QOX2 - BACSU - GREMLIN Contacts

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QOX2 - Quinol oxidase subunit 2

UniProt:	P34957	Sequences: MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSDLILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPILIVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIPVDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEHFADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVDHGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	321 (261)
Sequences:	2008 (1321)
Seq/√Len:	81.8

ECOLI - CYOA
BACSU - QOX2 COX2
HALSA - Q9HRJ9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
231_E	235_N	5.193	1.00
230_T	233_D	4.683	1.00
169_I	189_A	4.125	1.00
133_V	157_L	4.098	1.00
149_Q	234_F	3.984	1.00
177_S	186_Q	3.696	1.00
159_I	201_A	3.664	1.00
47_L	51_G	3.538	1.00
204_V	230_T	3.458	1.00
161_V	228_A	3.392	1.00
159_I	226_V	3.313	1.00
158_N	229_V	3.241	1.00
163_R	231_E	2.836	1.00
204_V	228_A	2.688	1.00
134_Y	168_K	2.639	1.00
208_E	225_D	2.572	1.00
206_T	225_D	2.493	1.00
201_A	228_A	2.452	1.00
137_S	189_A	2.374	1.00
23_L	26_C	2.352	1.00
204_V	233_D	2.332	1.00
184_G	199_L	2.316	1.00
102_L	106_A	2.315	1.00
176_A	211_N	2.261	1.00
98_V	102_L	2.250	1.00
37_P	202_D	2.197	1.00
233_D	236_S	2.161	1.00
263_D	266_T	2.156	1.00
211_N	215_T	2.125	1.00
255_E	258_L	2.113	1.00
177_S	212_A	2.107	1.00
130_P	163_R	2.081	1.00
151_I	238_V	2.059	1.00
176_A	215_T	1.991	1.00
167_F	199_L	1.985	1.00
132_V	166_L	1.975	1.00
91_F	95_V	1.945	1.00
113_Q	117_S	1.941	1.00
161_V	231_E	1.939	1.00
138_V	143_V	1.931	1.00
62_V	66_I	1.905	1.00
37_P	200_Q	1.842	1.00
161_V	204_V	1.815	1.00
166_L	196_D	1.777	1.00
206_T	227_N	1.776	1.00
65_T	69_V	1.740	1.00
61_F	65_T	1.720	1.00
134_Y	145_S	1.680	1.00
180_I	226_V	1.669	1.00
236_S	240_K	1.644	1.00
229_V	233_D	1.636	1.00
132_V	148_E	1.634	1.00
66_I	70_K	1.616	1.00
138_V	172_A	1.608	1.00
186_Q	213_N	1.592	1.00
133_V	149_Q	1.562	1.00
131_L	234_F	1.553	1.00
35_K	203_K	1.549	1.00
207_Y	228_A	1.518	0.99
158_N	227_N	1.507	0.99
162_D	202_D	1.487	0.99
49_S	107_L	1.469	0.99
41_Q	117_S	1.462	0.99
210_R	223_E	1.446	0.99
90_T	94_V	1.436	0.99
165_I	201_A	1.431	0.99
156_Y	227_N	1.414	0.99
139_D	174_S	1.399	0.99
211_N	222_Q	1.399	0.99
37_P	41_Q	1.398	0.99
136_T	145_S	1.390	0.99
40_E	202_D	1.388	0.99
204_V	207_Y	1.381	0.99
155_N	241_T	1.367	0.99
51_G	55_F	1.357	0.99
215_T	219_F	1.322	0.98
169_I	187_K	1.283	0.98
265_L	268_S	1.264	0.98
188_Y	213_N	1.255	0.98
44_D	48_L	1.253	0.98
209_G	224_F	1.246	0.98
