GREMLIN Database
SCPB - Segregation and condensation protein B
UniProt: P35155 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 197 (170)
Sequences: 2859 (1905)
Seq/√Len: 146.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_V149_G5.5621.00
9_K50_E4.5871.00
9_K46_D3.4491.00
11_I78_Y2.8191.00
14_A75_F2.7091.00
10_A75_F2.5871.00
138_R146_I2.4551.00
62_E161_K2.4441.00
50_E56_R2.4431.00
113_E120_S2.2351.00
60_L69_L2.1821.00
161_K165_E2.0201.00
8_W43_I1.9741.00
59_E72_K1.9691.00
47_V51_Y1.9621.00
36_E39_E1.9461.00
13_E51_Y1.9421.00
135_E146_I1.9251.00
150_T155_L1.8651.00
15_L24_L1.7951.00
131_A153_T1.7751.00
105_Q150_T1.7631.00
25_T28_Q1.7521.00
103_Y167_P1.7431.00
12_V43_I1.7311.00
45_A48_A1.6851.00
26_K41_N1.6781.00
111_E139_A1.6551.00
68_M156_E1.6461.00
142_P145_A1.6301.00
29_L40_L1.6271.00
61_I70_S1.6001.00
23_G66_T1.5991.00
162_T165_E1.5961.00
134_C149_G1.5771.00
91_S94_S1.5561.00
128_V133_L1.5421.00
26_K40_L1.5401.00
107_I111_E1.5361.00
30_L40_L1.5291.00
62_E67_Y1.5251.00
101_V124_L1.4901.00
9_K43_I1.4901.00
43_I46_D1.4531.00
34_E81_K1.4441.00
62_E65_D1.4031.00
28_Q31_T1.4011.00
14_A79_L1.3891.00
48_A60_L1.3731.00
33_L40_L1.3731.00
35_I40_L1.3661.00
13_E56_R1.3501.00
100_I115_I1.3331.00
44_M60_L1.3221.00
22_E28_Q1.3041.00
41_N62_E1.2931.00
105_Q163_L1.2891.00
137_G147_L1.2851.00
52_R72_K1.2731.00
45_A49_D1.2371.00
48_A62_E1.2251.00
27_K37_E1.2241.00
16_L69_L1.2161.00
17_Y58_I1.2141.00
168_P171_E1.2131.00
49_D52_R1.1931.00
153_T156_E1.1851.00
140_D144_R1.1841.00
112_I124_L1.1581.00
26_K67_Y1.1531.00
101_V133_L1.1410.99
15_L82_L1.1370.99
46_D49_D1.1300.99
42_T45_A1.0850.99
126_S130_K1.0600.99
57_G75_F1.0600.99
54_D72_K1.0590.99
104_K111_E1.0540.99
39_E42_T1.0520.99
100_I107_I1.0510.99
97_V118_V1.0370.99
52_R59_E1.0370.99
8_W35_I1.0240.99
50_E54_D1.0230.99
141_G145_A1.0200.99
41_N45_A1.0180.99
102_S154_F1.0120.99
72_K75_F1.0030.99
63_Y66_T0.9970.99
10_A72_K0.9750.98
15_L32_V0.9730.98
17_Y71_T0.9540.98
78_Y82_L0.9440.98
57_G71_T0.9420.98
16_L24_L0.9410.98
139_A145_A0.9330.98
154_F158_F0.9130.98
17_Y69_L0.9130.98
104_K115_I0.9080.97
134_C151_T0.9080.97
23_G129_A0.9060.97
24_L29_L0.9050.97
59_E73_K0.9050.97
15_L29_L0.9030.97
105_Q149_G0.8950.97
42_T46_D0.8820.97
48_A52_R0.8810.97
63_Y68_M0.8790.97
51_Y69_L0.8780.97
12_V29_L0.8740.97
108_T145_A0.8730.97
27_K31_T0.8720.97
25_T66_T0.8710.97
26_K62_E0.8680.97
35_I39_E0.8650.97
105_Q155_L0.8570.96
20_G23_G0.8540.96
73_K77_P0.8460.96
141_G147_L0.8450.96
10_A57_G0.8440.96
123_I126_S0.8360.96
90_L94_S0.8350.96
19_A24_L0.8300.96
12_V40_L0.8220.95
11_I14_A0.8190.95
46_D50_E0.8160.95
97_V120_S0.8130.95
32_V82_L0.8040.95
39_E43_I0.8010.95
124_L133_L0.8000.95
135_E148_Y0.7990.95
109_R121_E0.7970.95
93_A109_R0.7920.94
124_L148_Y0.7810.94
13_E57_G0.7760.94
37_E41_N0.7740.94
