YVYE - BACSU - GREMLIN Contacts

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YVYE - IMPACT family member YvyE

UniProt:	P32437	Sequences: MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIKKQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYFGGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFLLKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	217 (193)
Sequences:	3017 (2205)
Seq/√Len:	158.7

ECOLI - YIGZ
BACSU - YVYE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
30_V	95_C	3.479	1.00
54_C	82_M	2.922	1.00
15_E	22_R	2.861	1.00
96_A	120_V	2.738	1.00
27_L	96_A	2.585	1.00
82_M	120_V	2.483	1.00
77_T	109_A	2.468	1.00
26_H	99_T	2.376	1.00
39_F	95_C	2.347	1.00
28_S	39_F	2.266	1.00
53_N	99_T	2.228	1.00
122_E	125_N	2.192	1.00
89_R	125_N	2.130	1.00
102_F	106_K	2.122	1.00
16_I	118_K	2.062	1.00
14_H	122_E	2.061	1.00
147_L	172_F	1.947	1.00
53_N	97_V	1.938	1.00
44_K	71_D	1.917	1.00
66_Q	87_K	1.913	1.00
42_K	46_Q	1.899	1.00
180_E	183_A	1.892	1.00
26_H	47_H	1.858	1.00
8_V	27_L	1.817	1.00
16_I	119_S	1.806	1.00
26_H	43_I	1.772	1.00
40_I	95_C	1.769	1.00
31_S	35_E	1.765	1.00
147_L	166_Y	1.757	1.00
142_A	150_I	1.753	1.00
58_V	87_K	1.713	1.00
24_I	101_Y	1.706	1.00
25_C	119_S	1.696	1.00
163_E	173_E	1.684	1.00
139_H	171_E	1.679	1.00
192_T	196_S	1.659	1.00
33_E	37_Q	1.625	1.00
13_E	46_Q	1.582	1.00
188_M	196_S	1.573	1.00
32_T	35_E	1.573	1.00
28_S	95_C	1.563	1.00
84_E	87_K	1.505	1.00
82_M	98_V	1.490	1.00
141_S	169_N	1.463	1.00
16_I	122_E	1.460	1.00
45_K	48_W	1.450	1.00
147_L	151_E	1.447	1.00
165_H	171_E	1.443	1.00
136_R	178_E	1.428	1.00
151_E	164_I	1.425	1.00
151_E	155_R	1.386	1.00
165_H	173_E	1.380	1.00
33_E	67_K	1.379	1.00
139_H	173_E	1.370	1.00
140_T	196_S	1.365	1.00
86_L	96_A	1.362	1.00
60_G	92_K	1.337	1.00
28_S	42_K	1.298	1.00
137_I	173_E	1.269	1.00
154_L	159_F	1.253	1.00
85_V	121_S	1.246	1.00
43_I	99_T	1.241	1.00
25_C	123_G	1.240	1.00
26_H	53_N	1.237	1.00
141_S	171_E	1.208	1.00
11_A	28_S	1.194	1.00
63_D	92_K	1.188	1.00
6_F	131_E	1.177	1.00
20_K	105_I	1.174	1.00
7_T	130_V	1.174	1.00
152_N	156_E	1.174	1.00
6_F	129_V	1.173	1.00
185_S	198_I	1.170	1.00
91_L	94_T	1.168	1.00
25_C	120_V	1.163	1.00
137_I	162_K	1.163	1.00
137_I	175_Y	1.158	1.00
54_C	78_A	1.149	1.00
51_T	102_F	1.141	1.00
43_I	97_V	1.140	1.00
157_S	187_W	1.138	1.00
138_M	181_T	1.135	1.00
13_E	47_H	1.132	1.00
148_G	151_E	1.132	1.00
162_K	175_Y	1.126	1.00
86_L	120_V	1.125	1.00
182_N	186_E	1.098	1.00
11_A	29_R	1.092	0.99
57_Y	67_K	1.088	0.99
109_A	113_I	1.079	0.99