41_Q	44_D	1.225	0.97
241_T	267_F	1.224	0.97
271_H	274_Y	1.203	0.97
208_E	223_E	1.202	0.97
92_L	96_W	1.192	0.97
132_V	168_K	1.189	0.97
149_Q	238_V	1.186	0.97
131_L	163_R	1.165	0.97
241_T	244_E	1.162	0.97
256_L	260_E	1.151	0.96
168_K	194_L	1.150	0.96
94_V	98_V	1.149	0.96
18_T	22_V	1.147	0.96
43_S	47_L	1.133	0.96
211_N	219_F	1.125	0.96
179_W	212_A	1.119	0.96
51_G	54_L	1.088	0.95
105_I	109_V	1.081	0.95
109_V	113_Q	1.079	0.95
22_V	25_G	1.071	0.94
221_D	262_V	1.069	0.94
67_I	71_Y	1.068	0.94
40_E	44_D	1.059	0.94
89_N	93_E	1.055	0.94
35_K	182_Q	1.055	0.94
273_K	276_D	1.053	0.94
32_L	182_Q	1.045	0.94
240_K	244_E	1.041	0.94
235_N	239_K	1.035	0.93
264_E	268_S	1.032	0.93
47_L	50_I	1.030	0.93
249_T	252_K	1.030	0.93
157_L	226_V	1.030	0.93
159_I	165_I	1.024	0.93
251_E	254_D	1.023	0.93
162_D	231_E	1.022	0.93
267_F	271_H	1.021	0.93
234_F	238_V	1.017	0.93
263_D	267_F	1.014	0.93
34_P	39_A	1.013	0.93
15_A	19_V	1.009	0.93
48_L	110_P	1.005	0.92
114_T	117_S	0.993	0.92
186_Q	212_A	0.976	0.91
239_K	242_Q	0.964	0.91
106_A	109_V	0.956	0.90
183_L	228_A	0.955	0.90
121_A	195_M	0.949	0.90
21_F	24_G	0.948	0.90
66_I	71_Y	0.947	0.90
236_S	239_K	0.946	0.90
175_M	190_M	0.942	0.90
268_S	271_H	0.937	0.89
248_L	253_Y	0.918	0.88
159_I	228_A	0.918	0.88
42_Q	184_G	0.915	0.88
37_P	184_G	0.913	0.88
130_P	164_P	0.912	0.88
144_F	157_L	0.911	0.88
253_Y	256_L	0.910	0.88
133_V	137_S	0.907	0.88
144_F	224_F	0.903	0.88
179_W	210_R	0.902	0.88
271_H	275_V	0.902	0.88
167_F	197_Q	0.884	0.87
183_L	226_V	0.880	0.86
20_V	24_G	0.877	0.86
135_A	178_L	0.870	0.86
30_S	182_Q	0.868	0.86
46_I	114_T	0.868	0.86
161_V	201_A	0.867	0.85
19_V	23_L	0.863	0.85
135_A	144_F	0.855	0.85
159_I	199_L	0.852	0.84
212_A	219_F	0.847	0.84
40_E	43_S	0.840	0.84
182_Q	214_F	0.837	0.83
227_N	230_T	0.835	0.83
174_S	213_N	0.832	0.83
13_V	17_L	0.831	0.83
190_M	193_M	0.831	0.83
33_D	43_S	0.828	0.83
183_L	201_A	0.828	0.83
150_D	242_Q	0.822	0.82
14_L	17_L	0.822	0.82
174_S	215_T	0.821	0.82
128_K	231_E	0.819	0.82
94_V	105_I	0.819	0.82
21_F	26_C	0.816	0.82
55_F	99_I	0.798	0.80
179_W	186_Q	0.787	0.79
22_V	26_C	0.786	0.79
48_L	106_A	0.778	0.79
39_A	42_Q	0.775	0.78
128_K	162_D	0.769	0.78
65_T	68_L	0.768	0.78
156_Y	214_F	0.768	0.78
77_K	81_S	0.768	0.78
176_A	219_F	0.765	0.78
18_T	21_F	0.762	0.77
215_T	222_Q	0.762	0.77
36_G	183_L	0.762	0.77
232_K	236_S	0.754	0.76
112_V	116_Y	0.751	0.76
19_V	22_V	0.748	0.76
50_I	54_L	0.747	0.76
129_E	163_R	0.744	0.76
41_Q	114_T	0.741	0.75
14_L	19_V	0.741	0.75
159_I	183_L	0.733	0.74
75_K	80_G	0.726	0.74
31_V	46_I	0.718	0.73
