GREMLIN Database
SPMB - Spore maturation protein B
UniProt: P35158 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 178 (170)
Sequences: 918 (590)
Seq/√Len: 45.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_F122_L6.0121.00
125_V171_V3.7791.00
28_V33_S3.4681.00
141_F152_A3.0581.00
23_G30_T2.6311.00
139_V143_A2.5801.00
137_L153_L2.5411.00
29_P32_E2.5071.00
131_D136_V2.4501.00
133_T160_D2.4021.00
157_L161_L2.2091.00
152_A156_G2.1621.00
43_E47_S2.1161.00
109_L119_I2.0510.99
62_F68_L2.0080.99
96_P133_T1.9700.99
42_I49_I1.9570.99
49_I53_V1.9370.99
21_L25_I1.9350.99
113_Y119_I1.8710.99
165_V169_I1.8220.99
99_G128_G1.7950.98
106_T110_I1.7690.98
149_M153_L1.7230.98
158_L162_I1.7210.98
60_T64_S1.6830.98
161_L175_F1.6670.98
62_F67_A1.6280.97
63_R108_D1.6000.97
115_P124_S1.5670.96
127_Q136_V1.5580.96
96_P130_T1.5450.96
151_D155_V1.5290.96
42_I46_F1.5200.96
137_L152_A1.5160.96
149_M154_K1.5000.95
18_G22_Y1.4990.95
141_F156_G1.4910.95
161_L165_V1.4900.95
94_I101_A1.4540.95
136_V156_G1.4520.94
16_I20_L1.4280.94
110_I124_S1.4040.93
133_T136_V1.4000.93
94_I102_A1.3550.92
68_L131_D1.3470.92
15_I19_I1.3470.92
87_E113_Y1.3360.92
87_E119_I1.3310.91
55_M97_I1.3270.91
91_L109_L1.3240.91
122_L127_Q1.3210.91
131_D155_V1.3160.91
78_A82_I1.2960.90
85_P88_V1.2930.90
40_E43_E1.2800.90
91_L123_A1.2680.89
91_L106_T1.2600.89
127_Q131_D1.2520.89
92_A164_V1.2520.89
92_A126_M1.2470.89
130_T163_G1.2370.88
78_A81_A1.2280.88
13_P85_P1.2050.87
92_A133_T1.1750.85
55_M138_T1.1710.85
103_L107_T1.1630.85
129_S137_L1.1520.84
102_A134_L1.1460.84
77_P81_A1.1170.82
22_Y26_K1.1120.82
91_L105_M1.0980.81
120_G124_S1.0980.81
107_T110_I1.0860.80
62_F101_A1.0850.80
56_L63_R1.0780.80
134_L156_G1.0540.78
131_D134_L1.0400.77
153_L158_L1.0240.76
79_F84_I1.0140.76
117_S120_G1.0100.75
35_V51_Y1.0100.75
97_I134_L1.0100.75
166_A170_I1.0040.75
162_I166_A0.9960.74
136_V152_A0.9940.74
84_I87_E0.9940.74
44_I57_V0.9910.74
84_I88_V0.9870.74
158_L161_L0.9790.73
133_T156_G0.9710.72
110_I130_T0.9680.72
38_G44_I0.9580.71
96_P99_G0.9520.71
46_F49_I0.9420.70
55_M152_A0.9410.70
23_G168_I0.9370.70
74_L77_P0.9370.70
44_I48_I0.9360.70
20_L23_G0.9200.68
12_I174_L0.9130.68
82_I126_M0.9020.67
95_R141_F0.8980.66
110_I120_G0.8930.66
70_F73_D0.8920.66
71_I74_L0.8920.66
68_L130_T0.8850.65
51_Y55_M0.8840.65
6_W161_L0.8810.65
80_S86_A0.8810.65
13_P61_V0.8730.64
108_D112_V0.8720.64
45_A49_I0.8680.64
30_T38_G0.8680.64
40_E151_D0.8530.62
92_A96_P0.8500.62
154_K158_L0.8450.62
154_K171_V0.8320.60
133_T152_A0.8280.60
98_S159_A0.8220.59
28_V67_A0.8200.59
96_P104_G0.8200.59
48_I163_G0.8180.59
116_D120_G0.8150.59
47_S139_V0.8130.59
104_G134_L0.8090.58
54_G97_I0.8060.58
131_D139_V0.8050.58
80_S158_L0.8010.57
52_L63_R0.7990.57
133_T137_L0.7950.57
18_G33_S0.7930.57
94_I104_G0.7900.56
110_I115_P0.7870.56
