GREMLIN Database
EFTU - Elongation factor Tu
UniProt: P33166 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 396 (349)
Sequences: 18154 (8436)
Seq/√Len: 451.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
271_A277_I5.5011.00
239_K270_Y4.5901.00
135_F174_G4.5871.00
237_Q270_Y4.3761.00
172_V196_A3.5891.00
145_E150_L2.9401.00
242_D297_K2.7971.00
213_M235_R2.7931.00
145_E149_E2.7421.00
110_A141_M2.6461.00
239_K242_D2.5741.00
178_K188_A2.5261.00
212_F233_V2.5061.00
243_E255_K2.4791.00
195_D199_E2.3961.00
174_G193_L2.3561.00
40_S43_G2.3421.00
240_V269_D2.2751.00
152_E156_R2.1821.00
370_A373_E2.1451.00
16_G100_M2.0751.00
72_E77_H2.0741.00
55_P59_E2.0521.00
353_V359_T2.0341.00
207_D210_K2.0271.00
102_G201_I2.0071.00
237_Q272_E1.9981.00
212_F238_V1.9881.00
210_K235_R1.9811.00
29_T80_H1.9521.00
370_A374_G1.8921.00
153_M157_D1.8721.00
39_K42_K1.8721.00
231_G279_A1.8581.00
15_I78_Y1.8261.00
220_F230_T1.8121.00
240_V267_L1.8111.00
260_G267_L1.8111.00
56_E64_I1.8071.00
233_V277_I1.8021.00
229_A289_I1.7911.00
228_V278_G1.7911.00
150_L154_E1.7821.00
272_E275_D1.7801.00
212_F244_V1.7781.00
152_E171_V1.7761.00
109_A136_L1.7721.00
214_M231_G1.7621.00
152_E173_K1.7601.00
104_I135_F1.7541.00
121_I155_V1.7501.00
233_V271_A1.7151.00
70_E77_H1.6981.00
189_K192_E1.6811.00
216_V229_A1.6691.00
51_I69_V1.6571.00
39_K43_G1.6521.00
17_T29_T1.6421.00
255_K261_V1.6391.00
108_S111_D1.6351.00
35_V191_F1.6071.00
74_E195_D1.5931.00
137_N176_A1.5831.00
196_A200_Y1.5791.00
227_T337_T1.5771.00
135_F176_A1.5711.00
245_E298_P1.5641.00
247_I296_A1.5621.00
107_V117_T1.5611.00
263_M266_K1.5491.00
151_V154_E1.5291.00
255_K263_M1.5131.00
46_M50_Q1.5121.00
372_E375_T1.5111.00
191_F195_D1.5091.00
257_T282_R1.5061.00
31_A179_A1.4901.00
348_E352_M1.4781.00
72_E75_T1.4711.00
28_L106_V1.4681.00
260_G268_L1.4161.00
32_I190_I1.4131.00
369_I373_E1.4071.00
45_A48_Y1.4001.00
37_H41_G1.4001.00
349_G352_M1.3981.00
368_T372_E1.3941.00
81_V100_M1.3901.00
103_A124_S1.3861.00
324_P327_S1.3781.00
39_K50_Q1.3721.00
149_E153_M1.3631.00
76_R198_D1.3611.00
105_L134_V1.3601.00
43_G46_M1.3521.00
111_D114_M1.3441.00
28_L176_A1.3381.00
279_A295_L1.3111.00
47_A50_Q1.3081.00
31_A34_T1.3071.00
214_M233_V1.3061.00
268_L271_A1.3051.00
346_L350_V1.3041.00
175_S178_K1.3011.00
336_R342_G1.2941.00
73_T195_D1.2921.00
232_R276_N1.2911.00
113_P117_T1.2911.00
18_I124_S1.2891.00
46_M49_D1.2781.00
261_V264_F1.2761.00
28_L193_L1.2631.00
94_I123_L1.2621.00
369_I374_G1.2621.00
103_A129_V1.2611.00
370_A375_T1.2591.00
51_I63_T1.2571.00
311_V343_I1.2571.00
245_E252_E1.2571.00
32_I71_Y1.2521.00
238_V258_V1.2511.00
243_E252_E1.2401.00
134_V155_V1.2341.00
345_H354_M1.2231.00
14_N79_A1.2181.00
29_T51_I1.2171.00
36_L194_M1.2151.00
153_M156_R1.2121.00
359_T362_N1.2101.00
