GREMLIN Database
NUSA - Transcription termination/antitermination protein NusA
UniProt: P32727 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (348)
Sequences: 2043 (1041)
Seq/√Len: 55.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
310_D341_T5.9631.00
204_L233_S5.2541.00
46_R94_E4.9601.00
206_R209_E4.6481.00
223_K238_R4.4031.00
182_I194_I3.8731.00
180_V196_V3.8721.00
159_A196_V3.6951.00
57_R96_E3.6561.00
63_D92_V3.6401.00
63_D74_E3.4201.00
276_S281_E3.3981.00
312_Q315_L3.3971.00
134_E184_K3.3601.00
298_N301_E3.3311.00
10_T20_K3.1061.00
67_E78_E2.9891.00
172_Y178_I2.9501.00
219_T244_V2.8561.00
129_E156_K2.7491.00
167_M170_E2.6821.00
183_T200_H2.5921.00
69_Y74_E2.5591.00
258_V272_I2.5161.00
235_I258_V2.5071.00
68_V76_S2.5061.00
62_K95_I2.4731.00
236_S282_F2.4411.00
81_Q88_M2.3431.00
208_F258_V2.3431.00
61_R94_E2.2791.00
24_I51_R2.2291.00
75_I79_E2.1641.00
247_V251_V2.0591.00
150_I172_Y2.0341.00
212_V258_V1.9921.00
98_T101_D1.9861.00
223_K275_W1.9831.00
224_S282_F1.9311.00
140_G152_V1.9241.00
162_P165_E1.9191.00
124_G128_S1.9031.00
70_D73_L1.8911.00
283_V304_T1.8821.00
221_E240_D1.8350.99
68_V74_E1.8150.99
275_W282_F1.7900.99
173_K176_D1.7880.99
28_E51_R1.7750.99
127_Y131_I1.7740.99
278_D281_E1.7680.99
46_R61_R1.7300.99
220_V244_V1.7170.99
87_Y91_D1.6920.99
76_S79_E1.6920.99
133_R136_D1.6850.99
212_V235_I1.6780.99
162_P195_Y1.6740.99
152_V196_V1.6710.99
48_D57_R1.6670.99
29_A117_R1.6570.99
309_P340_E1.6450.99
63_D90_G1.5790.98
153_S156_K1.5310.98
302_K333_W1.5250.98
126_I157_I1.5190.98
225_V233_S1.5130.98
77_I81_Q1.5050.98
87_Y93_V1.5010.98
181_Y202_G1.4960.98
10_T14_K1.4930.97
61_R92_V1.4920.97
165_E183_T1.4720.97
273_V282_F1.4520.97
66_D89_V1.4420.97
32_I45_V1.4390.97
127_Y185_V1.4160.97
29_A33_S1.4160.97
307_I310_D1.3860.96
279_P333_W1.3790.96
282_F330_L1.3780.96
105_I113_V1.3720.96
124_G187_K1.3660.96
9_L13_E1.3590.96
343_A347_G1.3530.95
88_M91_D1.3490.95
310_D339_S1.3420.95
79_E82_G1.3360.95
149_F160_L1.3270.95
136_D206_R1.3230.95
228_E329_K1.3100.95
25_E29_A1.3070.95
150_I166_Q1.3070.95
13_E19_S1.3020.94
64_V80_A1.2740.94
84_H91_D1.2740.94
293_L340_E1.2730.94
208_F222_L1.2610.93
138_M182_I1.2480.93
130_F134_E1.2450.93
205_K209_E1.2390.93
143_Q153_S1.2250.92
60_A95_I1.2240.92
103_G106_A1.2220.92
251_V262_V1.2150.92
306_V335_I1.2120.92
202_G205_K1.2110.92
161_L180_V1.2040.92
304_T331_T1.1990.92
228_E325_R1.1900.91
287_L306_V1.1840.91
26_A117_R1.1840.91
276_S285_N1.1810.91
340_E344_R1.1770.91
34_A120_E1.1720.91
181_Y200_H1.1650.90
254_K259_Q1.1550.90
75_I80_A1.1530.90
8_A12_L1.1510.90
64_V87_Y1.1490.90
11_I15_E1.1480.90
6_L54_G1.1470.90
290_S327_A1.1340.89
81_Q85_P1.1310.89
145_L150_I1.1180.88
6_L49_L1.1180.88
141_I177_R1.1170.88
67_E76_S1.1140.88
