GREMLIN Database
RACX - Probable amino-acid racemase
UniProt: P32960 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (218)
Sequences: 2249 (1711)
Seq/√Len: 115.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_D58_E3.7541.00
117_K142_E3.4291.00
155_Q159_A3.0671.00
4_I81_P3.0621.00
149_W178_E3.0291.00
79_A218_T2.8561.00
77_F221_T2.7581.00
128_Q150_Q2.6711.00
71_E97_S2.5751.00
35_D45_P2.5251.00
119_V179_E2.4801.00
105_E135_V2.4691.00
18_D22_D2.4681.00
80_L100_M2.4411.00
116_K185_D2.3731.00
130_A134_K2.3211.00
106_E213_C2.0911.00
40_M73_T2.0911.00
124_E151_Q2.0731.00
13_T41_I2.0611.00
176_L187_I2.0501.00
71_E98_V2.0051.00
110_E113_H1.9711.00
152_A171_A1.9591.00
2_I77_F1.9331.00
23_Y216_K1.9221.00
89_Y100_M1.8761.00
83_N132_Y1.7761.00
17_I41_I1.7571.00
156_L168_H1.7381.00
20_V219_V1.7271.00
60_K64_I1.6791.00
110_E216_K1.6731.00
111_I208_I1.6591.00
152_A155_Q1.6291.00
111_I118_A1.6171.00
208_I213_C1.6041.00
30_A220_S1.6011.00
34_I161_K1.5931.00
180_I205_I1.5911.00
71_E96_L1.5801.00
147_D182_Q1.5561.00
107_T210_S1.5501.00
23_Y219_V1.5481.00
42_Y69_K1.5421.00
195_N209_D1.5201.00
171_A174_Q1.5191.00
42_Y66_G1.4751.00
60_K91_E1.4741.00
109_K217_S1.4581.00
2_I222_Y1.4561.00
15_P195_N1.4501.00
144_I184_A1.4351.00
124_E154_N1.4021.00
217_S220_S1.3931.00
115_A186_I1.3901.00
176_L198_L1.3871.00
109_K139_N1.3801.00
108_I139_N1.3511.00
8_M82_C1.3451.00
15_P18_D1.3451.00
189_S194_L1.3271.00
67_A96_L1.3161.00
217_S221_T1.3051.00
186_I208_I1.3011.00
60_K88_Y1.2891.00
64_I95_A1.2881.00
119_V187_I1.2620.99
171_A175_T1.2610.99
5_L66_G1.2540.99
2_I218_T1.2510.99
169_T202_Q1.2500.99
115_A185_D1.2470.99
154_N158_A1.2460.99
20_V39_M1.2080.99
212_A216_K1.1890.99
90_E93_Q1.1880.99
87_V129_S1.1850.99
130_A133_Q1.1850.99
134_K137_K1.1850.99
80_L92_I1.1840.99
15_P211_S1.1740.99
60_K92_I1.1630.99
106_E109_K1.1540.99
40_M70_L1.1540.99
58_E91_E1.1540.99
177_Y181_S1.1510.99
19_K212_A1.1300.99
120_V126_T1.1170.99
215_A219_V1.1160.99
152_A156_L1.1150.99
172_L197_V1.1140.99
172_L194_L1.1110.99
38_H48_F1.1030.98
58_E61_K1.0980.98
93_Q100_M1.0940.98
67_A78_I1.0890.98
110_E213_C1.0880.98
125_P154_N1.0730.98
83_N103_I1.0730.98
47_P51_D1.0690.98
13_T39_M1.0680.98
65_D69_K1.0660.98
133_Q137_K1.0650.98
20_V215_A1.0640.98
68_V71_E1.0610.98
23_Y29_G1.0360.98
19_K23_Y1.0360.98
63_I88_Y1.0350.98
102_H105_E1.0340.98
