GREMLIN Database
DEGV - Protein DegV
UniProt: P32436 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (274)
Sequences: 4509 (3639)
Seq/√Len: 219.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
244_I248_S3.3291.00
139_S143_D3.0401.00
82_A110_D3.0111.00
218_D250_K2.9411.00
15_K19_E2.6821.00
168_Q178_A2.5581.00
91_G196_V2.4581.00
50_E54_K2.3811.00
237_E241_A2.3801.00
129_K132_E2.3691.00
84_I141_P2.3641.00
138_A143_D2.3521.00
96_F100_A2.2991.00
67_G71_A2.1831.00
44_D47_S2.1741.00
73_Y85_S2.1581.00
86_I116_S2.1501.00
112_Y141_P2.1451.00
38_R68_E2.1191.00
201_E212_R2.0571.00
166_H271_E2.0541.00
5_V134_I1.9661.00
63_Q94_G1.9241.00
77_G109_I1.9181.00
149_E152_K1.8471.00
14_P17_M1.8461.00
38_R42_E1.8351.00
241_A244_I1.7921.00
130_A148_L1.7871.00
236_R239_E1.7371.00
133_L147_E1.7321.00
145_I149_E1.7211.00
168_Q175_S1.7181.00
69_L99_A1.6851.00
133_L144_I1.6481.00
4_A24_H1.6381.00
24_H75_E1.6331.00
29_Q68_E1.6301.00
6_V72_L1.6291.00
24_H76_L1.6241.00
70_V105_M1.6211.00
112_Y145_I1.6151.00
82_A141_P1.6101.00
212_R215_E1.6021.00
35_E51_E1.6011.00
70_V74_E1.5931.00
33_R57_E1.5901.00
46_K50_E1.5671.00
206_R239_E1.5661.00
133_L138_A1.5651.00
49_Y266_G1.5651.00
147_E150_E1.5601.00
146_K150_E1.5601.00
90_S115_D1.5541.00
29_Q36_T1.5441.00
75_E78_K1.5381.00
3_I134_I1.5281.00
16_E20_Q1.5161.00
131_A135_K1.4951.00
6_V85_S1.4931.00
53_K235_N1.4881.00
47_S50_E1.4871.00
132_E136_N1.4831.00
117_E152_K1.4791.00
31_V36_T1.4741.00
156_R220_D1.4691.00
246_E249_A1.4611.00
24_H72_L1.4211.00
74_E106_V1.4201.00
240_A258_N1.4151.00
212_R216_L1.4051.00
31_V60_T1.3811.00
114_F145_I1.3741.00
18_R25_M1.3741.00
138_A147_E1.3691.00
72_L75_E1.3571.00
241_A245_E1.3531.00
114_F149_E1.3451.00
150_E154_T1.3391.00
69_L95_T1.3381.00
26_I72_L1.3371.00
74_E78_K1.3361.00
98_S102_A1.3341.00
114_F148_L1.3301.00
21_H135_K1.3261.00
4_A80_Y1.3201.00
244_I258_N1.3201.00
28_L95_T1.3181.00
133_L136_N1.3001.00
46_K260_Y1.2971.00
100_A104_S1.2721.00
12_Y262_G1.2711.00
118_I122_A1.2611.00
10_T123_Q1.2601.00
242_K245_E1.2521.00
193_D198_V1.2511.00
129_K147_E1.2511.00
82_A112_Y1.2491.00
100_A103_D1.2491.00
245_E249_A1.2471.00
21_H131_A1.2431.00
233_H236_R1.2321.00
7_T127_A1.2251.00
32_F51_E1.2241.00
17_M21_H1.2231.00
218_D251_Y1.2221.00
129_K133_L1.2191.00
83_V109_I1.2171.00
73_Y87_H1.2091.00
160_M209_A1.2091.00
142_E146_K1.2041.00
231_V240_A1.2001.00
7_T123_Q1.1911.00
97_S100_A1.1871.00
215_E250_K1.1791.00
233_H258_N1.1751.00
216_L219_E1.1741.00
6_V76_L1.1711.00
7_T25_M1.1641.00
4_A76_L1.1611.00
53_K271_E1.1441.00
20_Q135_K1.1431.00
138_A144_I1.1381.00
5_V127_A1.1371.00
77_G106_V1.1291.00
47_S51_E1.1221.00
191_H200_F1.1201.00
245_E248_S1.1181.00
23_I131_A1.1061.00
68_E71_A1.1051.00
17_M128_L1.0791.00
241_A258_N1.0751.00
94_G98_S1.0701.00
143_D146_K1.0691.00
269_L273_A1.0691.00
90_S96_F1.0611.00
72_L76_L1.0581.00
175_S178_A1.0561.00
96_F113_P1.0511.00
112_Y142_E1.0471.00
