GREMLIN Database
QOX2 - Quinol oxidase subunit 2
UniProt: P34957 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 321 (261)
Sequences: 2008 (1321)
Seq/√Len: 81.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
231_E235_N5.1931.00
230_T233_D4.6831.00
169_I189_A4.1251.00
133_V157_L4.0981.00
149_Q234_F3.9841.00
177_S186_Q3.6961.00
159_I201_A3.6641.00
47_L51_G3.5381.00
204_V230_T3.4581.00
161_V228_A3.3921.00
159_I226_V3.3131.00
158_N229_V3.2411.00
163_R231_E2.8361.00
204_V228_A2.6881.00
134_Y168_K2.6391.00
208_E225_D2.5721.00
206_T225_D2.4931.00
201_A228_A2.4521.00
137_S189_A2.3741.00
23_L26_C2.3521.00
204_V233_D2.3321.00
184_G199_L2.3161.00
102_L106_A2.3151.00
176_A211_N2.2611.00
98_V102_L2.2501.00
37_P202_D2.1971.00
233_D236_S2.1611.00
263_D266_T2.1561.00
211_N215_T2.1251.00
255_E258_L2.1131.00
177_S212_A2.1071.00
130_P163_R2.0811.00
151_I238_V2.0591.00
176_A215_T1.9911.00
167_F199_L1.9851.00
132_V166_L1.9751.00
91_F95_V1.9451.00
113_Q117_S1.9411.00
161_V231_E1.9391.00
138_V143_V1.9311.00
62_V66_I1.9051.00
37_P200_Q1.8421.00
161_V204_V1.8151.00
166_L196_D1.7771.00
206_T227_N1.7761.00
65_T69_V1.7401.00
61_F65_T1.7201.00
134_Y145_S1.6801.00
180_I226_V1.6691.00
236_S240_K1.6441.00
229_V233_D1.6361.00
132_V148_E1.6341.00
66_I70_K1.6161.00
138_V172_A1.6081.00
186_Q213_N1.5921.00
133_V149_Q1.5621.00
131_L234_F1.5531.00
35_K203_K1.5491.00
207_Y228_A1.5180.99
158_N227_N1.5070.99
162_D202_D1.4870.99
49_S107_L1.4690.99
41_Q117_S1.4620.99
210_R223_E1.4460.99
90_T94_V1.4360.99
165_I201_A1.4310.99
156_Y227_N1.4140.99
139_D174_S1.3990.99
211_N222_Q1.3990.99
37_P41_Q1.3980.99
136_T145_S1.3900.99
40_E202_D1.3880.99
204_V207_Y1.3810.99
155_N241_T1.3670.99
51_G55_F1.3570.99
215_T219_F1.3220.98
169_I187_K1.2830.98
265_L268_S1.2640.98
188_Y213_N1.2550.98
44_D48_L1.2530.98
209_G224_F1.2460.98
41_Q44_D1.2250.97
241_T267_F1.2240.97
271_H274_Y1.2030.97
208_E223_E1.2020.97
92_L96_W1.1920.97
132_V168_K1.1890.97
149_Q238_V1.1860.97
131_L163_R1.1650.97
241_T244_E1.1620.97
256_L260_E1.1510.96
168_K194_L1.1500.96
94_V98_V1.1490.96
18_T22_V1.1470.96
43_S47_L1.1330.96
211_N219_F1.1250.96
179_W212_A1.1190.96
51_G54_L1.0880.95
105_I109_V1.0810.95
109_V113_Q1.0790.95
22_V25_G1.0710.94
221_D262_V1.0690.94
67_I71_Y1.0680.94
40_E44_D1.0590.94
89_N93_E1.0550.94
35_K182_Q1.0550.94
273_K276_D1.0530.94
32_L182_Q1.0450.94
240_K244_E1.0410.94
235_N239_K1.0350.93
264_E268_S1.0320.93
47_L50_I1.0300.93
249_T252_K1.0300.93
157_L226_V1.0300.93
159_I165_I1.0240.93
251_E254_D1.0230.93
162_D231_E1.0220.93
267_F271_H1.0210.93
234_F238_V1.0170.93
263_D267_F1.0140.93
34_P39_A1.0130.93
15_A19_V1.0090.93
48_L110_P1.0050.92
114_T117_S0.9930.92
186_Q212_A0.9760.91
239_K242_Q0.9640.91
106_A109_V0.9560.90
183_L228_A0.9550.90
121_A195_M0.9490.90
21_F24_G0.9480.90
66_I71_Y0.9470.90
