GREMLIN Database
COMQ - Competence regulatory protein ComQ
UniProt: P33690 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (275)
Sequences: 7367 (4975)
Seq/√Len: 300.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_Y265_K3.1661.00
221_D241_K3.1441.00
177_Y262_Y3.0721.00
267_I288_L3.0111.00
214_L254_Y2.9991.00
244_E248_K2.8331.00
157_V172_E2.7551.00
267_I284_K2.7521.00
258_L261_I2.7221.00
210_Y254_Y2.6531.00
145_R176_Y2.5711.00
235_S238_D2.5671.00
153_A172_E2.5401.00
210_Y251_V2.4851.00
250_G253_Q2.3861.00
264_Q268_S2.3171.00
173_R269_A2.2611.00
38_Y48_V2.2531.00
37_H171_V2.1751.00
70_E126_Q2.1331.00
271_E284_K2.1301.00
188_Y255_I2.1031.00
169_E173_R2.0211.00
280_K284_K1.9261.00
253_Q257_V1.8871.00
153_A176_Y1.8761.00
261_I265_K1.8611.00
114_Y157_V1.8591.00
160_V171_V1.8311.00
126_Q129_D1.8291.00
65_I82_I1.8121.00
114_Y161_L1.8081.00
268_S271_E1.7731.00
247_I252_T1.7671.00
136_T139_E1.7511.00
66_M92_L1.7181.00
184_I255_I1.7181.00
156_N175_S1.7171.00
260_E264_Q1.7111.00
51_R104_S1.7021.00
111_I158_A1.6951.00
257_V261_I1.6781.00
37_H156_N1.6641.00
69_L84_R1.6591.00
211_L246_L1.6511.00
253_Q256_S1.6471.00
241_K244_E1.6431.00
66_M91_A1.5901.00
210_Y213_R1.5791.00
173_R177_Y1.5771.00
219_S223_L1.5581.00
63_S122_A1.5571.00
188_Y252_T1.5561.00
246_L251_V1.5531.00
257_V260_E1.5521.00
140_S144_I1.5511.00
137_E213_R1.5401.00
188_Y256_S1.5331.00
100_T117_K1.5091.00
221_D224_Y1.5061.00
258_L262_Y1.4961.00
170_T272_Q1.4871.00
137_E258_L1.4751.00
267_I287_L1.4621.00
160_V165_G1.4401.00
145_R180_I1.4391.00
135_K139_E1.4341.00
104_S113_K1.4251.00
222_L242_F1.4151.00
180_I262_Y1.4151.00
97_V100_T1.4061.00
241_K245_K1.4031.00
153_A157_V1.3981.00
274_N280_K1.3931.00
55_G102_I1.3851.00
142_E146_L1.3801.00
110_L167_Y1.3771.00
269_A272_Q1.3671.00
73_D197_S1.3641.00
159_G163_A1.3641.00
210_Y214_L1.3621.00
228_H238_D1.3611.00
263_K267_I1.3541.00
276_D280_K1.3521.00
221_D225_L1.3491.00
151_L155_A1.3431.00
25_K28_F1.3421.00
110_L113_K1.3411.00
213_R254_Y1.3401.00
220_E224_Y1.3371.00
281_E285_E1.3251.00
277_K280_K1.3251.00
144_I180_I1.3201.00
211_L251_V1.3111.00
75_H80_M1.3061.00
237_L240_E1.3041.00
142_E145_R1.3031.00
243_Q247_I1.2971.00
263_K291_T1.2971.00
177_Y269_A1.2861.00
254_Y257_V1.2731.00
223_L227_S1.2561.00
121_E146_L1.2541.00
185_S259_L1.2431.00
174_Y270_I1.2431.00
157_V169_E1.2301.00
132_N143_V1.2251.00
118_Y154_L1.2241.00
70_E89_N1.2161.00
100_T120_N1.2131.00
185_S256_S1.2061.00
19_Y23_D1.1931.00
277_K281_E1.1841.00
251_V254_Y1.1791.00
271_E280_K1.1731.00
137_E210_Y1.1721.00
276_D281_E1.1691.00
137_E254_Y1.1661.00
170_T269_A1.1621.00
192_L252_T1.1561.00
262_Y265_K1.1491.00
200_E236_L1.1451.00
220_E223_L1.1421.00
140_S209_L1.1371.00
240_E244_E1.1271.00
215_F249_A1.1261.00
103_Y112_F1.1251.00
288_L292_K1.1191.00
174_Y287_L1.1181.00
281_E284_K1.1181.00
211_L249_A1.1151.00
41_F159_G1.1071.00
37_H41_F1.1071.00
72_E84_R1.0931.00
206_L258_L1.0921.00
150_S153_A1.0851.00
35_I53_G1.0821.00
