1.1690.83
404_T407_K1.1690.83
279_F282_A1.1660.83
437_I447_L1.1640.83
54_D127_L1.1640.83
109_L221_I1.1630.83
472_A475_G1.1510.82
137_I210_R1.1490.82
278_V286_V1.1490.82
483_I487_Y1.1480.82
181_E198_E1.1460.82
243_V246_G1.1440.82
188_K525_D1.1370.81
441_G445_Y1.1290.81
219_G223_F1.1290.81
341_D459_G1.1280.81
295_F411_N1.1270.81
210_R213_P1.1210.80
131_I138_C1.1190.80
147_Y151_K1.1170.80
51_T55_K1.1150.80
243_V286_V1.1150.80
86_E111_Y1.1140.80
70_I123_W1.1130.80
406_T410_N1.1120.80
230_R465_D1.1110.80
284_D524_A1.1090.80
243_V341_D1.1030.79
182_K186_L1.0910.78
139_S214_Y1.0900.78
460_L465_D1.0880.78
126_L500_G1.0860.78
105_T108_Q1.0830.78
230_R466_L1.0750.77
94_Q97_T1.0690.77
170_E501_A1.0680.77
53_I225_I1.0650.77
436_T448_K1.0610.76
435_E449_F1.0600.76
67_I183_I1.0570.76
184_V188_K1.0550.76
462_V468_L1.0540.76
473_V477_I1.0540.76
474_G487_Y1.0520.76
363_F366_L1.0510.76
55_K58_N1.0500.76
101_E425_K1.0460.75
465_D508_T1.0440.75
175_L179_S1.0410.75
508_T512_W1.0230.74
138_C218_I1.0210.74
226_G234_G1.0190.73
133_I150_L1.0080.73
404_T411_N1.0070.73
501_A529_T1.0070.73
125_L129_A1.0070.73
348_D447_L1.0040.72
222_I477_I1.0020.72
324_I380_G1.0000.72
146_L149_A0.9950.72
234_G467_T0.9930.71
146_L211_W0.9920.71
146_L150_L0.9900.71
136_V449_F0.9870.71
136_V161_F0.9860.71
48_Y52_I0.9860.71
143_V234_G0.9840.71
350_M449_F0.9820.71
226_G338_Y0.9790.70
188_K349_Q0.9770.70
153_Q195_R0.9700.70
260_L265_F0.9670.69
521_F525_D0.9670.69
57_W61_S0.9660.69
75_A232_V0.9640.69
119_Y499_D0.9620.69
285_R370_L0.9610.69
231_F514_G0.9600.69
349_Q448_K0.9580.69
260_L264_Q0.9560.69
205_K474_G0.9550.68
222_I226_G0.9520.68
222_I473_V0.9480.68
110_Y484_Q0.9470.68
292_A296_Q0.9460.68
113_L179_S0.9460.68
204_E207_R0.9420.67
111_Y116_H0.9400.67
169_S520_A0.9370.67
406_T409_P0.9360.67
505_A518_D0.9350.67
147_Y150_L0.9340.67
119_Y125_L0.9340.67
303_K332_F0.9310.66
235_M461_T0.9300.66
303_K317_E0.9290.66
180_K196_E0.9280.66
246_G460_L0.9270.66
350_M370_L0.9270.66
440_S443_N0.9230.66
63_V213_P0.9220.66
168_F503_M0.9220.66
392_P415_V0.9180.65
386_E417_N0.9160.65
183_I522_I0.9150.65
90_P97_T0.9130.65
87_A98_Y0.9090.65
177_G180_K0.9010.64
205_K518_D0.9000.64
337_V460_L0.8980.64
57_W62_S0.8960.63
407_K412_P0.8960.63
76_A412_P0.8940.63
302_Y306_G0.8930.63
48_Y51_T0.8920.63
180_K201_I0.8920.63
61_S137_I0.8920.63
254_T467_T0.8850.63
504_V519_L0.8810.62
138_C143_V0.8800.62
408_I412_P0.8790.62
282_A285_R0.8780.62
474_G510_K0.8780.62
121_S220_L0.8740.62
336_S471_L0.8740.62
195_R416_F0.8670.61
296_Q464_K0.8660.61
132_G194_I0.8650.61
213_P216_N0.8640.61
284_D293_K0.8610.60
134_S492_R0.8590.60
63_V216_N0.8580.60
245_E253_G0.8570.60
133_I225_I0.8480.59
404_T413_A0.8470.59
284_D294_N0.8460.59
295_F495_L0.8460.59
435_E522_I0.8440.59
510_K519_L0.8390.58
301_L320_T0.8390.58
