EFTU - BACSU - GREMLIN Contacts

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EFTU - Elongation factor Tu

UniProt:	P33166	Sequences: MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGTAMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLSEYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVEDVFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDNIGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFYFRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVSTITE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	396 (349)
Sequences:	18154 (8436)
Seq/√Len:	451.6

ECOLI - EFTU2 EFTU1 CYSN TYPA LEPA SELB EFG RF3 IF2
BACSU - EFTU TYPA LEPA EFG IF2
HALSA - EF1A IF2G Q9HPE4 EF2 IF2P
SULSO - EF1A Q97W17 IF2G IF2P EF2 Q97ZV5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
271_A	277_I	5.501	1.00
239_K	270_Y	4.590	1.00
135_F	174_G	4.587	1.00
237_Q	270_Y	4.376	1.00
172_V	196_A	3.589	1.00
145_E	150_L	2.940	1.00
242_D	297_K	2.797	1.00
213_M	235_R	2.793	1.00
145_E	149_E	2.742	1.00
110_A	141_M	2.646	1.00
239_K	242_D	2.574	1.00
178_K	188_A	2.526	1.00
212_F	233_V	2.506	1.00
243_E	255_K	2.479	1.00
195_D	199_E	2.396	1.00
174_G	193_L	2.356	1.00
40_S	43_G	2.342	1.00
240_V	269_D	2.275	1.00
152_E	156_R	2.182	1.00
370_A	373_E	2.145	1.00
16_G	100_M	2.075	1.00
72_E	77_H	2.074	1.00
55_P	59_E	2.052	1.00
353_V	359_T	2.034	1.00
207_D	210_K	2.027	1.00
102_G	201_I	2.007	1.00
237_Q	272_E	1.998	1.00
212_F	238_V	1.988	1.00
210_K	235_R	1.981	1.00
29_T	80_H	1.952	1.00
370_A	374_G	1.892	1.00
153_M	157_D	1.872	1.00
39_K	42_K	1.872	1.00
231_G	279_A	1.858	1.00
15_I	78_Y	1.826	1.00
220_F	230_T	1.812	1.00
240_V	267_L	1.811	1.00
260_G	267_L	1.811	1.00
56_E	64_I	1.807	1.00
233_V	277_I	1.802	1.00
229_A	289_I	1.791	1.00
228_V	278_G	1.791	1.00
150_L	154_E	1.782	1.00
272_E	275_D	1.780	1.00
212_F	244_V	1.778	1.00
152_E	171_V	1.776	1.00
109_A	136_L	1.772	1.00
214_M	231_G	1.762	1.00
152_E	173_K	1.760	1.00
104_I	135_F	1.754	1.00
121_I	155_V	1.750	1.00
233_V	271_A	1.715	1.00
70_E	77_H	1.698	1.00
189_K	192_E	1.681	1.00
216_V	229_A	1.669	1.00
51_I	69_V	1.657	1.00
39_K	43_G	1.652	1.00
17_T	29_T	1.642	1.00
255_K	261_V	1.639	1.00
108_S	111_D	1.635	1.00
35_V	191_F	1.607	1.00
74_E	195_D	1.593	1.00
137_N	176_A	1.583	1.00
196_A	200_Y	1.579	1.00
227_T	337_T	1.577	1.00
135_F	176_A	1.571	1.00
245_E	298_P	1.564	1.00
247_I	296_A	1.562	1.00
107_V	117_T	1.561	1.00
263_M	266_K	1.549	1.00
151_V	154_E	1.529	1.00
255_K	263_M	1.513	1.00
46_M	50_Q	1.512	1.00
372_E	375_T	1.511	1.00
191_F	195_D	1.509	1.00
257_T	282_R	1.506	1.00
31_A	179_A	1.490	1.00
348_E	352_M	1.478	1.00
72_E	75_T	1.471	1.00
28_L	106_V	1.468	1.00
260_G	268_L	1.416	1.00