40_L43_I0.7700.94
18_A82_L0.7670.93
65_D161_K0.7630.93
17_Y51_Y0.7570.93
51_Y58_I0.7490.93
18_A71_T0.7440.92
158_F167_P0.7440.92
93_A122_R0.7420.92
137_G145_A0.7340.92
12_V44_M0.7330.92
23_G68_M0.7330.92
26_K30_L0.7100.90
171_E175_E0.7050.90
134_C152_P0.7040.90
109_R148_Y0.6990.90
10_A74_D0.6960.90
94_S123_I0.6940.89
153_T157_Q0.6920.89
100_I113_E0.6920.89
7_N75_F0.6910.89
27_K30_L0.6910.89
17_Y158_F0.6880.89
11_I75_F0.6870.89
7_N55_T0.6790.88
137_G149_G0.6790.88
105_Q108_T0.6730.88
119_K122_R0.6680.88
64_A152_P0.6680.88
9_K56_R0.6660.87
55_T72_K0.6660.87
24_L82_L0.6650.87
68_M151_T0.6630.87
30_L37_E0.6400.85
43_I47_V0.6340.85
25_T65_D0.6300.84
120_S124_L0.6290.84
35_I43_I0.6260.84
50_E55_T0.6220.84
15_L79_L0.6210.84
24_L32_V0.6200.83
14_A57_G0.6190.83
15_L19_A0.6180.83
48_A67_Y0.6160.83
106_P147_L0.6150.83
94_S122_R0.6130.83
63_Y150_T0.6100.82
64_A68_M0.6080.82
137_G143_G0.6070.82
31_T55_T0.6060.82
57_G60_L0.6040.82
96_E118_V0.6030.82
45_A67_Y0.6030.82
18_A80_K0.6030.82
128_V135_E0.6000.81
171_E174_E0.5990.81
25_T41_N0.5940.81
96_E113_E0.5910.80
160_L167_P0.5910.80
11_I32_V0.5870.80
90_L132_L0.5810.79
44_M48_A0.5780.79
88_K125_H0.5780.79
44_M67_Y0.5750.79
119_K132_L0.5730.78
9_K47_V0.5720.78
140_D147_L0.5710.78
172_N175_E0.5640.77
11_I57_G0.5630.77
23_G156_E0.5630.77
143_G146_I0.5600.77
84_E170_P0.5590.77
121_E148_Y0.5570.76
7_N74_D0.5550.76
22_E88_K0.5540.76
109_R113_E0.5540.76
30_L34_E0.5530.76
146_I149_G0.5480.75
96_E112_I0.5480.75
110_A142_P0.5470.75
15_L134_C0.5470.75
112_I177_V0.5470.75
144_R159_G0.5460.75
129_A141_G0.5450.75
96_E116_R0.5440.75
89_G97_V0.5430.75
87_S121_E0.5410.74
110_A124_L0.5390.74
11_I81_K0.5390.74
15_L33_L0.5380.74
168_P172_N0.5370.74
65_D121_E0.5350.74
34_E42_T0.5320.73
89_G130_K0.5280.73
119_K138_R0.5270.72
61_I159_G0.5270.72
112_I120_S0.5250.72
44_M93_A0.5250.72
115_I118_V0.5250.72
16_L151_T0.5200.71
103_Y155_L0.5200.71
136_V147_L0.5200.71
89_G112_I0.5190.71
7_N52_R0.5180.71
20_G66_T0.5170.71
89_G110_A0.5160.71
93_A116_R0.5160.71
26_K44_M0.5150.71
51_Y56_R0.5120.70
105_Q159_G0.5120.70
174_E177_V0.5100.70
155_L163_L0.5100.70
110_A113_E0.5070.70
114_E170_P0.5070.70
132_L157_Q0.5060.69
79_L130_K0.5050.69
79_L83_I0.5040.69
173_A178_L0.5040.69
66_T152_P0.5010.69
56_R69_L0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w6jB 2 0.8477 100 0.098 Contact Map
2z99A 2 0.8071 100 0.118 Contact Map
4i98B 2 0.8325 100 0.127 Contact Map
1t6sA 4 0.8071 100 0.161 Contact Map
3w6kB 2 0.4416 99.8 0.688 Contact Map
1p4xA 1 0.8934 96.7 0.885 Contact Map
4asnA 2 0.401 94.7 0.902 Contact Map
2k4bA 1 0.3147 93.8 0.906 Contact Map
1okrA 2 0.5482 93.8 0.906 Contact Map
1p6rA 1 0.3807 93.6 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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