GREMLIN Database
YPUI - Uncharacterized protein YpuI
UniProt: P35156 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 179 (155)
Sequences: 103 (76)
Seq/√Len: 6.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_N76_A3.0010.79
79_C82_G2.8180.74
89_L103_T2.6490.69
70_S80_E2.5920.67
65_C69_L2.5300.65
69_L78_F2.3690.60
74_R96_Q2.2960.57
106_N114_E2.2200.55
32_G66_C2.1830.53
31_T107_V2.1490.52
51_L69_L2.1210.51
87_R167_H2.0960.50
93_E99_R2.0530.49
158_F164_E2.0080.47
68_V96_Q1.9110.44
53_S59_P1.8730.42
43_N66_C1.8470.41
51_L88_R1.7740.39
105_Y133_G1.7680.39
48_Q52_E1.7340.38
29_Q108_Y1.7270.37
42_V111_C1.7160.37
95_F132_T1.6970.36
68_V155_S1.6710.35
142_A145_A1.6180.34
98_A167_H1.6120.34
154_L158_F1.5910.33
68_V151_L1.5880.33
86_C112_I1.5700.32
139_F151_L1.5690.32
70_S107_V1.5590.32
26_A106_N1.5560.32
61_E141_H1.5250.31
22_S42_V1.5190.31
20_G93_E1.4800.29
37_M151_L1.4610.29
24_V130_S1.4520.29
36_S87_R1.4390.28
79_C170_A1.4320.28
84_E117_M1.4280.28
56_A99_R1.4160.28
21_H170_A1.4110.27
37_M59_P1.4030.27
67_D76_A1.3890.27
31_T164_E1.3680.26
54_L69_L1.3650.26
84_E88_R1.3610.26
79_C94_P1.3440.26
72_L103_T1.3230.25
76_A80_E1.3110.25
70_S106_N1.2990.24
46_L111_C1.2990.24
45_Y53_S1.2930.24
45_Y69_L1.2880.24
45_Y60_I1.2870.24
20_G114_E1.2710.24
68_V143_V1.2680.24
43_N116_F1.2450.23
30_K96_Q1.2430.23
43_N70_S1.2390.23
92_Q156_A1.2330.23
101_E168_Y1.2250.22
142_A147_L1.2210.22
75_M172_G1.2090.22
45_Y150_L1.2000.22
43_N142_A1.1950.22
145_A149_Q1.1680.21
72_L100_A1.1540.21
29_Q148_E1.1360.20
97_E114_E1.1210.20
143_V161_M1.1170.20
32_G58_L1.1150.20
64_Y136_A1.1020.20
36_S120_K1.0880.19
44_D62_K1.0810.19
123_W127_S1.0760.19
67_D145_A1.0750.19
41_T147_L1.0730.19
99_R170_A1.0660.19
40_N149_Q1.0590.19
123_W159_L1.0570.19
102_K114_E1.0530.18
89_L141_H1.0460.18
30_K43_N1.0380.18
127_S159_L1.0370.18
27_Q114_E1.0200.18
40_N44_D1.0190.18
54_L120_K1.0090.18
78_F142_A1.0040.17
81_G155_S1.0040.17
155_S159_L1.0020.17
70_S113_E0.9760.17
121_D127_S0.9750.17
45_Y84_E0.9640.17
42_V72_L0.9580.16
59_P140_Y0.9550.16
43_N96_Q0.9450.16
37_M141_H0.9370.16
37_M107_V0.9290.16
98_A156_A0.9260.16
119_K172_G0.9200.16
108_Y133_G0.9170.16
107_V115_F0.9150.16
27_Q155_S0.9090.16
54_L91_M0.9080.16
40_N63_G0.9050.15
38_V42_V0.9020.15
121_D159_L0.9010.15
68_V74_R0.8990.15
40_N164_E0.8900.15
33_E72_L0.8750.15
95_F109_H0.8680.15
61_E72_L0.8650.15
21_H114_E0.8640.15
55_Q58_L0.8630.15
24_V82_G0.8580.15
65_C133_G0.8150.14
68_V163_E0.8040.14
28_T68_V0.7980.14
21_H93_E0.7920.13
138_E173_S0.7860.13
70_S158_F0.7840.13
65_C105_Y0.7790.13