32_I	190_I	1.413	1.00
369_I	373_E	1.407	1.00
45_A	48_Y	1.400	1.00
37_H	41_G	1.400	1.00
349_G	352_M	1.398	1.00
368_T	372_E	1.394	1.00
81_V	100_M	1.390	1.00
103_A	124_S	1.386	1.00
324_P	327_S	1.378	1.00
39_K	50_Q	1.372	1.00
149_E	153_M	1.363	1.00
76_R	198_D	1.361	1.00
105_L	134_V	1.360	1.00
43_G	46_M	1.352	1.00
111_D	114_M	1.344	1.00
28_L	176_A	1.338	1.00
279_A	295_L	1.311	1.00
47_A	50_Q	1.308	1.00
31_A	34_T	1.307	1.00
214_M	233_V	1.306	1.00
268_L	271_A	1.305	1.00
346_L	350_V	1.304	1.00
175_S	178_K	1.301	1.00
336_R	342_G	1.294	1.00
73_T	195_D	1.292	1.00
232_R	276_N	1.291	1.00
113_P	117_T	1.291	1.00
18_I	124_S	1.289	1.00
46_M	49_D	1.278	1.00
261_V	264_F	1.276	1.00
28_L	193_L	1.263	1.00
94_I	123_L	1.262	1.00
369_I	374_G	1.262	1.00
103_A	129_V	1.261	1.00
370_A	375_T	1.259	1.00
51_I	63_T	1.257	1.00
311_V	343_I	1.257	1.00
245_E	252_E	1.257	1.00
32_I	71_Y	1.252	1.00
238_V	258_V	1.251	1.00
243_E	252_E	1.240	1.00
134_V	155_V	1.234	1.00
345_H	354_M	1.223	1.00
14_N	79_A	1.218	1.00
29_T	51_I	1.217	1.00
36_L	194_M	1.215	1.00
153_M	156_R	1.212	1.00
359_T	362_N	1.210	1.00
159_L	163_D	1.209	1.00
11_S	76_R	1.207	1.00
170_P	196_A	1.206	1.00
54_A	65_S	1.205	1.00
36_L	71_Y	1.203	1.00
238_V	279_A	1.191	1.00
159_L	162_Y	1.190	1.00
120_H	123_L	1.180	1.00
134_V	171_V	1.180	1.00
369_I	372_E	1.176	1.00
257_T	267_L	1.176	1.00
347_P	350_V	1.174	1.00
71_Y	78_Y	1.171	1.00
208_T	272_E	1.170	1.00
71_Y	80_H	1.162	1.00
45_A	49_D	1.151	1.00
154_E	157_D	1.149	1.00
331_P	335_F	1.140	1.00
244_V	295_L	1.134	1.00
327_S	330_R	1.130	1.00
259_T	263_M	1.110	1.00
231_G	277_I	1.106	1.00
353_V	364_E	1.104	1.00
136_L	173_K	1.098	1.00
148_L	151_V	1.096	1.00
43_G	48_Y	1.094	1.00
139_C	173_K	1.092	1.00
251_E	288_E	1.090	1.00
41_G	45_A	1.077	1.00
356_G	359_T	1.074	1.00
259_T	262_E	1.072	1.00
306_K	362_N	1.071	1.00
297_K	300_T	1.069	1.00
208_T	237_Q	1.060	1.00
355_P	360_E	1.060	1.00
346_L	349_G	1.051	1.00
15_I	197_V	1.046	1.00
18_I	103_A	1.045	1.00
40_S	46_M	1.041	1.00
328_N	331_P	1.038	1.00
31_A	35_V	1.033	1.00
306_K	364_E	1.032	1.00
335_F	338_T	1.022	1.00
245_E	255_K	1.017	1.00
144_D	148_L	1.010	1.00
39_K	45_A	1.010	1.00
244_V	255_K	1.009	1.00
238_V	271_A	1.004	1.00
245_E	250_Q	1.003	1.00
198_D	202_P	0.996	1.00
43_G	50_Q	0.996	1.00
259_T	264_F	0.996	1.00
248_G	293_Q	0.994	1.00
74_E	198_D	0.991	1.00
357_D	360_E	0.987	1.00
28_L	135_F	0.986	1.00
290_Q	293_Q	0.983	1.00
346_L	352_M	0.983	1.00
55_P	58_R	0.980	1.00
11_S	75_T	0.980	1.00
239_K	269_D	0.977	1.00
308_K	360_E	0.976	1.00
18_I	105_L	0.972	1.00
326_F	335_F	0.971	1.00
271_A	275_D	0.966	1.00
35_V	179_A	0.963	1.00
78_Y	198_D	0.961	1.00
31_A	190_I	0.961	1.00
257_T	261_V	0.959	1.00
