HEMH - BACSU - GREMLIN Contacts

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HEMH - Ferrochelatase

UniProt:	P32396	Sequences: MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLKDRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHKDGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDRVKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAVGWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVVTDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	310 (292)
Sequences:	3152 (1926)
Seq/√Len:	112.7

ECOLI - HEMH
BACSU - HEMH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
155_T	210_G	3.710	1.00
70_H	298_D	3.510	1.00
182_A	204_A	3.290	1.00
60_T	84_I	3.056	1.00
187_E	191_E	3.018	1.00
62_Q	292_A	2.981	1.00
83_Y	99_E	2.903	1.00
177_M	217_A	2.900	1.00
229_P	232_G	2.787	1.00
274_K	278_D	2.610	1.00
150_E	306_K	2.590	1.00
66_N	294_P	2.584	1.00
146_S	199_Q	2.472	1.00
128_R	131_E	2.413	1.00
17_Y	90_E	2.407	1.00
187_E	229_P	2.370	1.00
249_Q	283_S	2.348	1.00
159_D	295_E	2.271	1.00
239_T	251_F	2.209	1.00
98_A	102_K	2.174	1.00
18_K	21_D	2.145	1.00
70_H	301_A	2.121	1.00
163_E	293_K	2.079	1.00
208_A	216_Y	2.077	1.00
241_D	246_K	2.043	1.00
11_M	125_Y	2.042	1.00
63_Q	297_I	1.982	1.00
188_K	228_D	1.956	1.00
83_Y	103_D	1.940	1.00
83_Y	100_M	1.940	1.00
149_D	202_E	1.912	1.00
190_K	197_P	1.890	1.00
107_E	140_T	1.864	1.00
162_K	210_G	1.827	1.00
255_P	269_N	1.809	1.00
152_K	302_T	1.758	1.00
204_A	218_V	1.732	1.00
205_K	209_E	1.717	1.00
238_L	241_D	1.710	1.00
66_N	297_I	1.681	1.00
202_E	206_L	1.665	1.00
6_M	107_E	1.646	1.00
161_V	254_V	1.635	1.00
87_K	124_S	1.626	1.00
219_G	235_V	1.622	1.00
81_K	103_D	1.605	1.00
180_V	207_I	1.604	1.00
197_P	201_H	1.578	1.00
67_L	297_I	1.565	1.00
110_S	129_A	1.558	1.00
90_E	95_D	1.557	1.00
198_D	202_E	1.542	1.00
57_A	61_E	1.534	1.00
202_E	205_K	1.530	1.00
53_I	58_Q	1.530	1.00
201_H	220_W	1.529	1.00
237_D	240_R	1.484	1.00
27_T	37_P	1.464	1.00
180_V	254_V	1.446	1.00
182_A	218_V	1.444	1.00
180_V	216_Y	1.444	1.00
52_G	62_Q	1.433	1.00
147_W	259_V	1.433	1.00
131_E	134_E	1.428	1.00
217_A	238_L	1.402	1.00
15_T	57_A	1.393	1.00
37_P	40_L	1.390	1.00
99_E	103_D	1.390	1.00
153_F	157_W	1.385	1.00
270_D	286_R	1.383	1.00
154_V	210_G	1.378	1.00
157_W	207_I	1.342	1.00
22_I	43_L	1.340	1.00
58_Q	62_Q	1.335	1.00
59_I	260_A	1.329	1.00
142_T	307_K	1.320	1.00
7_G	105_I	1.318	1.00
66_N	292_A	1.317	1.00
96_A	99_E	1.304	0.99
236_Q	276_V	1.301	0.99
185_L	189_I	1.295	0.99
160_R	293_K	1.293	0.99
239_T	273_C	1.290	0.99
85_G	96_A	1.276	0.99
185_L	190_K	1.273	0.99
7_G	96_A	1.256	0.99
17_Y	24_R	1.253	0.99
219_G	238_L	1.253	0.99
101_H	136_L	1.250	0.99
83_Y	96_A	1.248	0.99
150_E	303_V	1.248	0.99
65_H	69_Q	1.246	0.99
164_T	285_Y	1.245	0.99
204_A	216_Y	1.245	0.99
126_N	143_S	1.243	0.99