99_Y117_H0.8390.58
183_I497_S0.8360.58
393_D410_N0.8320.58
113_L504_V0.8310.58
201_I208_F0.8300.58
343_K459_G0.8300.58
174_V476_A0.8290.57
187_L493_I0.8270.57
172_V504_V0.8270.57
292_A342_Y0.8220.57
60_F349_Q0.8210.57
299_A458_T0.8180.56
251_I337_V0.8180.56
63_V137_I0.8140.56
239_E292_A0.8130.56
278_V285_R0.8130.56
144_I147_Y0.8120.56
99_Y104_G0.8110.56
493_I518_D0.8080.55
338_Y508_T0.8040.55
144_I148_R0.8030.55
112_L473_V0.8030.55
334_S471_L0.8020.55
219_G478_F0.8000.55
171_T527_G0.7990.55
480_I526_S0.7970.54
75_A299_A0.7950.54
379_L382_G0.7910.54
169_S519_L0.7910.54
115_F129_A0.7910.54
102_Q215_V0.7850.53
192_Y205_K0.7850.53
408_I456_N0.7850.53
173_T176_N0.7850.53
385_V418_I0.7830.53
215_V484_Q0.7780.53
440_S444_K0.7780.53
125_L509_N0.7780.53
134_S494_W0.7760.52
139_S143_V0.7750.52
138_C281_D0.7750.52
467_T478_F0.7750.52
493_I530_E0.7710.52
409_P412_P0.7710.52
347_L452_V0.7690.52
281_D297_T0.7680.52
360_K365_S0.7680.52
224_L227_A0.7670.52
79_F115_F0.7650.51
405_K410_N0.7630.51
124_Y407_K0.7620.51
137_I490_H0.7610.51
495_L526_S0.7600.51
230_R461_T0.7590.51
474_G477_I0.7570.51
440_S445_Y0.7570.51
110_Y474_G0.7570.51
159_P206_G0.7550.51
248_T277_K0.7540.50
493_I528_L0.7530.50
113_L323_D0.7500.50
330_L394_F0.7500.50
445_Y449_F0.7500.50
279_F318_K0.7490.50
184_V201_I0.7490.50
66_G431_V0.7470.50
239_E243_V0.7460.50
140_L227_A0.7460.50
152_N175_L0.7440.49
246_G481_G0.7440.49
63_V214_Y0.7440.49
100_K111_Y0.7430.49
150_L211_W0.7380.49
304_R317_E0.7380.49
122_W218_I0.7350.49
184_V194_I0.7330.48
338_Y473_V0.7330.48
367_K387_I0.7320.48
82_I237_V0.7320.48
103_Y295_F0.7300.48
163_R170_E0.7300.48
151_K499_D0.7280.48
382_G505_A0.7260.48
351_V365_S0.7240.48
305_E333_D0.7240.48
418_I449_F0.7240.48
226_G229_L0.7240.48
362_S372_D0.7230.47
204_E490_H0.7200.47
65_V489_Q0.7200.47
528_L531_P0.7190.47
173_T525_D0.7180.47
261_K264_Q0.7170.47
243_V460_L0.7140.47
169_S498_Q0.7140.47
68_W72_I0.7130.47
213_P509_N0.7120.46
154_G407_K0.7110.46
169_S523_L0.7100.46
100_K106_F0.7090.46
205_K377_Y0.7080.46
78_A124_Y0.7080.46
135_L140_L0.7070.46
133_I521_F0.7050.46
135_L338_Y0.7050.46
159_P164_R0.7040.46
107_G115_F0.7040.46
305_E501_A0.7030.46
353_Q380_G0.7030.46
282_A296_Q0.7030.46
179_S502_V0.7020.46
216_N509_N0.7020.46
163_R503_M0.7020.46
504_V523_L0.7010.45
451_H455_K0.7000.45
262_N266_S0.6970.45
69_L127_L0.6970.45
62_S412_P0.6960.45
342_Y370_L0.6950.45
376_V380_G0.6950.45
229_L477_I0.6950.45
135_L249_A0.6950.45
178_E500_G0.6950.45
113_L247_E0.6930.45
389_S393_D0.6930.45
199_G498_Q0.6920.45
115_F162_L0.6920.45
394_F406_T0.6910.44
479_M506_G0.6910.44
296_Q462_V0.6890.44
149_A165_Q0.6890.44
223_F474_G0.6890.44
284_D506_G0.6880.44
58_N62_S0.6860.44
133_I147_Y0.6860.44
278_V281_D0.6860.44
72_I126_L0.6840.44
74_L393_D0.6830.44