140_D	175_S	0.959	1.00
342_G	364_E	0.958	1.00
366_I	369_I	0.948	1.00
133_V	196_A	0.945	1.00
109_A	139_C	0.941	1.00
315_S	354_M	0.937	1.00
160_S	163_D	0.933	1.00
149_E	152_E	0.928	1.00
170_P	200_Y	0.927	1.00
165_P	168_D	0.926	1.00
335_F	340_V	0.924	1.00
52_D	57_E	0.920	1.00
359_T	363_V	0.918	1.00
342_G	353_V	0.916	1.00
134_V	169_V	0.912	1.00
354_M	357_D	0.911	1.00
346_L	351_E	0.911	1.00
356_G	362_N	0.910	1.00
32_I	194_M	0.908	1.00
27_T	176_A	0.905	1.00
360_E	364_E	0.903	1.00
149_E	173_K	0.901	1.00
355_P	359_T	0.900	1.00
42_K	45_A	0.897	1.00
53_G	65_S	0.897	1.00
325_F	328_N	0.895	1.00
333_F	336_R	0.892	1.00
284_V	289_I	0.891	1.00
246_I	289_I	0.890	1.00
355_P	358_N	0.887	1.00
56_E	60_R	0.887	1.00
41_G	48_Y	0.886	1.00
66_T	81_V	0.884	1.00
347_P	351_E	0.883	1.00
246_I	295_L	0.883	1.00
43_G	49_D	0.882	1.00
51_I	67_A	0.881	1.00
53_G	67_A	0.879	1.00
107_V	155_V	0.875	1.00
105_L	117_T	0.874	1.00
321_R	324_P	0.874	1.00
357_D	362_N	0.872	1.00
121_I	132_I	0.872	1.00
104_I	197_V	0.869	1.00
118_R	158_L	0.868	1.00
329_Y	333_F	0.866	1.00
124_S	132_I	0.865	1.00
216_V	289_I	0.863	1.00
319_G	322_H	0.856	1.00
200_Y	203_T	0.852	1.00
192_E	195_D	0.851	1.00
336_R	344_I	0.846	1.00
22_D	86_H	0.845	1.00
17_T	104_I	0.840	1.00
369_I	375_T	0.837	1.00
243_E	298_P	0.831	1.00
335_F	339_D	0.826	1.00
42_K	46_M	0.826	1.00
366_I	372_E	0.825	1.00
37_H	40_S	0.825	1.00
208_T	273_A	0.822	1.00
145_E	151_V	0.821	1.00
209_E	237_Q	0.821	1.00
255_K	264_F	0.820	1.00
110_A	143_D	0.820	1.00
148_L	173_K	0.817	1.00
348_E	351_E	0.817	1.00
258_V	279_A	0.809	1.00
245_E	253_N	0.807	1.00
40_S	49_D	0.807	1.00
20_H	23_H	0.806	1.00
310_E	360_E	0.803	1.00
150_L	153_M	0.802	1.00
144_D	150_L	0.801	1.00
41_G	46_M	0.798	1.00
331_P	367_S	0.797	1.00
325_F	329_Y	0.797	1.00
16_G	83_C	0.794	1.00
12_H	79_A	0.794	1.00
158_L	163_D	0.793	1.00
208_T	211_P	0.793	1.00
327_S	332_Q	0.789	1.00
28_L	190_I	0.789	1.00
39_K	49_D	0.782	1.00
366_I	370_A	0.780	1.00
37_H	45_A	0.777	1.00
35_V	190_I	0.777	1.00
136_L	148_L	0.774	1.00
257_T	263_M	0.772	1.00
102_G	202_P	0.771	1.00
245_E	301_I	0.770	1.00
313_V	316_K	0.768	1.00
19_G	23_H	0.765	1.00
42_K	49_D	0.765	1.00
366_I	373_E	0.764	1.00
356_G	360_E	0.764	1.00
211_P	297_K	0.764	1.00
296_A	302_T	0.763	1.00
260_G	264_F	0.761	1.00
308_K	362_N	0.760	1.00
311_V	361_M	0.759	1.00
238_V	244_V	0.757	1.00
206_R	235_R	0.755	1.00
41_G	49_D	0.754	1.00
307_F	310_E	0.754	1.00
133_V	172_V	0.749	1.00
341_T	362_N	0.748	1.00
256_T	261_V	0.744	1.00
235_R	302_T	0.737	1.00
308_K	311_V	0.737	1.00
43_G	47_A	0.736	1.00
358_N	362_N	0.733	1.00
368_T	374_G	0.730	1.00
353_V	356_G	0.727	1.00
107_V	134_V	0.724	1.00
367_S	374_G	0.722	1.00
