GREMLIN Database
DACB - D-alanyl-D-alanine carboxypeptidase DacB
UniProt: P35150 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 382 (353)
Sequences: 4177 (3322)
Seq/√Len: 176.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_A52_E3.7831.00
53_H169_Y3.7011.00
128_G137_M3.0221.00
104_L123_I3.0071.00
79_T101_K2.9911.00
83_S125_E2.9031.00
70_A123_I2.8051.00
334_H346_K2.7601.00
38_I263_V2.5751.00
51_D54_Q2.5461.00
217_T241_D2.5381.00
175_T219_G2.5271.00
84_A98_E2.5251.00
78_Q126_H2.5101.00
109_Y190_T2.4711.00
147_M174_L2.4661.00
331_I348_P2.4541.00
242_L263_V2.4401.00
141_K144_Q2.4221.00
72_E141_K2.4001.00
111_L123_I2.3841.00
55_K165_Y2.3631.00
68_V177_Y2.3571.00
217_T234_T2.2641.00
215_Y237_K2.2631.00
110_G116_G2.2201.00
53_H149_N2.1691.00
103_K106_D2.1491.00
64_I232_V2.1411.00
160_D163_N2.1251.00
65_M150_T2.1151.00
271_L274_K2.0711.00
326_S351_Y2.0661.00
36_A48_Y2.0441.00
131_L155_P2.0321.00
285_F353_N2.0251.00
111_L120_A2.0041.00
41_G243_I1.9941.00
236_S239_G1.9871.00
81_T101_K1.9871.00
133_G136_Y1.9651.00
169_Y173_I1.9331.00
244_A256_H1.8591.00
291_F352_E1.8351.00
130_S133_G1.8161.00
55_K149_N1.8091.00
136_Y140_Q1.7941.00
65_M142_A1.7661.00
338_M343_T1.7571.00
255_D258_K1.7451.00
80_V126_H1.7421.00
84_A88_R1.7271.00
235_A264_F1.7231.00
145_L177_Y1.7211.00
175_T232_V1.7191.00
82_V122_A1.7101.00
343_T346_K1.6691.00
61_I232_V1.6661.00
35_S56_R1.6641.00
79_T103_K1.6581.00
331_I334_H1.6431.00
85_N125_E1.6391.00
35_S168_A1.6321.00
80_V122_A1.6321.00
67_A111_L1.6241.00
183_D186_K1.6161.00
61_I171_M1.6121.00
38_I242_L1.6061.00
293_K348_P1.6031.00
40_D240_I1.5951.00
128_G133_G1.5921.00
330_D351_Y1.5891.00
311_N338_M1.5861.00
67_A112_M1.5781.00
147_M173_I1.5751.00
150_T166_S1.5661.00
176_K243_I1.5641.00
83_S86_A1.5621.00
77_D105_K1.5591.00
66_T120_A1.5561.00
332_V351_Y1.5511.00
34_K248_N1.5411.00
318_K332_V1.5331.00
168_A247_I1.5101.00
153_Q163_N1.5041.00
113_L190_T1.5021.00
105_K109_Y1.5021.00
151_R165_Y1.5011.00
224_T227_A1.4721.00
177_Y180_K1.4641.00
192_I201_V1.4461.00
140_Q144_Q1.4341.00
213_Y261_N1.4331.00
153_Q160_D1.4241.00
82_V96_L1.3991.00
70_A104_L1.3991.00
105_K186_K1.3961.00
58_I166_S1.3861.00
159_D226_L1.3831.00
336_E346_K1.3781.00
105_K187_I1.3691.00
313_T336_E1.3651.00
327_K330_D1.3481.00
327_K354_E1.3411.00
171_M232_V1.3341.00
336_E343_T1.3271.00
62_T164_H1.3191.00
328_I354_E1.3181.00
37_I169_Y1.3181.00
109_Y193_Y1.3141.00
109_Y113_L1.3101.00
288_S351_Y1.3091.00
67_A108_V1.2931.00
176_K180_K1.2931.00
194_K201_V1.2921.00
37_I52_E1.2911.00
312_T349_I1.2861.00
38_I244_A1.2751.00
74_G104_L1.2701.00
110_G119_A1.2661.00
137_M140_Q1.2561.00
57_R226_L1.2521.00
236_S241_D1.2491.00
57_R159_D1.2401.00
216_S233_S1.2401.00
61_I247_I1.2401.00
268_Q302_E1.2351.00
271_L297_T1.2331.00
76_M108_V1.2311.00
76_M105_K1.2301.00
