SCPA - BACSU - GREMLIN Contacts

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SCPA - Segregation and condensation protein A

UniProt:	P35154	Sequences: MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLYVHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLIEYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKVLKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFLAVLELMKNQLVLIEQEHNFSDIYITGSESIHGA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	251 (228)
Sequences:	2752 (1834)
Seq/√Len:	121.4

BACSU - SCPA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
189_V	228_L	4.803	1.00
235_H	238_S	4.169	1.00
7_K	12_E	3.910	1.00
198_R	243_T	3.502	1.00
11_F	20_H	3.367	1.00
195_R	203_D	3.329	1.00
224_M	231_I	3.317	1.00
36_K	39_E	2.924	1.00
23_N	105_R	2.895	1.00
202_M	239_D	2.847	1.00
180_P	183_A	2.824	1.00
184_R	187_E	2.768	1.00
184_R	212_H	2.736	1.00
184_R	216_T	2.587	1.00
149_T	152_D	2.575	1.00
95_E	99_E	2.550	1.00
94_R	98_I	2.380	1.00
200_N	239_D	2.341	1.00
189_V	223_L	2.206	1.00
103_E	106_K	2.144	1.00
48_M	55_I	2.132	1.00
191_S	195_R	2.130	1.00
230_L	243_T	2.121	1.00
127_K	130_S	2.119	1.00
185_M	223_L	2.090	1.00
220_V	229_V	2.090	1.00
27_I	33_P	1.989	1.00
10_T	27_I	1.943	1.00
109_D	113_D	1.856	1.00
208_E	212_H	1.801	1.00
61_V	65_T	1.763	1.00
233_Q	237_F	1.729	1.00
29_I	69_I	1.724	1.00
198_R	241_Y	1.716	1.00
233_Q	240_I	1.705	1.00
20_H	24_R	1.689	1.00
96_E	100_K	1.644	1.00
43_L	47_T	1.642	1.00
39_E	43_L	1.639	1.00
47_T	50_V	1.609	1.00
73_M	94_R	1.574	1.00
34_V	37_I	1.557	1.00
200_N	203_D	1.548	1.00
152_D	155_G	1.544	1.00
229_V	242_I	1.541	1.00
115_K	119_E	1.523	1.00
5_Q	12_E	1.505	1.00
28_D	31_D	1.494	1.00
109_D	112_K	1.489	1.00
220_V	242_I	1.486	1.00
46_H	49_R	1.484	1.00
33_P	98_I	1.483	1.00
30_Y	102_I	1.470	1.00
195_R	199_I	1.447	1.00
157_F	161_L	1.444	1.00
22_I	28_D	1.438	1.00
232_E	243_T	1.385	1.00
113_D	117_R	1.376	1.00
94_R	102_I	1.372	1.00
115_K	118_E	1.371	1.00
31_D	94_R	1.367	1.00
19_L	101_L	1.327	1.00
199_I	203_D	1.305	1.00
183_A	187_E	1.297	1.00
25_L	36_K	1.279	1.00
105_R	223_L	1.274	1.00
35_A	39_E	1.261	1.00
69_I	98_I	1.259	1.00
57_S	67_L	1.252	0.99
193_K	244_G	1.248	0.99
45_V	55_I	1.241	0.99
179_I	212_H	1.226	0.99
132_L	135_Y	1.221	0.99
155_G	159_K	1.217	0.99
32_I	94_R	1.211	0.99
116_E	119_E	1.210	0.99
44_Y	48_M	1.195	0.99
230_L	245_S	1.188	0.99
197_T	244_G	1.173	0.99
200_N	241_Y	1.172	0.99
181_I	192_L	1.165	0.99
49_R	56_A	1.161	0.99
209_Q	212_H	1.146	0.99
131_D	135_Y	1.144	0.99
68_S	71_S	1.131	0.99
220_V	231_I	1.126	0.99
179_I	184_R	1.126	0.99
8_I	11_F	1.125	0.99
68_S	72_R	1.119	0.99
182_E	185_M	1.104	0.99
191_S	203_D	1.101	0.99
51_L	56_A	1.098	0.99
73_M	93_P	1.096	0.99
15_L	62_M	1.066	0.98
179_I	215_V	1.062	0.98
127_K	133_S	1.051	0.98
52_E	55_I	1.044	0.98
30_Y	33_P	1.041	0.98
69_I	93_P	1.039	0.98
20_H	41_Y	1.037	0.98
150_V	154_I	1.031	0.98
49_R	55_I	1.025	0.98
7_K	48_M	1.024	0.98
188_I	220_V	1.014	0.98