368_T	371_I	0.722	1.00
307_F	311_V	0.721	1.00
148_L	152_E	0.721	1.00
268_L	275_D	0.718	1.00
196_A	199_E	0.717	1.00
106_V	137_N	0.717	1.00
21_V	86_H	0.716	1.00
359_T	364_E	0.715	1.00
199_E	203_T	0.715	1.00
352_M	356_G	0.710	1.00
135_F	193_L	0.708	1.00
139_C	148_L	0.706	1.00
16_G	97_A	0.702	1.00
250_Q	253_N	0.702	1.00
327_S	331_P	0.700	1.00
307_F	365_L	0.695	1.00
330_R	334_Y	0.695	1.00
213_M	302_T	0.693	1.00
47_A	51_I	0.691	1.00
330_R	333_F	0.691	1.00
260_G	263_M	0.690	1.00
368_T	373_E	0.690	1.00
263_M	268_L	0.689	1.00
193_L	197_V	0.689	1.00
371_I	375_T	0.687	1.00
206_R	273_A	0.683	1.00
350_V	357_D	0.682	1.00
351_E	357_D	0.681	1.00
16_G	103_A	0.678	1.00
244_V	256_T	0.677	1.00
339_D	362_N	0.676	1.00
357_D	361_M	0.675	1.00
73_T	198_D	0.674	1.00
246_I	256_T	0.674	1.00
206_R	210_K	0.673	1.00
91_K	341_T	0.673	1.00
255_K	259_T	0.672	1.00
22_D	62_I	0.672	1.00
145_E	148_L	0.671	1.00
352_M	359_T	0.667	1.00
256_T	262_E	0.666	1.00
148_L	156_R	0.663	1.00
256_T	283_G	0.663	1.00
135_F	189_K	0.662	1.00
33_T	69_V	0.662	1.00
22_D	61_G	0.661	1.00
259_T	282_R	0.661	1.00
65_S	92_N	0.660	1.00
237_Q	273_A	0.659	1.00
42_K	48_Y	0.658	1.00
214_M	279_A	0.658	1.00
102_G	133_V	0.657	1.00
144_D	151_V	0.656	1.00
156_R	159_L	0.655	1.00
323_T	331_P	0.654	1.00
52_D	58_R	0.654	1.00
105_L	120_H	0.651	1.00
118_R	122_L	0.651	1.00
113_P	151_V	0.647	1.00
158_L	162_Y	0.645	1.00
347_P	352_M	0.645	1.00
101_D	232_R	0.645	1.00
48_Y	58_R	0.643	0.99
245_E	299_G	0.642	0.99
156_R	160_S	0.637	0.99
243_E	254_K	0.636	0.99
104_I	193_L	0.632	0.99
57_E	61_G	0.630	0.99
362_N	365_L	0.629	0.99
326_F	329_Y	0.629	0.99
33_T	50_Q	0.628	0.99
37_H	43_G	0.628	0.99
39_K	47_A	0.627	0.99
233_V	238_V	0.626	0.99
268_L	277_I	0.623	0.99
174_G	189_K	0.622	0.99
70_E	79_A	0.622	0.99
108_S	141_M	0.621	0.99
367_S	370_A	0.621	0.99
360_E	366_I	0.618	0.99
256_T	284_V	0.617	0.99
312_Y	316_K	0.617	0.99
156_R	168_D	0.616	0.99
262_E	266_K	0.615	0.99
326_F	330_R	0.615	0.99
144_D	154_E	0.614	0.99
214_M	217_E	0.613	0.99
139_C	188_A	0.610	0.99
77_H	275_D	0.608	0.99
198_D	201_I	0.607	0.99
39_K	48_Y	0.605	0.99
262_E	267_L	0.604	0.99
245_E	296_A	0.604	0.99
195_D	198_D	0.604	0.99
21_V	62_I	0.601	0.99
37_H	49_D	0.601	0.99
333_F	337_T	0.600	0.99
243_E	257_T	0.600	0.99
328_N	332_Q	0.597	0.99
296_A	301_I	0.596	0.99
355_P	361_M	0.595	0.99
325_F	331_P	0.594	0.99
93_M	120_H	0.590	0.99
32_I	36_L	0.590	0.99
255_K	260_G	0.587	0.99
343_I	357_D	0.587	0.99
73_T	194_M	0.586	0.99
222_I	228_V	0.586	0.99
45_A	50_Q	0.585	0.99
211_P	300_T	0.585	0.99
259_T	267_L	0.584	0.99
157_D	160_S	0.584	0.99
328_N	337_T	0.584	0.99
40_S	45_A	0.583	0.99
40_S	48_Y	0.583	0.99
222_I	225_R	0.578	0.99