12_G	127_I	1.067	0.99
91_L	124_L	1.053	0.99
136_R	181_T	1.044	0.99
30_V	59_I	1.044	0.99
36_A	40_I	1.037	0.99
38_E	41_Q	1.034	0.99
46_Q	49_N	1.033	0.99
143_D	146_W	1.032	0.99
13_E	26_H	1.025	0.99
140_T	174_T	1.019	0.99
14_H	25_C	1.017	0.99
89_R	121_S	1.016	0.99
51_T	106_K	1.016	0.99
177_E	180_E	1.016	0.99
25_C	96_A	1.014	0.99
55_S	69_N	1.012	0.99
121_S	125_N	1.005	0.99
38_E	42_K	0.999	0.99
134_L	178_E	0.990	0.99
27_L	120_V	0.981	0.99
12_G	126_H	0.979	0.99
133_K	177_E	0.977	0.99
9_K	128_G	0.974	0.99
34_Q	38_E	0.973	0.99
48_W	53_N	0.966	0.99
182_N	185_S	0.963	0.99
10_E	128_G	0.962	0.99
14_H	119_S	0.962	0.99
181_T	185_S	0.956	0.99
153_E	187_W	0.954	0.99
58_V	66_Q	0.950	0.99
44_K	55_S	0.948	0.99
142_A	147_L	0.940	0.98
14_H	126_H	0.928	0.98
143_D	169_N	0.909	0.98
88_K	117_G	0.908	0.98
144_Y	170_V	0.907	0.98
39_F	97_V	0.900	0.98
17_V	20_K	0.897	0.98
82_M	86_L	0.893	0.98
184_F	187_W	0.893	0.98
110_G	114_R	0.890	0.98
84_E	88_K	0.889	0.98
142_A	172_F	0.889	0.98
118_K	122_E	0.888	0.98
186_E	190_E	0.876	0.98
159_F	184_F	0.876	0.98
39_F	42_K	0.876	0.98
44_K	53_N	0.875	0.98
113_I	117_G	0.874	0.98
12_G	128_G	0.870	0.97
58_V	86_L	0.862	0.97
174_T	184_F	0.858	0.97
27_L	124_L	0.855	0.97
11_A	42_K	0.844	0.97
144_Y	169_N	0.842	0.97
122_E	126_H	0.841	0.97
59_I	93_D	0.832	0.97
27_L	127_I	0.830	0.97
156_E	187_W	0.822	0.96
146_W	195_K	0.820	0.96
9_K	130_V	0.820	0.96
8_V	127_I	0.818	0.96
6_F	90_R	0.815	0.96
43_I	47_H	0.813	0.96
88_K	109_A	0.813	0.96
33_E	65_I	0.811	0.96
35_E	38_E	0.810	0.96
82_M	96_A	0.806	0.96
63_D	90_R	0.805	0.96
162_K	173_E	0.797	0.96
118_K	121_S	0.796	0.96
105_I	109_A	0.792	0.96
30_V	36_A	0.788	0.95
154_L	174_T	0.787	0.95
27_L	123_G	0.777	0.95
160_L	175_Y	0.769	0.95
161_L	164_I	0.769	0.95
96_A	123_G	0.766	0.95
36_A	95_C	0.766	0.95
135_M	175_Y	0.763	0.95
31_S	93_D	0.754	0.94
154_L	161_L	0.748	0.94
77_T	112_L	0.747	0.94
144_Y	166_Y	0.747	0.94
153_E	157_S	0.742	0.94
56_A	79_G	0.740	0.94
176_V	184_F	0.740	0.94
26_H	46_Q	0.739	0.94
183_A	187_W	0.733	0.93
80_V	87_K	0.731	0.93
39_F	43_I	0.728	0.93
148_G	152_N	0.724	0.93
51_T	105_I	0.722	0.93
117_G	121_S	0.721	0.93
185_S	189_T	0.719	0.93
144_Y	147_L	0.719	0.93
61_E	64_H	0.717	0.93
91_L	129_V	0.712	0.92
55_S	67_K	0.711	0.92
158_Q	180_E	0.709	0.92
186_E	189_T	0.707	0.92
18_I	105_I	0.696	0.91
77_T	105_I	0.696	0.91
149_K	152_N	0.693	0.91
153_E	191_L	0.690	0.91
146_W	192_T	0.673	0.90
93_D	132_R	0.671	0.90
86_L	94_T	0.670	0.90
89_R	129_V	0.667	0.90
98_V	119_S	0.667	0.90
