GREMLIN Database
AROD - 3-dehydroquinate dehydratase
UniProt: P35146 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 255 (228)
Sequences: 1387 (1093)
Seq/√Len: 72.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_L139_V4.2411.00
226_G242_L3.3121.00
188_T202_T3.1781.00
19_I223_C3.1221.00
144_D147_K3.0221.00
49_V79_F3.0221.00
154_I171_M2.9531.00
175_P204_S2.7971.00
201_I223_C2.5191.00
151_K190_T2.1821.00
225_F232_S2.0281.00
189_Y193_T1.9581.00
143_H205_M1.9501.00
79_F104_A1.9341.00
179_G189_Y1.9151.00
191_M196_A1.8851.00
78_L112_L1.8791.00
83_T97_Y1.8711.00
41_N75_K1.8541.00
80_T143_H1.8341.00
169_P198_R1.8281.00
188_T203_M1.8251.00
81_F90_M1.8081.00
205_M233_A1.7921.00
112_L139_V1.7861.00
22_L30_I1.7681.00
172_A203_M1.7681.00
238_P241_E1.7661.00
143_H233_A1.7631.00
162_Q196_A1.7541.00
233_A236_Q1.7491.00
181_L204_S1.7131.00
245_V248_I1.7121.00
145_F174_M1.6881.00
44_I223_C1.6721.00
93_D96_S1.6601.00
80_T114_D1.6591.00
241_E244_S1.6501.00
34_A71_S1.6491.00
162_Q191_M1.6160.99
154_I187_A1.6130.99
143_H236_Q1.6100.99
207_A210_L1.6060.99
137_Y167_H1.6020.99
102_E130_L1.5800.99
145_F205_M1.5730.99
114_D143_H1.5460.99
140_M166_A1.5370.99
151_K186_D1.5230.99
175_P181_L1.5210.99
158_L202_T1.5160.99
155_I187_A1.5130.99
48_R80_T1.5030.99
143_H213_R1.4980.99
80_T205_M1.4650.99
142_N157_R1.4540.99
117_L140_M1.4480.99
27_E67_K1.4440.99
151_K183_T1.4220.99
216_G221_S1.4120.98
102_E126_A1.4060.98
33_E229_E1.3910.98
181_L212_S1.3870.98
26_T29_Q1.3730.98
80_T116_E1.3720.98
175_P208_T1.3450.98
172_A205_M1.3200.98
86_E118_F1.3100.98
24_G29_Q1.3050.97
24_G33_E1.3050.97
154_I173_V1.3010.97
188_T200_I1.2820.97
47_W65_I1.2760.97
184_L202_T1.2680.97
37_V42_P1.2650.97
155_I190_T1.2480.97
204_S212_S1.2420.97
117_L161_M1.2410.97
182_L189_Y1.2190.96
48_R82_R1.2100.96
15_M247_D1.2090.96
51_V89_S1.2010.96
48_R116_E1.1990.96
186_D190_T1.1980.96
213_R233_A1.1880.96
173_V184_L1.1790.95
162_Q198_R1.1780.95
184_L204_S1.1720.95
114_D233_A1.1650.95
55_A81_F1.1530.95
95_S99_A1.1410.95
42_P239_V1.1370.94
112_L168_I1.1310.94
76_L168_I1.1230.94
69_R111_D1.1180.94
214_L245_V1.1180.94
140_M161_M1.1170.94
27_E52_F1.1120.94
205_M235_G1.1020.93
101_L113_I1.1010.93
84_H91_E1.0840.93
128_V138_V1.0830.93
145_F172_A1.0820.93
82_R116_E1.0780.93
65_I107_T1.0760.93
185_L219_F1.0700.92
48_R114_D1.0670.92
79_F110_I1.0670.92
98_L123_N1.0660.92
42_P75_K1.0630.92
26_T53_E1.0620.92
112_L137_Y1.0600.92
17_K97_Y1.0580.92
132_E167_H1.0560.92
52_F64_L1.0560.92