197_P	220_W	1.242	0.99
158_V	210_G	1.232	0.99
96_A	100_M	1.230	0.99
28_H	128_R	1.230	0.99
275_V	278_D	1.230	0.99
100_M	108_A	1.230	0.99
151_P	210_G	1.229	0.99
165_Y	252_V	1.221	0.99
252_V	285_Y	1.216	0.99
223_E	234_D	1.216	0.99
159_D	162_K	1.215	0.99
180_V	208_A	1.214	0.99
155_T	159_D	1.206	0.99
27_T	31_R	1.204	0.99
274_K	284_Y	1.198	0.99
7_G	100_M	1.198	0.99
158_V	162_K	1.195	0.99
111_I	300_L	1.172	0.99
250_A	283_S	1.163	0.99
154_V	206_L	1.160	0.99
164_T	167_S	1.159	0.99
240_R	276_V	1.158	0.99
67_L	301_A	1.156	0.99
157_W	290_P	1.156	0.99
64_A	68_E	1.150	0.99
148_Y	199_Q	1.148	0.99
38_E	42_D	1.148	0.99
301_A	305_L	1.145	0.99
190_K	198_D	1.141	0.99
52_G	58_Q	1.141	0.99
299_A	303_V	1.131	0.99
206_L	209_E	1.128	0.99
259_V	296_F	1.125	0.98
68_E	72_N	1.125	0.98
28_H	89_I	1.118	0.98
107_E	142_T	1.117	0.98
36_E	40_L	1.115	0.98
240_R	279_D	1.110	0.98
59_I	292_A	1.106	0.98
100_M	105_I	1.103	0.98
65_H	68_E	1.101	0.98
45_D	48_E	1.097	0.98
261_D	291_N	1.096	0.98
61_E	65_H	1.094	0.98
266_L	270_D	1.090	0.98
41_Q	45_D	1.075	0.98
64_A	84_I	1.073	0.98
98_A	136_L	1.073	0.98
176_A	249_Q	1.060	0.98
204_A	208_A	1.056	0.98
152_K	298_D	1.046	0.98
150_E	302_T	1.045	0.98
253_Y	284_Y	1.044	0.98
170_E	215_E	1.041	0.97
98_A	132_E	1.040	0.97
273_C	276_V	1.040	0.97
17_Y	21_D	1.029	0.97
105_I	108_A	1.029	0.97
275_V	279_D	1.028	0.97
179_I	251_F	1.020	0.97
66_N	69_Q	1.014	0.97
147_W	296_F	1.012	0.97
181_S	221_Q	1.011	0.97
126_N	130_K	1.010	0.97
148_Y	206_L	1.008	0.97
57_A	84_I	1.004	0.97
177_M	248_Y	1.002	0.97
188_K	192_F	0.999	0.97
67_L	300_L	0.995	0.97
152_K	155_T	0.982	0.96
158_V	207_I	0.979	0.96
175_N	249_Q	0.973	0.96
140_T	307_K	0.972	0.96
160_R	288_E	0.972	0.96
179_I	217_A	0.971	0.96
70_H	73_E	0.970	0.96
109_V	304_V	0.966	0.96
11_M	93_I	0.958	0.96
93_I	125_Y	0.952	0.96
255_P	286_R	0.947	0.96
232_G	237_D	0.943	0.96
277_T	282_A	0.941	0.95
157_W	254_V	0.939	0.95
272_E	276_V	0.936	0.95
120_F	185_L	0.935	0.95
28_H	92_F	0.931	0.95
161_V	178_L	0.922	0.95
19_E	22_I	0.922	0.95
71_L	301_A	0.920	0.95
5_K	106_T	0.920	0.95
9_L	85_G	0.917	0.95
156_Y	290_P	0.910	0.95
155_T	295_E	0.908	0.94
111_I	144_V	0.902	0.94
49_A	271_Y	0.898	0.94
6_M	109_V	0.892	0.94
161_V	207_I	0.890	0.94
175_N	250_A	0.888	0.94
109_V	144_V	0.886	0.94
9_L	96_A	0.885	0.94
128_R	132_E	0.883	0.94
239_T	280_I	0.883	0.94
165_Y	170_E	0.882	0.94
98_A	101_H	0.879	0.93
100_M	103_D	0.876	0.93
116_H	200_L	0.871	0.93
132_E	136_L	0.864	0.93
149_D	206_L	0.859	0.93
109_V	307_K	0.857	0.93
118_S	189_I	0.854	0.92
176_A	250_A	0.854	0.92
110_S	143_S	0.853	0.92
243_F	280_I	0.850	0.92
240_R	245_Q	0.846	0.92
167_S	285_Y	0.845	0.92
38_E	41_Q	0.844	0.92
93_I	128_R	0.843	0.92
63_Q	300_L	0.840	0.92
162_K	166_A	0.840	0.92
176_A	252_V	0.834	0.92
23_E	40_L	0.834	0.92
198_D	201_H	0.830	0.91
