GREMLIN Database
SPMA - Spore maturation protein A
UniProt: P35157 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 196 (189)
Sequences: 895 (569)
Seq/√Len: 41.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_K59_E4.4581.00
117_Q120_K4.0241.00
81_D131_S3.1851.00
86_H121_L3.0511.00
82_I118_M2.9661.00
81_D130_R2.9631.00
141_S177_G2.9571.00
119_K126_S2.8701.00
82_I131_S2.8081.00
137_A180_A2.7521.00
83_P86_H2.7471.00
83_P121_L2.6351.00
165_I169_S2.5851.00
130_R188_Y2.5751.00
8_S12_I2.2181.00
159_S164_D2.1720.99
100_F170_I2.1070.99
91_Y117_Q2.0840.99
142_C176_S2.0750.99
78_L181_I2.0360.99
66_I69_R2.0100.99
82_I121_L1.9880.99
28_E32_K1.9450.99
38_I45_M1.9280.99
18_M23_L1.8720.98
35_K39_T1.8670.98
76_S84_P1.7830.98
122_N125_R1.7570.98
63_L66_I1.7200.97
124_N127_E1.7050.97
174_L178_I1.6640.97
141_S172_A1.6620.97
82_I86_H1.6530.97
161_T164_D1.6440.96
113_K116_E1.6090.96
4_I8_S1.5520.95
22_T25_D1.5470.95
135_F141_S1.5400.95
112_I118_M1.5170.94
134_T184_D1.4700.93
106_A109_P1.4590.93
20_N170_I1.4580.93
112_I145_L1.4530.93
182_I186_Y1.4520.93
91_Y94_S1.4310.92
179_G183_I1.3820.91
24_Q28_E1.3810.91
75_I89_M1.3780.91
150_V169_S1.3610.90
103_L109_P1.3300.89
134_T181_I1.3280.89
88_A118_M1.2840.88
49_V170_I1.2700.87
87_P121_L1.2450.86
96_L142_C1.2330.85
119_K122_N1.2260.85
83_P87_P1.2200.85
2_V6_W1.2200.85
185_R188_Y1.2120.84
163_T173_T1.2110.84
50_F101_F1.2030.84
173_T176_S1.1960.84
72_R85_D1.1670.82
140_T187_F1.1630.82
80_P112_I1.1440.81
17_A26_V1.1440.81
142_C170_I1.1420.81
74_F78_L1.1420.81
61_S66_I1.1390.81
134_T185_R1.1360.80
103_L106_A1.1320.80
181_I185_R1.1320.80
141_S173_T1.1190.79
38_I142_C1.1130.79
7_V11_V1.1100.79
64_L94_S1.1090.79
170_I174_L1.1090.79
94_S130_R1.1070.79
88_A117_Q1.1030.78
95_N139_N1.0960.78
172_A177_G1.0920.78
8_S65_D1.0800.77
89_M181_I1.0800.77
148_T156_A1.0410.74
44_L105_N1.0400.74
168_P171_L1.0360.74
27_N30_V1.0280.73
142_C177_G1.0200.73
18_M167_G1.0150.72
16_F20_N1.0150.72
96_L138_V1.0070.72
141_S176_S1.0010.71
125_R129_S0.9930.71
151_I163_T0.9910.70
13_G167_G0.9750.69
47_V152_A0.9710.69
2_V101_F0.9700.69
184_D188_Y0.9690.69
85_D182_I0.9690.69
148_T153_V0.9590.68
77_K133_I0.9590.68
170_I173_T0.9590.68
13_G184_D0.9560.68
92_I118_M0.9550.68
95_N107_A0.9530.67
50_F54_L0.9490.67
136_L163_T0.9460.67
26_V67_F0.9410.66
152_A170_I0.9400.66
153_V156_A0.9310.66
144_T184_D0.9310.66
59_E65_D0.9300.65
159_S162_P0.9120.64
51_W139_N0.9110.64
122_N126_S0.8960.63
158_S162_P0.8910.62
96_L100_F0.8900.62
134_T188_Y0.8900.62
32_K35_K0.8860.62
37_A162_P0.8800.61
46_S49_V0.8780.61
60_Q65_D0.8740.61
72_R84_P0.8620.60
115_M132_M0.8580.59
65_D69_R0.8570.59
48_L52_L0.8540.59
9_L13_G0.8520.59
46_S50_F0.8400.58
121_L125_R0.8360.57
27_N64_L0.8140.55
135_F177_G0.8000.54
51_W110_L0.7960.53
121_L129_S0.7950.53
166_V185_R0.7940.53
59_E90_G0.7930.53
129_S157_Y0.7930.53
31_F110_L0.7910.53
136_L173_T0.7910.53
14_L23_L0.7870.53
11_V15_V0.7820.52
82_I122_N0.7810.52
167_G171_L0.7750.52
82_I88_A0.7660.51
137_A167_G0.7620.50
134_T166_V0.7570.50
168_P173_T0.7550.50
93_L137_A0.7530.49
130_R189_Y0.7510.49
45_M52_L0.7470.49