20_I228_G1.0470.92
174_M205_M1.0470.92
104_A108_K1.0450.91
23_M232_S1.0450.91
237_I242_L1.0400.91
121_D160_K1.0380.91
184_L212_S1.0380.91
65_I104_A1.0360.91
23_M51_V1.0290.91
80_T213_R1.0280.91
33_E37_V1.0250.91
205_M213_R1.0230.91
172_A233_A1.0190.90
154_I158_L1.0170.90
88_G116_E1.0100.90
62_T103_S1.0090.90
38_K75_K0.9980.89
105_I115_I0.9960.89
48_R213_R0.9950.89
103_S106_Q0.9940.89
27_E31_L0.9840.89
84_H89_S0.9830.89
41_N243_R0.9820.89
105_I134_N0.9810.89
102_E106_Q0.9730.88
20_I239_V0.9720.88
82_R114_D0.9710.88
49_V101_L0.9550.87
244_S248_I0.9540.87
114_D236_Q0.9460.87
188_T221_S0.9450.87
42_P228_G0.9410.87
160_K179_G0.9380.86
20_I37_V0.9370.86
104_A113_I0.9340.86
80_T233_A0.9320.86
216_G232_S0.9270.86
167_H199_P0.9210.85
92_M96_S0.9130.85
21_P232_S0.9100.85
97_Y119_S0.9100.85
143_H170_K0.9090.85
42_P243_R0.9080.84
47_W52_F0.9080.84
211_I215_S0.9070.84
17_K51_V0.9070.84
44_I76_L0.9020.84
150_V153_E0.8990.84
35_E71_S0.8980.84
116_E143_H0.8920.83
148_T180_D0.8820.83
21_P225_F0.8690.82
22_L34_A0.8660.82
142_N171_M0.8620.81
144_D205_M0.8560.81
115_I124_V0.8530.81
96_S99_A0.8430.80
88_G114_D0.8410.80
168_I221_S0.8350.79
110_I136_V0.8330.79
97_Y101_L0.8330.79
76_L199_P0.8320.79
144_D157_R0.8270.79
114_D205_M0.8160.78
94_E97_Y0.8160.78
58_R62_T0.8150.77
180_D183_T0.8120.77
87_G116_E0.8120.77
185_L188_T0.8110.77
213_R236_Q0.8100.77
210_L214_L0.7900.75
25_K53_E0.7890.75
139_V201_I0.7870.75
159_R162_Q0.7860.75
155_I159_R0.7840.75
27_E64_L0.7840.75
177_D208_T0.7830.75
141_S170_K0.7770.74
182_L218_V0.7690.73
20_I42_P0.7680.73
79_F101_L0.7670.73
82_R170_K0.7660.73
154_I183_T0.7620.73
106_Q130_L0.7550.72
86_E142_N0.7520.72
145_F236_Q0.7510.72
153_E156_S0.7480.71
34_A45_V0.7480.71
117_L160_K0.7470.71
83_T86_E0.7450.71
33_E36_A0.7440.71
215_S246_L0.7420.71
214_L237_I0.7410.71
181_L187_A0.7390.70
82_R88_G0.7380.70
149_P180_D0.7320.70
186_D189_Y0.7270.69
181_L208_T0.7200.68
47_W232_S0.7170.68
128_V140_M0.7140.68
20_I45_V0.7120.67
145_F233_A0.7120.67
28_K32_N0.7120.67
166_A199_P0.7020.66
80_T235_G0.7000.66
114_D213_R0.6930.65
159_R196_A0.6910.65
18_I242_L0.6910.65
217_E246_L0.6900.65
82_R213_R0.6870.65
143_H203_M0.6870.65
35_E38_K0.6850.64
94_E120_G0.6850.64
179_G243_R0.6800.64
114_D170_K0.6760.63
56_N96_S0.6720.63
98_L102_E0.6660.62
128_V239_V0.6620.62
84_H241_E0.6600.62
81_F100_L0.6590.61
175_P180_D0.6570.61
99_A103_S0.6560.61
121_D125_K0.6560.61
113_I177_D0.6520.61
205_M234_P0.6490.60
104_A107_T0.6420.59