131_D138_T0.7840.56
10_A95_R0.7750.55
55_M136_V0.7710.55
75_L80_S0.7510.53
137_L160_D0.7510.53
17_A24_T0.7480.52
75_L89_V0.7450.52
55_M104_G0.7450.52
106_T131_D0.7410.52
7_L94_I0.7390.51
127_Q133_T0.7330.51
76_K170_I0.7280.50
122_L171_V0.7240.50
34_F114_G0.7190.50
7_L11_M0.7170.49
118_F172_T0.7110.49
95_R102_A0.7050.48
75_L79_F0.7020.48
76_K80_S0.7010.48
95_R155_V0.6990.48
150_G155_V0.6970.47
77_P85_P0.6950.47
91_L103_L0.6950.47
9_L95_R0.6910.47
109_L123_A0.6910.47
31_Y137_L0.6840.46
38_G58_A0.6820.46
55_M61_V0.6800.46
99_G160_D0.6750.45
59_I110_I0.6740.45
44_I121_R0.6740.45
10_A13_P0.6720.45
51_Y97_I0.6710.45
44_I131_D0.6680.45
95_R172_T0.6670.44
13_P95_R0.6590.44
9_L88_V0.6580.44
109_L115_P0.6570.44
38_G139_V0.6530.43
147_K169_I0.6530.43
55_M156_G0.6500.43
9_L16_I0.6490.43
71_I124_S0.6480.43
31_Y130_T0.6480.43
122_L156_G0.6460.42
55_M129_S0.6460.42
7_L167_S0.6440.42
23_G166_A0.6440.42
97_I101_A0.6410.42
89_V168_I0.6410.42
29_P33_S0.6380.42
102_A106_T0.6380.42
93_L134_L0.6370.42
121_R175_F0.6330.41
106_T127_Q0.6290.41
27_K39_K0.6280.41
55_M60_T0.6270.41
99_G142_G0.6210.40
93_L107_T0.6060.39
85_P119_I0.6010.38
30_T149_M0.6010.38
21_L43_E0.5990.38
54_G94_I0.5990.38
123_A158_L0.5930.38
31_Y83_G0.5930.38
24_T70_F0.5930.38
112_V174_L0.5800.36
109_L164_V0.5790.36
61_V169_I0.5780.36
62_F71_I0.5780.36
10_A23_G0.5760.36
14_I17_A0.5760.36
48_I149_M0.5760.36
44_I117_S0.5650.35
96_P160_D0.5630.35
107_T111_A0.5630.35
170_I173_L0.5630.35
7_L153_L0.5620.35
32_E48_I0.5580.34
60_T63_R0.5550.34
51_Y134_L0.5540.34
101_A148_K0.5520.34
108_D111_A0.5510.34
26_K81_A0.5490.34
60_T131_D0.5490.34
6_W14_I0.5480.33
122_L168_I0.5480.33
27_K77_P0.5470.33
16_I79_F0.5460.33
91_L131_D0.5430.33
130_T139_V0.5420.33
145_G149_M0.5400.33
73_D173_L0.5400.33
103_L127_Q0.5360.32
121_R124_S0.5350.32
98_S102_A0.5300.32
61_V170_I0.5290.32
97_I125_V0.5280.32
99_G132_T0.5260.32
94_I118_F0.5250.32
12_I76_K0.5240.31
153_L157_L0.5240.31
63_R141_F0.5230.31
24_T30_T0.5220.31
114_G120_G0.5210.31
91_L164_V0.5170.31
36_E39_K0.5150.31
137_L155_V0.5150.31
56_L85_P0.5140.31
10_A14_I0.5120.30
125_V174_L0.5110.30
51_Y114_G0.5110.30
103_L145_G0.5110.30
79_F124_S0.5090.30
124_S130_T0.5050.30
70_F74_L0.5050.30
23_G121_R0.5050.30
56_L60_T0.5040.30
44_I56_L0.5040.30
7_L17_A0.5030.30
24_T32_E0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pd6A 3 0.8876 90 0.925 Contact Map
4r0cA 3 0.9494 82.5 0.933 Contact Map
4r1iA 2 0.9551 58.4 0.944 Contact Map
4f35D 2 0.9157 16.9 0.958 Contact Map
3nd0A 2 0.2416 9.5 0.963 Contact Map
2a65A 2 0.3876 4.7 0.967 Contact Map
1jb0L 1 0.3876 4.3 0.968 Contact Map
2l6wA 2 0.1798 3.9 0.969 Contact Map
4ev6A 3 0.3371 3.7 0.969 Contact Map
4xk8L 1 0.3989 3.6 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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