GREMLIN Database
YHXA - Uncharacterized aminotransferase YhxA
UniProt: P33189 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 450 (385)
Sequences: 20879 (12224)
Seq/√Len: 623.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_Y82_K4.4411.00
241_E245_R3.9751.00
405_K445_E3.8831.00
45_W53_R3.5731.00
352_K437_S3.2281.00
40_K47_T3.1111.00
102_K335_Q3.0441.00
200_A239_K3.0271.00
352_K433_E2.8871.00
265_E271_H2.8591.00
341_Q344_Q2.7831.00
345_R349_L2.7161.00
72_E339_D2.6401.00
432_T435_D2.6381.00
362_E444_K2.5331.00
75_E79_E2.4771.00
57_A439_I2.4401.00
102_K338_E2.4211.00
332_K335_Q2.3701.00
72_E336_I2.3341.00
45_W435_D2.3131.00
239_K242_D2.2971.00
39_Q49_T2.2611.00
356_E440_V2.2121.00
242_D246_R2.2031.00
70_R336_I2.1911.00
47_T53_R2.1641.00
72_E332_K2.1091.00
348_D433_E2.1081.00
356_E437_S2.1021.00
102_K331_L2.0741.00
144_K214_T2.0631.00
401_A404_E2.0451.00
99_L330_A1.9791.00
74_A78_Y1.9761.00
204_D246_R1.9751.00
438_F442_T1.9621.00
183_A202_E1.9081.00
363_H444_K1.8831.00
354_L358_Q1.8821.00
48_D52_R1.8811.00
351_A355_G1.8531.00
401_A405_K1.8391.00
52_R406_G1.8371.00
407_L442_T1.8211.00
336_I340_E1.8001.00
219_I252_I1.7771.00
299_R303_E1.7761.00
144_K180_L1.7751.00
367_G381_V1.7731.00
45_W438_F1.7721.00
354_L371_G1.7701.00
39_Q83_E1.7631.00
94_A98_Q1.7521.00
356_E359_A1.7471.00
204_D208_T1.7471.00
203_I240_V1.7131.00
116_S293_S1.6921.00
106_W338_E1.6841.00
101_E105_E1.6381.00
123_N280_T1.6361.00
363_H448_Q1.6271.00
77_A329_L1.6081.00
77_A81_L1.5961.00
265_E347_R1.5891.00
98_Q331_L1.5801.00
102_K105_E1.5791.00
354_L376_I1.5771.00
401_A446_S1.5651.00
358_Q361_R1.5631.00
42_E71_K1.5591.00
149_Y183_A1.5571.00
220_M240_V1.5551.00
44_A435_D1.5281.00
349_L352_K1.5231.00
207_M249_A1.5211.00
253_C269_F1.5141.00
286_T292_L1.5141.00
112_V299_R1.5141.00
281_M294_A1.5081.00
201_N205_R1.5051.00
290_L326_A1.5041.00
79_E83_E1.4971.00
218_V244_C1.4961.00
204_D239_K1.4911.00
349_L436_L1.4741.00
125_T295_T1.4561.00
235_G238_K1.4511.00
402_C409_I1.4491.00
53_R438_F1.4441.00
146_I215_I1.4391.00
44_A430_C1.4381.00
281_M296_A1.4371.00
133_Y301_I1.4351.00
71_K75_E1.4071.00
241_E244_C1.4031.00
145_F217_G1.3971.00
104_N113_I1.3971.00
241_E251_L1.3951.00
405_K446_S1.3951.00
345_R348_D1.3941.00
113_I296_A1.3731.00
107_L296_A1.3691.00
331_L335_Q1.3671.00
266_P270_M1.3651.00
147_S181_H1.3511.00
444_K448_Q1.3451.00
360_L444_K1.3441.00
127_F145_F1.3441.00
100_A115_F1.3331.00
349_L433_E1.3331.00