122_W125_L0.6820.44
335_F464_K0.6800.43
236_Y461_T0.6790.43
204_E210_R0.6750.43
299_A504_V0.6740.43
55_K445_Y0.6730.43
49_N56_I0.6710.43
128_I132_G0.6710.43
406_T506_G0.6710.43
140_L462_V0.6690.42
109_L223_F0.6690.42
332_F337_V0.6680.42
51_T499_D0.6680.42
290_R471_L0.6650.42
406_T411_N0.6650.42
519_L525_D0.6650.42
94_Q471_L0.6640.42
150_L221_I0.6620.42
190_K525_D0.6610.42
155_V195_R0.6610.42
199_G495_L0.6600.42
63_V210_R0.6600.42
134_S295_F0.6590.42
83_F283_I0.6590.42
199_G212_G0.6590.42
65_V216_N0.6580.41
238_D254_T0.6570.41
251_I254_T0.6560.41
116_H343_K0.6550.41
114_G463_R0.6540.41
306_G317_E0.6540.41
118_L123_W0.6520.41
84_P142_R0.6520.41
115_F514_G0.6490.41
425_K442_N0.6480.41
213_P344_E0.6470.40
174_V182_K0.6470.40
62_S119_Y0.6460.40
110_Y116_H0.6420.40
177_G450_D0.6420.40
68_W189_K0.6420.40
184_V219_G0.6420.40
427_E431_V0.6390.40
395_Y474_G0.6370.40
209_S213_P0.6370.40
132_G150_L0.6360.39
224_L281_D0.6350.39
250_A519_L0.6350.39
353_Q381_N0.6350.39
63_V131_I0.6330.39
408_I411_N0.6320.39
220_L224_L0.6310.39
131_I290_R0.6310.39
196_E301_L0.6300.39
281_D286_V0.6280.39
49_N52_I0.6260.39
119_Y474_G0.6260.39
167_L516_K0.6250.38
53_I182_K0.6250.38
212_G246_G0.6240.38
214_Y490_H0.6240.38
480_I517_K0.6220.38
159_P498_Q0.6220.38
126_L372_D0.6210.38
99_Y106_F0.6210.38
489_Q512_W0.6190.38
84_P412_P0.6190.38
90_P350_M0.6180.38
339_Q458_T0.6170.38
467_T471_L0.6170.38
67_I324_I0.6160.38
235_M254_T0.6150.38
470_V529_T0.6150.38
192_Y487_Y0.6140.37
219_G252_P0.6110.37
186_L522_I0.6090.37
66_G191_H0.6090.37
163_R318_K0.6090.37
56_I59_F0.6080.37
52_I55_K0.6080.37
278_V490_H0.6070.37
339_Q342_Y0.6050.37
458_T490_H0.6010.36
152_N522_I0.6010.36
188_K521_F0.5990.36
55_K59_F0.5990.36
209_S486_M0.5980.36
449_F471_L0.5970.36
135_L441_G0.5960.36
99_Y196_E0.5960.36
167_L505_A0.5950.36
401_E404_T0.5940.36
119_Y468_L0.5940.36
437_I444_K0.5930.36
223_F475_G0.5920.36
216_N490_H0.5920.36
150_L460_L0.5920.36
406_T413_A0.5920.36
213_P485_G0.5920.36
61_S210_R0.5890.35
54_D60_F0.5880.35
496_H503_M0.5880.35
128_I293_K0.5870.35
387_I416_F0.5870.35
451_H524_A0.5870.35
107_G390_Y0.5860.35
449_F452_V0.5860.35
113_L502_V0.5860.35
130_S193_R0.5830.35
506_G519_L0.5830.35
138_C149_A0.5820.35
405_K413_A0.5820.35
64_K71_V0.5810.35
377_Y380_G0.5810.35
59_F65_V0.5800.35
176_N275_E0.5800.35
52_I435_E0.5790.34
162_L168_F0.5780.34
115_F499_D0.5770.34
328_Q337_V0.5770.34
387_I418_I0.5750.34
295_F406_T0.5750.34
324_I390_Y0.5750.34
197_K200_S0.5740.34
126_L440_S0.5740.34
160_A501_A0.5740.34
322_E448_K0.5740.34
171_T178_E0.5730.34
360_K381_N0.5720.34
110_Y254_T0.5720.34
238_D463_R0.5720.34
351_V451_H0.5720.34
422_D494_W0.5720.34
299_A318_K0.5710.34
106_F274_T0.5700.34
411_N435_E0.5700.34
88_Y95_A0.5690.34
177_G197_K0.5690.34
130_S466_L0.5670.33
172_V225_I0.5670.33