289_K352_E1.2241.00
311_N336_E1.2221.00
86_A125_E1.2191.00
94_I110_G1.2151.00
68_V141_K1.2151.00
233_S256_H1.2031.00
304_E307_N1.1881.00
191_K210_T1.1851.00
75_K183_D1.1851.00
185_Q234_T1.1841.00
142_A147_M1.1771.00
234_T241_D1.1721.00
64_I175_T1.1581.00
37_I46_V1.1571.00
313_T334_H1.1541.00
69_L73_S1.1511.00
115_S220_K1.1341.00
358_K362_Q1.1301.00
133_G137_M1.1301.00
351_Y354_E1.1251.00
271_L295_D1.1191.00
73_S137_M1.1181.00
35_S51_D1.1151.00
249_D255_D1.1121.00
53_H167_T1.1091.00
39_I172_A1.1081.00
246_T256_H1.1011.00
52_E169_Y1.0921.00
141_K177_Y1.0851.00
89_T121_V1.0851.00
227_A230_T1.0841.00
64_I219_G1.0841.00
70_A111_L1.0781.00
36_A50_K1.0721.00
44_G176_K1.0651.00
274_K277_D1.0541.00
135_V155_P1.0531.00
257_M261_N1.0501.00
213_Y216_S1.0330.99
284_T356_H1.0310.99
13_I16_L1.0290.99
309_K338_M1.0290.99
293_K350_Y1.0230.99
359_P362_Q1.0200.99
135_V139_N1.0190.99
188_S219_G1.0180.99
55_K167_T1.0170.99
82_V102_V1.0140.99
290_A332_V1.0140.99
120_A155_P1.0110.99
153_Q164_H1.0080.99
87_V98_E1.0060.99
33_A249_D1.0060.99
233_S260_F0.9890.99
85_N132_D0.9800.99
179_M185_Q0.9760.99
77_D103_K0.9720.99
216_S260_F0.9630.99
121_V131_L0.9560.99
71_I184_Y0.9560.99
75_K78_Q0.9530.99
115_S221_T0.9520.99
280_K324_D0.9520.99
235_A260_F0.9480.99
185_Q241_D0.9470.99
273_A292_I0.9460.99
278_I290_A0.9430.99
74_G184_Y0.9420.99
338_M341_D0.9420.99
73_S127_V0.9380.99
269_T299_L0.9360.99
34_K56_R0.9340.99
142_A174_L0.9250.99
40_D269_T0.9230.99
274_K295_D0.9230.99
58_I247_I0.9200.99
23_N26_H0.9190.99
64_I178_A0.9180.99
97_T100_Q0.9170.99
289_K353_N0.9160.99
69_L141_K0.9130.99
80_V104_L0.9130.99
237_K264_F0.9110.99
280_K283_G0.9080.99
213_Y235_A0.9060.99
148_K169_Y0.9050.99
69_L127_V0.9040.99
116_G119_A0.9020.99
358_K366_T0.9010.99
149_N167_T0.8990.99
186_K189_G0.8980.99
30_D50_K0.8980.99
32_S255_D0.8940.98
288_S326_S0.8930.98
151_R163_N0.8910.98
96_L122_A0.8910.98
42_A241_D0.8790.98
270_Y305_K0.8770.98
12_M15_F0.8770.98
102_V106_D0.8770.98
269_T297_T0.8760.98
140_Q143_E0.8750.98
42_A269_T0.8730.98
21_N24_T0.8680.98
85_N131_L0.8670.98
40_D299_L0.8650.98
68_V181_L0.8650.98
236_S264_F0.8630.98
275_K295_D0.8620.98
70_A127_V0.8610.98
171_M247_I0.8610.98
288_S355_R0.8600.98
296_I347_V0.8590.98
215_Y261_N0.8590.98
76_M187_I0.8580.98
82_V107_L0.8570.98
237_K261_N0.8570.98
172_A245_V0.8550.98
178_A219_G0.8540.98
75_K181_L0.8520.98
37_I245_V0.8490.98
60_S220_K0.8470.98
139_N151_R0.8470.98
232_V245_V0.8460.98
159_D224_T0.8420.98
335_M347_V0.8390.98
262_Y267_Y0.8360.98
326_S332_V0.8340.98
185_Q188_S0.8330.98
127_V137_M0.8320.98
112_M188_S0.8310.98
192_I203_K0.8300.98
166_S171_M0.8280.98
357_Q363_F0.8270.98
283_G324_D0.8250.97
219_G234_T0.8230.97
81_T126_H0.8210.97
213_Y257_M0.8210.97
59_A227_A0.8200.97
37_I172_A0.8190.97
195_A202_W0.8160.97