332_K336_I1.3311.00
352_K356_E1.3301.00
185_P233_P1.3301.00
265_E270_M1.3281.00
75_E78_Y1.3231.00
271_H372_K1.3211.00
220_M237_M1.3181.00
148_R236_Y1.3181.00
356_E444_K1.3181.00
208_T247_H1.3161.00
48_D54_Y1.3141.00
133_Y304_A1.3131.00
201_N204_D1.3091.00
356_E441_K1.3071.00
344_Q348_D1.3071.00
292_L327_C1.2971.00
126_A280_T1.2881.00
105_E338_E1.2831.00
42_E69_G1.2821.00
123_N219_I1.2761.00
269_F279_I1.2751.00
431_L436_L1.2721.00
275_K298_K1.2711.00
278_I297_V1.2681.00
360_L440_V1.2661.00
66_I336_I1.2511.00
70_R340_E1.2511.00
218_V240_V1.2471.00
130_A252_I1.2451.00
74_A82_K1.2321.00
435_D438_F1.2321.00
76_A332_K1.2291.00
40_K83_E1.2291.00
69_G74_A1.2211.00
74_A81_L1.2191.00
272_Y372_K1.2141.00
204_D243_I1.2111.00
116_S295_T1.2091.00
38_A46_V1.2081.00
335_Q339_D1.2031.00
285_I292_L1.2021.00
98_Q335_Q1.2021.00
292_L330_A1.1921.00
238_K242_D1.1851.00
347_R351_A1.1751.00
235_G272_Y1.1751.00
77_A325_A1.1601.00
441_K445_E1.1571.00
134_H216_A1.1561.00
162_A179_F1.1531.00
261_G343_I1.1491.00
402_C446_S1.1481.00
115_F327_C1.1421.00
285_I294_A1.1371.00
112_V303_E1.1351.00
108_G111_Y1.1321.00
182_A206_I1.1321.00
405_K442_T1.1241.00
78_Y81_L1.1241.00
250_L301_I1.1211.00
267_F281_M1.1151.00
402_C442_T1.1081.00
238_K273_G1.1011.00
162_A219_I1.0961.00
200_A243_I1.0941.00
278_I295_T1.0931.00
253_C274_V1.0891.00
37_I49_T1.0861.00
438_F441_K1.0841.00
44_A55_L1.0771.00
45_W55_L1.0751.00
202_E205_R1.0711.00
336_I339_D1.0661.00
39_Q94_A1.0461.00
433_E437_S1.0381.00
102_K106_W1.0371.00
42_E53_R1.0371.00
437_S441_K1.0291.00
39_Q47_T1.0271.00
407_L439_I1.0241.00
72_E335_Q1.0211.00
122_A280_T1.0181.00
42_E47_T1.0161.00
142_R248_G1.0091.00
99_L331_L1.0081.00
287_S333_N1.0061.00
397_Q401_A1.0031.00
242_D245_R0.9971.00
244_C249_A0.9961.00
120_S159_A0.9951.00
129_I295_T0.9941.00
355_G359_A0.9911.00
234_D238_K0.9871.00
402_C407_L0.9851.00
143_Y214_T0.9821.00
39_Q51_G0.9821.00
204_D242_D0.9791.00
199_S202_E0.9791.00
204_D247_H0.9761.00
106_W266_P0.9761.00
222_P253_C0.9721.00
344_Q347_R0.9691.00
367_G379_E0.9581.00
260_F337_M0.9531.00
217_G252_I0.9511.00
75_E82_K0.9501.00
264_G270_M0.9501.00
147_S219_I0.9431.00
65_N284_G0.9421.00
79_E328_A0.9401.00
66_I333_N0.9391.00
343_I346_S0.9351.00
400_A404_E0.9291.00
37_I97_I0.9271.00
134_H141_S0.9271.00
55_L435_D0.9261.00
434_E437_S0.9211.00
205_R210_E0.9211.00
237_M272_Y0.9211.00
196_T199_S0.9201.00
350_G354_L0.9191.00
379_E421_N0.9181.00
109_G279_I0.9171.00
223_I372_K0.9171.00