36_S45_Y0.7730.13
123_W129_A0.7730.13
50_T100_A0.7710.13
30_K50_T0.7610.13
31_T117_M0.7600.13
29_Q134_V0.7580.13
32_G51_L0.7580.13
111_C158_F0.7570.13
39_V79_C0.7570.13
57_E60_I0.7520.13
42_V164_E0.7500.13
64_Y142_A0.7500.13
111_C122_T0.7330.13
142_A149_Q0.7310.12
65_C88_R0.7210.12
22_S63_G0.7200.12
37_M63_G0.7190.12
50_T143_V0.7190.12
55_Q63_G0.7140.12
83_A159_L0.7110.12
123_W155_S0.7090.12
111_C147_L0.7080.12
108_Y119_K0.7040.12
90_L147_L0.7000.12
46_L140_Y0.7000.12
67_D161_M0.6970.12
72_L153_P0.6950.12
60_I65_C0.6950.12
62_K145_A0.6910.12
68_V154_L0.6900.12
88_R99_R0.6900.12
44_D149_Q0.6830.12
34_F154_L0.6800.12
81_G159_L0.6790.12
24_V89_L0.6790.12
130_S138_E0.6770.12
121_D129_A0.6760.12
155_S163_E0.6760.12
23_I28_T0.6750.12
71_T134_V0.6560.11
59_P112_I0.6530.11
94_P105_Y0.6530.11
89_L110_Q0.6520.11
49_T160_K0.6480.11
36_S83_A0.6460.11
96_Q124_C0.6460.11
66_C116_F0.6270.11
41_T146_S0.6230.11
28_T84_E0.6230.11
101_E165_L0.6170.11
38_V54_L0.6090.11
26_A58_L0.6080.11
62_K155_S0.6070.11
62_K98_A0.6060.11
123_W163_E0.6040.11
40_N56_A0.6040.11
89_L102_K0.6030.11
37_M52_E0.6020.11
105_Y119_K0.6000.11
25_R111_C0.5990.11
33_E48_Q0.5970.11
24_V110_Q0.5950.10
84_E107_V0.5950.10
51_L133_G0.5940.10
126_N138_E0.5940.10
67_D87_R0.5920.10
96_Q151_L0.5890.10
64_Y78_F0.5880.10
79_C158_F0.5860.10
59_P89_L0.5860.10
30_K90_L0.5850.10
51_L65_C0.5850.10
157_A164_E0.5830.10
109_H168_Y0.5820.10
25_R154_L0.5770.10
39_V48_Q0.5710.10
83_A129_A0.5690.10
86_C106_N0.5670.10
41_T112_I0.5650.10
80_E132_T0.5580.10
40_N48_Q0.5570.10
50_T122_T0.5530.10
78_F91_M0.5520.10
138_E170_A0.5500.10
26_A99_R0.5500.10
102_K143_V0.5440.10
89_L150_L0.5410.10
29_Q107_V0.5400.10
102_K142_A0.5370.10
129_A135_S0.5320.10
31_T136_A0.5270.10
45_Y79_C0.5270.10
27_Q123_W0.5260.10
121_D163_E0.5250.10
71_T83_A0.5230.10
115_F137_I0.5230.10
30_K117_M0.5210.10
120_K172_G0.5190.10
55_Q153_P0.5180.09
147_L152_L0.5160.09
86_C113_E0.5150.09
132_T171_S0.5140.09
27_Q129_A0.5140.09
41_T67_D0.5110.09
121_D155_S0.5080.09
65_C76_A0.5050.09
43_N79_C0.5030.09
99_R103_T0.5000.09
57_E72_L0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ov9A 2 0.2123 9.4 0.969 Contact Map
4nqiA 2 0.6089 8.1 0.97 Contact Map
4wyqA 1 0.5754 7.9 0.97 Contact Map
1pd3A 2 0.2905 7.2 0.971 Contact Map
2y75A 5 0.3184 6.6 0.971 Contact Map
4aurA 1 0.4246 6.4 0.972 Contact Map
2k0mA 1 0.4972 6.3 0.972 Contact Map
3iqtA 1 0.2346 6 0.972 Contact Map
3zqsA 3 0.514 5.6 0.972 Contact Map
1gs9A 1 0.3184 4.9 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0068 seconds.