113_K117_K1.0821.00
141_L180_I1.0671.00
174_Y269_A1.0671.00
264_Q267_I1.0651.00
215_F245_K1.0601.00
24_S79_W1.0601.00
206_L255_I1.0551.00
173_R265_K1.0531.00
260_E292_K1.0521.00
284_K288_L1.0421.00
40_V273_L1.0411.00
39_V279_K1.0341.00
128_D142_E1.0281.00
111_I162_L1.0241.00
224_Y228_H1.0171.00
38_Y43_G1.0061.00
33_S156_N1.0041.00
143_V203_K1.0041.00
129_D203_K1.0021.00
69_L88_L0.9961.00
41_F165_G0.9941.00
52_L158_A0.9891.00
211_L245_K0.9741.00
28_F31_A0.9671.00
265_K268_S0.9601.00
141_L262_Y0.9551.00
41_F163_A0.9471.00
244_E247_I0.9461.00
40_V171_V0.9451.00
189_Y193_S0.9411.00
212_K223_L0.9381.00
54_A101_S0.9361.00
169_E172_E0.9351.00
18_L94_L0.9311.00
263_K287_L0.9211.00
153_A175_S0.9201.00
38_Y163_A0.9191.00
176_Y180_I0.9191.00
225_L242_F0.9181.00
102_I111_I0.9071.00
29_S290_Y0.9071.00
110_L161_L0.9061.00
210_Y258_L0.9001.00
128_D146_L0.8981.00
34_T56_I0.8891.00
107_N110_L0.8871.00
63_S151_L0.8861.00
256_S260_E0.8781.00
43_G48_V0.8741.00
132_N139_E0.8691.00
240_E243_Q0.8651.00
188_Y259_L0.8631.00
141_L258_L0.8601.00
74_N83_N0.8591.00
52_L111_I0.8561.00
272_Q280_K0.8561.00
44_E47_D0.8551.00
33_S178_K0.8551.00
238_D241_K0.8441.00
52_L162_L0.8431.00
137_E209_L0.8351.00
182_A186_G0.8301.00
170_T174_Y0.8301.00
149_G180_I0.8271.00
36_L39_V0.8201.00
252_T256_S0.8131.00
239_K243_Q0.8051.00
197_S201_K0.8011.00
36_L282_L0.8011.00
261_I264_Q0.8001.00
247_I253_Q0.7941.00
186_G189_Y0.7941.00
69_L85_S0.7920.99
173_R176_Y0.7920.99
254_Y258_L0.7910.99
148_C182_A0.7890.99
156_N171_V0.7840.99
208_Y226_I0.7810.99
65_I69_L0.7810.99
188_Y192_L0.7760.99
30_F60_I0.7740.99
60_I63_S0.7730.99
156_N174_Y0.7730.99
30_F182_A0.7720.99
211_L222_L0.7720.99
65_I94_L0.7670.99
114_Y154_L0.7650.99
97_V120_N0.7620.99
70_E123_M0.7570.99
137_E206_L0.7560.99
251_V255_I0.7540.99
192_L256_S0.7520.99
285_E288_L0.7510.99
15_S19_Y0.7440.99
73_D190_V0.7410.99
225_L238_D0.7410.99
246_L249_A0.7360.99
70_E130_I0.7350.99
84_R87_S0.7340.99
23_D79_W0.7310.99
268_S272_Q0.7310.99
40_V279_K0.7310.99
34_T53_G0.7240.99
214_L250_G0.7210.99
67_D71_D0.7210.99
114_Y118_Y0.7190.99
278_E281_E0.7180.99
55_G105_L0.7150.99
174_Y283_I0.7110.99
18_L93_S0.7070.99
55_G115_V0.7050.99
236_L240_E0.7040.99
181_I266_C0.7030.99
227_S231_L0.7020.99
86_E127_H0.7000.99
206_L210_Y0.7000.99
122_A152_I0.6990.99
44_E48_V0.6960.99
148_C152_I0.6950.99
260_E291_T0.6940.99
279_K282_L0.6920.99
106_N113_K0.6920.99
62_S70_E0.6910.99
221_D245_K0.6900.99
191_L207_I0.6870.99
192_L247_I0.6820.98
181_I263_K0.6720.98
155_A159_G0.6720.98
211_L242_F0.6720.98
59_L98_G0.6690.98
64_D77_A0.6680.98
100_T113_K0.6660.98
138_D142_E0.6660.98
186_G196_R0.6660.98
99_L116_L0.6640.98
51_R101_S0.6630.98
222_L245_K0.6620.98
181_I259_L0.6600.98
148_C186_G0.6570.98
128_D131_T0.6560.98
245_K248_K0.6550.98
147_K183_Q0.6530.98
34_T159_G0.6510.98
242_F246_L0.6510.98
282_L285_E0.6510.98
131_T135_K0.6510.98
146_L150_S0.6500.98
118_Y150_S0.6500.98
100_T104_S0.6480.98
184_I259_L0.6460.98
