GREMLIN Database
DCUP - Uroporphyrinogen decarboxylase
UniProt: P32395 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 353 (330)
Sequences: 3887 (2554)
Seq/√Len: 140.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_T21_D4.8911.00
13_K18_E3.9571.00
183_S229_R3.6661.00
190_I233_E3.4211.00
179_N221_T3.3631.00
302_K305_E3.2801.00
300_E342_E3.1381.00
220_R254_D3.1341.00
106_S109_D3.0981.00
179_N226_V2.9711.00
174_M177_A2.7371.00
15_A262_V2.7261.00
58_A131_L2.6191.00
89_D101_D2.5451.00
133_V202_K2.4861.00
303_T336_L2.4741.00
304_K339_F2.4691.00
10_T22_H2.4631.00
253_G277_K2.4601.00
329_S332_V2.3121.00
296_W335_K2.2591.00
197_I204_I2.2321.00
305_E309_Q2.2261.00
187_D229_R2.2001.00
11_F203_A2.1801.00
195_A198_E2.1761.00
273_E276_S2.1761.00
228_N232_S2.1491.00
156_I170_F2.0981.00
300_E339_F2.0921.00
66_E138_N2.0881.00
107_L174_M2.0821.00
335_K339_F2.0681.00
126_L195_A2.0621.00
300_E335_K2.0351.00
40_K43_E2.0331.00
304_K308_D2.0261.00
190_I229_R2.0181.00
295_P298_V2.0141.00
297_E301_Q2.0091.00
186_A190_I1.9171.00
194_K233_E1.9051.00
270_G309_Q1.9001.00
145_S189_I1.8641.00
235_A261_D1.8601.00
255_W263_V1.8591.00
17_G315_G1.8571.00
296_W332_V1.8571.00
272_D309_Q1.8461.00
27_Y336_L1.8171.00
110_I177_A1.8101.00
111_E180_L1.8041.00
179_N222_Y1.7971.00
318_F340_V1.7691.00
9_E13_K1.7621.00
303_T339_F1.7351.00
220_R257_D1.7081.00
123_P127_E1.7071.00
46_G49_E1.7011.00
186_A230_I1.6671.00
109_D112_K1.6581.00
334_K338_A1.6451.00
170_F177_A1.6071.00
219_Y227_M1.6071.00
180_L184_K1.5971.00
127_E130_K1.5911.00
272_D276_S1.5731.00
105_R166_K1.5521.00
13_K21_D1.5451.00
190_I230_I1.5441.00
131_L135_E1.5191.00
231_F241_L1.5181.00
308_D343_Y1.5111.00
299_I335_K1.4891.00
183_S187_D1.4621.00
27_Y333_L1.4591.00
197_I239_V1.4541.00
107_L177_A1.4351.00
167_T178_W1.4181.00
304_K343_Y1.4161.00
183_S226_V1.4061.00
55_E131_L1.4061.00
235_A241_L1.4001.00
14_A282_T1.3961.00
299_I332_V1.3921.00
17_G282_T1.3811.00
338_A342_E1.3681.00
14_A24_P1.3421.00
13_K20_A1.3411.00
11_F242_I1.3281.00
307_L343_Y1.3281.00
16_R240_P1.3241.00
68_Y330_P1.3221.00
75_L132_L1.3171.00
282_T315_G1.3151.00
339_F342_E1.3071.00
224_K228_N1.3051.00
67_Q334_K1.3031.00
296_W300_E1.2781.00
231_F260_L1.2721.00
194_K198_E1.2691.00
50_I60_V1.2681.00
215_N218_D1.2671.00
332_V335_K1.2661.00
294_A298_V1.2631.00
131_L134_N1.2601.00
49_E53_Q1.2561.00
273_E277_K1.2531.00
335_K338_A1.2501.00
128_T132_L1.2451.00
224_K257_D1.2401.00
300_E304_K1.2191.00
68_Y334_K1.2121.00
107_L180_L1.2101.00
259_P281_K1.2041.00
298_V301_Q1.2021.00
194_K236_K1.1891.00
194_K237_E1.1791.00
187_D190_I1.1781.00
10_T20_A1.1711.00
175_P221_T1.1691.00
63_L67_Q1.1610.99