152_K	295_E	0.829	0.91
276_V	279_D	0.829	0.91
243_F	282_A	0.828	0.91
154_V	203_S	0.827	0.91
270_D	274_K	0.827	0.91
163_E	167_S	0.821	0.91
61_E	84_I	0.818	0.91
269_N	284_Y	0.817	0.91
8_L	304_V	0.815	0.91
94_E	132_E	0.815	0.91
160_R	163_E	0.811	0.90
23_E	37_P	0.810	0.90
178_L	254_V	0.808	0.90
113_L	259_V	0.807	0.90
243_F	247_G	0.804	0.90
59_I	62_Q	0.804	0.90
157_W	161_V	0.796	0.90
19_E	48_E	0.795	0.90
59_I	291_N	0.795	0.90
37_P	41_Q	0.793	0.89
180_V	204_A	0.793	0.89
243_F	246_K	0.792	0.89
94_E	135_K	0.791	0.89
198_D	205_K	0.791	0.89
87_K	128_R	0.790	0.89
179_I	219_G	0.787	0.89
133_A	136_L	0.780	0.89
49_A	267_Y	0.775	0.88
240_R	280_I	0.774	0.88
109_V	142_T	0.773	0.88
25_Y	43_L	0.770	0.88
7_G	83_Y	0.770	0.88
62_Q	65_H	0.767	0.88
157_W	203_S	0.766	0.88
177_M	246_K	0.765	0.88
72_N	79_T	0.762	0.87
152_K	299_A	0.762	0.87
157_W	160_R	0.761	0.87
182_A	200_L	0.760	0.87
130_K	143_S	0.759	0.87
132_E	135_K	0.757	0.87
253_Y	269_N	0.754	0.87
164_T	288_E	0.754	0.87
243_F	249_Q	0.752	0.87
243_F	248_Y	0.750	0.87
19_E	44_K	0.749	0.87
120_F	189_I	0.745	0.86
111_I	304_V	0.740	0.86
203_S	207_I	0.738	0.86
241_D	245_Q	0.736	0.86
239_T	284_Y	0.735	0.86
238_L	242_L	0.735	0.86
17_Y	61_E	0.732	0.85
97_V	101_H	0.728	0.85
7_G	85_G	0.724	0.85
25_Y	28_H	0.722	0.85
159_D	163_E	0.719	0.84
201_H	218_V	0.717	0.84
302_T	306_K	0.716	0.84
301_A	304_V	0.713	0.84
97_V	132_E	0.710	0.84
72_N	80_F	0.709	0.83
296_F	299_A	0.706	0.83
35_P	39_M	0.705	0.83
163_E	288_E	0.704	0.83
108_A	139_L	0.699	0.83
34_K	127_K	0.698	0.82
154_V	207_I	0.697	0.82
273_C	289_M	0.696	0.82
189_I	228_D	0.693	0.82
10_V	64_A	0.692	0.82
175_N	252_V	0.690	0.82
22_I	44_K	0.688	0.82
123_Q	127_K	0.688	0.82
64_A	82_A	0.687	0.81
97_V	108_A	0.684	0.81
68_E	81_K	0.683	0.81
46_R	267_Y	0.677	0.81
13_Y	114_A	0.675	0.80
168_M	176_A	0.671	0.80
92_F	95_D	0.671	0.80
95_D	98_A	0.670	0.80
62_Q	66_N	0.668	0.80
140_T	145_E	0.668	0.80
165_Y	178_L	0.668	0.80
298_D	302_T	0.667	0.80
163_E	166_A	0.667	0.80
164_T	168_M	0.666	0.79
243_F	283_S	0.666	0.79
60_T	64_A	0.664	0.79
119_T	123_Q	0.663	0.79
251_F	282_A	0.662	0.79
154_V	158_V	0.662	0.79
206_L	210_G	0.659	0.79
201_H	205_K	0.659	0.79
168_M	285_Y	0.658	0.79
11_M	129_A	0.657	0.79
208_A	213_V	0.652	0.78
296_F	300_L	0.651	0.78
252_V	287_P	0.650	0.78
271_Y	275_V	0.649	0.78
50_I	267_Y	0.647	0.77
148_Y	202_E	0.646	0.77
179_I	238_L	0.644	0.77
15_T	54_S	0.642	0.77
261_D	289_M	0.642	0.77
270_D	273_C	0.641	0.77
32_G	88_H	0.639	0.77
101_H	133_A	0.639	0.77
168_M	250_A	0.638	0.76
136_L	139_L	0.636	0.76
67_L	304_V	0.633	0.76
213_V	216_Y	0.633	0.76
273_C	284_Y	0.633	0.76
13_Y	29_I	0.633	0.76
8_L	80_F	0.631	0.76
42_D	46_R	0.631	0.76
197_P	231_L	0.629	0.75
116_H	121_S	0.628	0.75
177_M	215_E	0.628	0.75
177_M	251_F	0.627	0.75
150_E	299_A	0.625	0.75
