GREMLIN Database
PPIB - Peptidyl-prolyl cis-trans isomerase B
UniProt: P35137 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 143 (130)
Sequences: 10060 (5326)
Seq/√Len: 467.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_A128_K3.7921.00
8_L13_K3.2941.00
15_E122_S3.1041.00
84_G124_L2.8591.00
82_E119_K2.7041.00
104_H131_S2.6431.00
87_S101_F2.4771.00
81_H87_S2.2791.00
32_K36_E2.2401.00
42_L55_G2.2161.00
17_E119_K1.9491.00
14_I127_A1.9441.00
28_A32_K1.9311.00
17_E121_T1.8941.00
18_L27_V1.8001.00
20_P27_V1.7781.00
16_F86_L1.7701.00
82_E85_A1.7081.00
53_S104_H1.6921.00
72_C75_E1.6881.00
11_G129_N1.6341.00
49_P131_S1.5861.00
19_Y22_A1.5771.00
14_I120_V1.5401.00
19_Y119_K1.5311.00
103_V107_Q1.5291.00
44_F55_G1.5281.00
48_I52_V1.5001.00
85_A119_K1.4791.00
70_I73_E1.4711.00
59_H63_T1.4651.00
31_E35_N1.4321.00
85_A103_V1.4081.00
38_F66_P1.4031.00
53_S130_M1.3941.00
49_P132_N1.3751.00
22_A78_P1.3281.00
17_E20_P1.3131.00
37_G40_D1.2421.00
26_T117_F1.2391.00
85_A116_V1.2291.00
81_H101_F1.2131.00
43_T60_G1.2061.00
66_P97_G1.1961.00
26_T88_M1.1951.00
128_K131_S1.1931.00
25_G28_A1.1831.00
47_V130_M1.1801.00
58_P64_G1.1681.00
87_S111_N1.1631.00
49_P135_V1.1501.00
42_L57_C1.1411.00
120_V124_L1.1401.00
81_H111_N1.1321.00
84_G128_K1.1221.00
16_F102_I1.1201.00
11_G133_G1.1171.00
22_A79_H1.1011.00
14_I102_I1.0521.00
65_G98_S1.0381.00
70_I96_G1.0361.00
15_E121_T1.0351.00
120_V127_A1.0311.00
82_E106_P1.0291.00
58_P65_G1.0251.00
38_F58_P1.0181.00
25_G71_K1.0141.00
87_S116_V1.0081.00
71_K74_T1.0071.00
50_G105_E0.9991.00
86_L117_F0.9961.00
23_A27_V0.9911.00
102_I127_A0.9871.00
80_T111_N0.9841.00
32_K35_N0.9831.00
26_T115_T0.9831.00
33_L36_E0.9781.00
70_I74_T0.9781.00
124_L127_A0.9631.00
69_T72_C0.9631.00
47_V53_S0.9511.00
90_H95_T0.9451.00
46_R54_Q0.9451.00
90_H114_H0.9271.00
15_E123_G0.9201.00
94_D112_G0.9201.00
80_T108_P0.9171.00
124_L128_K0.9151.00
28_A31_E0.9051.00
27_V31_E0.8871.00
67_G97_G0.8791.00
23_A115_T0.8761.00
90_H96_G0.8721.00
38_F98_S0.8621.00
9_E12_N0.8541.00
12_N126_F0.8521.00
47_V104_H0.8381.00
104_H127_A0.8361.00
134_D137_K0.8111.00
16_F120_V0.8101.00
45_H60_G0.8101.00
125_E129_N0.8041.00
62_G65_G0.8001.00
91_A95_T0.8001.00
52_V104_H0.7961.00
70_I75_E0.7871.00
83_A124_L0.7871.00
57_C62_G0.7801.00
126_F129_N0.7791.00
58_P61_T0.7591.00
79_H116_V0.7561.00
51_F54_Q0.7561.00
72_C96_G0.7481.00
8_L11_G0.7471.00
32_K37_G0.7461.00
54_Q99_Q0.7441.00
33_L38_F0.7331.00
83_A105_E0.7321.00
133_G136_M0.7201.00
68_Y97_G0.7101.00
78_P81_H0.7101.00
45_H99_Q0.7051.00
20_P28_A0.6901.00
81_H103_V0.6891.00
38_F42_L0.6831.00
102_I120_V0.6781.00
29_N68_Y0.6761.00
69_T75_E0.6741.00
88_M96_G0.6711.00
30_F117_F0.6711.00
52_V109_H0.6651.00
12_N129_N0.6631.00
123_G126_F0.6621.00
68_Y72_C0.6581.00
108_P111_N0.6551.00
69_T97_G0.6551.00
74_T112_G0.6481.00
83_A106_P0.6451.00
9_E14_I0.6411.00
121_T125_E0.6411.00
72_C90_H0.6300.99
73_E94_D0.6290.99
20_P31_E0.6260.99
122_S125_E0.6260.99
11_G126_F0.6190.99
54_Q89_A0.6170.99
83_A104_H0.6120.99
13_K126_F0.6080.99
93_K112_G0.6060.99
48_I51_F0.6060.99
93_K96_G0.6020.99
19_Y85_A0.5930.99
69_T74_T0.5880.99
77_N115_T0.5870.99
8_L15_E0.5860.99
43_T61_T0.5840.99
9_E126_F0.5730.99
49_P134_D0.5730.99
49_P104_H0.5730.99
89_A99_Q0.5730.99
129_N132_N0.5680.99
18_L117_F0.5680.99
71_K94_D0.5670.99
103_V106_P0.5670.99
75_E78_P0.5660.99
25_G73_E0.5630.99
14_I124_L0.5630.99
44_F48_I0.5590.99
58_P98_S0.5570.99
64_G67_G0.5570.99
46_R101_F0.5560.99
105_E109_H0.5560.99
50_G131_S0.5510.99
71_K91_A0.5500.99
11_G130_M0.5490.99
92_G96_G0.5440.99
51_F110_L0.5420.98
29_N32_K0.5390.98
82_E111_N0.5390.98
46_R89_A0.5380.98
52_V102_I0.5370.98
53_S102_I0.5320.98
32_K68_Y0.5310.98
23_A26_T0.5300.98
68_Y71_K0.5220.98
74_T93_K0.5150.98
71_K75_E0.5110.98
28_A68_Y0.5100.98
19_Y79_H0.5100.98
68_Y74_T0.5070.98
128_K132_N0.5040.98
92_G95_T0.5030.98
120_V123_G0.5020.97
55_G86_L0.5010.97
80_T112_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b71A 1 1 100 0.123 Contact Map
3bo7A 3 0.979 100 0.123 Contact Map
1zkcA 1 1 100 0.123 Contact Map
2k7nA 1 1 100 0.125 Contact Map
2x7kA 1 1 100 0.127 Contact Map
2poeA 1 1 100 0.128 Contact Map
2ok3A 1 0.986 100 0.129 Contact Map
2fu0A 1 0.993 100 0.129 Contact Map
1w74A 1 0.986 100 0.134 Contact Map
2mvzA 1 1 100 0.135 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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