108_A111_E1.1590.99
107_L111_E1.1590.99
130_K199_A1.1550.99
216_Q220_R1.1510.99
191_V194_K1.1430.99
287_L318_F1.1410.99
91_E101_D1.1370.99
186_A229_R1.1310.99
62_R66_E1.1280.99
23_T307_L1.1240.99
216_Q254_D1.1240.99
169_A173_S1.1230.99
58_A132_L1.1220.99
130_K134_N1.1210.99
270_G273_E1.1150.99
220_R224_K1.1030.99
187_D191_V1.1010.99
22_H341_H1.0620.99
194_K234_L1.0620.99
289_P321_G1.0600.99
53_Q56_L1.0520.99
331_E334_K1.0480.99
287_L336_L1.0430.99
11_F15_A1.0430.99
25_V337_T1.0430.99
19_K314_D1.0380.99
23_T316_F1.0350.99
111_E184_K1.0340.99
228_N257_D1.0330.99
324_V328_V1.0330.99
19_K313_S1.0320.99
117_D120_Q1.0310.99
69_G341_H1.0310.99
14_A20_A1.0270.99
93_K96_I1.0250.99
291_I299_I1.0240.99
291_I302_K1.0240.99
69_G139_V1.0200.99
52_H84_P1.0170.99
324_V333_L1.0130.99
189_I230_I1.0090.99
325_F328_V1.0060.99
179_N183_S0.9990.98
300_E338_A0.9910.98
297_E300_E0.9900.98
177_A180_L0.9900.98
232_S236_K0.9890.98
257_D280_T0.9850.98
293_L327_D0.9800.98
306_I318_F0.9780.98
15_A317_I0.9640.98
318_F336_L0.9630.98
118_P126_L0.9460.98
227_M243_M0.9410.98
228_N259_P0.9360.98
34_S68_Y0.9350.98
171_M178_W0.9310.98
55_E58_A0.9300.98
252_A274_A0.9140.97
206_I230_I0.9140.97
306_I316_F0.9130.97
296_W299_I0.9080.97
292_L328_V0.9070.97
254_D257_D0.9010.97
205_Q264_G0.8980.97
224_K258_L0.8980.97
224_K254_D0.8940.97
127_E131_L0.8910.97
166_K169_A0.8900.97
39_R43_E0.8890.97
10_T13_K0.8860.97
40_K44_K0.8860.97
190_I194_K0.8810.97
301_Q305_E0.8800.97
152_A181_L0.8770.96
206_I231_F0.8760.96
105_R109_D0.8730.96
108_A112_K0.8690.96
300_E303_T0.8690.96
45_Y56_L0.8680.96
296_W331_E0.8630.96
119_E195_A0.8630.96
311_M314_D0.8630.96
54_P58_A0.8610.96
110_I170_F0.8580.96
240_P261_D0.8560.96
229_R233_E0.8530.96
206_I227_M0.8530.96
77_K81_T0.8520.96
303_T307_L0.8480.96
243_M260_L0.8460.96
232_S235_A0.8450.96
23_T318_F0.8450.96
75_L129_I0.8420.96
70_V337_T0.8410.95
170_F174_M0.8400.95
65_V139_V0.8380.95
241_L261_D0.8360.95
178_W182_M0.8330.95
249_S273_E0.8280.95
110_I184_K0.8260.95
115_Q187_D0.8250.95
198_E237_E0.8240.95
57_C128_T0.8210.95
45_Y50_I0.8200.95
151_L189_I0.8180.95
55_E127_E0.8180.95
182_M226_V0.8180.95
145_S193_V0.8170.95
20_A23_T0.8150.95
46_G50_I0.8130.95
193_V234_L0.8130.95
256_H281_K0.8120.95
275_R283_V0.8100.94
278_G281_K0.8060.94
293_L325_F0.8030.94
203_A242_I0.8020.94
50_I56_L0.8000.94
269_L274_A0.8000.94
153_S167_T0.7990.94
171_M218_D0.7970.94
187_D233_E0.7970.94
129_I199_A0.7970.94
27_Y70_V0.7950.94
104_I109_D0.7950.94
45_Y53_Q0.7940.94
232_S259_P0.7910.94
243_M258_L0.7870.94
110_I181_L0.7860.94
88_V155_M0.7860.94
58_A62_R0.7830.93
233_E236_K0.7800.93
12_L16_R0.7790.93