53_M	218_H	0.718	0.73
213_N	219_F	0.717	0.73
38_V	42_Q	0.713	0.72
119_E	187_K	0.712	0.72
252_K	255_E	0.711	0.72
232_K	235_N	0.710	0.72
139_D	173_D	0.707	0.72
240_K	267_F	0.700	0.71
19_V	95_V	0.698	0.71
173_D	176_A	0.694	0.70
173_D	211_N	0.693	0.70
256_L	259_P	0.691	0.70
23_L	27_S	0.691	0.70
73_D	76_G	0.690	0.70
93_E	100_P	0.690	0.70
180_I	186_Q	0.688	0.70
64_F	68_L	0.686	0.69
55_F	59_V	0.686	0.69
135_A	177_S	0.685	0.69
52_F	107_L	0.682	0.69
175_M	191_A	0.679	0.69
204_V	232_K	0.679	0.69
15_A	18_T	0.678	0.69
103_I	256_L	0.677	0.68
19_V	109_V	0.675	0.68
52_F	55_F	0.670	0.68
263_D	268_S	0.669	0.68
265_L	269_S	0.668	0.67
38_V	62_V	0.662	0.67
147_P	190_M	0.657	0.66
134_Y	170_S	0.657	0.66
173_D	191_A	0.655	0.66
169_I	197_Q	0.654	0.66
17_L	21_F	0.652	0.66
171_S	189_A	0.651	0.65
259_P	274_Y	0.650	0.65
29_A	32_L	0.650	0.65
260_E	263_D	0.648	0.65
102_L	105_I	0.646	0.65
232_K	251_E	0.645	0.65
44_D	47_L	0.645	0.65
165_I	226_V	0.644	0.65
119_E	138_V	0.642	0.64
135_A	167_F	0.639	0.64
263_D	271_H	0.633	0.63
158_N	174_S	0.631	0.63
250_K	254_D	0.628	0.63
140_W	217_E	0.627	0.63
253_Y	257_M	0.625	0.62
71_Y	93_E	0.624	0.62
48_L	52_F	0.622	0.62
137_S	213_N	0.621	0.62
243_N	247_K	0.617	0.61
138_V	141_K	0.617	0.61
132_V	163_R	0.617	0.61
111_T	213_N	0.617	0.61
42_Q	118_L	0.615	0.61
176_A	213_N	0.615	0.61
214_F	217_E	0.612	0.61
166_L	198_Y	0.611	0.61
144_F	178_L	0.607	0.60
259_P	262_V	0.606	0.60
18_T	25_G	0.604	0.60
34_P	112_V	0.603	0.60
62_V	87_H	0.601	0.59
120_K	123_E	0.600	0.59
48_L	55_F	0.599	0.59
93_E	96_W	0.598	0.59
201_A	226_V	0.598	0.59
52_F	106_A	0.597	0.59
221_D	261_N	0.596	0.59
177_S	210_R	0.595	0.59
88_G	107_L	0.594	0.58
266_T	271_H	0.594	0.58
173_D	186_Q	0.593	0.58
20_V	23_L	0.590	0.58
67_I	107_L	0.588	0.58
53_M	57_V	0.588	0.58
163_R	235_N	0.587	0.58
149_Q	242_Q	0.586	0.57
108_S	111_T	0.585	0.57
109_V	243_N	0.585	0.57
199_L	226_V	0.585	0.57
184_G	209_G	0.585	0.57
20_V	69_V	0.583	0.57
12_L	18_T	0.581	0.57
138_V	190_M	0.581	0.57
87_H	90_T	0.581	0.57
67_I	70_K	0.580	0.57
144_F	154_V	0.579	0.57
93_E	97_T	0.578	0.56
69_V	262_V	0.577	0.56
186_Q	211_N	0.576	0.56
49_S	57_V	0.576	0.56
220_A	264_E	0.574	0.56
164_P	200_Q	0.573	0.56
143_V	152_E	0.572	0.56
57_V	61_F	0.572	0.56
42_Q	185_G	0.572	0.56
246_P	255_E	0.572	0.56
87_H	94_V	0.571	0.55
180_I	183_L	0.571	0.55
37_P	201_A	0.570	0.55
70_K	81_S	0.570	0.55
83_N	86_I	0.566	0.55
36_G	185_G	0.566	0.55
31_V	179_W	0.565	0.55
157_L	167_F	0.564	0.55
14_L	18_T	0.564	0.55
73_D	77_K	0.563	0.54
93_E	144_F	0.563	0.54