102_V107_L0.8120.97
37_I49_A0.8080.97
262_Y266_H0.8080.97
296_I345_A0.8070.97
42_A297_T0.8060.97
325_A355_R0.8050.97
207_K253_W0.8040.97
17_I20_V0.8040.97
65_M138_M0.8010.97
330_D354_E0.8010.97
173_I176_K0.7980.97
229_R252_D0.7950.97
74_G123_I0.7930.97
307_N340_N0.7910.97
34_K54_Q0.7810.96
179_M217_T0.7790.96
143_E148_K0.7780.96
231_L256_H0.7770.96
71_I181_L0.7700.96
106_D196_E0.7690.96
184_Y188_S0.7690.96
107_L119_A0.7690.96
244_A260_F0.7680.96
92_S116_G0.7640.96
64_I112_M0.7610.96
246_T249_D0.7560.96
175_T218_G0.7540.96
178_A184_Y0.7520.96
108_V187_I0.7510.96
106_D109_Y0.7490.96
114_R205_K0.7440.95
39_I176_K0.7410.95
138_M142_A0.7380.95
206_N233_S0.7380.95
57_R160_D0.7360.95
132_D136_Y0.7350.95
89_T93_A0.7330.95
171_M175_T0.7290.95
142_A145_L0.7290.95
179_M241_D0.7260.95
152_F171_M0.7260.95
93_A96_L0.7240.95
35_S247_I0.7240.95
224_T230_T0.7210.95
315_L318_K0.7200.94
223_Y229_R0.7180.94
244_A259_M0.7170.94
109_Y187_I0.7160.94
193_Y202_W0.7160.94
310_I337_I0.7150.94
69_L72_E0.7130.94
65_M69_L0.7120.94
178_A181_L0.7110.94
202_W205_K0.7090.94
142_A152_F0.7070.94
61_I230_T0.7060.94
22_V26_H0.7030.94
240_I269_T0.7010.94
71_I108_V0.6990.94
67_A188_S0.6990.94
47_L267_Y0.6970.93
15_F18_A0.6910.93
276_G292_I0.6890.93
60_S63_K0.6890.93
329_P351_Y0.6890.93
139_N152_F0.6880.93
258_K261_N0.6850.93
188_S218_G0.6840.93
67_A71_I0.6800.93
112_M184_Y0.6790.93
301_T304_E0.6790.93
83_S122_A0.6740.92
145_L174_L0.6730.92
292_I349_I0.6720.92
65_M152_F0.6710.92
60_S115_S0.6710.92
21_N26_H0.6700.92
69_L138_M0.6690.92
65_M147_M0.6670.92
206_N231_L0.6670.92
308_V339_F0.6660.92
49_A169_Y0.6640.92
45_R342_A0.6640.92
194_K197_T0.6630.92
279_P287_E0.6630.92
102_V195_A0.6630.92
137_M141_K0.6620.92
76_M79_T0.6620.92
213_Y260_F0.6540.91
64_I174_L0.6540.91
149_N170_D0.6540.91
270_Y300_L0.6510.91
233_S244_A0.6490.91
283_G355_R0.6480.91
80_V107_L0.6480.91
21_N25_A0.6440.91
65_M174_L0.6430.90
18_A22_V0.6420.90
72_E144_Q0.6410.90
74_G127_V0.6370.90
40_D43_S0.6350.90
114_R202_W0.6330.90
90_E93_A0.6320.90
56_R247_I0.6320.90
240_I267_Y0.6310.90
360_K364_F0.6300.90
58_I62_T0.6290.89
63_K117_N0.6270.89
310_I335_M0.6260.89
94_I114_R0.6260.89
69_L137_M0.6250.89
39_I243_I0.6250.89
33_A255_D0.6250.89
10_V13_I0.6250.89
113_L193_Y0.6240.89
273_A276_G0.6230.89
364_F368_K0.6210.89
45_R299_L0.6180.89
106_D193_Y0.6180.89
105_K183_D0.6180.89
49_A53_H0.6170.89
60_S222_G0.6170.89
282_K367_F0.6100.88
19_T23_N0.6080.88
94_I102_V0.6080.88
151_R164_H0.6080.88
107_L123_I0.6050.88
184_Y187_I0.6050.88
16_L19_T0.6010.87
71_I183_D0.6000.87
166_S170_D0.6000.87
318_K326_S0.6000.87
184_Y219_G0.5960.87
148_K173_I0.5960.87
74_G78_Q0.5960.87
223_Y252_D0.5960.87
19_T22_V0.5910.86
18_A23_N0.5910.86
14_S17_I0.5890.86
339_F344_I0.5880.86
339_F342_A0.5870.86
334_H348_P0.5860.86
260_F263_V0.5850.86