159_L163_D1.2091.00
11_S76_R1.2071.00
170_P196_A1.2061.00
54_A65_S1.2051.00
36_L71_Y1.2031.00
238_V279_A1.1911.00
159_L162_Y1.1901.00
120_H123_L1.1801.00
134_V171_V1.1801.00
369_I372_E1.1761.00
257_T267_L1.1761.00
347_P350_V1.1741.00
71_Y78_Y1.1711.00
208_T272_E1.1701.00
71_Y80_H1.1621.00
45_A49_D1.1511.00
154_E157_D1.1491.00
331_P335_F1.1401.00
244_V295_L1.1341.00
327_S330_R1.1301.00
259_T263_M1.1101.00
231_G277_I1.1061.00
353_V364_E1.1041.00
136_L173_K1.0981.00
148_L151_V1.0961.00
43_G48_Y1.0941.00
139_C173_K1.0921.00
251_E288_E1.0901.00
41_G45_A1.0771.00
356_G359_T1.0741.00
259_T262_E1.0721.00
306_K362_N1.0711.00
297_K300_T1.0691.00
208_T237_Q1.0601.00
355_P360_E1.0601.00
346_L349_G1.0511.00
15_I197_V1.0461.00
18_I103_A1.0451.00
40_S46_M1.0411.00
328_N331_P1.0381.00
31_A35_V1.0331.00
306_K364_E1.0321.00
335_F338_T1.0221.00
245_E255_K1.0171.00
144_D148_L1.0101.00
39_K45_A1.0101.00
244_V255_K1.0091.00
238_V271_A1.0041.00
245_E250_Q1.0031.00
198_D202_P0.9961.00
43_G50_Q0.9961.00
259_T264_F0.9961.00
248_G293_Q0.9941.00
74_E198_D0.9911.00
357_D360_E0.9871.00
28_L135_F0.9861.00
290_Q293_Q0.9831.00
346_L352_M0.9831.00
55_P58_R0.9801.00
11_S75_T0.9801.00
239_K269_D0.9771.00
308_K360_E0.9761.00
18_I105_L0.9721.00
326_F335_F0.9711.00
271_A275_D0.9661.00
35_V179_A0.9631.00
78_Y198_D0.9611.00
31_A190_I0.9611.00
257_T261_V0.9591.00
140_D175_S0.9591.00
342_G364_E0.9581.00
366_I369_I0.9481.00
133_V196_A0.9451.00
109_A139_C0.9411.00
315_S354_M0.9371.00
160_S163_D0.9331.00
149_E152_E0.9281.00
170_P200_Y0.9271.00
165_P168_D0.9261.00
335_F340_V0.9241.00
52_D57_E0.9201.00
359_T363_V0.9181.00
342_G353_V0.9161.00
134_V169_V0.9121.00
354_M357_D0.9111.00
346_L351_E0.9111.00
356_G362_N0.9101.00
32_I194_M0.9081.00
27_T176_A0.9051.00
360_E364_E0.9031.00
149_E173_K0.9011.00
355_P359_T0.9001.00
42_K45_A0.8971.00
53_G65_S0.8971.00
325_F328_N0.8951.00
333_F336_R0.8921.00
284_V289_I0.8911.00
246_I289_I0.8901.00
355_P358_N0.8871.00
56_E60_R0.8871.00
41_G48_Y0.8861.00
66_T81_V0.8841.00
347_P351_E0.8831.00
246_I295_L0.8831.00
43_G49_D0.8821.00
51_I67_A0.8811.00
53_G67_A0.8791.00
107_V155_V0.8751.00
105_L117_T0.8741.00
321_R324_P0.8741.00
357_D362_N0.8721.00
121_I132_I0.8721.00
104_I197_V0.8691.00
118_R158_L0.8681.00
329_Y333_F0.8661.00
124_S132_I0.8651.00
216_V289_I0.8631.00
319_G322_H0.8561.00
200_Y203_T0.8521.00
192_E195_D0.8511.00
336_R344_I0.8461.00
22_D86_H0.8451.00
17_T104_I0.8401.00
369_I375_T0.8371.00
243_E298_P0.8311.00
335_F339_D0.8261.00
42_K46_M0.8261.00
366_I372_E0.8251.00
37_H40_S0.8251.00
208_T273_A0.8221.00
145_E151_V0.8211.00
209_E237_Q0.8211.00
255_K264_F0.8201.00
110_A143_D0.8201.00
148_L173_K0.8171.00
348_E351_E0.8171.00
258_V279_A0.8091.00
245_E253_N0.8071.00
40_S49_D0.8071.00
20_H23_H0.8061.00
310_E360_E0.8031.00
