GREMLIN Database
RIMP - Ribosome maturation factor RimP
UniProt: P32726 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 156 (145)
Sequences: 3271 (2334)
Seq/√Len: 193.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_A130_E2.9441.00
17_V56_V2.7551.00
14_Q18_D2.4991.00
126_T141_N2.4591.00
105_T115_F2.3961.00
90_K144_Y2.3071.00
143_P146_K2.1771.00
26_D88_K2.1141.00
29_F38_L2.0671.00
40_V60_L1.9961.00
42_I56_V1.9271.00
100_N118_E1.8891.00
122_F144_Y1.8631.00
10_Q14_Q1.8481.00
128_T141_N1.8241.00
25_V92_D1.8111.00
13_A60_L1.7921.00
123_D126_T1.6851.00
41_F79_S1.6731.00
49_D52_E1.6581.00
97_L121_E1.6291.00
121_E128_T1.6221.00
63_K66_E1.6111.00
120_A139_R1.5821.00
23_E95_K1.5441.00
20_L59_A1.5441.00
89_K92_D1.5311.00
118_E130_E1.5281.00
17_V24_L1.5101.00
93_F150_A1.4881.00
91_A94_E1.4811.00
130_E139_R1.4531.00
147_I150_A1.4431.00
43_D48_V1.4331.00
90_K122_F1.4221.00
19_S59_A1.4191.00
107_E146_K1.4171.00
28_E39_R1.4161.00
25_V86_P1.4071.00
8_T11_E1.4021.00
44_S52_E1.3931.00
131_I138_K1.3921.00
54_A58_E1.3891.00
128_T139_R1.3871.00
63_K67_A1.3851.00
117_G129_V1.3751.00
51_E54_A1.3691.00
101_V119_L1.3671.00
96_S152_L1.3551.00
42_I48_V1.3261.00
22_L48_V1.3001.00
10_Q89_K1.2921.00
123_D141_N1.2831.00
23_E91_A1.2701.00
106_Y148_A1.2471.00
101_V150_A1.2471.00
39_R77_E1.2401.00
7_D11_E1.2321.00
127_V147_I1.2251.00
53_C57_S1.2131.00
12_M63_K1.2061.00
48_V80_S1.2051.00
120_A128_T1.1861.00
90_K94_E1.1841.00
62_E66_E1.1741.00
20_L55_K1.1741.00
130_E137_K1.1301.00
116_E153_A1.1271.00
132_T137_K1.1201.00
104_K114_V1.1011.00
81_P85_R1.0991.00
97_L122_F1.0931.00
35_S75_F1.0921.00
93_F144_Y1.0921.00
29_F72_Q1.0871.00
102_Y114_V1.0831.00
20_L56_V1.0801.00
96_S99_K1.0701.00
8_T67_A1.0441.00
105_T109_I1.0291.00
29_F36_W1.0231.00
22_L52_E1.0201.00
10_Q24_L1.0121.00
50_I53_C1.0091.00
13_A40_V1.0051.00
57_S61_S1.0011.00
101_V129_V1.0011.00
9_V13_A1.0001.00
83_A154_V0.9911.00
102_Y153_A0.9890.99
16_I63_K0.9850.99
123_D128_T0.9770.99
100_N153_A0.9730.99
25_V96_S0.9720.99
53_C80_S0.9650.99
30_V39_R0.9610.99
28_E41_F0.9400.99
32_E36_W0.9400.99
61_S65_D0.9360.99
7_D10_Q0.9300.99
15_P18_D0.9280.99
13_A17_V0.9230.99
104_K149_N0.9110.99
105_T142_I0.9000.99
17_V20_L0.8960.99
36_W72_Q0.8960.99
87_L92_D0.8890.99
31_K36_W0.8770.99
12_M67_A0.8550.99
102_Y116_E0.8540.99
90_K125_Q0.8530.98
60_L76_L0.8490.98
125_Q145_E0.8340.98
109_I146_K0.8340.98
22_L55_K0.8300.98
92_D95_K0.8280.98