157_S	184_F	0.663	0.89
28_S	43_I	0.656	0.89
43_I	46_Q	0.656	0.89
19_E	51_T	0.654	0.89
36_A	53_N	0.654	0.89
183_A	186_E	0.647	0.88
146_W	149_K	0.647	0.88
109_A	121_S	0.644	0.88
159_F	176_V	0.643	0.88
138_M	185_S	0.641	0.88
27_L	86_L	0.639	0.88
84_E	117_G	0.639	0.88
39_F	53_N	0.637	0.87
15_E	24_I	0.633	0.87
109_A	114_R	0.627	0.87
18_I	106_K	0.619	0.86
28_S	97_V	0.617	0.86
30_V	39_F	0.617	0.86
37_Q	57_Y	0.616	0.86
153_E	156_E	0.613	0.85
76_G	80_V	0.613	0.85
147_L	164_I	0.609	0.85
68_A	80_V	0.607	0.85
110_G	113_I	0.607	0.85
24_I	99_T	0.605	0.85
135_M	160_L	0.602	0.84
61_E	92_K	0.602	0.84
54_C	98_V	0.601	0.84
51_T	78_A	0.599	0.84
41_Q	45_K	0.596	0.84
85_V	117_G	0.596	0.84
40_I	99_T	0.593	0.83
140_T	172_F	0.591	0.83
18_I	118_K	0.588	0.83
147_L	170_V	0.586	0.83
167_S	171_E	0.584	0.82
169_N	197_D	0.581	0.82
58_V	92_K	0.579	0.82
51_T	101_Y	0.579	0.82
20_K	114_R	0.578	0.82
138_M	198_I	0.577	0.82
135_M	177_E	0.574	0.81
43_I	53_N	0.573	0.81
47_H	53_N	0.569	0.81
12_G	27_L	0.569	0.81
176_V	181_T	0.562	0.80
20_K	109_A	0.561	0.80
54_C	75_S	0.561	0.80
37_Q	67_K	0.559	0.80
124_L	128_G	0.557	0.79
190_E	193_N	0.554	0.79
41_Q	44_K	0.553	0.79
20_K	49_N	0.550	0.79
59_I	65_I	0.550	0.79
33_E	59_I	0.550	0.79
81_P	111_G	0.549	0.78
85_V	114_R	0.545	0.78
178_E	181_T	0.543	0.78
141_S	197_D	0.543	0.78
139_H	165_H	0.540	0.77
12_G	123_G	0.540	0.77
14_H	123_G	0.538	0.77
144_Y	148_G	0.538	0.77
51_T	99_T	0.537	0.77
57_Y	65_I	0.535	0.77
30_V	38_E	0.535	0.77
18_I	114_R	0.529	0.76
150_I	172_F	0.529	0.76
78_A	82_M	0.521	0.75
187_W	190_E	0.520	0.75
55_S	82_M	0.518	0.74
68_A	75_S	0.518	0.74
123_G	126_H	0.518	0.74
152_N	155_R	0.517	0.74
14_H	18_I	0.515	0.74
37_Q	41_Q	0.515	0.74
75_S	78_A	0.514	0.74
17_V	105_I	0.508	0.73
29_R	93_D	0.507	0.73
176_V	180_E	0.506	0.73
33_E	57_Y	0.505	0.73
30_V	35_E	0.505	0.73
145_T	148_G	0.504	0.72
62_N	66_Q	0.503	0.72
84_E	109_A	0.502	0.72
94_T	130_V	0.502	0.72
119_S	126_H	0.502	0.72
49_N	53_N	0.501	0.72
66_Q	88_K	0.500	0.72

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vi7A	1	0.9401	100	0.154	Contact Map
2cveA	1	0.871	100	0.196	Contact Map
3lh2S	2	0.318	98.8	0.851	Contact Map
4w224	1	0.9585	96.8	0.906	Contact Map
4fn5A	1	0.9124	96.5	0.909	Contact Map
1n0uA	1	0.9585	96	0.914	Contact Map
3j25A	1	0.9078	95.7	0.916	Contact Map
1darA	1	0.9309	93.5	0.925	Contact Map
2dy1A	1	0.8618	93.2	0.926	Contact Map
4kiyV	1	0.8848	92.7	0.927	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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