150_L153_M0.8021.00
144_D150_L0.8011.00
41_G46_M0.7981.00
331_P367_S0.7971.00
325_F329_Y0.7971.00
16_G83_C0.7941.00
12_H79_A0.7941.00
158_L163_D0.7931.00
208_T211_P0.7931.00
327_S332_Q0.7891.00
28_L190_I0.7891.00
39_K49_D0.7821.00
366_I370_A0.7801.00
37_H45_A0.7771.00
35_V190_I0.7771.00
136_L148_L0.7741.00
257_T263_M0.7721.00
102_G202_P0.7711.00
245_E301_I0.7701.00
313_V316_K0.7681.00
19_G23_H0.7651.00
42_K49_D0.7651.00
366_I373_E0.7641.00
356_G360_E0.7641.00
211_P297_K0.7641.00
296_A302_T0.7631.00
260_G264_F0.7611.00
308_K362_N0.7601.00
311_V361_M0.7591.00
238_V244_V0.7571.00
206_R235_R0.7551.00
41_G49_D0.7541.00
307_F310_E0.7541.00
133_V172_V0.7491.00
341_T362_N0.7481.00
256_T261_V0.7441.00
235_R302_T0.7371.00
308_K311_V0.7371.00
43_G47_A0.7361.00
358_N362_N0.7331.00
368_T374_G0.7301.00
353_V356_G0.7271.00
107_V134_V0.7241.00
367_S374_G0.7221.00
368_T371_I0.7221.00
307_F311_V0.7211.00
148_L152_E0.7211.00
268_L275_D0.7181.00
196_A199_E0.7171.00
106_V137_N0.7171.00
21_V86_H0.7161.00
359_T364_E0.7151.00
199_E203_T0.7151.00
352_M356_G0.7101.00
135_F193_L0.7081.00
139_C148_L0.7061.00
16_G97_A0.7021.00
250_Q253_N0.7021.00
327_S331_P0.7001.00
307_F365_L0.6951.00
330_R334_Y0.6951.00
213_M302_T0.6931.00
47_A51_I0.6911.00
330_R333_F0.6911.00
260_G263_M0.6901.00
368_T373_E0.6901.00
263_M268_L0.6891.00
193_L197_V0.6891.00
371_I375_T0.6871.00
206_R273_A0.6831.00
350_V357_D0.6821.00
351_E357_D0.6811.00
16_G103_A0.6781.00
244_V256_T0.6771.00
339_D362_N0.6761.00
357_D361_M0.6751.00
73_T198_D0.6741.00
246_I256_T0.6741.00
206_R210_K0.6731.00
91_K341_T0.6731.00
255_K259_T0.6721.00
22_D62_I0.6721.00
145_E148_L0.6711.00
352_M359_T0.6671.00
256_T262_E0.6661.00
148_L156_R0.6631.00
256_T283_G0.6631.00
135_F189_K0.6621.00
33_T69_V0.6621.00
22_D61_G0.6611.00
259_T282_R0.6611.00
65_S92_N0.6601.00
237_Q273_A0.6591.00
42_K48_Y0.6581.00
214_M279_A0.6581.00
102_G133_V0.6571.00
144_D151_V0.6561.00
156_R159_L0.6551.00
323_T331_P0.6541.00
52_D58_R0.6541.00
105_L120_H0.6511.00
118_R122_L0.6511.00
113_P151_V0.6471.00
158_L162_Y0.6451.00
347_P352_M0.6451.00
101_D232_R0.6451.00
48_Y58_R0.6430.99
245_E299_G0.6420.99
156_R160_S0.6370.99
243_E254_K0.6360.99
104_I193_L0.6320.99
57_E61_G0.6300.99
362_N365_L0.6290.99
326_F329_Y0.6290.99
33_T50_Q0.6280.99
37_H43_G0.6280.99
39_K47_A0.6270.99
233_V238_V0.6260.99
268_L277_I0.6230.99
174_G189_K0.6220.99
70_E79_A0.6220.99
108_S141_M0.6210.99
367_S370_A0.6210.99
360_E366_I0.6180.99
256_T284_V0.6170.99
312_Y316_K0.6170.99
156_R168_D0.6160.99
262_E266_K0.6150.99
326_F330_R0.6150.99
144_D154_E0.6140.99
214_M217_E0.6130.99
139_C188_A0.6100.99
77_H275_D0.6080.99
198_D201_I0.6070.99
39_K48_Y0.6050.99
262_E267_L0.6040.99
245_E296_A0.6040.99
195_D198_D0.6040.99
21_V62_I0.6010.99
37_H49_D0.6010.99
