GREMLIN Database
CSRA - Carbon storage regulator homolog
UniProt: P33911 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 74 (62)
Sequences: 897 (569)
Seq/√Len: 72.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_V32_L3.0281.00
19_E45_K2.9681.00
19_E35_D2.8331.00
55_N58_A2.6491.00
43_H51_I2.5731.00
43_H47_I2.3431.00
45_K49_L2.2331.00
28_D50_T2.0951.00
54_E57_R1.9651.00
13_Q45_K1.9091.00
21_K35_D1.8181.00
49_L52_Q1.8101.00
50_T53_E1.7871.00
23_I33_G1.7141.00
49_L53_E1.6190.99
43_H48_Y1.4610.99
7_K45_K1.3930.98
4_L28_D1.3910.98
53_E57_R1.3710.98
48_Y51_I1.3630.98
7_K51_I1.2180.96
3_V26_E1.2030.96
14_I40_I1.1760.95
3_V50_T1.0740.92
21_K26_E1.0280.91
13_Q19_E1.0150.90
4_L33_G1.0150.90
57_R60_A0.9900.89
41_D52_Q0.9860.89
11_A22_V0.9800.89
11_A19_E0.9600.88
12_I41_D0.9200.85
28_D36_A0.9170.85
39_H42_I0.8920.83
7_K10_E0.8920.83
11_A45_K0.8860.83
26_E31_K0.8840.83
9_N12_I0.8820.83
22_V55_N0.8130.77
24_A31_K0.8080.77
22_V53_E0.8030.76
25_V29_Q0.7760.74
52_Q55_N0.7740.74
14_I22_V0.7710.73
21_K54_E0.7680.73
29_Q43_H0.7470.71
59_A62_S0.7440.71
4_L27_G0.7210.68
14_I20_V0.7000.66
14_I39_H0.6990.66
48_Y52_Q0.6980.66
10_E32_L0.6940.65
5_S8_I0.6870.65
13_Q33_G0.6860.65
15_G18_I0.6840.64
56_N60_A0.6810.64
3_V43_H0.6810.64
55_N59_A0.6810.64
34_I42_I0.6780.64
25_V30_V0.6740.63
5_S29_Q0.6720.63
53_E56_N0.6670.62
15_G58_A0.6630.62
17_D39_H0.6340.58
17_D52_Q0.6340.58
11_A20_V0.6330.58
32_L35_D0.6290.58
10_E20_V0.6220.57
14_I36_A0.6210.57
17_D20_V0.6210.57
3_V28_D0.6060.55
5_S26_E0.5980.54
57_R61_L0.5960.54
3_V33_G0.5840.52
13_Q49_L0.5730.51
4_L20_V0.5680.50
26_E50_T0.5430.47
38_K45_K0.5420.47
21_K25_V0.5350.46
26_E29_Q0.5320.46
15_G29_Q0.5300.46
3_V42_I0.5300.46
52_Q59_A0.5280.45
18_I56_N0.5240.45
15_G42_I0.5190.44
7_K55_N0.5190.44
32_L55_N0.5190.44
4_L49_L0.5170.44
9_N27_G0.5140.44
25_V61_L0.5070.43
7_K58_A0.5070.43
9_N29_Q0.5050.43
56_N59_A0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t3oA 1 1 99.9 0.092 Contact Map
1vpzA 2 0.7432 99.9 0.168 Contact Map
2btiA 2 0.7703 99.9 0.187 Contact Map
2jppA 2 0.7162 99.9 0.189 Contact Map
4krwA 2 0.6486 99.8 0.284 Contact Map
2vnuD 1 0.3919 55.3 0.869 Contact Map
4ifdJ 1 0.5 52.5 0.871 Contact Map
2id0A 1 0.473 30.8 0.888 Contact Map
1go3E 1 0.7162 29.7 0.889 Contact Map
1e3pA 3 0.2432 29 0.889 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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