GREMLIN Database
YVYE - IMPACT family member YvyE
UniProt: P32437 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (193)
Sequences: 3017 (2205)
Seq/√Len: 158.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_V95_C3.4791.00
54_C82_M2.9221.00
15_E22_R2.8611.00
96_A120_V2.7381.00
27_L96_A2.5851.00
82_M120_V2.4831.00
77_T109_A2.4681.00
26_H99_T2.3761.00
39_F95_C2.3471.00
28_S39_F2.2661.00
53_N99_T2.2281.00
122_E125_N2.1921.00
89_R125_N2.1301.00
102_F106_K2.1221.00
16_I118_K2.0621.00
14_H122_E2.0611.00
147_L172_F1.9471.00
53_N97_V1.9381.00
44_K71_D1.9171.00
66_Q87_K1.9131.00
42_K46_Q1.8991.00
180_E183_A1.8921.00
26_H47_H1.8581.00
8_V27_L1.8171.00
16_I119_S1.8061.00
26_H43_I1.7721.00
40_I95_C1.7691.00
31_S35_E1.7651.00
147_L166_Y1.7571.00
142_A150_I1.7531.00
58_V87_K1.7131.00
24_I101_Y1.7061.00
25_C119_S1.6961.00
163_E173_E1.6841.00
139_H171_E1.6791.00
192_T196_S1.6591.00
33_E37_Q1.6251.00
13_E46_Q1.5821.00
188_M196_S1.5731.00
32_T35_E1.5731.00
28_S95_C1.5631.00
84_E87_K1.5051.00
82_M98_V1.4901.00
141_S169_N1.4631.00
16_I122_E1.4601.00
45_K48_W1.4501.00
147_L151_E1.4471.00
165_H171_E1.4431.00
136_R178_E1.4281.00
151_E164_I1.4251.00
151_E155_R1.3861.00
165_H173_E1.3801.00
33_E67_K1.3791.00
139_H173_E1.3701.00
140_T196_S1.3651.00
86_L96_A1.3621.00
60_G92_K1.3371.00
28_S42_K1.2981.00
137_I173_E1.2691.00
154_L159_F1.2531.00
85_V121_S1.2461.00
43_I99_T1.2411.00
25_C123_G1.2401.00
26_H53_N1.2371.00
141_S171_E1.2081.00
11_A28_S1.1941.00
63_D92_K1.1881.00
6_F131_E1.1771.00
20_K105_I1.1741.00
7_T130_V1.1741.00
152_N156_E1.1741.00
6_F129_V1.1731.00
185_S198_I1.1701.00
91_L94_T1.1681.00
25_C120_V1.1631.00
137_I162_K1.1631.00
137_I175_Y1.1581.00
54_C78_A1.1491.00
51_T102_F1.1411.00
43_I97_V1.1401.00
157_S187_W1.1381.00
138_M181_T1.1351.00
13_E47_H1.1321.00
148_G151_E1.1321.00
162_K175_Y1.1261.00
86_L120_V1.1251.00
182_N186_E1.0981.00
11_A29_R1.0920.99
57_Y67_K1.0880.99
109_A113_I1.0790.99
12_G127_I1.0670.99
91_L124_L1.0530.99
136_R181_T1.0440.99
30_V59_I1.0440.99
36_A40_I1.0370.99
38_E41_Q1.0340.99
46_Q49_N1.0330.99
143_D146_W1.0320.99
13_E26_H1.0250.99
140_T174_T1.0190.99
14_H25_C1.0170.99
89_R121_S1.0160.99
51_T106_K1.0160.99
177_E180_E1.0160.99
25_C96_A1.0140.99
55_S69_N1.0120.99
121_S125_N1.0050.99
38_E42_K0.9990.99
134_L178_E0.9900.99
27_L120_V0.9810.99
12_G126_H0.9790.99
133_K177_E0.9770.99
9_K128_G0.9740.99
34_Q38_E0.9730.99
48_W53_N0.9660.99
182_N185_S0.9630.99
10_E128_G0.9620.99
14_H119_S0.9620.99
181_T185_S0.9560.99
153_E187_W0.9540.99
58_V66_Q0.9500.99
44_K55_S0.9480.99
142_A147_L0.9400.98
14_H126_H0.9280.98
143_D169_N0.9090.98
88_K117_G0.9080.98
144_Y170_V0.9070.98
39_F97_V0.9000.98
17_V20_K0.8970.98
82_M86_L0.8930.98
184_F187_W0.8930.98
110_G114_R0.8900.98
84_E88_K0.8890.98
142_A172_F0.8890.98
118_K122_E0.8880.98
186_E190_E0.8760.98
159_F184_F0.8760.98
39_F42_K0.8760.98
44_K53_N0.8750.98
113_I117_G0.8740.98
12_G128_G0.8700.97
58_V86_L0.8620.97
174_T184_F0.8580.97
27_L124_L0.8550.97
11_A42_K0.8440.97
144_Y169_N0.8420.97
122_E126_H0.8410.97
59_I93_D0.8320.97
27_L127_I0.8300.97
156_E187_W0.8220.96
146_W195_K0.8200.96
9_K130_V0.8200.96
8_V127_I0.8180.96
