GREMLIN Database
SCPA - Segregation and condensation protein A
UniProt: P35154 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 251 (228)
Sequences: 2752 (1834)
Seq/√Len: 121.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
189_V228_L4.8031.00
235_H238_S4.1691.00
7_K12_E3.9101.00
198_R243_T3.5021.00
11_F20_H3.3671.00
195_R203_D3.3291.00
224_M231_I3.3171.00
36_K39_E2.9241.00
23_N105_R2.8951.00
202_M239_D2.8471.00
180_P183_A2.8241.00
184_R187_E2.7681.00
184_R212_H2.7361.00
184_R216_T2.5871.00
149_T152_D2.5751.00
95_E99_E2.5501.00
94_R98_I2.3801.00
200_N239_D2.3411.00
189_V223_L2.2061.00
103_E106_K2.1441.00
48_M55_I2.1321.00
191_S195_R2.1301.00
230_L243_T2.1211.00
127_K130_S2.1191.00
185_M223_L2.0901.00
220_V229_V2.0901.00
27_I33_P1.9891.00
10_T27_I1.9431.00
109_D113_D1.8561.00
208_E212_H1.8011.00
61_V65_T1.7631.00
233_Q237_F1.7291.00
29_I69_I1.7241.00
198_R241_Y1.7161.00
233_Q240_I1.7051.00
20_H24_R1.6891.00
96_E100_K1.6441.00
43_L47_T1.6421.00
39_E43_L1.6391.00
47_T50_V1.6091.00
73_M94_R1.5741.00
34_V37_I1.5571.00
200_N203_D1.5481.00
152_D155_G1.5441.00
229_V242_I1.5411.00
115_K119_E1.5231.00
5_Q12_E1.5051.00
28_D31_D1.4941.00
109_D112_K1.4891.00
220_V242_I1.4861.00
46_H49_R1.4841.00
33_P98_I1.4831.00
30_Y102_I1.4701.00
195_R199_I1.4471.00
157_F161_L1.4441.00
22_I28_D1.4381.00
232_E243_T1.3851.00
113_D117_R1.3761.00
94_R102_I1.3721.00
115_K118_E1.3711.00
31_D94_R1.3671.00
19_L101_L1.3271.00
199_I203_D1.3051.00
183_A187_E1.2971.00
25_L36_K1.2791.00
105_R223_L1.2741.00
35_A39_E1.2611.00
69_I98_I1.2591.00
57_S67_L1.2520.99
193_K244_G1.2480.99
45_V55_I1.2410.99
179_I212_H1.2260.99
132_L135_Y1.2210.99
155_G159_K1.2170.99
32_I94_R1.2110.99
116_E119_E1.2100.99
44_Y48_M1.1950.99
230_L245_S1.1880.99
197_T244_G1.1730.99
200_N241_Y1.1720.99
181_I192_L1.1650.99
49_R56_A1.1610.99
209_Q212_H1.1460.99
131_D135_Y1.1440.99
68_S71_S1.1310.99
220_V231_I1.1260.99
179_I184_R1.1260.99
8_I11_F1.1250.99
68_S72_R1.1190.99
182_E185_M1.1040.99
191_S203_D1.1010.99
51_L56_A1.0980.99
73_M93_P1.0960.99
15_L62_M1.0660.98
179_I215_V1.0620.98
127_K133_S1.0510.98
52_E55_I1.0440.98
30_Y33_P1.0410.98
69_I93_P1.0390.98
20_H41_Y1.0370.98
150_V154_I1.0310.98
49_R55_I1.0250.98
7_K48_M1.0240.98
188_I220_V1.0140.98
31_D93_P1.0070.98
52_E59_Y1.0060.98
204_L242_I0.9950.97
113_D116_E0.9890.97
99_E103_E0.9890.97
154_I158_Q0.9890.97
25_L40_Q0.9870.97
120_E123_K0.9840.97
159_K162_K0.9810.97
98_I102_I0.9780.97
6_V148_V0.9720.97