72_E75_E0.9161.00
196_T202_E0.9131.00
126_A252_I0.9111.00
127_F162_A0.9101.00
355_G358_Q0.9081.00
377_G422_V0.9051.00
66_I73_L0.8981.00
129_I297_V0.8981.00
235_G239_K0.8961.00
240_V251_L0.8921.00
231_M372_K0.8911.00
148_R232_P0.8881.00
359_A444_K0.8861.00
111_Y299_R0.8851.00
271_H347_R0.8851.00
328_A332_K0.8841.00
73_L329_L0.8841.00
55_L438_F0.8831.00
345_R433_E0.8811.00
133_Y250_L0.8811.00
110_D275_K0.8781.00
359_A362_E0.8781.00
106_W334_L0.8771.00
144_K215_I0.8751.00
337_M343_I0.8731.00
95_P328_A0.8721.00
57_A431_L0.8711.00
143_Y178_G0.8711.00
337_M342_L0.8701.00
49_T94_A0.8671.00
108_G269_F0.8631.00
148_R184_P0.8631.00
212_S247_H0.8621.00
161_S176_S0.8581.00
245_R275_K0.8571.00
207_M215_I0.8551.00
120_S156_T0.8541.00
79_E82_K0.8531.00
361_R366_V0.8491.00
130_A217_G0.8481.00
243_I247_H0.8451.00
184_P232_P0.8431.00
44_A432_T0.8401.00
144_K208_T0.8401.00
396_N400_A0.8391.00
362_E448_Q0.8391.00
64_V287_S0.8341.00
98_Q102_K0.8271.00
266_P343_I0.8271.00
141_S214_T0.8171.00
368_D379_E0.8161.00
431_L439_I0.8161.00
258_C375_L0.8101.00
72_E76_A0.8091.00
342_L346_S0.8091.00
343_I347_R0.8071.00
202_E206_I0.8031.00
130_A250_L0.7991.00
95_P331_L0.7981.00
132_Q315_R0.7971.00
348_D352_K0.7911.00
103_L296_A0.7871.00
374_L431_L0.7851.00
55_L439_I0.7831.00
352_K355_G0.7791.00
244_C251_L0.7781.00
356_E436_L0.7771.00
370_R379_E0.7771.00
211_L214_T0.7761.00
113_I294_A0.7761.00
180_L206_I0.7741.00
260_F334_L0.7731.00
197_L239_K0.7721.00
183_A199_S0.7721.00
239_K243_I0.7701.00
197_L201_N0.7691.00
290_L325_A0.7691.00
399_V411_K0.7661.00
95_P98_Q0.7621.00
222_P237_M0.7581.00
369_V376_I0.7561.00
375_L426_A0.7551.00
43_G430_C0.7551.00
269_F274_V0.7541.00
99_L327_C0.7531.00
134_H248_G0.7521.00
62_W426_A0.7431.00
425_L443_V0.7411.00
207_M243_I0.7391.00
241_E274_V0.7371.00
267_F279_I0.7371.00
349_L374_L0.7301.00
398_V443_V0.7291.00
371_G376_I0.7271.00
130_A278_I0.7261.00
260_F281_M0.7251.00
95_P327_C0.7241.00
318_N321_G0.7221.00
248_G300_D0.7221.00
263_T271_H0.7221.00
55_L407_L0.7221.00
76_A329_L0.7221.00
220_M251_L0.7201.00
300_D303_E0.7191.00
260_F266_P0.7181.00
218_V249_A0.7151.00
182_A185_P0.7151.00
44_A428_P0.7141.00
238_K272_Y0.7141.00
126_A278_I0.7131.00
397_Q400_A0.7071.00
261_G337_M0.7071.00
116_S122_A0.7061.00
266_P338_E0.7041.00
346_S350_G0.7021.00
127_F219_I0.7011.00
25_H28_K0.7001.00
298_K301_I0.6991.00
196_T200_A0.6991.00
306_Q315_R0.6981.00
129_I305_Y0.6981.00
215_I249_A0.6951.00