274_A283_V0.7760.93
331_E335_K0.7760.93
339_F343_Y0.7750.93
172_Y218_D0.7750.93
217_A221_T0.7750.93
330_P334_K0.7750.93
62_R135_E0.7720.93
66_E135_E0.7680.93
296_W339_F0.7670.93
197_I237_E0.7650.93
278_G314_D0.7650.93
226_V229_R0.7640.93
54_P131_L0.7640.93
299_I339_F0.7620.92
83_L155_M0.7600.92
245_G248_A0.7570.92
298_V302_K0.7560.92
20_A314_D0.7540.92
137_L140_P0.7540.92
65_V69_G0.7530.92
299_I303_T0.7470.92
176_D183_S0.7470.92
143_G196_Q0.7440.92
262_V317_I0.7430.92
186_A226_V0.7430.92
265_L274_A0.7420.91
152_A178_W0.7410.91
110_I180_L0.7360.91
295_P332_V0.7360.91
293_L328_V0.7350.91
54_P127_E0.7350.91
256_H280_T0.7340.91
58_A135_E0.7300.91
223_I227_M0.7270.91
217_A220_R0.7230.90
188_M191_V0.7200.90
304_K307_L0.7200.90
75_L128_T0.7160.90
59_Y63_L0.7120.90
59_Y66_E0.7110.90
223_I226_V0.7090.90
41_L45_Y0.7070.89
211_V223_I0.7050.89
145_S206_I0.7020.89
88_V100_I0.7010.89
305_E308_D0.6980.89
129_I201_A0.6970.89
142_I203_A0.6930.88
250_H277_K0.6920.88
186_A233_E0.6910.88
193_V204_I0.6900.88
41_L56_L0.6890.88
294_A332_V0.6890.88
303_T335_K0.6880.88
82_P188_M0.6870.88
55_E59_Y0.6850.88
150_T207_F0.6820.88
234_L241_L0.6790.87
164_Y209_S0.6790.87
253_G280_T0.6780.87
8_N202_K0.6740.87
14_A315_G0.6740.87
114_G184_K0.6710.87
287_L302_K0.6710.87
275_R313_S0.6710.87
303_T318_F0.6700.87
115_Q184_K0.6680.87
165_N169_A0.6670.86
126_L130_K0.6670.86
235_A238_N0.6670.86
250_H269_L0.6660.86
65_V70_V0.6650.86
119_E191_V0.6640.86
136_Q139_V0.6610.86
292_L320_L0.6610.86
251_L255_W0.6610.86
337_T341_H0.6610.86
89_D102_Q0.6590.86
262_V282_T0.6540.85
45_Y49_E0.6540.85
102_Q112_K0.6540.85
307_L340_V0.6530.85
308_D311_M0.6520.85
9_E202_K0.6510.85
123_P126_L0.6500.85
126_L192_Y0.6420.84
30_Q33_R0.6420.84
47_L50_I0.6380.84
244_F322_H0.6380.84
176_D180_L0.6370.84
209_S212_G0.6360.84
275_R278_G0.6360.84
307_L311_M0.6340.84
299_I336_L0.6320.83
301_Q304_K0.6320.83
149_F153_S0.6310.83
272_D305_E0.6300.83
271_I286_N0.6290.83
249_S252_A0.6290.83
301_Q308_D0.6280.83
225_P229_R0.6280.83
180_L183_S0.6270.83
156_I167_T0.6270.83
204_I234_L0.6270.83
11_F72_A0.6220.82
331_E338_A0.6210.82
265_L271_I0.6210.82
152_A185_L0.6190.82
207_F323_G0.6180.82
218_D221_T0.6180.82
25_V340_V0.6170.82
142_I242_I0.6170.82
214_L223_I0.6160.82
303_T342_E0.6150.82
249_S269_L0.6150.82
49_E56_L0.6130.82
216_Q250_H0.6120.81
67_Q330_P0.6090.81
118_P195_A0.6090.81
275_R314_D0.6090.81
255_W258_L0.6060.81
294_A299_I0.6060.81
41_L60_V0.6050.81
287_L306_I0.6030.80
193_V200_G0.6020.80
118_P191_V0.6020.80
218_D222_Y0.6010.80
52_H124_Y0.6010.80
269_L273_E0.6010.80
183_S186_A0.6010.80
243_M255_W0.6000.80
284_Q319_N0.5990.80
266_D321_G0.5980.80