6_F90_R0.8150.96
43_I47_H0.8130.96
88_K109_A0.8130.96
33_E65_I0.8110.96
35_E38_E0.8100.96
82_M96_A0.8060.96
63_D90_R0.8050.96
162_K173_E0.7970.96
118_K121_S0.7960.96
105_I109_A0.7920.96
30_V36_A0.7880.95
154_L174_T0.7870.95
27_L123_G0.7770.95
160_L175_Y0.7690.95
161_L164_I0.7690.95
96_A123_G0.7660.95
36_A95_C0.7660.95
135_M175_Y0.7630.95
31_S93_D0.7540.94
154_L161_L0.7480.94
77_T112_L0.7470.94
144_Y166_Y0.7470.94
153_E157_S0.7420.94
56_A79_G0.7400.94
176_V184_F0.7400.94
26_H46_Q0.7390.94
183_A187_W0.7330.93
80_V87_K0.7310.93
39_F43_I0.7280.93
148_G152_N0.7240.93
51_T105_I0.7220.93
117_G121_S0.7210.93
185_S189_T0.7190.93
144_Y147_L0.7190.93
61_E64_H0.7170.93
91_L129_V0.7120.92
55_S67_K0.7110.92
158_Q180_E0.7090.92
186_E189_T0.7070.92
18_I105_I0.6960.91
77_T105_I0.6960.91
149_K152_N0.6930.91
153_E191_L0.6900.91
146_W192_T0.6730.90
93_D132_R0.6710.90
86_L94_T0.6700.90
89_R129_V0.6670.90
98_V119_S0.6670.90
157_S184_F0.6630.89
28_S43_I0.6560.89
43_I46_Q0.6560.89
19_E51_T0.6540.89
36_A53_N0.6540.89
183_A186_E0.6470.88
146_W149_K0.6470.88
109_A121_S0.6440.88
159_F176_V0.6430.88
138_M185_S0.6410.88
27_L86_L0.6390.88
84_E117_G0.6390.88
39_F53_N0.6370.87
15_E24_I0.6330.87
109_A114_R0.6270.87
18_I106_K0.6190.86
28_S97_V0.6170.86
30_V39_F0.6170.86
37_Q57_Y0.6160.86
153_E156_E0.6130.85
76_G80_V0.6130.85
147_L164_I0.6090.85
68_A80_V0.6070.85
110_G113_I0.6070.85
24_I99_T0.6050.85
135_M160_L0.6020.84
61_E92_K0.6020.84
54_C98_V0.6010.84
51_T78_A0.5990.84
41_Q45_K0.5960.84
85_V117_G0.5960.84
40_I99_T0.5930.83
140_T172_F0.5910.83
18_I118_K0.5880.83
147_L170_V0.5860.83
167_S171_E0.5840.82
169_N197_D0.5810.82
58_V92_K0.5790.82
51_T101_Y0.5790.82
20_K114_R0.5780.82
138_M198_I0.5770.82
135_M177_E0.5740.81
43_I53_N0.5730.81
47_H53_N0.5690.81
12_G27_L0.5690.81
176_V181_T0.5620.80
20_K109_A0.5610.80
54_C75_S0.5610.80
37_Q67_K0.5590.80
124_L128_G0.5570.79
190_E193_N0.5540.79
41_Q44_K0.5530.79
20_K49_N0.5500.79
59_I65_I0.5500.79
33_E59_I0.5500.79
81_P111_G0.5490.78
85_V114_R0.5450.78
178_E181_T0.5430.78
141_S197_D0.5430.78
139_H165_H0.5400.77
12_G123_G0.5400.77
14_H123_G0.5380.77
144_Y148_G0.5380.77
51_T99_T0.5370.77
57_Y65_I0.5350.77
30_V38_E0.5350.77
18_I114_R0.5290.76
150_I172_F0.5290.76
78_A82_M0.5210.75
187_W190_E0.5200.75
55_S82_M0.5180.74
68_A75_S0.5180.74
123_G126_H0.5180.74
152_N155_R0.5170.74
14_H18_I0.5150.74
37_Q41_Q0.5150.74
75_S78_A0.5140.74
17_V105_I0.5080.73
29_R93_D0.5070.73
176_V180_E0.5060.73
33_E57_Y0.5050.73
30_V35_E0.5050.73
145_T148_G0.5040.72
62_N66_Q0.5030.72
84_E109_A0.5020.72
94_T130_V0.5020.72
119_S126_H0.5020.72
49_N53_N0.5010.72
66_Q88_K0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vi7A 1 0.9401 100 0.154 Contact Map
2cveA 1 0.871 100 0.196 Contact Map
3lh2S 2 0.318 98.8 0.851 Contact Map
4w224 1 0.9585 96.8 0.906 Contact Map
4fn5A 1 0.9124 96.5 0.909 Contact Map
1n0uA 1 0.9585 96 0.914 Contact Map
3j25A 1 0.9078 95.7 0.916 Contact Map
1darA 1 0.9309 93.5 0.925 Contact Map
2dy1A 1 0.8618 93.2 0.926 Contact Map
4kiyV 1 0.8848 92.7 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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