41_S52_L0.7460.49
3_N6_W0.7450.49
2_V13_G0.7450.49
22_T26_V0.7440.49
105_N153_V0.7400.48
54_L113_K0.7390.48
55_M58_A0.7340.48
6_W170_I0.7340.48
9_L141_S0.7330.48
48_L91_Y0.7320.47
72_R150_V0.7320.47
159_S165_I0.7300.47
92_I132_M0.7300.47
46_S184_D0.7290.47
122_N131_S0.7240.47
11_V25_D0.7230.47
7_V37_A0.7160.46
8_S15_V0.7140.46
144_T154_R0.7110.46
112_I116_E0.7050.45
54_L58_A0.7050.45
10_T22_T0.7040.45
9_L20_N0.7020.45
131_S144_T0.6960.44
151_I159_S0.6960.44
47_V50_F0.6930.44
186_Y189_Y0.6910.44
183_I187_F0.6880.43
32_K179_G0.6870.43
16_F138_V0.6860.43
26_V169_S0.6860.43
87_P117_Q0.6840.43
14_L17_A0.6790.43
37_A155_M0.6780.43
44_L94_S0.6740.42
138_V177_G0.6740.42
119_K123_G0.6720.42
142_C172_A0.6720.42
178_I182_I0.6710.42
98_A109_P0.6700.42
83_P115_M0.6640.41
93_L142_C0.6600.41
74_F118_M0.6590.41
23_L163_T0.6550.40
136_L172_A0.6530.40
173_T181_I0.6510.40
81_D188_Y0.6470.40
4_I7_V0.6460.40
164_D168_P0.6450.40
151_I165_I0.6430.39
48_L157_Y0.6420.39
112_I135_F0.6390.39
128_A136_L0.6390.39
81_D161_T0.6370.39
3_N31_F0.6300.38
130_R185_R0.6290.38
6_W57_I0.6280.38
69_R186_Y0.6270.38
54_L65_D0.6260.38
128_A133_I0.6240.38
77_K181_I0.6230.38
33_G135_F0.6220.38
19_C160_K0.6180.37
100_F180_A0.6160.37
75_I93_L0.6150.37
142_C151_I0.6140.37
33_G141_S0.6120.37
5_I161_T0.6100.36
36_E39_T0.6100.36
30_V150_V0.6090.36
29_A43_G0.6070.36
136_L177_G0.6050.36
46_S94_S0.5990.36
91_Y110_L0.5990.36
15_V183_I0.5980.35
96_L130_R0.5970.35
89_M137_A0.5960.35
34_A96_L0.5950.35
123_G127_E0.5950.35
100_F136_L0.5940.35
34_A70_M0.5930.35
47_V149_T0.5930.35
142_C173_T0.5920.35
36_E97_M0.5900.35
70_M127_E0.5850.34
55_M152_A0.5850.34
70_M125_R0.5810.34
51_W180_A0.5730.33
31_F58_A0.5670.33
42_F74_F0.5660.33
91_Y120_K0.5650.33
112_I134_T0.5630.32
52_L87_P0.5630.32
27_N149_T0.5620.32
38_I161_T0.5590.32
21_G30_V0.5580.32
27_N104_G0.5570.32
130_R184_D0.5550.32
79_F151_I0.5550.32
150_V165_I0.5540.32
110_L135_F0.5540.32
28_E49_V0.5530.32
162_P165_I0.5520.32
65_D138_V0.5500.31
81_D129_S0.5480.31
38_I77_K0.5470.31
51_W92_I0.5450.31
97_M110_L0.5420.31
168_P184_D0.5350.30
153_V165_I0.5300.30
89_M93_L0.5290.30
20_N157_Y0.5260.30
79_F132_M0.5260.30
33_G42_F0.5250.29
95_N111_G0.5230.29
57_I65_D0.5220.29
143_I153_V0.5210.29
146_I161_T0.5210.29
104_G185_R0.5200.29
15_V25_D0.5170.29
152_A175_I0.5160.29
104_G132_M0.5160.29
45_M60_Q0.5140.29
82_I92_I0.5120.28
33_G143_I0.5110.28
52_L86_H0.5090.28
140_T144_T0.5070.28
48_L110_L0.5070.28
39_T43_G0.5070.28
105_N140_T0.5060.28
153_V158_S0.5030.28
48_L79_F0.5030.28
160_K182_I0.5030.28
34_A37_A0.5010.28
2_V152_A0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pd6A 3 0.8673 64.8 0.948 Contact Map
4f35D 2 0.898 51.6 0.952 Contact Map
4r1iA 2 0.8827 38.4 0.956 Contact Map
2kluA 1 0.199 30.1 0.958 Contact Map
2kv5A 1 0.1684 29.9 0.958 Contact Map
2m20A 2 0.1837 19.6 0.962 Contact Map
2ks1B 1 0.2194 12.9 0.965 Contact Map
4n7wA 2 0.8724 9.5 0.967 Contact Map
4b19A 1 0.1531 9.3 0.967 Contact Map
2mofA 1 0.1939 8.7 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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