316_A327_A1.1120.88
66_D69_Y1.1040.88
140_G180_V1.1030.88
306_V324_A1.1020.88
294_D343_A1.1010.88
33_S36_K1.1000.88
47_V58_V1.0930.87
21_E51_R1.0920.87
68_V71_Q1.0780.87
23_I27_I1.0780.87
55_S233_S1.0770.87
142_V172_Y1.0740.86
18_I276_S1.0660.86
277_S282_F1.0610.86
133_R182_I1.0560.85
105_I108_Q1.0500.85
24_I49_L1.0420.85
9_L24_I1.0410.85
77_I89_V1.0360.84
27_I282_F1.0350.84
251_V258_V1.0330.84
19_S249_S1.0330.84
5_L27_I1.0300.84
109_T113_V1.0180.83
127_Y251_V1.0170.83
129_E155_G1.0130.83
284_A295_V1.0060.83
139_T179_K1.0000.82
304_T333_W0.9960.82
83_I87_Y0.9950.82
200_H205_K0.9940.82
85_P88_M0.9940.82
309_P312_Q0.9900.81
170_E198_R0.9900.81
247_V262_V0.9890.81
117_R120_E0.9870.81
183_T195_Y0.9840.81
204_L225_V0.9810.81
70_D74_E0.9800.81
161_L196_V0.9770.81
138_M180_V0.9720.80
314_S325_R0.9600.79
58_V98_T0.9540.79
84_H87_Y0.9520.79
28_E48_D0.9490.79
6_L51_R0.9480.79
165_E200_H0.9470.79
224_S275_W0.9400.78
145_L174_P0.9320.77
21_E25_E0.9270.77
157_I194_I0.9260.77
121_A124_G0.9240.77
238_R277_S0.9240.77
80_A83_I0.9220.77
80_A93_V0.9190.76
343_A348_I0.9170.76
30_A113_V0.9160.76
166_Q172_Y0.9160.76
22_I26_A0.9120.76
5_L38_N0.9120.76
342_D345_E0.9070.75
20_K24_I0.9020.75
256_Q260_A0.9010.75
84_H88_M0.8990.75
119_R272_I0.8970.75
44_N61_R0.8920.74
236_S330_L0.8910.74
338_K346_L0.8900.74
309_P341_T0.8890.74
345_E348_I0.8820.73
119_R122_E0.8740.73
253_P259_Q0.8730.73
145_L175_H0.8710.72
128_S131_I0.8700.72
212_V261_I0.8690.72
312_Q337_I0.8660.72
341_T345_E0.8660.72
307_I338_K0.8650.72
77_I80_A0.8620.72
247_V274_N0.8610.72
79_E85_P0.8560.71
259_Q263_N0.8560.71
91_D138_M0.8550.71
167_M233_S0.8530.71
295_V304_T0.8520.71
65_V89_V0.8490.70
16_K122_E0.8470.70
292_V308_V0.8460.70
152_V178_I0.8450.70
196_V223_K0.8430.70
39_F44_N0.8430.70
121_A193_Q0.8400.70
142_V145_L0.8370.69
215_I222_L0.8370.69
31_L47_V0.8350.69
129_E133_R0.8340.69
165_E195_Y0.8340.69
12_L157_I0.8280.69
212_V272_I0.8280.69
235_I261_I0.8260.68
116_Q122_E0.8230.68
293_L309_P0.8220.68
173_K299_E0.8220.68
204_L270_I0.8210.68
29_A112_Q0.8170.68
149_F161_L0.8140.67
152_V180_V0.8140.67
231_D322_Q0.8130.67
201_P329_K0.8130.67
315_L336_D0.8090.67
307_I339_S0.8050.66
205_K225_V0.8030.66
13_E20_K0.8000.66
31_L275_W0.8000.66
33_S113_V0.7960.66
180_V203_L0.7950.65
131_I134_E0.7920.65
313_L339_S0.7840.64
127_Y130_F0.7750.63
75_I93_V0.7740.63
267_G295_V0.7710.63
77_I84_H0.7700.63
229_A233_S0.7670.63
313_L328_A0.7630.62
290_S316_A0.7610.62
127_Y187_K0.7600.62
83_I95_I0.7570.62
283_V331_T0.7570.62
198_R207_L0.7560.61
228_E322_Q0.7450.60
27_I114_V0.7420.60
281_E284_A0.7410.60
219_T241_D0.7400.60
155_G191_G0.7390.60
80_A87_Y0.7360.59
304_T320_R0.7300.59
114_V267_G0.7300.59
113_V121_A0.7290.59
37_R109_T0.7290.59
9_L20_K0.7270.58