236_S239_K0.9460.90
175_M190_M0.9420.90
268_S271_H0.9370.89
248_L253_Y0.9180.88
159_I228_A0.9180.88
42_Q184_G0.9150.88
37_P184_G0.9130.88
130_P164_P0.9120.88
144_F157_L0.9110.88
253_Y256_L0.9100.88
133_V137_S0.9070.88
144_F224_F0.9030.88
179_W210_R0.9020.88
271_H275_V0.9020.88
167_F197_Q0.8840.87
183_L226_V0.8800.86
20_V24_G0.8770.86
135_A178_L0.8700.86
30_S182_Q0.8680.86
46_I114_T0.8680.86
161_V201_A0.8670.85
19_V23_L0.8630.85
135_A144_F0.8550.85
159_I199_L0.8520.84
212_A219_F0.8470.84
40_E43_S0.8400.84
182_Q214_F0.8370.83
227_N230_T0.8350.83
174_S213_N0.8320.83
13_V17_L0.8310.83
190_M193_M0.8310.83
33_D43_S0.8280.83
183_L201_A0.8280.83
150_D242_Q0.8220.82
14_L17_L0.8220.82
174_S215_T0.8210.82
128_K231_E0.8190.82
94_V105_I0.8190.82
21_F26_C0.8160.82
55_F99_I0.7980.80
179_W186_Q0.7870.79
22_V26_C0.7860.79
48_L106_A0.7780.79
39_A42_Q0.7750.78
128_K162_D0.7690.78
65_T68_L0.7680.78
156_Y214_F0.7680.78
77_K81_S0.7680.78
176_A219_F0.7650.78
18_T21_F0.7620.77
215_T222_Q0.7620.77
36_G183_L0.7620.77
232_K236_S0.7540.76
112_V116_Y0.7510.76
19_V22_V0.7480.76
50_I54_L0.7470.76
129_E163_R0.7440.76
41_Q114_T0.7410.75
14_L19_V0.7410.75
159_I183_L0.7330.74
75_K80_G0.7260.74
31_V46_I0.7180.73
53_M218_H0.7180.73
213_N219_F0.7170.73
38_V42_Q0.7130.72
119_E187_K0.7120.72
252_K255_E0.7110.72
232_K235_N0.7100.72
139_D173_D0.7070.72
240_K267_F0.7000.71
19_V95_V0.6980.71
173_D176_A0.6940.70
173_D211_N0.6930.70
256_L259_P0.6910.70
23_L27_S0.6910.70
73_D76_G0.6900.70
93_E100_P0.6900.70
180_I186_Q0.6880.70
64_F68_L0.6860.69
55_F59_V0.6860.69
135_A177_S0.6850.69
52_F107_L0.6820.69
175_M191_A0.6790.69
204_V232_K0.6790.69
15_A18_T0.6780.69
103_I256_L0.6770.68
19_V109_V0.6750.68
52_F55_F0.6700.68
263_D268_S0.6690.68
265_L269_S0.6680.67
38_V62_V0.6620.67
147_P190_M0.6570.66
134_Y170_S0.6570.66
173_D191_A0.6550.66
169_I197_Q0.6540.66
17_L21_F0.6520.66
171_S189_A0.6510.65
259_P274_Y0.6500.65
29_A32_L0.6500.65
260_E263_D0.6480.65
102_L105_I0.6460.65
232_K251_E0.6450.65
44_D47_L0.6450.65
165_I226_V0.6440.65
119_E138_V0.6420.64
135_A167_F0.6390.64
263_D271_H0.6330.63
158_N174_S0.6310.63
250_K254_D0.6280.63
140_W217_E0.6270.63
253_Y257_M0.6250.62
71_Y93_E0.6240.62
48_L52_F0.6220.62
137_S213_N0.6210.62
243_N247_K0.6170.61
138_V141_K0.6170.61
132_V163_R0.6170.61
111_T213_N0.6170.61
42_Q118_L0.6150.61
176_A213_N0.6150.61
214_F217_E0.6120.61
166_L198_Y0.6110.61
144_F178_L0.6070.60
259_P262_V0.6060.60
18_T25_G0.6040.60
34_P112_V0.6030.60
62_V87_H0.6010.59
120_K123_E0.6000.59
48_L55_F0.5990.59
93_E96_W0.5980.59
201_A226_V0.5980.59
52_F106_A0.5970.59
221_D261_N0.5960.59
177_S210_R0.5950.59
88_G107_L0.5940.58
266_T271_H0.5940.58
173_D186_Q0.5930.58
20_V23_L0.5900.58
67_I107_L0.5880.58
53_M57_V0.5880.58
163_R235_N0.5870.58
149_Q242_Q0.5860.57
108_S111_T0.5850.57