9_V27_I0.8250.98
12_M15_P0.8230.98
84_E154_V0.8180.98
32_E37_F0.7940.98
44_S47_G0.7920.98
43_D95_K0.7860.97
30_V37_F0.7700.97
16_I59_A0.7670.97
24_L27_I0.7650.97
103_I147_I0.7650.97
56_V60_L0.7630.97
45_D95_K0.7570.97
86_P96_S0.7520.97
39_R79_S0.7500.97
106_Y113_K0.7470.97
41_F88_K0.7440.96
38_L64_L0.7430.96
61_S76_L0.7400.96
33_G36_W0.7350.96
89_K93_F0.7270.96
124_G144_Y0.7250.96
92_D152_L0.7250.96
93_F127_V0.7190.96
84_E153_A0.7110.95
8_T69_P0.7100.95
84_E152_L0.7010.95
86_P92_D0.7000.95
126_T144_Y0.6990.95
16_I56_V0.6950.95
93_F119_L0.6950.95
32_E39_R0.6940.95
92_D96_S0.6910.95
110_D140_I0.6830.94
52_E55_K0.6830.94
87_L152_L0.6790.94
23_E45_D0.6630.93
31_K39_R0.6630.93
115_F142_I0.6600.93
83_A151_R0.6570.93
6_T10_Q0.6540.93
93_F147_I0.6490.93
37_F75_F0.6440.92
25_V50_I0.6410.92
104_K148_A0.6370.92
131_I140_I0.6340.92
94_E124_G0.6310.92
87_L93_F0.6260.91
94_E121_E0.6230.91
51_E55_K0.6230.91
14_Q89_K0.6150.91
65_D74_Y0.6130.90
88_K92_D0.6130.90
125_Q143_P0.6090.90
103_I150_A0.6030.90
26_D41_F0.6010.90
59_A62_E0.6010.90
103_I129_V0.6000.89
17_V21_Q0.5990.89
59_A63_K0.5960.89
34_Q72_Q0.5890.89
50_I54_A0.5890.89
13_A56_V0.5860.88
73_N79_S0.5840.88
151_R154_V0.5820.88
64_L74_Y0.5790.88
44_S48_V0.5770.88
105_T113_K0.5770.88
29_F70_I0.5750.87
16_I20_L0.5730.87
42_I53_C0.5620.86
110_D138_K0.5610.86
74_Y148_A0.5560.86
53_C152_L0.5540.85
86_P150_A0.5530.85
144_Y150_A0.5480.85
103_I142_I0.5440.84
100_N116_E0.5410.84
84_E96_S0.5410.84
57_S64_L0.5370.84
90_K124_G0.5370.84
23_E43_D0.5350.83
117_G142_I0.5350.83
83_A96_S0.5340.83
11_E15_P0.5330.83
105_T140_I0.5330.83
61_S68_D0.5300.83
48_V52_E0.5260.82
97_L120_A0.5230.82
12_M70_I0.5210.82
23_E92_D0.5210.82
41_F48_V0.5200.82
94_E97_L0.5190.82
53_C93_F0.5190.82
132_T138_K0.5170.81
50_I63_K0.5160.81
91_A96_S0.5090.80
23_E89_K0.5080.80
34_Q83_A0.5060.80
115_F129_V0.5030.80
87_L95_K0.5010.79
126_T143_P0.5010.79
99_K118_E0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ib8A 1 0.9872 100 0.054 Contact Map
3pgwB 1 0.391 68.7 0.908 Contact Map
1y96A 1 0.4551 61.2 0.913 Contact Map
4c92A 1 0.4038 56.6 0.915 Contact Map
4m77A 1 0.391 45.2 0.92 Contact Map
4m7dA 1 0.3782 44.9 0.921 Contact Map
3fb9A 1 0.5256 44.7 0.921 Contact Map
3j1zP 8 0.5577 44.6 0.921 Contact Map
4c92C 1 0.4103 39 0.924 Contact Map
3h90A 3 0.5321 36 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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