29_A109_T0.7260.58
281_E285_N0.7250.58
328_A334_K0.7250.58
179_K304_T0.7240.58
79_E83_I0.7230.58
215_I250_C0.7220.58
157_I175_H0.7210.58
77_I83_I0.7200.58
54_G112_Q0.7200.58
167_M204_L0.7160.57
25_E28_E0.7110.57
28_E31_L0.7100.57
6_L53_T0.7090.57
152_V194_I0.7090.57
249_S269_K0.7080.56
294_D307_I0.7050.56
204_L231_D0.7040.56
296_I305_T0.7030.56
64_V77_I0.7010.56
290_S324_A0.6990.56
35_Y99_P0.6960.55
67_E233_S0.6960.55
126_I156_K0.6950.55
77_I93_V0.6920.55
201_P258_V0.6910.55
17_G171_S0.6900.55
13_E229_A0.6890.54
123_R232_R0.6880.54
221_E292_V0.6880.54
347_G350_P0.6860.54
167_M256_Q0.6860.54
144_R151_Y0.6860.54
303_A334_K0.6850.54
20_K229_A0.6840.54
259_Q290_S0.6840.54
13_E324_A0.6830.54
33_S109_T0.6820.54
239_T244_V0.6810.54
180_V251_V0.6800.53
31_L56_I0.6760.53
154_L159_A0.6760.53
70_D185_V0.6730.53
78_E81_Q0.6730.53
226_A265_L0.6700.52
132_D157_I0.6690.52
19_S22_I0.6660.52
123_R203_L0.6650.52
221_E238_R0.6650.52
246_P274_N0.6630.52
208_F261_I0.6630.52
307_I342_D0.6610.51
6_L26_A0.6610.51
169_N249_S0.6600.51
182_I185_V0.6590.51
20_K51_R0.6580.51
208_F262_V0.6570.51
137_I140_G0.6550.51
81_Q87_Y0.6540.51
139_T291_K0.6530.51
274_N281_E0.6530.51
274_N285_N0.6520.50
233_S292_V0.6490.50
220_V295_V0.6460.50
314_S321_G0.6440.50
56_I115_T0.6430.49
132_D145_L0.6430.49
84_H133_R0.6420.49
38_N45_V0.6420.49
32_I36_K0.6400.49
19_S85_P0.6380.49
122_E155_G0.6370.49
198_R246_P0.6350.49
65_V90_G0.6330.48
88_M92_V0.6330.48
54_G117_R0.6330.48
85_P277_S0.6320.48
23_I26_A0.6300.48
233_S283_V0.6290.48
35_Y45_V0.6260.48
262_V269_K0.6250.48
288_S291_K0.6240.47
28_E54_G0.6230.47
185_V194_I0.6230.47
251_V296_I0.6220.47
46_R224_S0.6210.47
8_A35_Y0.6200.47
99_P278_D0.6190.47
114_V238_R0.6190.47
170_E191_G0.6170.47
212_V335_I0.6170.47
285_N288_S0.6170.47
72_R75_I0.6140.46
201_P229_A0.6140.46
158_E259_Q0.6140.46
263_N267_G0.6130.46
17_G129_E0.6110.46
96_E261_I0.6110.46
116_Q190_K0.6100.46
14_K127_Y0.6090.46
267_G282_F0.6080.46
106_A109_T0.6080.46
148_K212_V0.6080.46
40_N135_E0.6070.46
251_V319_K0.6050.45
17_G125_V0.6030.45
313_L337_I0.6020.45
144_R220_V0.6020.45
55_S89_V0.6010.45
54_G122_E0.6000.45
5_L210_I0.5990.45
103_G110_A0.5980.45
228_E314_S0.5980.45
312_Q322_Q0.5980.45
50_N79_E0.5970.45
30_A120_E0.5960.44
152_V263_N0.5950.44
26_A121_A0.5940.44
154_L345_E0.5930.44
185_V220_V0.5930.44
182_I340_E0.5920.44
231_D263_N0.5890.44
5_L151_Y0.5890.44
214_E257_R0.5870.43
217_D239_T0.5860.43
204_L208_F0.5840.43
43_Q62_K0.5830.43
110_A228_E0.5830.43
112_Q117_R0.5820.43
42_A225_V0.5810.43
57_R274_N0.5810.43
5_L202_G0.5810.43
66_D76_S0.5800.43
23_I279_P0.5800.43
17_G146_D0.5800.43
175_H249_S0.5790.43
142_V176_D0.5790.43
110_A114_V0.5780.42
240_D293_L0.5780.42
29_A32_I0.5760.42
305_T336_D0.5760.42
66_D71_Q0.5760.42