148_R503_M0.5670.33
194_I350_M0.5670.33
293_K474_G0.5670.33
238_D458_T0.5670.33
336_S468_L0.5660.33
73_T116_H0.5640.33
205_K244_R0.5630.33
68_W71_V0.5620.33
278_V282_A0.5600.33
60_F63_V0.5600.33
223_F301_L0.5590.33
124_Y471_L0.5590.33
219_G238_D0.5590.33
171_T182_K0.5590.33
450_D488_W0.5590.33
180_K246_G0.5590.33
149_A470_V0.5590.33
317_E470_V0.5570.33
149_A514_G0.5560.33
191_H278_V0.5550.32
292_A448_K0.5540.32
209_S485_G0.5520.32
101_E435_E0.5520.32
53_I302_Y0.5520.32
67_I131_I0.5520.32
243_V250_A0.5500.32
279_F323_D0.5490.32
389_S501_A0.5480.32
72_I500_G0.5460.32
82_I179_S0.5450.32
378_D480_I0.5450.32
98_Y119_Y0.5450.32
187_L290_R0.5440.32
61_S139_S0.5430.31
100_K105_T0.5420.31
286_V291_V0.5410.31
210_R214_Y0.5410.31
516_K520_A0.5410.31
183_I462_V0.5400.31
103_Y212_G0.5400.31
217_H327_N0.5390.31
187_L382_G0.5380.31
54_D62_S0.5380.31
136_V413_A0.5370.31
226_G469_W0.5360.31
64_K433_I0.5350.31
321_E400_G0.5340.31
448_K523_L0.5340.31
177_G521_F0.5340.31
319_V332_F0.5340.31
392_P402_P0.5340.31
65_V490_H0.5330.31
53_I418_I0.5320.31
335_F471_L0.5320.31
61_S220_L0.5310.30
123_W481_G0.5300.30
72_I424_P0.5290.30
248_T275_E0.5280.30
190_K521_F0.5260.30
124_Y343_K0.5260.30
82_I517_K0.5260.30
99_Y508_T0.5250.30
149_A465_D0.5250.30
141_D213_P0.5240.30
201_I321_E0.5230.30
508_T515_L0.5230.30
143_V479_M0.5220.30
489_Q506_G0.5220.30
119_Y480_I0.5220.30
229_L232_V0.5210.30
142_R164_R0.5210.30
338_Y463_R0.5200.30
65_V72_I0.5200.30
299_A469_W0.5180.29
233_P467_T0.5170.29
97_T292_A0.5160.29
394_F404_T0.5160.29
250_A451_H0.5160.29
210_R509_N0.5160.29
84_P204_E0.5150.29
228_M337_V0.5150.29
514_G518_D0.5150.29
128_I154_G0.5140.29
244_R345_N0.5130.29
391_L402_P0.5130.29
371_L430_F0.5130.29
334_S462_V0.5120.29
180_K470_V0.5120.29
124_Y227_A0.5120.29
334_S495_L0.5110.29
476_A528_L0.5110.29
317_E480_I0.5100.29
333_D480_I0.5100.29
364_G374_D0.5100.29
179_S498_Q0.5090.29
54_D57_W0.5090.29
385_V432_A0.5090.29
429_S433_I0.5080.29
100_K104_G0.5080.29
416_F447_L0.5080.29
489_Q511_N0.5080.29
411_N414_F0.5080.29
154_G346_Q0.5080.29
504_V526_S0.5070.29
520_A530_E0.5070.29
266_S269_T0.5070.29
396_F400_G0.5060.29
183_I186_L0.5050.28
330_L337_V0.5050.28
363_F415_V0.5030.28
71_V506_G0.5030.28
189_K525_D0.5010.28
78_A433_I0.5010.28
228_M231_F0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wkvA 3 0.2159 90.7 0.967 Contact Map
4h33A 3 0.1568 74.2 0.973 Contact Map
4g7vS 1 0.1993 66.8 0.975 Contact Map
3j21g 1 0.0646 55.6 0.976 Contact Map
1vd4A 1 0.072 54.4 0.976 Contact Map
5aunA 1 0.083 46.6 0.978 Contact Map
1h7bA 2 0.0369 45 0.978 Contact Map
3h0gL 1 0.0756 43 0.978 Contact Map
4g80S 1 0.2048 40.3 0.978 Contact Map
4qiwP 1 0.0664 36.6 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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