111_I115_A1.0310.98
68_V72_K1.0240.97
10_P21_I1.0200.97
19_K215_A1.0070.97
137_K142_E1.0070.97
52_R58_E0.9980.97
78_I98_V0.9920.97
89_Y93_Q0.9910.97
16_F20_V0.9890.97
176_L194_L0.9840.97
82_C85_A0.9810.97
9_G161_K0.9640.96
84_T123_T0.9640.96
118_A185_D0.9610.96
120_V143_V0.9580.96
49_Y53_P0.9540.96
83_N210_S0.9450.96
49_Y62_A0.9400.96
134_K138_G0.9390.96
44_C66_G0.9360.96
149_W175_T0.9350.96
3_G7_G0.9290.95
173_W203_S0.9230.95
106_E217_S0.9220.95
24_C219_V0.9160.95
174_Q178_E0.9090.95
50_A158_A0.9070.95
152_A174_Q0.8920.94
53_P87_V0.8880.94
136_L143_V0.8830.94
24_C37_P0.8770.94
118_A186_I0.8740.94
112_P139_N0.8650.93
52_R62_A0.8540.93
59_M62_A0.8530.93
77_F222_Y0.8500.93
14_S18_D0.8490.93
50_A54_I0.8480.93
5_L67_A0.8470.93
15_P19_K0.8400.92
169_T173_W0.8380.92
173_W177_Y0.8370.92
2_I39_M0.8320.92
117_K185_D0.8310.92
122_G127_I0.8250.92
103_I210_S0.8140.91
167_Q170_Q0.8130.91
54_I125_P0.8040.91
38_H42_Y0.8040.91
133_Q145_H0.8020.91
5_L8_M0.7990.90
21_I37_P0.7990.90
136_L188_I0.7930.90
32_N35_D0.7890.90
17_I43_S0.7860.90
39_M43_S0.7850.90
19_K195_N0.7850.90
112_P141_Q0.7820.89
117_K144_I0.7820.89
70_L78_I0.7790.89
11_K163_P0.7790.89
69_K72_K0.7780.89
108_I136_L0.7780.89
91_E94_Q0.7760.89
57_D91_E0.7750.89
82_C161_K0.7720.89
23_Y212_A0.7690.89
151_Q155_Q0.7680.89
199_D202_Q0.7660.88
89_Y102_H0.7660.88
101_L217_S0.7610.88
120_V145_H0.7590.88
54_I59_M0.7570.88
54_I158_A0.7550.88
76_D222_Y0.7510.87
178_E182_Q0.7480.87
66_G69_K0.7440.87
53_P59_M0.7430.87
16_F214_L0.7400.87
67_A92_I0.7400.87
147_D178_E0.7390.87
81_P214_L0.7360.86
64_I68_V0.7360.86
38_H45_P0.7320.86
144_I182_Q0.7320.86
195_N211_S0.7310.86
180_I204_E0.7300.86
34_I50_A0.7290.86
102_H135_V0.7290.86
156_L171_A0.7290.86
59_M85_A0.7270.86
4_I20_V0.7210.85
68_V95_A0.7190.85
193_D196_A0.7180.85
173_W202_Q0.7140.85
195_N212_A0.7040.84
50_A125_P0.7020.84
118_A188_I0.7020.84
121_L179_E0.7010.84
109_K113_H0.6980.83
148_H151_Q0.6940.83
152_A175_T0.6940.83
170_Q174_Q0.6930.83
127_I150_Q0.6870.82
170_Q173_W0.6830.82
53_P125_P0.6830.82
68_V96_L0.6770.81
156_L175_T0.6770.81
101_L221_T0.6760.81
111_I186_I0.6740.81
52_R154_N0.6690.81
149_W174_Q0.6660.80
119_V144_I0.6660.80
38_H46_T0.6620.80
198_L207_I0.6610.80
127_I145_H0.6580.80
117_K183_H0.6570.80
177_Y180_I0.6540.79
178_E181_S0.6510.79
14_S21_I0.6490.79
49_Y59_M0.6490.79
17_I39_M0.6490.79