158_L	161_E	0.577	0.99
121_I	125_K	0.576	0.99
214_M	238_V	0.576	0.99
358_N	363_V	0.575	0.99
199_E	202_P	0.575	0.99
256_T	259_T	0.574	0.99
21_V	63_T	0.573	0.99
360_E	363_V	0.573	0.99
339_D	342_G	0.572	0.99
219_V	291_R	0.571	0.99
145_E	156_R	0.571	0.99
20_H	114_M	0.571	0.99
47_A	58_R	0.570	0.99
213_M	304_H	0.569	0.99
261_V	271_A	0.569	0.99
94_I	120_H	0.567	0.99
333_F	342_G	0.565	0.99
337_T	340_V	0.563	0.99
205_E	210_K	0.563	0.99
362_N	366_I	0.562	0.99
57_E	60_R	0.562	0.99
248_G	252_E	0.562	0.99
248_G	251_E	0.561	0.99
324_P	335_F	0.559	0.99
309_A	312_Y	0.555	0.99
324_P	328_N	0.554	0.99
357_D	364_E	0.554	0.99
322_H	327_S	0.553	0.98
229_A	279_A	0.553	0.98
304_H	307_F	0.553	0.98
87_A	115_P	0.552	0.98
156_R	161_E	0.551	0.98
351_E	354_M	0.550	0.98
351_E	360_E	0.549	0.98
60_R	64_I	0.549	0.98
42_K	47_A	0.547	0.98
62_I	86_H	0.547	0.98
364_E	367_S	0.546	0.98
332_Q	335_F	0.546	0.98
350_V	356_G	0.546	0.98
312_Y	318_E	0.545	0.98
265_R	278_G	0.542	0.98
133_V	197_V	0.538	0.98
18_I	97_A	0.538	0.98
20_H	117_T	0.538	0.98
240_V	261_V	0.536	0.98
246_I	293_Q	0.536	0.98
312_Y	315_S	0.535	0.98
356_G	363_V	0.534	0.98
152_E	164_F	0.533	0.98
74_E	199_E	0.531	0.98
331_P	339_D	0.529	0.98
371_I	374_G	0.528	0.98
351_E	356_G	0.526	0.98
315_S	352_M	0.525	0.98
178_K	190_I	0.525	0.98
235_R	273_A	0.524	0.98
212_F	237_Q	0.524	0.98
216_V	231_G	0.523	0.98
49_D	58_R	0.523	0.98
66_T	96_G	0.522	0.98
39_K	46_M	0.521	0.98
194_M	197_V	0.521	0.98
351_E	362_N	0.519	0.98
331_P	342_G	0.518	0.98
223_T	226_G	0.517	0.98
136_L	152_E	0.517	0.98
97_A	127_V	0.516	0.98
351_E	359_T	0.515	0.98
37_H	42_K	0.513	0.98
13_A	204_P	0.513	0.98
102_G	197_V	0.512	0.98
196_A	201_I	0.512	0.98
163_D	167_D	0.511	0.97
314_L	318_E	0.510	0.97
353_V	360_E	0.509	0.97
279_A	282_R	0.509	0.97
164_F	167_D	0.508	0.97
365_L	369_I	0.507	0.97
331_P	337_T	0.506	0.97
257_T	260_G	0.506	0.97
75_T	199_E	0.505	0.97
78_Y	197_V	0.505	0.97
359_T	366_I	0.505	0.97
320_G	324_P	0.504	0.97
233_V	272_E	0.504	0.97
108_S	138_K	0.503	0.97
83_C	93_M	0.503	0.97
231_G	271_A	0.503	0.97
334_Y	338_T	0.502	0.97
240_V	260_G	0.501	0.97
367_S	371_I	0.500	0.97
23_H	111_D	0.500	0.97
358_N	361_M	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2c78A	1	0.9596	100	0.258	Contact Map
1d2eA	3	0.9545	100	0.273	Contact Map
1jnyA	1	0.9369	100	0.278	Contact Map
4crnP	1	0.9646	100	0.283	Contact Map
1f60A	1	0.9747	100	0.284	Contact Map
4d61i	1	0.9596	100	0.285	Contact Map
3wy9A	1	0.9672	100	0.287	Contact Map
3avxA	1	0.9167	100	0.288	Contact Map
3mcaA	1	0.8561	100	0.291	Contact Map
1r5bA	1	0.8813	100	0.299	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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