GREMLIN Database
RESA - Thiol-disulfide oxidoreductase ResA
UniProt: P35160 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 179 (143)
Sequences: 12907 (9961)
Seq/√Len: 833.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_G148_P3.8281.00
49_D53_K2.9901.00
85_A120_N2.8141.00
46_V54_R2.7521.00
147_N153_V2.5891.00
63_K97_E2.5641.00
147_N151_K2.5151.00
107_K111_H2.4671.00
48_E54_R2.3361.00
46_V56_E2.2391.00
56_E59_D2.0291.00
146_I152_V2.0231.00
42_A135_Y1.9861.00
41_D151_K1.9771.00
90_H166_H1.9541.00
85_A89_K1.8861.00
65_V97_E1.8841.00
49_D55_I1.8681.00
100_A121_F1.8571.00
55_I60_L1.8331.00
68_N80_E1.7861.00
88_Y92_K1.7561.00
44_N58_S1.7411.00
166_H170_N1.7241.00
50_T114_M1.7011.00
66_F145_L1.6841.00
78_K117_Y1.6551.00
106_S109_A1.5941.00
73_W110_V1.5191.00
44_N56_E1.5021.00
86_N162_E1.5001.00
81_F119_V1.4711.00
37_S40_S1.4581.00
111_H115_K1.4201.00
83_Y86_N1.3771.00
68_N143_T1.3741.00
64_G145_L1.3441.00
130_Q134_A1.3381.00
47_L124_V1.3041.00
164_M167_D1.2841.00
142_T155_V1.2391.00
107_K125_L1.2311.00
74_C77_C1.2091.00
108_I112_N1.1791.00
113_F117_Y1.1781.00
64_G153_V1.1601.00
102_N110_V1.1571.00
97_E122_P1.1441.00
74_C117_Y1.1391.00
112_N116_S1.1351.00
78_K116_S1.1251.00
103_V132_L1.1031.00
144_F152_V1.0871.00
78_K113_F1.0871.00
103_V129_R1.0871.00
80_E143_T1.0781.00
66_F143_T1.0761.00
88_Y120_N1.0741.00
69_F101_V1.0601.00
65_V146_I1.0541.00
60_L99_V1.0511.00
87_Q165_I1.0471.00
162_E166_H1.0401.00
83_Y162_E1.0371.00
60_L65_V1.0361.00
164_M168_Y1.0341.00
39_G151_K1.0321.00
66_F96_V1.0071.00
51_N111_H1.0041.00
86_N90_H1.0021.00
86_N89_K0.9941.00
72_T110_V0.9891.00
85_A121_F0.9891.00
55_I59_D0.9881.00
69_F135_Y0.9831.00
66_F84_M0.9771.00
44_N57_L0.9731.00
49_D124_V0.9671.00
89_K92_K0.9641.00
71_G140_L0.9601.00
92_K97_E0.9561.00
82_P86_N0.9481.00
58_S61_K0.9481.00
112_N115_K0.9441.00
154_K168_Y0.9291.00
154_K171_L0.9281.00
92_K95_G0.9281.00
45_F57_L0.9221.00
67_L146_I0.9211.00
87_Q90_H0.9161.00
126_D129_R0.9111.00
48_E107_K0.9081.00
79_K159_T0.9031.00
130_Q133_D0.9031.00
45_F131_V0.8801.00
114_M123_V0.8761.00
38_E154_K0.8681.00
62_G150_G0.8651.00
90_H162_E0.8641.00
71_G74_C0.8601.00
103_V140_L0.8511.00
84_M98_I0.8461.00
88_Y97_E0.8441.00
167_D171_L0.8401.00
165_I168_Y0.8391.00
72_T113_F0.8271.00
85_A118_G0.8201.00
65_V99_V0.8201.00
163_S167_D0.8191.00
110_V125_L0.8181.00
64_G96_V0.8101.00
79_K82_P0.8051.00
168_Y171_L0.8001.00
91_F170_N0.7991.00
68_N76_P0.7971.00