103_D111_V1.0471.00
161_V167_L1.0451.00
126_Y152_K1.0441.00
63_Q98_S1.0411.00
147_E151_M1.0361.00
162_D187_K1.0281.00
86_I130_A1.0271.00
231_V244_I1.0261.00
87_H96_F1.0201.00
3_I144_I1.0191.00
110_D142_E1.0131.00
70_V106_V1.0131.00
228_R255_E1.0051.00
26_I64_P1.0011.00
125_F230_A0.9971.00
215_E218_D0.9961.00
76_L83_V0.9951.00
70_V102_A0.9911.00
112_Y149_E0.9911.00
242_K246_E0.9851.00
99_A113_P0.9831.00
185_K205_T0.9831.00
214_Y246_E0.9821.00
235_N271_E0.9741.00
13_I124_G0.9741.00
190_L197_I0.9731.00
69_L102_A0.9711.00
211_S215_E0.9701.00
246_E250_K0.9691.00
21_H132_E0.9661.00
132_E228_R0.9661.00
211_S246_E0.9641.00
134_I144_I0.9591.00
33_R56_N0.9571.00
141_P145_I0.9511.00
131_A134_I0.9441.00
46_K235_N0.9411.00
16_E19_E0.9341.00
83_V111_V0.9280.99
21_H128_L0.9260.99
91_G117_E0.9200.99
244_I256_F0.9200.99
3_I84_I0.9090.99
126_Y148_L0.9060.99
177_Q202_K0.9000.99
4_A81_D0.8900.99
103_D113_P0.8870.99
233_H237_E0.8830.99
6_V83_V0.8820.99
77_G110_D0.8780.99
191_H198_V0.8680.99
233_H240_A0.8630.99
151_M154_T0.8610.99
232_I261_F0.8550.99
26_I69_L0.8520.99
210_I243_I0.8500.99
240_A244_I0.8500.99
110_D141_P0.8480.99
129_K151_M0.8480.99
28_L264_V0.8470.99
32_F59_P0.8460.99
118_I192_F0.8440.99
220_D278_W0.8430.99
4_A22_Q0.8410.99
49_Y234_A0.8400.99
174_S177_Q0.8400.99
181_G188_P0.8380.99
37_Y43_L0.8300.99
165_A169_R0.8280.99
92_I119_S0.8270.99
66_I101_A0.8250.99
215_E219_E0.8240.99
228_R257_Y0.8180.99
31_V34_E0.8170.99
208_K211_S0.8170.99
94_G97_S0.8170.99
238_E241_A0.8130.99
7_T11_A0.8120.99
232_I275_G0.8080.99
57_E169_R0.8020.99
146_K149_E0.8010.99
52_V166_H0.8000.99
106_V109_I0.8000.99
71_A75_E0.7980.98
238_E242_K0.7970.98
121_L232_I0.7940.98
163_D166_H0.7940.98
10_T264_V0.7930.98
73_Y99_A0.7910.98
164_L181_G0.7900.98
121_L230_A0.7870.98
84_I114_F0.7800.98
193_D196_V0.7800.98
217_L276_I0.7800.98
75_E79_S0.7770.98
122_A277_C0.7760.98
128_L132_E0.7720.98
128_L131_A0.7710.98
6_V73_Y0.7670.98
199_P202_K0.7670.98
139_S142_E0.7660.98
38_R41_I0.7640.98
127_A131_A0.7630.98
239_E242_K0.7620.98
9_S39_E0.7600.98
126_Y151_M0.7590.98
233_H260_Y0.7540.98
141_P144_I0.7520.98
17_M131_A0.7520.98
101_A104_S0.7500.98
189_I209_A0.7450.98
33_R51_E0.7440.98
118_I157_A0.7380.97
170_G268_H0.7360.97
61_T267_T0.7350.97
176_A179_F0.7350.97
67_G70_V0.7330.97
48_F266_G0.7320.97
261_F266_G0.7220.97
5_V131_A0.7200.97
122_A155_V0.7190.97
168_Q173_L0.7170.97
92_I197_I0.7150.97
79_S109_I0.7150.97
43_L48_F0.7140.97
50_E53_K0.7110.97
57_E60_T0.7110.97
69_L73_Y0.7060.97
88_L92_I0.7030.97
234_A273_A0.7020.97
216_L220_D0.7000.97
90_S117_E0.6960.96
142_E145_I0.6930.96
12_Y120_C0.6930.96
158_Y216_L0.6920.96
217_L221_A0.6910.96
59_P267_T0.6900.96
51_E55_H0.6900.96
23_I127_A0.6850.96
208_K215_E0.6850.96
4_A79_S0.6780.96
29_Q38_R0.6770.96
148_L152_K0.6740.96
158_Y200_F0.6740.96
3_I82_A0.6740.96
159_F275_G0.6730.96
150_E153_K0.6720.96
214_Y250_K0.6710.96