23_M119_S0.6410.59
40_L75_K0.6380.59
40_L228_G0.6340.59
224_T233_A0.6320.58
104_A110_I0.6310.58
35_E67_K0.6290.58
162_Q169_P0.6280.58
77_F191_M0.6270.58
19_I24_G0.6270.58
170_K213_R0.6270.58
26_T192_K0.6250.57
156_S159_R0.6200.57
172_A175_P0.6180.57
118_F157_R0.6180.57
172_A213_R0.6160.56
145_F234_P0.6160.56
246_L249_L0.6150.56
106_Q134_N0.6120.56
18_I239_V0.6090.55
191_M198_R0.6080.55
16_P224_T0.6050.55
152_D163_D0.6040.55
53_E240_S0.6030.55
180_D209_G0.6030.55
30_I47_W0.6030.55
52_F60_A0.6000.54
36_A63_K0.5980.54
174_M224_T0.5960.54
82_R143_H0.5940.54
151_K187_A0.5930.54
240_S245_V0.5880.53
188_T220_G0.5860.53
48_R88_G0.5850.53
94_E98_L0.5850.53
116_E205_M0.5840.52
58_R103_S0.5820.52
205_M236_Q0.5800.52
43_D76_L0.5790.52
169_P201_I0.5730.51
173_V204_S0.5710.51
129_S133_E0.5710.51
60_A64_L0.5700.51
89_S212_S0.5690.51
80_T236_Q0.5690.51
84_H230_E0.5690.51
132_E138_V0.5670.50
55_A129_S0.5660.50
192_K196_A0.5630.50
48_R170_K0.5630.50
81_F97_Y0.5630.50
41_N240_S0.5590.49
120_G123_N0.5580.49
102_E127_L0.5570.49
19_I44_I0.5570.49
80_T172_A0.5560.49
126_A135_N0.5560.49
48_R143_H0.5550.49
31_L67_K0.5520.48
116_E213_R0.5500.48
22_L37_V0.5500.48
76_L232_S0.5480.48
78_L161_M0.5470.48
151_K155_I0.5460.48
145_F148_T0.5450.48
54_K59_E0.5390.47
26_T60_A0.5380.47
116_E233_A0.5370.47
31_L35_E0.5350.46
49_V81_F0.5350.46
244_S247_D0.5330.46
239_V243_R0.5320.46
61_V79_F0.5320.46
87_G141_S0.5310.46
124_V127_L0.5300.46
184_L203_M0.5260.45
24_G30_I0.5240.45
22_L45_V0.5220.45
38_K41_N0.5210.45
182_L185_L0.5170.44
25_K51_V0.5160.44
185_L216_G0.5160.44
44_I129_S0.5160.44
66_S69_R0.5160.44
77_F230_E0.5160.44
54_K60_A0.5150.44
15_M113_I0.5130.44
217_E227_A0.5130.44
215_S218_V0.5120.44
88_G213_R0.5100.43
86_E232_S0.5100.43
94_E119_S0.5090.43
25_K89_S0.5080.43
44_I216_G0.5070.43
209_G224_T0.5070.43
68_L227_A0.5070.43
114_D141_S0.5060.43
32_N240_S0.5050.43
106_Q171_M0.5040.43
46_E213_R0.5040.43
66_S125_K0.5030.42
29_Q45_V0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cnnA 2 0.9686 100 0.069 Contact Map
4ph6A 2 0.9412 100 0.073 Contact Map
4h3dA 2 0.9961 100 0.088 Contact Map
3l9cA 1 0.8784 100 0.167 Contact Map
2yr1A 2 0.9882 100 0.171 Contact Map
1sflA 2 0.9059 100 0.179 Contact Map
2oczA 2 0.8549 100 0.185 Contact Map
2o7sA 2 0.9098 100 0.215 Contact Map
2egzA 1 0.8471 100 0.242 Contact Map
2ox1A 2 0.7647 100 0.268 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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