57_A407_L0.6921.00
348_D351_A0.6921.00
117_N121_E0.6911.00
92_S97_I0.6891.00
109_G275_K0.6881.00
93_H96_A0.6881.00
269_F276_P0.6871.00
123_N159_A0.6851.00
203_I218_V0.6851.00
52_R404_E0.6841.00
223_I263_T0.6831.00
225_T257_I0.6821.00
58_M410_G0.6821.00
80_Q83_E0.6801.00
158_G176_S0.6801.00
434_E438_F0.6761.00
83_E94_A0.6751.00
281_M285_I0.6741.00
379_E422_V0.6721.00
361_R368_D0.6701.00
73_L287_S0.6691.00
251_L274_V0.6681.00
380_L398_V0.6671.00
360_L363_H0.6671.00
106_W267_F0.6641.00
102_K334_L0.6641.00
439_I442_T0.6641.00
180_L183_A0.6641.00
234_D272_Y0.6631.00
96_A100_A0.6611.00
38_A41_A0.6591.00
252_I278_I0.6581.00
382_K394_K0.6561.00
95_P99_L0.6561.00
234_D372_K0.6561.00
231_M371_G0.6551.00
245_R251_L0.6531.00
207_M247_H0.6521.00
345_R432_T0.6511.00
431_L435_D0.6501.00
83_E95_P0.6491.00
260_F285_I0.6491.00
232_P235_G0.6471.00
44_A431_L0.6461.00
398_V402_C0.6451.00
118_S121_E0.6451.00
352_K436_L0.6431.00
398_V446_S0.6431.00
237_M253_C0.6421.00
351_A354_L0.6411.00
381_V384_K0.6391.00
380_L447_F0.6391.00
81_L325_A0.6391.00
224_I227_G0.6391.00
350_G371_G0.6391.00
205_R208_T0.6391.00
37_I92_S0.6391.00
346_S429_F0.6371.00
110_D298_K0.6361.00
76_A79_E0.6361.00
80_Q95_P0.6361.00
224_I375_L0.6331.00
369_V378_I0.6321.00
97_I101_E0.6321.00
402_C443_V0.6321.00
129_I278_I0.6311.00
243_I246_R0.6311.00
400_A403_K0.6311.00
109_G269_F0.6301.00
128_K316_H0.6291.00
107_L279_I0.6281.00
59_S426_A0.6281.00
440_V444_K0.6271.00
106_W265_E0.6261.00
107_L267_F0.6251.00
365_A381_V0.6251.00
442_T446_S0.6241.00
182_A203_I0.6241.00
256_V280_T0.6241.00
69_G81_L0.6211.00
133_Y300_D0.6171.00
66_I342_L0.6171.00
108_G275_K0.6161.00
144_K211_L0.6151.00
393_A397_Q0.6151.00
99_L292_L0.6151.00
144_K178_G0.6141.00
200_A204_D0.6121.00
119_G256_V0.6121.00
53_R442_T0.6111.00
107_L111_Y0.6111.00
353_L440_V0.6111.00
297_V302_F0.6111.00
71_K82_K0.6101.00
201_N239_K0.6101.00
423_I443_V0.6091.00
41_A84_L0.6081.00
394_K397_Q0.6071.00
407_L438_F0.6061.00
282_A293_S0.6051.00
301_I304_A0.6051.00
131_R174_P0.6051.00
149_Y181_H0.6041.00
46_V408_I0.6031.00
425_L439_I0.6021.00
81_L329_L0.6021.00
146_I203_I0.6011.00
108_G270_M0.6001.00
59_S428_P0.6001.00
346_S374_L0.5991.00
144_K210_E0.5951.00
142_R214_T0.5941.00
329_L332_K0.5931.00
58_M408_I0.5931.00
142_R249_A0.5921.00
222_P258_C0.5921.00
148_R220_M0.5911.00
65_N429_F0.5891.00
378_I443_V0.5891.00
356_E360_L0.5881.00
131_R157_L0.5871.00
442_T445_E0.5871.00
360_L441_K0.5861.00
363_H447_F0.5841.00