96_T123_M0.6430.98
157_V161_L0.6400.98
141_L145_R0.6400.98
101_S104_S0.6400.98
158_A162_L0.6390.98
41_F171_V0.6380.98
222_L231_L0.6360.98
129_D133_K0.6360.98
257_V264_Q0.6360.98
121_E145_R0.6330.98
235_S240_E0.6320.98
96_T119_V0.6320.98
177_Y180_I0.6300.97
208_Y222_L0.6270.97
154_L158_A0.6250.97
56_I158_A0.6250.97
208_Y242_F0.6240.97
46_L51_R0.6190.97
222_L229_K0.6170.97
17_L82_I0.6140.97
37_H159_G0.6130.97
65_I87_S0.6130.97
51_R105_L0.6100.97
35_I39_V0.6080.97
20_S79_W0.6060.97
52_L105_L0.6050.97
276_D279_K0.5960.97
258_L265_K0.5950.96
237_L241_K0.5930.96
128_D143_V0.5930.96
29_S286_C0.5920.96
34_T155_A0.5910.96
21_F61_L0.5890.96
260_E288_L0.5890.96
58_I94_L0.5880.96
50_T54_A0.5850.96
225_L229_K0.5830.96
285_E289_S0.5810.96
30_F64_D0.5810.96
252_T255_I0.5790.96
278_E282_L0.5770.96
59_L62_S0.5740.96
216_N219_S0.5730.96
103_Y113_K0.5730.96
225_L230_D0.5730.96
27_T186_G0.5730.96
197_S200_E0.5720.96
172_E176_Y0.5720.96
145_R150_S0.5720.96
190_V197_S0.5700.96
207_I255_I0.5680.95
21_F82_I0.5680.95
225_L241_K0.5660.95
35_I50_T0.5650.95
224_Y238_D0.5650.95
174_Y178_K0.5650.95
130_I203_K0.5630.95
39_V42_G0.5620.95
139_E143_V0.5600.95
225_L228_H0.5600.95
285_E292_K0.5590.95
184_I258_L0.5590.95
77_A186_G0.5580.95
99_L119_V0.5570.95
260_E263_K0.5550.95
170_T273_L0.5520.95
68_D71_D0.5520.95
16_Q20_S0.5510.95
14_L17_L0.5500.95
129_D204_H0.5500.95
32_E289_S0.5490.95
69_L83_N0.5470.94
250_G254_Y0.5440.94
206_L254_Y0.5440.94
263_K290_Y0.5420.94
185_S290_Y0.5420.94
99_L115_V0.5420.94
230_D237_L0.5410.94
141_L184_I0.5400.94
219_S226_I0.5400.94
62_S95_Y0.5390.94
43_G46_L0.5370.94
160_V175_S0.5370.94
141_L144_I0.5360.94
67_D187_D0.5350.94
222_L227_S0.5350.94
55_G59_L0.5330.94
174_Y266_C0.5310.93
15_S124_Q0.5300.93
63_S148_C0.5300.93
185_S188_Y0.5290.93
13_D131_T0.5280.93
73_D83_N0.5260.93
214_L249_A0.5260.93
115_V158_A0.5250.93
96_T116_L0.5240.93
99_L102_I0.5240.93
137_E141_L0.5230.93
264_Q271_E0.5230.93
145_R153_A0.5220.93
185_S291_T0.5210.93
121_E124_Q0.5200.93
140_S143_V0.5200.93
68_D76_H0.5200.93
125_G146_L0.5200.93
276_D284_K0.5200.93
95_Y99_L0.5200.93
133_K201_K0.5180.93
259_L263_K0.5160.93
222_L225_L0.5160.93
126_Q191_L0.5140.92
184_I262_Y0.5130.92
59_L154_L0.5120.92
170_T173_R0.5100.92
143_V204_H0.5090.92
60_I148_C0.5080.92
64_D186_G0.5070.92
28_F32_E0.5070.92
129_D143_V0.5060.92
73_D81_K0.5060.92
245_K249_A0.5060.92
72_E83_N0.5030.92
27_T182_A0.5020.91
198_D205_T0.5000.91
59_L115_V0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oyrA 2 0.9599 100 0.169 Contact Map
4jxyA 5 0.9164 100 0.175 Contact Map
1wy0A 2 0.9565 100 0.184 Contact Map
3wjkA 2 0.9431 100 0.184 Contact Map
3rmgA 2 0.9064 100 0.185 Contact Map
3mzvA 2 0.9666 100 0.185 Contact Map
3lmdA 2 0.9231 100 0.185 Contact Map
3aqbB 1 0.9532 100 0.185 Contact Map
3pkoA 2 0.9532 100 0.188 Contact Map
4lobA 2 0.9064 100 0.188 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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