38_H76_D0.6490.79
165_H168_H0.6480.79
136_L141_Q0.6460.78
64_I88_Y0.6440.78
203_S207_I0.6440.78
48_F123_T0.6430.78
36_Y81_P0.6420.78
116_K142_E0.6400.78
153_V175_T0.6400.78
84_T191_C0.6380.78
8_M85_A0.6330.77
24_C36_Y0.6320.77
5_L69_K0.6300.77
101_L218_T0.6270.76
54_I154_N0.6250.76
118_A141_Q0.6240.76
174_Q177_Y0.6240.76
20_V24_C0.6210.76
36_Y161_K0.6190.75
200_H207_I0.6160.75
49_Y125_P0.6150.75
115_A118_A0.6100.74
122_G126_T0.6070.74
34_I48_F0.6050.74
13_T17_I0.6050.74
175_T179_E0.6040.74
119_V183_H0.6030.73
9_G82_C0.6020.73
16_F79_A0.6010.73
119_V175_T0.6000.73
108_I112_P0.5990.73
153_V172_L0.5960.73
90_E94_Q0.5940.72
3_G6_A0.5860.71
107_T208_I0.5820.71
31_S35_D0.5820.71
52_R125_P0.5820.71
78_I96_L0.5790.70
39_M77_F0.5770.70
169_T197_V0.5760.70
21_I24_C0.5750.70
4_I79_A0.5740.70
3_G70_L0.5730.70
64_I67_A0.5720.70
67_A71_E0.5710.69
157_I191_C0.5700.69
19_K22_D0.5660.69
15_P196_A0.5660.69
124_E128_Q0.5640.68
216_K220_S0.5620.68
52_R59_M0.5620.68
59_M63_I0.5590.68
210_S213_C0.5590.68
36_Y43_S0.5590.68
36_Y132_Y0.5580.68
149_W182_Q0.5550.67
172_L198_L0.5550.67
160_I196_A0.5520.67
109_K112_P0.5470.66
8_M161_K0.5450.66
77_F218_T0.5440.66
83_N191_C0.5400.65
219_V223_L0.5400.65
125_P158_A0.5400.65
65_D72_K0.5380.65
108_I135_V0.5360.65
155_Q171_A0.5350.64
45_P214_L0.5340.64
24_C222_Y0.5330.64
121_L153_V0.5320.64
10_P45_P0.5310.64
69_K205_I0.5290.64
48_F52_R0.5290.64
111_I209_D0.5230.63
210_S214_L0.5230.63
104_V136_L0.5230.63
96_L99_P0.5210.62
204_E207_I0.5210.62
82_C125_P0.5200.62
13_T16_F0.5200.62
118_A143_V0.5160.62
59_M88_Y0.5140.61
38_H44_C0.5140.61
96_L100_M0.5130.61
164_N167_Q0.5120.61
37_P219_V0.5120.61
95_A100_M0.5090.61
107_T110_E0.5050.60
48_F51_D0.5050.60
45_P49_Y0.5040.60
48_F58_E0.5040.60
67_A100_M0.5010.59
72_K138_G0.5010.59
50_A157_I0.5000.59
124_E150_Q0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jflA 2 0.9736 100 0.304 Contact Map
3s81A 2 0.9824 100 0.331 Contact Map
2zskA 2 0.9692 100 0.333 Contact Map
3ojcA 4 0.9692 100 0.342 Contact Map
4ix1A 2 0.8634 100 0.491 Contact Map
2jfnA 1 0.9339 100 0.507 Contact Map
2dgdA 4 0.8987 100 0.515 Contact Map
3outA 5 0.9207 100 0.523 Contact Map
2gzmA 3 0.9251 100 0.529 Contact Map
3uhfA 1 0.9031 100 0.533 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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