347_R350_G0.5821.00
245_R300_D0.5811.00
370_R422_V0.5811.00
353_L376_I0.5801.00
398_V423_I0.5801.00
182_A202_E0.5801.00
349_L431_L0.5791.00
125_T316_H0.5781.00
361_R369_V0.5781.00
76_A335_Q0.5781.00
38_A91_Q0.5751.00
99_L115_F0.5731.00
36_L39_Q0.5721.00
238_K241_E0.5691.00
148_R182_A0.5691.00
353_L436_L0.5691.00
55_L431_L0.5681.00
370_R377_G0.5681.00
278_I301_I0.5681.00
225_T375_L0.5661.00
98_Q101_E0.5661.00
338_E341_Q0.5661.00
395_V411_K0.5651.00
42_E45_W0.5651.00
410_G413_G0.5651.00
399_V403_K0.5641.00
80_Q84_L0.5631.00
28_K31_H0.5621.00
41_A46_V0.5611.00
164_G181_H0.5601.00
152_Y155_N0.5591.00
366_V447_F0.5561.00
260_F267_F0.5561.00
208_T214_T0.5541.00
134_H142_R0.5531.00
36_L403_K0.5531.00
208_T246_R0.5511.00
81_L85_P0.5501.00
104_N109_G0.5491.00
65_N337_M0.5461.00
127_F158_G0.5450.99
437_S440_V0.5450.99
146_I182_A0.5430.99
38_A84_L0.5430.99
303_E306_Q0.5420.99
220_M253_C0.5410.99
39_Q42_E0.5380.99
203_I243_I0.5370.99
146_I206_I0.5360.99
279_I296_A0.5360.99
227_G230_L0.5360.99
166_A170_Y0.5350.99
37_I94_A0.5340.99
203_I239_K0.5340.99
79_E332_K0.5340.99
240_V249_A0.5320.99
439_I443_V0.5320.99
26_A31_H0.5310.99
349_L432_T0.5310.99
234_D273_G0.5290.99
104_N296_A0.5290.99
147_S179_F0.5280.99
213_E247_H0.5280.99
203_I207_M0.5270.99
27_M31_H0.5260.99
352_K440_V0.5260.99
116_S121_E0.5260.99
257_I375_L0.5250.99
323_S326_A0.5240.99
436_L440_V0.5240.99
222_P269_F0.5220.99
334_L338_E0.5210.99
443_V447_F0.5200.99
266_P337_M0.5190.99
73_L333_N0.5180.99
150_R227_G0.5170.99
148_R240_V0.5170.99
428_P431_L0.5170.99
406_G442_T0.5170.99
436_L439_I0.5160.99
340_E345_R0.5150.99
107_L113_I0.5150.99
166_A169_K0.5110.99
232_P237_M0.5100.99
104_N111_Y0.5100.99
250_L278_I0.5090.99
91_Q408_I0.5080.99
107_L281_M0.5060.99
71_K74_A0.5060.99
236_Y240_V0.5030.99
276_P279_I0.5030.99
241_E253_C0.5030.99
353_L439_I0.5020.99
266_P334_L0.5020.99
268_G272_Y0.5010.99
238_K274_V0.5000.99
73_L332_K0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4a0gA 2 0.9533 100 0.374 Contact Map
4e3qA 3 0.96 100 0.382 Contact Map
4atqA 7 0.9511 100 0.388 Contact Map
3hmuA 2 0.9622 100 0.391 Contact Map
3oksA 2 0.9489 100 0.392 Contact Map
4uoxA 3 0.9267 100 0.392 Contact Map
1z7dA 2 0.8356 100 0.394 Contact Map
2epjA 2 0.8889 100 0.402 Contact Map
4ffcA 4 0.9444 100 0.404 Contact Map
3i5tA 2 0.9444 100 0.405 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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