82_P85_A0.7971.00
64_G95_G0.7941.00
91_F166_H0.7921.00
71_G76_P0.7861.00
145_L156_V0.7841.00
108_I111_H0.7841.00
75_E79_K0.7811.00
68_N81_F0.7781.00
57_L60_L0.7771.00
163_S166_H0.7741.00
81_F113_F0.7691.00
50_T111_H0.7671.00
81_F85_A0.7651.00
95_G148_P0.7631.00
49_D122_P0.7561.00
137_V140_L0.7501.00
89_K120_N0.7461.00
36_I39_G0.7431.00
47_L131_V0.7431.00
161_T164_M0.7411.00
152_V155_V0.7381.00
131_V135_Y0.7321.00
131_V134_A0.7211.00
145_L154_K0.7111.00
57_L65_V0.7101.00
81_F117_Y0.7081.00
62_G148_P0.7011.00
55_I124_V0.7011.00
77_C80_E0.6951.00
85_A88_Y0.6931.00
109_A112_N0.6931.00
167_D170_N0.6921.00
137_V142_T0.6921.00
38_E155_V0.6911.00
48_E127_T0.6901.00
91_F96_V0.6901.00
36_I40_S0.6731.00
66_F98_I0.6731.00
114_M119_V0.6681.00
70_W123_V0.6681.00
61_K150_G0.6651.00
42_A146_I0.6641.00
156_V160_M0.6631.00
87_Q91_F0.6631.00
68_N84_M0.6601.00
41_D61_K0.6581.00
83_Y159_T0.6521.00
100_A123_V0.6511.00
145_L168_Y0.6511.00
110_V123_V0.6491.00
76_P140_L0.6481.00
71_G75_E0.6481.00
162_E165_I0.6481.00
60_L97_E0.6471.00
139_P142_T0.6421.00
146_I150_G0.6391.00
64_G172_I0.6381.00
91_F94_Q0.6251.00
157_T161_T0.6221.00
156_V159_T0.6201.00
70_W100_A0.6171.00
132_L137_V0.6161.00
156_V168_Y0.6151.00
83_Y87_Q0.6141.00
129_R132_L0.6121.00
129_R133_D0.6071.00
100_A119_V0.6041.00
69_F131_V0.6031.00
69_F137_V0.5941.00
72_T76_P0.5941.00
142_T157_T0.5861.00
73_W76_P0.5861.00
67_L135_Y0.5851.00
62_G147_N0.5721.00
65_V150_G0.5721.00
153_V172_I0.5621.00
42_A57_L0.5571.00
110_V113_F0.5511.00
81_F121_F0.5481.00
61_K65_V0.5451.00
74_C116_S0.5451.00
123_V126_D0.5441.00
73_W140_L0.5311.00
74_C141_P0.5301.00
145_L172_I0.5291.00
57_L135_Y0.5291.00
105_E109_A0.5281.00
80_E84_M0.5271.00
84_M143_T0.5231.00
74_C112_N0.5221.00
30_F34_E0.5141.00
165_I169_M0.5111.00
85_A117_Y0.5091.00
57_L61_K0.5091.00
168_Y172_I0.5081.00
87_Q169_M0.5081.00
48_E52_G0.5011.00
76_P159_T0.5001.00
126_D130_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hyxA 2 0.9665 100 0.282 Contact Map
3eytA 4 0.7989 100 0.322 Contact Map
3lorA 3 0.7821 100 0.324 Contact Map
2p5qA 3 0.7654 100 0.337 Contact Map
2f9sA 1 0.7765 100 0.339 Contact Map
3fw2A 2 0.7821 100 0.34 Contact Map
3hczA 2 0.8045 100 0.347 Contact Map
3eurA 1 0.7542 100 0.349 Contact Map
4nmuA 2 0.8212 100 0.349 Contact Map
2b1kA 1 0.7989 100 0.35 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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