22_Q135_K0.6680.95
24_H78_K0.6650.95
217_L278_W0.6640.95
89_S92_I0.6630.95
13_I18_R0.6620.95
30_V263_A0.6610.95
162_D206_R0.6610.95
5_V130_A0.6600.95
130_A134_I0.6590.95
17_M20_Q0.6590.95
243_I274_L0.6570.95
231_V258_N0.6540.95
102_A106_V0.6540.95
85_S99_A0.6530.95
51_E54_K0.6520.95
232_I277_C0.6500.95
218_D222_S0.6490.95
86_I148_L0.6480.95
48_F263_A0.6420.94
97_S101_A0.6410.94
71_A74_E0.6370.94
116_S123_Q0.6350.94
100_A113_P0.6340.94
80_Y109_I0.6330.94
18_R22_Q0.6330.94
27_P41_I0.6320.94
119_S123_Q0.6300.94
76_L81_D0.6300.94
203_I208_K0.6290.94
239_E274_L0.6270.94
101_A105_M0.6260.94
14_P124_G0.6240.94
76_L79_S0.6230.93
119_S265_I0.6220.93
82_A109_I0.6210.93
158_Y220_D0.6190.93
89_S117_E0.6190.93
10_T88_L0.6190.93
77_G83_V0.6160.93
73_Y111_V0.6140.93
77_G107_D0.6110.93
166_H169_R0.6110.93
189_I203_I0.6080.93
159_F273_A0.6050.92
12_Y39_E0.6040.92
98_S101_A0.6040.92
119_S197_I0.6030.92
88_L119_S0.6020.92
214_Y243_I0.6010.92
128_L257_Y0.6010.92
77_G80_Y0.5960.92
162_D272_G0.5960.92
126_Y155_V0.5950.92
203_I212_R0.5910.92
35_E42_E0.5900.92
36_T42_E0.5890.91
177_Q199_P0.5880.91
87_H113_P0.5870.91
156_R191_H0.5860.91
162_D178_A0.5850.91
9_S28_L0.5840.91
84_I112_Y0.5830.91
73_Y83_V0.5820.91
32_F35_E0.5790.91
13_I23_I0.5790.91
116_S126_Y0.5770.91
234_A261_F0.5760.91
84_I145_I0.5750.90
66_I102_A0.5720.90
210_I274_L0.5710.90
65_P68_E0.5710.90
120_C273_A0.5700.90
206_R209_A0.5690.90
159_F190_L0.5690.90
86_I123_Q0.5690.90
79_S83_V0.5680.90
248_S256_F0.5680.90
248_S255_E0.5650.90
128_L228_R0.5650.90
114_F152_K0.5640.90
117_E195_K0.5630.90
159_F197_I0.5590.89
217_L251_Y0.5550.89
165_A168_Q0.5530.89
214_Y218_D0.5530.89
231_V256_F0.5530.89
99_A102_A0.5490.88
84_I130_A0.5480.88
77_G81_D0.5440.88
210_I246_E0.5390.87
221_A224_G0.5380.87
78_K81_D0.5370.87
73_Y103_D0.5370.87
186_V202_K0.5360.87
90_S97_S0.5330.87
14_P257_Y0.5290.86
102_A105_M0.5280.86
209_A213_I0.5270.86
144_I148_L0.5250.86
15_K18_R0.5230.86
200_F216_L0.5230.86
132_E135_K0.5220.86
58_L166_H0.5200.86
184_L204_R0.5190.85
237_E240_A0.5190.85
55_H59_P0.5180.85
86_I127_A0.5160.85
85_S113_P0.5150.85
189_I201_E0.5140.85
18_R21_H0.5110.85
247_L276_I0.5110.85
89_S195_K0.5110.85
179_F199_P0.5100.84
66_I98_S0.5070.84
18_R40_E0.5060.84
124_G131_A0.5060.84
129_K228_R0.5060.84
217_L247_L0.5030.84
160_M206_R0.5030.84
189_I212_R0.5010.83
5_V86_I0.5000.83
15_K40_E0.5000.83
92_I192_F0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fysA 1 0.9964 100 -0.008 Contact Map
2dt8A 1 0.9929 100 0.001 Contact Map
3lupA 1 0.9929 100 0.002 Contact Map
1pzxA 1 0.9929 100 0.003 Contact Map
3nyiA 1 0.9893 100 0.017 Contact Map
3pl5A 1 0.9502 100 0.018 Contact Map
2g7zA 3 0.9715 100 0.021 Contact Map
3jr7A 1 0.9751 100 0.031 Contact Map
1mgpA 1 0.9537 100 0.035 Contact Map
3fdjA 1 0.9644 100 0.046 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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