209_S322_H0.5960.80
260_L263_V0.5960.80
115_Q191_V0.5950.80
163_N166_K0.5910.79
38_Y42_K0.5900.79
57_C60_V0.5900.79
190_I234_L0.5890.79
288_D291_I0.5880.79
216_Q251_L0.5870.79
172_Y291_I0.5860.79
244_F264_G0.5830.78
74_I144_F0.5820.78
216_Q253_G0.5780.78
175_P222_Y0.5760.77
126_L199_A0.5760.77
245_G255_W0.5750.77
119_E130_K0.5750.77
128_T131_L0.5740.77
198_E235_A0.5730.77
194_K197_I0.5730.77
29_R33_R0.5720.77
91_E99_V0.5710.77
275_R312_E0.5710.77
276_S301_Q0.5700.77
182_M186_A0.5690.77
29_R32_G0.5690.77
328_V333_L0.5690.77
292_L299_I0.5690.77
300_E343_Y0.5680.76
246_V322_H0.5650.76
147_A208_D0.5640.76
16_R238_N0.5630.76
290_S293_L0.5630.76
65_V341_H0.5610.76
296_W338_A0.5600.75
83_L88_V0.5590.75
287_L303_T0.5590.75
162_K165_N0.5590.75
15_A242_I0.5590.75
147_A223_I0.5580.75
166_K170_F0.5580.75
69_G337_T0.5570.75
173_S295_P0.5570.75
35_Q63_L0.5550.75
209_S246_V0.5540.75
201_A204_I0.5540.75
64_P79_I0.5520.74
227_M231_F0.5520.74
177_A181_L0.5520.74
99_V103_P0.5510.74
250_H255_W0.5510.74
176_D221_T0.5480.74
219_Y224_K0.5470.74
118_P123_P0.5470.74
204_I241_L0.5460.74
227_M255_W0.5440.73
168_K213_A0.5420.73
291_I294_A0.5420.73
266_D286_N0.5410.73
176_D179_N0.5390.73
165_N327_D0.5390.73
82_P122_V0.5390.73
171_M222_Y0.5370.72
47_L51_T0.5360.72
151_L185_L0.5350.72
16_R20_A0.5320.72
290_S325_F0.5310.72
110_I152_A0.5290.71
182_M222_Y0.5290.71
252_A269_L0.5280.71
169_A327_D0.5280.71
191_V195_A0.5270.71
170_F173_S0.5270.71
271_I306_I0.5270.71
181_L185_L0.5270.71
271_I309_Q0.5260.71
217_A305_E0.5260.71
69_G334_K0.5250.71
132_L135_E0.5250.71
79_I323_G0.5240.71
36_P40_K0.5230.70
183_S190_I0.5210.70
227_M230_I0.5210.70
170_F178_W0.5210.70
35_Q67_Q0.5200.70
195_A199_A0.5170.70
231_F258_L0.5170.70
172_Y222_Y0.5170.70
279_I282_T0.5160.69
26_W323_G0.5160.69
228_N258_L0.5150.69
14_A17_G0.5130.69
150_T154_Y0.5130.69
27_Y337_T0.5120.69
320_L323_G0.5110.69
208_D212_G0.5110.69
264_G322_H0.5110.69
245_G322_H0.5110.69
216_Q270_G0.5110.69
221_T225_P0.5090.68
275_R309_Q0.5080.68
220_R225_P0.5070.68
41_L44_K0.5060.68
245_G251_L0.5040.68
333_L336_L0.5040.68
173_S217_A0.5020.67
114_G121_D0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2infA 2 0.9717 100 0.178 Contact Map
1r3sA 2 0.9773 100 0.203 Contact Map
4zr8A 2 0.9773 100 0.216 Contact Map
4exqA 2 0.9717 100 0.234 Contact Map
1j93A 2 0.9547 100 0.236 Contact Map
4wshA 2 0.9745 100 0.237 Contact Map
2ejaA 2 0.9462 100 0.243 Contact Map
4ay7A 1 0.915 100 0.305 Contact Map
1u1jA 1 0.8924 99.9 0.712 Contact Map
3rpdA 1 0.8782 99.9 0.72 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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