175_T192_L0.9600.97
41_Y61_V0.9580.97
73_M98_I0.9490.97
48_M51_L0.9460.96
191_S204_L0.9450.96
31_D34_V0.9370.96
185_M226_N0.9350.96
33_P36_K0.9290.96
129_P132_L0.9220.96
53_L56_A0.9210.96
44_Y217_F0.9170.96
185_M219_A0.9040.95
222_E225_K0.9040.95
38_T45_V0.9020.95
34_V62_M0.9010.95
238_S241_Y0.9010.95
19_L23_N0.9000.95
192_L229_V0.8990.95
6_V10_T0.8930.95
23_N59_Y0.8890.95
119_E122_Q0.8750.95
152_D156_A0.8740.95
74_L204_L0.8650.94
18_L233_Q0.8640.94
105_R109_D0.8620.94
189_V193_K0.8620.94
33_P94_R0.8580.94
198_R232_E0.8570.94
104_Y108_K0.8550.94
191_S199_I0.8510.94
158_Q162_K0.8510.94
191_S207_Y0.8430.93
22_I29_I0.8420.93
187_E191_S0.8380.93
207_Y218_L0.8370.93
33_P93_P0.8270.93
82_L88_L0.8260.93
211_E215_V0.8240.93
127_K131_D0.8210.92
14_P17_L0.8180.92
193_K228_L0.8130.92
223_L228_L0.8110.92
57_S100_K0.8080.92
149_T226_N0.8060.92
48_M53_L0.8060.92
97_L101_L0.8010.92
76_P222_E0.7940.91
184_R215_V0.7900.91
22_I98_I0.7900.91
15_L19_L0.7900.91
11_F17_L0.7810.90
37_I210_K0.7800.90
37_I157_F0.7790.90
27_I154_I0.7760.90
34_V67_L0.7730.90
34_V59_Y0.7690.90
176_R180_P0.7670.90
134_E200_N0.7670.90
61_V125_F0.7640.89
71_S91_E0.7630.89
151_Y154_I0.7610.89
4_Y109_D0.7570.89
32_I98_I0.7560.89
111_A114_L0.7550.89
101_L219_A0.7530.89
29_I222_E0.7480.88
33_P73_M0.7470.88
91_E96_E0.7400.88
24_R222_E0.7380.88
56_A219_A0.7370.88
92_D96_E0.7350.88
189_V244_G0.7350.88
192_L244_G0.7320.87
32_I35_A0.7290.87
188_I219_A0.7240.87
40_Q152_D0.7180.86
188_I223_L0.7160.86
177_Q215_V0.7160.86
100_K111_A0.7150.86
181_I219_A0.7140.86
129_P201_F0.7130.86
38_T94_R0.7120.86
12_E108_K0.7120.86
25_L52_E0.7110.86
114_L117_R0.7110.86
72_R98_I0.7100.86
82_L128_P0.7060.85
204_L220_V0.7060.85
42_L78_Q0.7020.85
181_I226_N0.6970.85
7_K105_R0.6920.84
197_T206_P0.6900.84
92_D98_I0.6860.84
42_L69_I0.6800.83
234_E238_S0.6800.83
234_E241_Y0.6800.83
188_I216_T0.6790.83
41_Y171_E0.6790.83
43_L46_H0.6790.83
25_L59_Y0.6760.83
143_E230_L0.6760.83
180_P184_R0.6730.83
42_L51_L0.6710.82
194_S199_I0.6700.82
35_A73_M0.6680.82
106_K227_Q0.6680.82
15_L100_K0.6660.82
21_L233_Q0.6650.82
22_I38_T0.6650.82
23_N57_S0.6640.82
95_E98_I0.6630.82
23_N56_A0.6610.81
27_I37_I0.6600.81
75_L100_K0.6580.81
192_L197_T0.6580.81
118_E122_Q0.6540.81
214_V218_L0.6540.81
100_K103_E0.6520.81
26_E30_Y0.6480.80
27_I32_I0.6480.80
230_L235_H0.6470.80
33_P92_D0.6400.79
175_T216_T0.6380.79
120_E190_H0.6310.78
156_A205_F0.6300.78
37_I124_S0.6280.78
44_Y76_P0.6240.78