31_D	93_P	1.007	0.98
52_E	59_Y	1.006	0.98
204_L	242_I	0.995	0.97
113_D	116_E	0.989	0.97
99_E	103_E	0.989	0.97
154_I	158_Q	0.989	0.97
25_L	40_Q	0.987	0.97
120_E	123_K	0.984	0.97
159_K	162_K	0.981	0.97
98_I	102_I	0.978	0.97
6_V	148_V	0.972	0.97
175_T	192_L	0.960	0.97
41_Y	61_V	0.958	0.97
73_M	98_I	0.949	0.97
48_M	51_L	0.946	0.96
191_S	204_L	0.945	0.96
31_D	34_V	0.937	0.96
185_M	226_N	0.935	0.96
33_P	36_K	0.929	0.96
129_P	132_L	0.922	0.96
53_L	56_A	0.921	0.96
44_Y	217_F	0.917	0.96
185_M	219_A	0.904	0.95
222_E	225_K	0.904	0.95
38_T	45_V	0.902	0.95
34_V	62_M	0.901	0.95
238_S	241_Y	0.901	0.95
19_L	23_N	0.900	0.95
192_L	229_V	0.899	0.95
6_V	10_T	0.893	0.95
23_N	59_Y	0.889	0.95
119_E	122_Q	0.875	0.95
152_D	156_A	0.874	0.95
74_L	204_L	0.865	0.94
18_L	233_Q	0.864	0.94
105_R	109_D	0.862	0.94
189_V	193_K	0.862	0.94
33_P	94_R	0.858	0.94
198_R	232_E	0.857	0.94
104_Y	108_K	0.855	0.94
191_S	199_I	0.851	0.94
158_Q	162_K	0.851	0.94
191_S	207_Y	0.843	0.93
22_I	29_I	0.842	0.93
187_E	191_S	0.838	0.93
207_Y	218_L	0.837	0.93
33_P	93_P	0.827	0.93
82_L	88_L	0.826	0.93
211_E	215_V	0.824	0.93
127_K	131_D	0.821	0.92
14_P	17_L	0.818	0.92
193_K	228_L	0.813	0.92
223_L	228_L	0.811	0.92
57_S	100_K	0.808	0.92
149_T	226_N	0.806	0.92
48_M	53_L	0.806	0.92
97_L	101_L	0.801	0.92
76_P	222_E	0.794	0.91
184_R	215_V	0.790	0.91
22_I	98_I	0.790	0.91
15_L	19_L	0.790	0.91
11_F	17_L	0.781	0.90
37_I	210_K	0.780	0.90
37_I	157_F	0.779	0.90
27_I	154_I	0.776	0.90
34_V	67_L	0.773	0.90
34_V	59_Y	0.769	0.90
176_R	180_P	0.767	0.90
134_E	200_N	0.767	0.90
61_V	125_F	0.764	0.89
71_S	91_E	0.763	0.89
151_Y	154_I	0.761	0.89
4_Y	109_D	0.757	0.89
32_I	98_I	0.756	0.89
111_A	114_L	0.755	0.89
101_L	219_A	0.753	0.89
29_I	222_E	0.748	0.88
33_P	73_M	0.747	0.88
91_E	96_E	0.740	0.88
24_R	222_E	0.738	0.88
56_A	219_A	0.737	0.88
92_D	96_E	0.735	0.88
189_V	244_G	0.735	0.88
192_L	244_G	0.732	0.87
32_I	35_A	0.729	0.87
188_I	219_A	0.724	0.87
40_Q	152_D	0.718	0.86
188_I	223_L	0.716	0.86
177_Q	215_V	0.716	0.86
100_K	111_A	0.715	0.86
181_I	219_A	0.714	0.86
129_P	201_F	0.713	0.86
38_T	94_R	0.712	0.86
12_E	108_K	0.712	0.86
25_L	52_E	0.711	0.86
114_L	117_R	0.711	0.86
72_R	98_I	0.710	0.86
82_L	128_P	0.706	0.85
204_L	220_V	0.706	0.85
42_L	78_Q	0.702	0.85
181_I	226_N	0.697	0.85
7_K	105_R	0.692	0.84
197_T	206_P	0.690	0.84
92_D	98_I	0.686	0.84
42_L	69_I	0.680	0.83
234_E	238_S	0.680	0.83
234_E	241_Y	0.680	0.83
188_I	216_T	0.679	0.83
41_Y	171_E	0.679	0.83
43_L	46_H	0.679	0.83
25_L	59_Y	0.676	0.83
143_E	230_L	0.676	0.83
180_P	184_R	0.673	0.83
42_L	51_L	0.671	0.82
194_S	199_I	0.670	0.82
35_A	73_M	0.668	0.82
106_K	227_Q	0.668	0.82
15_L	100_K	0.666	0.82
21_L	233_Q	0.665	0.82
22_I	38_T	0.665	0.82
23_N	57_S	0.664	0.82
95_E	98_I	0.663	0.82
23_N	56_A	0.661	0.81
27_I	37_I	0.660	0.81
75_L	100_K	0.658	0.81
192_L	197_T	0.658	0.81
118_E	122_Q	0.654	0.81
214_V	218_L	0.654	0.81
100_K	103_E	0.652	0.81
26_E	30_Y	0.648	0.80
27_I	32_I	0.648	0.80