89_N	123_E	0.562	0.54
76_G	80_G	0.561	0.54
76_G	127_D	0.559	0.54
119_E	122_P	0.558	0.54
136_T	170_S	0.558	0.54
248_L	252_K	0.558	0.54
57_V	167_F	0.557	0.54
91_F	94_V	0.557	0.54
38_V	118_L	0.555	0.53
35_K	226_V	0.554	0.53
188_Y	219_F	0.554	0.53
39_A	185_G	0.553	0.53
16_L	22_V	0.553	0.53
63_L	92_L	0.553	0.53
220_A	223_E	0.553	0.53
138_V	187_K	0.552	0.53
154_V	224_F	0.550	0.53
219_F	222_Q	0.550	0.53
17_L	20_V	0.549	0.53
83_N	87_H	0.548	0.52
72_R	76_G	0.548	0.52
162_D	226_V	0.547	0.52
231_E	273_K	0.546	0.52
180_I	196_D	0.545	0.52
121_A	196_D	0.544	0.52
52_F	189_A	0.543	0.52
43_S	182_Q	0.542	0.52
176_A	222_Q	0.541	0.52
232_K	240_K	0.541	0.52
21_F	106_A	0.541	0.52
266_T	270_T	0.539	0.51
131_L	166_L	0.539	0.51
133_V	234_F	0.539	0.51
260_E	264_E	0.537	0.51
148_E	257_M	0.537	0.51
39_A	182_Q	0.535	0.51
32_L	36_G	0.534	0.51
90_T	95_V	0.534	0.51
31_V	213_N	0.532	0.50
103_I	189_A	0.530	0.50
21_F	157_L	0.529	0.50
263_D	274_Y	0.527	0.50
167_F	178_L	0.527	0.50
133_V	239_K	0.526	0.50
137_S	215_T	0.525	0.49
33_D	39_A	0.524	0.49
251_E	256_L	0.524	0.49
11_L	19_V	0.524	0.49
176_A	186_Q	0.522	0.49
56_I	212_A	0.522	0.49
87_H	92_L	0.521	0.49
64_F	111_T	0.521	0.49
258_L	262_V	0.521	0.49
100_P	108_S	0.519	0.49
83_N	101_I	0.519	0.49
213_N	223_E	0.519	0.49
191_A	198_Y	0.519	0.49
35_K	159_I	0.518	0.49
104_V	178_L	0.516	0.48
67_I	86_I	0.516	0.48
140_W	155_N	0.514	0.48
205_G	220_A	0.514	0.48
64_F	191_A	0.514	0.48
130_P	145_S	0.513	0.48
141_K	260_E	0.512	0.48
12_L	15_A	0.511	0.48
168_K	196_D	0.511	0.48
56_I	111_T	0.511	0.48
212_A	215_T	0.511	0.48
153_T	156_Y	0.510	0.47
137_S	171_S	0.510	0.47
141_K	154_V	0.510	0.47
260_E	268_S	0.509	0.47
51_G	62_V	0.509	0.47
104_V	144_F	0.508	0.47
63_L	67_I	0.508	0.47
265_L	271_H	0.508	0.47
43_S	179_W	0.507	0.47
35_K	46_I	0.506	0.47
210_R	225_D	0.506	0.47
254_D	259_P	0.506	0.47
46_I	213_N	0.505	0.47
128_K	166_L	0.504	0.47
74_R	77_K	0.503	0.47
20_V	26_C	0.503	0.47
188_Y	215_T	0.501	0.46
51_G	236_S	0.500	0.46
95_V	99_I	0.500	0.46

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1fftB	1	0.7913	100	0.23	Contact Map
3hb3B	1	0.676	100	0.368	Contact Map
2yevB	1	0.8847	100	0.387	Contact Map
2gsmB	1	0.6791	100	0.398	Contact Map
1v54B	1	0.6386	100	0.436	Contact Map
1cyxA	1	0.4829	100	0.48	Contact Map
4txvB	1	0.3956	100	0.558	Contact Map
3s8fB	1	0.4517	100	0.641	Contact Map
2cuaA	1	0.3956	100	0.747	Contact Map
3sbqA	2	0.6293	99.9	0.759	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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