29_I	262_H	0.624	0.75
97_V	136_L	0.621	0.75
276_V	280_I	0.620	0.74
160_R	254_V	0.619	0.74
165_Y	175_N	0.619	0.74
5_K	81_K	0.617	0.74
226_T	268_D	0.616	0.74
94_E	131_E	0.615	0.74
28_H	88_H	0.614	0.74
298_D	301_A	0.614	0.74
9_L	97_V	0.614	0.74
81_K	85_G	0.610	0.73
25_Y	29_I	0.609	0.73
99_E	102_K	0.607	0.73
97_V	129_A	0.607	0.73
165_Y	168_M	0.606	0.73
297_I	300_L	0.605	0.73
46_R	263_L	0.604	0.73
176_A	248_Y	0.603	0.72
236_Q	273_C	0.601	0.72
84_I	96_A	0.600	0.72
18_K	53_I	0.598	0.72
26_Y	39_M	0.598	0.72
6_M	80_F	0.593	0.71
125_Y	128_R	0.592	0.71
110_S	141_I	0.591	0.71
68_E	82_A	0.588	0.71
190_K	205_K	0.587	0.70
113_L	260_A	0.585	0.70
219_G	251_F	0.584	0.70
269_N	272_E	0.580	0.69
156_Y	299_A	0.577	0.69
94_E	98_A	0.576	0.69
184_S	232_G	0.576	0.69
15_T	56_L	0.576	0.69
44_K	48_E	0.574	0.69
63_Q	260_A	0.573	0.69
23_E	44_K	0.573	0.69
156_Y	295_E	0.569	0.68
69_Q	102_K	0.569	0.68
106_T	140_T	0.568	0.68
43_L	124_S	0.567	0.68
168_M	252_V	0.567	0.68
26_Y	35_P	0.560	0.67
267_Y	271_Y	0.558	0.67
238_L	246_K	0.556	0.66
11_M	110_S	0.554	0.66
24_R	90_E	0.554	0.66
34_K	123_Q	0.553	0.66
119_T	137_G	0.553	0.66
161_V	287_P	0.552	0.66
119_T	189_I	0.552	0.66
151_P	155_T	0.550	0.65
43_L	46_R	0.550	0.65
92_F	96_A	0.548	0.65
51_G	58_Q	0.546	0.65
197_P	202_E	0.545	0.65
286_R	289_M	0.544	0.65
45_D	272_E	0.543	0.64
129_A	133_A	0.542	0.64
124_S	138_G	0.540	0.64
42_D	45_D	0.538	0.64
163_E	295_E	0.538	0.64
151_P	206_L	0.537	0.64
245_Q	249_Q	0.536	0.63
177_M	242_L	0.534	0.63
159_D	293_K	0.534	0.63
190_K	202_E	0.533	0.63
85_G	125_Y	0.530	0.63
12_A	114_A	0.530	0.63
18_K	24_R	0.529	0.62
9_L	93_I	0.529	0.62
265_V	268_D	0.529	0.62
63_Q	71_L	0.528	0.62
28_H	94_E	0.527	0.62
162_K	214_S	0.527	0.62
117_F	123_Q	0.527	0.62
184_S	234_D	0.526	0.62
250_A	285_Y	0.525	0.62
70_H	297_I	0.525	0.62
70_H	294_P	0.523	0.62
11_M	85_G	0.521	0.61
247_G	283_S	0.520	0.61
237_D	276_V	0.517	0.61
278_D	283_S	0.516	0.61
162_K	211_A	0.516	0.61
63_Q	66_N	0.515	0.60
145_E	307_K	0.515	0.60
295_E	298_D	0.515	0.60
160_R	287_P	0.514	0.60
271_Y	276_V	0.512	0.60
179_I	235_V	0.512	0.60
217_A	246_K	0.508	0.59
21_D	89_I	0.506	0.59
63_Q	67_L	0.506	0.59
40_L	44_K	0.504	0.59
165_Y	169_P	0.503	0.59
202_E	209_E	0.503	0.59
101_H	139_L	0.500	0.58

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2h1vA	1	0.9935	100	0.19	Contact Map
1lbqA	2	0.9806	100	0.192	Contact Map
3hcnA	2	0.9903	100	0.202	Contact Map
2xwpA	5	0.7903	100	0.595	Contact Map
2xvyA	3	0.7677	100	0.645	Contact Map
4ccsA	1	0.729	99.8	0.794	Contact Map
2jh3A	2	0.7935	99.7	0.816	Contact Map
3lyhA	2	0.3935	99.7	0.82	Contact Map
1tjnA	4	0.3742	99.5	0.842	Contact Map
2xwsA	2	0.3774	99.4	0.846	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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