230_L	235_H	0.647	0.80
33_P	92_D	0.640	0.79
175_T	216_T	0.638	0.79
120_E	190_H	0.631	0.78
156_A	205_F	0.630	0.78
37_I	124_S	0.628	0.78
44_Y	76_P	0.624	0.78
56_A	62_M	0.623	0.78
126_T	129_P	0.620	0.77
57_S	68_S	0.616	0.77
63_A	214_V	0.616	0.77
194_S	198_R	0.614	0.77
63_A	66_L	0.614	0.77
82_L	89_E	0.610	0.76
193_K	202_M	0.609	0.76
48_M	56_A	0.609	0.76
65_T	100_K	0.605	0.75
199_I	244_G	0.604	0.75
184_R	210_K	0.604	0.75
61_V	233_Q	0.603	0.75
201_F	205_F	0.603	0.75
47_T	162_K	0.602	0.75
97_L	100_K	0.601	0.75
104_Y	201_F	0.601	0.75
75_L	180_P	0.600	0.75
16_D	19_L	0.596	0.74
233_Q	238_S	0.596	0.74
151_Y	155_G	0.596	0.74
151_Y	241_Y	0.594	0.74
69_I	92_D	0.593	0.74
107_Y	213_L	0.593	0.74
162_K	165_K	0.592	0.74
61_V	201_F	0.592	0.74
67_L	102_I	0.588	0.73
148_V	156_A	0.588	0.73
194_S	197_T	0.587	0.73
94_R	174_I	0.587	0.73
231_I	242_I	0.585	0.73
7_K	127_K	0.580	0.72
186_N	189_V	0.578	0.72
36_K	40_Q	0.577	0.72
99_E	106_K	0.576	0.72
38_T	92_D	0.575	0.72
197_T	230_L	0.573	0.72
21_L	24_R	0.572	0.71
177_Q	240_I	0.571	0.71
29_I	65_T	0.571	0.71
80_E	234_E	0.568	0.71
125_F	213_L	0.566	0.71
190_H	194_S	0.562	0.70
26_E	45_V	0.561	0.70
30_Y	73_M	0.561	0.70
186_N	190_H	0.557	0.69
187_E	207_Y	0.557	0.69
32_I	73_M	0.557	0.69
53_L	59_Y	0.556	0.69
100_K	187_E	0.555	0.69
117_R	120_E	0.554	0.69
76_P	219_A	0.553	0.69
112_K	190_H	0.551	0.69
118_E	179_I	0.549	0.68
102_I	105_R	0.549	0.68
24_R	177_Q	0.549	0.68
129_P	133_S	0.548	0.68
100_K	143_E	0.548	0.68
23_N	68_S	0.547	0.68
188_I	227_Q	0.547	0.68
166_I	227_Q	0.546	0.68
57_S	65_T	0.546	0.68
24_R	59_Y	0.545	0.68
118_E	123_K	0.544	0.68
155_G	158_Q	0.542	0.67
7_K	10_T	0.542	0.67
20_H	215_V	0.541	0.67
227_Q	241_Y	0.540	0.67
188_I	194_S	0.539	0.67
204_L	214_V	0.537	0.67
65_T	68_S	0.534	0.66
39_E	53_L	0.534	0.66
34_V	98_I	0.533	0.66
105_R	164_K	0.533	0.66
59_Y	121_R	0.532	0.66
233_Q	236_N	0.531	0.66
151_Y	158_Q	0.529	0.65
53_L	74_L	0.528	0.65
180_P	201_F	0.528	0.65
181_I	188_I	0.524	0.65
76_P	157_F	0.523	0.65
34_V	53_L	0.523	0.65
161_L	186_N	0.522	0.64
32_I	237_F	0.520	0.64
80_E	89_E	0.519	0.64
26_E	106_K	0.518	0.64
22_I	102_I	0.516	0.64
51_L	67_L	0.514	0.63
22_I	203_D	0.513	0.63
22_I	97_L	0.513	0.63
3_E	6_V	0.512	0.63
173_T	201_F	0.512	0.63
60_L	100_K	0.510	0.63
49_R	165_K	0.510	0.63
121_R	126_T	0.509	0.63
22_I	104_Y	0.509	0.63
80_E	143_E	0.506	0.62
90_E	218_L	0.502	0.61
19_L	69_I	0.500	0.61
53_L	149_T	0.500	0.61

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i98A	1	0.5857	100	0.357	Contact Map
3w6jA	1	0.5976	100	0.361	Contact Map
3zgxC	2	0.2669	100	0.559	Contact Map
4i99C	1	0.2629	99.4	0.768	Contact Map
1w1wE	1	0.2629	97.2	0.882	Contact Map
2l02A	2	0.2869	69.1	0.936	Contact Map
2l01A	2	0.2988	42.1	0.945	Contact Map
4y66A	1	0.2789	28.1	0.95	Contact Map
3j39U	1	0.3347	13.6	0.957	Contact Map
2dk8A	1	0.3147	13.2	0.957	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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