109_V243_N0.5850.57
199_L226_V0.5850.57
184_G209_G0.5850.57
20_V69_V0.5830.57
12_L18_T0.5810.57
138_V190_M0.5810.57
87_H90_T0.5810.57
67_I70_K0.5800.57
144_F154_V0.5790.57
93_E97_T0.5780.56
69_V262_V0.5770.56
186_Q211_N0.5760.56
49_S57_V0.5760.56
220_A264_E0.5740.56
164_P200_Q0.5730.56
143_V152_E0.5720.56
57_V61_F0.5720.56
42_Q185_G0.5720.56
246_P255_E0.5720.56
87_H94_V0.5710.55
180_I183_L0.5710.55
37_P201_A0.5700.55
70_K81_S0.5700.55
83_N86_I0.5660.55
36_G185_G0.5660.55
31_V179_W0.5650.55
157_L167_F0.5640.55
14_L18_T0.5640.55
73_D77_K0.5630.54
93_E144_F0.5630.54
89_N123_E0.5620.54
76_G80_G0.5610.54
76_G127_D0.5590.54
119_E122_P0.5580.54
136_T170_S0.5580.54
248_L252_K0.5580.54
57_V167_F0.5570.54
91_F94_V0.5570.54
38_V118_L0.5550.53
35_K226_V0.5540.53
188_Y219_F0.5540.53
39_A185_G0.5530.53
16_L22_V0.5530.53
63_L92_L0.5530.53
220_A223_E0.5530.53
138_V187_K0.5520.53
154_V224_F0.5500.53
219_F222_Q0.5500.53
17_L20_V0.5490.53
83_N87_H0.5480.52
72_R76_G0.5480.52
162_D226_V0.5470.52
231_E273_K0.5460.52
180_I196_D0.5450.52
121_A196_D0.5440.52
52_F189_A0.5430.52
43_S182_Q0.5420.52
176_A222_Q0.5410.52
232_K240_K0.5410.52
21_F106_A0.5410.52
266_T270_T0.5390.51
131_L166_L0.5390.51
133_V234_F0.5390.51
260_E264_E0.5370.51
148_E257_M0.5370.51
39_A182_Q0.5350.51
32_L36_G0.5340.51
90_T95_V0.5340.51
31_V213_N0.5320.50
103_I189_A0.5300.50
21_F157_L0.5290.50
263_D274_Y0.5270.50
167_F178_L0.5270.50
133_V239_K0.5260.50
137_S215_T0.5250.49
33_D39_A0.5240.49
251_E256_L0.5240.49
11_L19_V0.5240.49
176_A186_Q0.5220.49
56_I212_A0.5220.49
87_H92_L0.5210.49
64_F111_T0.5210.49
258_L262_V0.5210.49
100_P108_S0.5190.49
83_N101_I0.5190.49
213_N223_E0.5190.49
191_A198_Y0.5190.49
35_K159_I0.5180.49
104_V178_L0.5160.48
67_I86_I0.5160.48
140_W155_N0.5140.48
205_G220_A0.5140.48
64_F191_A0.5140.48
130_P145_S0.5130.48
141_K260_E0.5120.48
12_L15_A0.5110.48
168_K196_D0.5110.48
56_I111_T0.5110.48
212_A215_T0.5110.48
153_T156_Y0.5100.47
137_S171_S0.5100.47
141_K154_V0.5100.47
260_E268_S0.5090.47
51_G62_V0.5090.47
104_V144_F0.5080.47
63_L67_I0.5080.47
265_L271_H0.5080.47
43_S179_W0.5070.47
35_K46_I0.5060.47
210_R225_D0.5060.47
254_D259_P0.5060.47
46_I213_N0.5050.47
128_K166_L0.5040.47
74_R77_K0.5030.47
20_V26_C0.5030.47
188_Y215_T0.5010.46
51_G236_S0.5000.46
95_V99_I0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fftB 1 0.7913 100 0.23 Contact Map
3hb3B 1 0.676 100 0.368 Contact Map
2yevB 1 0.8847 100 0.387 Contact Map
2gsmB 1 0.6791 100 0.398 Contact Map
1v54B 1 0.6386 100 0.436 Contact Map
1cyxA 1 0.4829 100 0.48 Contact Map
4txvB 1 0.3956 100 0.558 Contact Map
3s8fB 1 0.4517 100 0.641 Contact Map
2cuaA 1 0.3956 100 0.747 Contact Map
3sbqA 2 0.6293 99.9 0.759 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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