333_F337_T0.6000.99
243_E257_T0.6000.99
328_N332_Q0.5970.99
296_A301_I0.5960.99
355_P361_M0.5950.99
325_F331_P0.5940.99
93_M120_H0.5900.99
32_I36_L0.5900.99
255_K260_G0.5870.99
343_I357_D0.5870.99
73_T194_M0.5860.99
222_I228_V0.5860.99
45_A50_Q0.5850.99
211_P300_T0.5850.99
259_T267_L0.5840.99
157_D160_S0.5840.99
328_N337_T0.5840.99
40_S45_A0.5830.99
40_S48_Y0.5830.99
222_I225_R0.5780.99
158_L161_E0.5770.99
121_I125_K0.5760.99
214_M238_V0.5760.99
358_N363_V0.5750.99
199_E202_P0.5750.99
256_T259_T0.5740.99
21_V63_T0.5730.99
360_E363_V0.5730.99
339_D342_G0.5720.99
219_V291_R0.5710.99
145_E156_R0.5710.99
20_H114_M0.5710.99
47_A58_R0.5700.99
213_M304_H0.5690.99
261_V271_A0.5690.99
94_I120_H0.5670.99
333_F342_G0.5650.99
337_T340_V0.5630.99
205_E210_K0.5630.99
362_N366_I0.5620.99
57_E60_R0.5620.99
248_G252_E0.5620.99
248_G251_E0.5610.99
324_P335_F0.5590.99
309_A312_Y0.5550.99
324_P328_N0.5540.99
357_D364_E0.5540.99
322_H327_S0.5530.98
229_A279_A0.5530.98
304_H307_F0.5530.98
87_A115_P0.5520.98
156_R161_E0.5510.98
351_E354_M0.5500.98
351_E360_E0.5490.98
60_R64_I0.5490.98
42_K47_A0.5470.98
62_I86_H0.5470.98
364_E367_S0.5460.98
332_Q335_F0.5460.98
350_V356_G0.5460.98
312_Y318_E0.5450.98
265_R278_G0.5420.98
133_V197_V0.5380.98
18_I97_A0.5380.98
20_H117_T0.5380.98
240_V261_V0.5360.98
246_I293_Q0.5360.98
312_Y315_S0.5350.98
356_G363_V0.5340.98
152_E164_F0.5330.98
74_E199_E0.5310.98
331_P339_D0.5290.98
371_I374_G0.5280.98
351_E356_G0.5260.98
315_S352_M0.5250.98
178_K190_I0.5250.98
235_R273_A0.5240.98
212_F237_Q0.5240.98
216_V231_G0.5230.98
49_D58_R0.5230.98
66_T96_G0.5220.98
39_K46_M0.5210.98
194_M197_V0.5210.98
351_E362_N0.5190.98
331_P342_G0.5180.98
223_T226_G0.5170.98
136_L152_E0.5170.98
97_A127_V0.5160.98
351_E359_T0.5150.98
37_H42_K0.5130.98
13_A204_P0.5130.98
102_G197_V0.5120.98
196_A201_I0.5120.98
163_D167_D0.5110.97
314_L318_E0.5100.97
353_V360_E0.5090.97
279_A282_R0.5090.97
164_F167_D0.5080.97
365_L369_I0.5070.97
331_P337_T0.5060.97
257_T260_G0.5060.97
75_T199_E0.5050.97
78_Y197_V0.5050.97
359_T366_I0.5050.97
320_G324_P0.5040.97
233_V272_E0.5040.97
108_S138_K0.5030.97
83_C93_M0.5030.97
231_G271_A0.5030.97
334_Y338_T0.5020.97
240_V260_G0.5010.97
367_S371_I0.5000.97
23_H111_D0.5000.97
358_N361_M0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c78A 1 0.9596 100 0.258 Contact Map
1d2eA 3 0.9545 100 0.273 Contact Map
1jnyA 1 0.9369 100 0.278 Contact Map
4crnP 1 0.9646 100 0.283 Contact Map
1f60A 1 0.9747 100 0.284 Contact Map
4d61i 1 0.9596 100 0.285 Contact Map
3wy9A 1 0.9672 100 0.287 Contact Map
3avxA 1 0.9167 100 0.288 Contact Map
3mcaA 1 0.8561 100 0.291 Contact Map
1r5bA 1 0.8813 100 0.299 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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