GREMLIN Database
QOX4 - Quinol oxidase subunit 4
UniProt: P34959 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 124 (100)
Sequences: 796 (568)
Seq/√Len: 56.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_P16_I3.7341.00
80_F84_G3.0101.00
29_A47_I2.8161.00
22_S58_Q2.6351.00
29_A50_F2.2881.00
39_S42_A2.0081.00
87_V91_G2.0061.00
55_A58_Q1.9691.00
31_W35_Y1.9391.00
23_I27_L1.9361.00
48_F92_S1.8280.99
38_L43_K1.7790.99
99_H102_H1.7770.99
98_A102_H1.7470.99
38_L42_A1.7350.99
16_I20_I1.6550.99
10_H14_K1.6500.99
31_W71_G1.6230.99
30_L63_M1.6080.99
91_G99_H1.5900.98
42_A46_I1.5790.98
32_V38_L1.5430.98
82_F86_I1.5380.98
68_S75_V1.5070.98
20_I24_V1.4790.97
58_Q77_N1.4550.97
84_G88_I1.4360.97
24_V28_L1.4320.97
91_G96_F1.4140.97
58_Q63_M1.4010.96
6_A69_E1.3770.96
14_K61_M1.3600.96
57_L103_G1.2960.95
68_S71_G1.2480.93
45_W49_G1.2280.93
93_I97_A1.2180.93
87_V90_L1.2000.92
52_F55_A1.1990.92
32_V43_K1.1970.92
92_S100_Y1.1940.92
48_F93_I1.1800.91
51_A95_I1.1620.91
68_S72_T1.1280.89
8_H14_K1.1190.89
95_I99_H1.1130.89
24_V53_I1.1010.88
59_L95_I1.0950.88
93_I96_F1.0940.88
41_S45_W1.0890.88
59_L65_M1.0570.86
72_T98_A1.0530.86
42_A82_F1.0400.85
91_G98_A1.0350.85
39_S45_W1.0340.85
48_F89_V1.0200.84
84_G87_V1.0120.83
59_L78_T0.9570.80
96_F101_H0.9310.78
33_A57_L0.9260.78
75_V83_F0.9210.77
7_E47_I0.9140.77
85_A102_H0.8970.75
39_S82_F0.8940.75
33_A36_T0.8910.75
52_F56_A0.8840.74
39_S88_I0.8800.74
11_F82_F0.8790.74
73_I87_V0.8790.74
85_A89_V0.8740.73
69_E74_Q0.8490.71
96_F99_H0.8400.70
84_G93_I0.8400.70
80_F99_H0.8200.69
90_L97_A0.8060.67
12_P44_L0.8010.67
28_L50_F0.7930.66
80_F87_V0.7850.65
94_W100_Y0.7780.64
85_A99_H0.7730.64
73_I96_F0.7690.64
29_A58_Q0.7660.63
19_F87_V0.7610.63
23_I53_I0.7550.62
72_T77_N0.7530.62
17_V92_S0.7490.61
17_V20_I0.7460.61
23_I52_F0.7450.61
75_V96_F0.7400.61
48_F74_Q0.7340.60
36_T40_S0.7290.59
44_L83_F0.7240.59
53_I56_A0.7240.59
63_M103_G0.7150.58
76_G88_I0.7060.57
36_T48_F0.7030.57
6_A24_V0.7010.56
7_E86_I0.6990.56
79_L82_F0.6870.55
86_I101_H0.6860.55
23_I83_F0.6850.55
19_F53_I0.6820.54
31_W36_T0.6770.54
32_V50_F0.6680.53
58_Q88_I0.6630.52
69_E73_I0.6600.52
10_H22_S0.6530.51
31_W93_I0.6470.51
72_T85_A0.6370.49
73_I99_H0.6310.49
56_A78_T0.6300.49
32_V37_D0.6290.49
95_I104_D0.6270.48
60_L102_H0.6250.48
83_F86_I0.6200.48
33_A43_K0.6200.48
72_T75_V0.6160.47
20_I28_L0.6150.47
86_I90_L0.6130.47
46_I101_H0.6120.47
12_P40_S0.6030.46
56_A60_L0.6020.46
35_Y51_A0.5950.45
65_M69_E0.5930.45
21_L89_V0.5780.43
46_I53_I0.5740.43
36_T43_K0.5660.42
92_S97_A0.5630.41
5_S17_V0.5590.41
36_T94_W0.5570.41
46_I50_F0.5550.41
29_A66_T0.5520.40
36_T100_Y0.5520.40
91_G95_I0.5500.40
46_I51_A0.5430.39
21_L81_G0.5430.39
82_F89_V0.5380.39
7_E13_W0.5330.38
65_M78_T0.5300.38
82_F90_L0.5250.37
30_L57_L0.5180.37
26_T54_Q0.5170.37
97_A101_H0.5140.36
22_S51_A0.5140.36
78_T96_F0.5130.36
20_I41_S0.5110.36
81_G103_G0.5100.36
44_L59_L0.5080.36
9_S13_W0.5070.36
84_G90_L0.5000.35
16_I63_M0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bg9C 1 0.7823 17.5 0.935 Contact Map
2bg9A 1 0.7903 16.9 0.936 Contact Map
2bg9E 1 0.7823 15.4 0.937 Contact Map
2xq2A 2 0.5081 12.8 0.939 Contact Map
2bg9B 1 0.8065 9.6 0.942 Contact Map
2ksrA 1 0.7097 8.5 0.944 Contact Map
2l8sA 1 0.3629 5.3 0.949 Contact Map
3dh4A 3 0.75 5.2 0.949 Contact Map
2mfrA 1 0.4355 3.9 0.952 Contact Map
4hfiA 3 0.7258 3.3 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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