56_A62_M0.6230.78
126_T129_P0.6200.77
57_S68_S0.6160.77
63_A214_V0.6160.77
194_S198_R0.6140.77
63_A66_L0.6140.77
82_L89_E0.6100.76
193_K202_M0.6090.76
48_M56_A0.6090.76
65_T100_K0.6050.75
199_I244_G0.6040.75
184_R210_K0.6040.75
61_V233_Q0.6030.75
201_F205_F0.6030.75
47_T162_K0.6020.75
97_L100_K0.6010.75
104_Y201_F0.6010.75
75_L180_P0.6000.75
16_D19_L0.5960.74
233_Q238_S0.5960.74
151_Y155_G0.5960.74
151_Y241_Y0.5940.74
69_I92_D0.5930.74
107_Y213_L0.5930.74
162_K165_K0.5920.74
61_V201_F0.5920.74
67_L102_I0.5880.73
148_V156_A0.5880.73
194_S197_T0.5870.73
94_R174_I0.5870.73
231_I242_I0.5850.73
7_K127_K0.5800.72
186_N189_V0.5780.72
36_K40_Q0.5770.72
99_E106_K0.5760.72
38_T92_D0.5750.72
197_T230_L0.5730.72
21_L24_R0.5720.71
177_Q240_I0.5710.71
29_I65_T0.5710.71
80_E234_E0.5680.71
125_F213_L0.5660.71
190_H194_S0.5620.70
26_E45_V0.5610.70
30_Y73_M0.5610.70
186_N190_H0.5570.69
187_E207_Y0.5570.69
32_I73_M0.5570.69
53_L59_Y0.5560.69
100_K187_E0.5550.69
117_R120_E0.5540.69
76_P219_A0.5530.69
112_K190_H0.5510.69
118_E179_I0.5490.68
102_I105_R0.5490.68
24_R177_Q0.5490.68
129_P133_S0.5480.68
100_K143_E0.5480.68
23_N68_S0.5470.68
188_I227_Q0.5470.68
166_I227_Q0.5460.68
57_S65_T0.5460.68
24_R59_Y0.5450.68
118_E123_K0.5440.68
155_G158_Q0.5420.67
7_K10_T0.5420.67
20_H215_V0.5410.67
227_Q241_Y0.5400.67
188_I194_S0.5390.67
204_L214_V0.5370.67
65_T68_S0.5340.66
39_E53_L0.5340.66
34_V98_I0.5330.66
105_R164_K0.5330.66
59_Y121_R0.5320.66
233_Q236_N0.5310.66
151_Y158_Q0.5290.65
53_L74_L0.5280.65
180_P201_F0.5280.65
181_I188_I0.5240.65
76_P157_F0.5230.65
34_V53_L0.5230.65
161_L186_N0.5220.64
32_I237_F0.5200.64
80_E89_E0.5190.64
26_E106_K0.5180.64
22_I102_I0.5160.64
51_L67_L0.5140.63
22_I203_D0.5130.63
22_I97_L0.5130.63
3_E6_V0.5120.63
173_T201_F0.5120.63
60_L100_K0.5100.63
49_R165_K0.5100.63
121_R126_T0.5090.63
22_I104_Y0.5090.63
80_E143_E0.5060.62
90_E218_L0.5020.61
19_L69_I0.5000.61
53_L149_T0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i98A 1 0.5857 100 0.357 Contact Map
3w6jA 1 0.5976 100 0.361 Contact Map
3zgxC 2 0.2669 100 0.559 Contact Map
4i99C 1 0.2629 99.4 0.768 Contact Map
1w1wE 1 0.2629 97.2 0.882 Contact Map
2l02A 2 0.2869 69.1 0.936 Contact Map
2l01A 2 0.2988 42.1 0.945 Contact Map
4y66A 1 0.2789 28.1 0.95 Contact Map
3j39U 1 0.3347 13.6 0.957 Contact Map
2dk8A 1 0.3147 13.2 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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