346_L350_P0.5750.42
112_Q278_D0.5750.42
339_S342_D0.5740.42
48_D51_R0.5740.42
131_I185_V0.5740.42
307_I343_A0.5740.42
232_R315_L0.5740.42
121_A258_V0.5720.42
299_E333_W0.5710.42
23_I249_S0.5690.42
225_V261_I0.5690.42
167_M203_L0.5680.41
112_Q258_V0.5680.41
284_A333_W0.5680.41
277_S281_E0.5670.41
120_E259_Q0.5670.41
27_I312_Q0.5660.41
231_D320_R0.5660.41
76_S182_I0.5660.41
254_K273_V0.5630.41
18_I24_I0.5630.41
204_L235_I0.5620.41
327_A331_T0.5590.40
31_L35_Y0.5570.40
131_I194_I0.5550.40
35_Y38_N0.5550.40
236_S275_W0.5530.40
218_G240_D0.5530.40
81_Q84_H0.5530.40
110_A113_V0.5520.40
118_V148_K0.5520.40
283_V306_V0.5510.40
49_L93_V0.5490.39
145_L149_F0.5460.39
162_P213_P0.5460.39
30_A107_A0.5450.39
136_D150_I0.5440.39
26_A267_G0.5440.39
48_D94_E0.5430.39
134_E182_I0.5430.39
20_K33_S0.5420.39
59_F96_E0.5410.39
130_F171_S0.5400.39
80_A251_V0.5380.38
219_T239_T0.5380.38
187_K278_D0.5370.38
125_V129_E0.5360.38
238_R282_F0.5360.38
133_R180_V0.5340.38
110_A116_Q0.5330.38
36_K171_S0.5330.38
148_K282_F0.5330.38
42_A81_Q0.5330.38
115_T120_E0.5320.38
245_D254_K0.5310.38
30_A109_T0.5290.37
208_F215_I0.5290.37
280_V296_I0.5290.37
49_L290_S0.5280.37
18_I23_I0.5280.37
155_G159_A0.5270.37
31_L331_T0.5260.37
18_I131_I0.5250.37
117_R130_F0.5240.37
261_I279_P0.5230.37
226_A235_I0.5230.37
106_A110_A0.5230.37
317_I321_G0.5220.37
150_I176_D0.5220.37
199_T265_L0.5220.37
64_V83_I0.5210.37
54_G107_A0.5200.36
253_P256_Q0.5200.36
111_K322_Q0.5200.36
124_G275_W0.5180.36
142_V212_V0.5170.36
35_Y58_V0.5170.36
139_T177_R0.5170.36
244_V249_S0.5160.36
14_K337_I0.5160.36
133_R192_P0.5160.36
208_F272_I0.5150.36
75_I81_Q0.5150.36
122_E207_L0.5150.36
224_S236_S0.5150.36
6_L56_I0.5150.36
46_R59_F0.5140.36
287_L335_I0.5140.36
108_Q144_R0.5140.36
138_M175_H0.5130.36
246_P255_G0.5130.36
96_E167_M0.5130.36
33_S105_I0.5130.36
37_R112_Q0.5120.36
144_R262_V0.5120.36
254_K319_K0.5120.36
22_I121_A0.5110.36
161_L244_V0.5110.36
26_A146_D0.5110.36
105_I110_A0.5100.35
251_V255_G0.5090.35
282_F331_T0.5090.35
238_R275_W0.5090.35
12_L58_V0.5080.35
190_K272_I0.5070.35
267_G302_K0.5060.35
9_L51_R0.5050.35
30_A333_W0.5030.35
176_D266_K0.5030.35
344_R347_G0.5020.35
13_E27_I0.5010.35
193_Q233_S0.5010.35
279_P304_T0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k0rA 1 0.841 100 0.156 Contact Map
1hh2P 2 0.9245 100 0.181 Contact Map
4mtnA 1 0.9084 100 0.199 Contact Map
2asbA 1 0.5849 100 0.374 Contact Map
2cxcA 1 0.3666 100 0.709 Contact Map
2kwpA 1 0.3477 100 0.725 Contact Map
2mt4A 1 0.3342 100 0.733 Contact Map
2qndA 2 0.3612 99.5 0.875 Contact Map
4q7jD 1 0.4447 99.5 0.876 Contact Map
4aybE 1 0.3827 98.5 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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