39_I173_I0.5840.86
12_M18_A0.5830.86
127_V135_V0.5820.86
290_A349_I0.5810.85
91_G118_D0.5790.85
292_I296_I0.5790.85
113_L187_I0.5790.85
150_T170_D0.5780.85
59_A62_T0.5770.85
215_Y235_A0.5760.85
171_M230_T0.5760.85
31_V36_A0.5760.85
178_A188_S0.5750.85
9_F15_F0.5740.85
22_V25_A0.5730.85
29_I262_Y0.5720.85
359_P363_F0.5710.84
39_I44_G0.5700.84
91_G95_Y0.5690.84
246_T259_M0.5690.84
92_S221_T0.5680.84
20_V24_T0.5660.84
362_Q365_E0.5660.84
217_T236_S0.5660.84
122_A126_H0.5660.84
71_I187_I0.5630.84
179_M219_G0.5630.84
47_L242_L0.5630.84
272_I337_I0.5630.84
259_M263_V0.5630.84
62_T166_S0.5620.84
46_V49_A0.5610.83
300_L306_E0.5610.83
206_N209_L0.5590.83
268_Q303_E0.5570.83
141_K145_L0.5560.83
100_Q196_E0.5560.83
139_N143_E0.5550.83
71_I188_S0.5550.83
164_H230_T0.5550.83
205_K223_Y0.5540.83
153_Q162_E0.5530.83
76_M183_D0.5520.82
89_T158_L0.5520.82
72_E181_L0.5510.82
212_L257_M0.5480.82
61_I64_I0.5480.82
308_V344_I0.5470.82
59_A222_G0.5470.82
134_F138_M0.5460.82
207_K252_D0.5440.82
284_T362_Q0.5440.82
124_A131_L0.5440.82
189_G217_T0.5420.81
312_T335_M0.5410.81
96_L102_V0.5410.81
173_I177_Y0.5410.81
10_V18_A0.5400.81
48_Y259_M0.5400.81
112_M187_I0.5400.81
41_G176_K0.5390.81
60_S221_T0.5390.81
362_Q366_T0.5380.81
82_V100_Q0.5360.81
283_G325_A0.5360.81
68_V145_L0.5350.80
314_L333_G0.5350.80
89_T156_H0.5350.80
147_M170_D0.5340.80
188_S234_T0.5330.80
229_R251_N0.5310.80
59_A221_T0.5310.80
171_M174_L0.5290.80
198_M202_W0.5290.80
300_L308_V0.5280.80
242_L264_F0.5280.80
64_I184_Y0.5270.79
185_Q189_G0.5260.79
102_V110_G0.5250.79
69_L150_T0.5250.79
58_I164_H0.5250.79
58_I171_M0.5250.79
231_L253_W0.5240.79
92_S220_K0.5240.79
213_Y237_K0.5230.79
365_E368_K0.5230.79
266_H301_T0.5230.79
154_N159_D0.5220.79
361_K365_E0.5210.79
231_L244_A0.5210.79
159_D227_A0.5210.79
59_A115_S0.5200.79
59_A63_K0.5180.78
46_V52_E0.5180.78
41_G180_K0.5180.78
55_K166_S0.5170.78
68_V174_L0.5170.78
135_V150_T0.5170.78
216_S235_A0.5140.78
12_M16_L0.5140.78
152_F174_L0.5130.78
131_L135_V0.5130.78
253_W256_H0.5130.78
31_V255_D0.5120.78
110_G202_W0.5120.78
65_M145_L0.5090.77
208_L253_W0.5080.77
94_I116_G0.5070.77
41_G241_D0.5060.77
213_Y264_F0.5050.77
324_D355_R0.5050.77
331_I350_Y0.5030.76
175_T188_S0.5030.76
138_M152_F0.5010.76
329_P350_Y0.5000.76
125_E131_L0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mfdA 1 0.8534 100 0.262 Contact Map
3mzfA 1 0.8743 100 0.277 Contact Map
3itaA 1 0.8613 100 0.29 Contact Map
4k91A 1 0.8639 100 0.291 Contact Map
3a3jA 1 0.8508 100 0.304 Contact Map
1xp4A 3 0.8377 100 0.306 Contact Map
3hunA 1 0.7932 100 0.385 Contact Map
1tvfA 1 0.8272 100 0.423 Contact Map
4pprA 1 0.7461 100 0.477 Contact Map
4ryeA 1 0.6675 100 0.483 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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