GREMLIN Database
COMEB - ComE operon protein 2
UniProt: P32393 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 189 (148)
Sequences: 2765 (1834)
Seq/√Len: 150.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_E114_Y3.3691.00
88_G111_K2.9451.00
13_Q41_G2.7141.00
66_A77_L2.5421.00
13_Q16_L2.5391.00
115_Y118_D2.5071.00
13_Q38_M2.5021.00
22_T163_K2.4601.00
154_L158_A2.4541.00
7_N112_T2.4001.00
67_R80_S2.2361.00
130_E133_G2.2041.00
95_H157_V2.1801.00
17_L41_G2.1771.00
90_E112_T2.1311.00
32_I75_A2.0921.00
155_S159_G2.0921.00
126_Q130_E2.0901.00
17_L20_R1.9531.00
34_R89_A1.8801.00
163_K167_A1.8331.00
10_F38_M1.8311.00
42_G74_N1.7431.00
73_M104_S1.7051.00
15_H156_F1.6721.00
7_N114_Y1.6691.00
6_W36_K1.6611.00
17_L43_Y1.6241.00
118_D145_I1.5761.00
12_A149_K1.5741.00
19_L156_F1.5521.00
32_I89_A1.5461.00
90_E111_K1.5351.00
68_T73_M1.5331.00
13_Q17_L1.4811.00
116_A153_K1.4481.00
12_A152_E1.4471.00
112_T142_D1.4221.00
34_R39_I1.3521.00
20_R43_Y1.3261.00
34_R37_R1.3221.00
91_I105_I1.3111.00
113_V141_L1.2991.00
68_T104_S1.2931.00
40_A78_Q1.2681.00
32_I79_C1.2481.00
7_N144_M1.2451.00
113_V132_A1.2441.00
150_N154_L1.2211.00
65_C84_V1.1961.00
6_W9_Y1.1711.00
129_F134_V1.1401.00
128_L134_V1.1381.00
24_P43_Y1.1381.00
112_T144_M1.1261.00
76_I80_S1.1150.99
40_A82_F1.1100.99
149_K152_E1.0890.99
10_F33_V1.0880.99
153_K156_F1.0750.99
125_A132_A1.0620.99
115_Y126_Q1.0420.99
45_G64_H1.0270.99
118_D150_N1.0230.99
40_A75_A1.0070.99
8_Q12_A0.9920.99
159_G163_K0.9900.99
132_A141_L0.9830.99
105_I141_L0.9830.99
99_I131_Q0.9820.99
76_I105_I0.9820.99
159_G162_G0.9730.99
124_Y131_Q0.9730.99
15_H116_A0.9720.99
106_I132_A0.9700.98
22_T156_F0.9700.98
10_F36_K0.9670.98
32_I91_I0.9650.98
76_I104_S0.9630.98
30_A71_A0.9600.98
35_D88_G0.9600.98
87_D111_K0.9590.98
9_Y13_Q0.9590.98
15_H153_K0.9580.98
68_T77_L0.9570.98
163_K166_D0.9540.98
78_Q81_K0.9520.98
64_H69_I0.9520.98
15_H19_L0.9520.98
113_V125_A0.9480.98
102_C132_A0.9470.98
22_T159_G0.9370.98
20_R23_C0.9280.98
125_A130_E0.9250.98
151_R155_S0.9210.98
99_I102_C0.9160.98
42_G75_A0.9120.98
128_L136_V0.9100.98
5_S8_Q0.8930.97
78_Q82_F0.8890.97
16_L19_L0.8860.97
156_F159_G0.8780.97
155_S158_A0.8690.97
144_M148_L0.8670.97
20_R24_P0.8670.97
89_A110_I0.8610.97
7_N92_Y0.8590.97
102_C124_Y0.8560.97
112_T137_E0.8500.97
150_N153_K0.8480.96
124_Y129_F0.8420.96
32_I40_A0.8300.96
108_A111_K0.8210.96
139_V143_E0.8200.96
24_P63_D0.8170.96
45_G74_N0.8150.96
115_Y145_I0.8100.95
164_L167_A0.8060.95
38_M41_G0.8040.95
144_M147_D0.8010.95
95_H117_E0.7970.95
105_I113_V0.7960.95
7_N90_E0.7920.95
69_I74_N0.7890.95
138_Q143_E0.7800.94
106_I140_E0.7790.94
117_E150_N0.7750.94
127_E131_Q0.7720.94
134_V137_E0.7710.94
91_I115_Y0.7670.94
37_R82_F0.7630.94
6_W10_F0.7630.94
99_I119_Y0.7620.94
28_V122_H0.7570.94
138_Q141_L0.7470.93
155_S162_G0.7470.93
124_Y137_E0.7440.93
118_D126_Q0.7410.93
21_S119_Y0.7400.93
19_L22_T0.7290.92
61_I107_Q0.7200.92
64_H68_T0.7160.91
34_R88_G0.7150.91
107_Q122_H0.7070.91
19_L23_C0.7060.91
64_H81_K0.7060.91
72_E98_C0.7030.91
106_I137_E0.6990.90
137_E141_L0.6960.90
25_R63_D0.6880.90
106_I134_V0.6850.90
129_F137_E0.6840.90
41_G78_Q0.6780.89
160_L164_L0.6680.88
91_I110_I0.6670.88
129_F132_A0.6630.88
10_F13_Q0.6580.88
145_I148_L0.6470.87
43_Y74_N0.6450.87
99_I122_H0.6390.86
28_V95_H0.6380.86
61_I80_S0.6350.86
34_R83_G0.6340.86
158_A162_G0.6310.85
106_I141_L0.6230.85
14_S31_T0.6220.85
20_R41_G0.6190.84
39_I89_A0.6190.84
129_F136_V0.6160.84
24_P64_H0.6090.83
64_H77_L0.6060.83
99_I134_V0.6050.83
162_G166_D0.6040.83
36_K90_E0.6020.83
119_Y157_V0.5960.82
138_Q142_D0.5880.81
9_Y12_A0.5880.81
70_H101_C0.5860.81
8_Q149_K0.5830.81
32_I76_I0.5820.81
9_Y20_R0.5820.81
73_M77_L0.5810.80
98_C101_C0.5810.80
126_Q129_F0.5770.80
61_I122_H0.5760.80
62_D107_Q0.5720.79
152_E156_F0.5680.79
79_C86_T0.5650.79
161_I165_A0.5650.79
102_C129_F0.5630.78
85_P109_G0.5580.78
10_F92_Y0.5570.78
68_T80_S0.5540.77
126_Q131_Q0.5530.77
32_I110_I0.5510.77
74_N78_Q0.5500.77
122_H128_L0.5470.76
120_K158_A0.5470.76
16_L20_R0.5470.76
147_D150_N0.5460.76
27_S100_Q0.5390.75
148_L153_K0.5380.75
133_G140_E0.5350.75
19_L159_G0.5300.74
66_A69_I0.5270.74
73_M76_I0.5260.74
64_H74_N0.5260.74
27_S96_Y0.5260.74
159_G166_D0.5220.73
125_A128_L0.5220.73
120_K123_P0.5190.73
96_Y100_Q0.5190.73
94_T116_A0.5180.72
131_Q137_E0.5180.72
130_E136_V0.5160.72
34_R90_E0.5150.72
124_Y127_E0.5110.71
9_Y82_F0.5090.71
79_C100_Q0.5020.70
40_A83_G0.5000.70
136_V140_E0.5000.70
99_I128_L0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hvwA 3 0.7778 100 0.381 Contact Map
1vq2A 3 0.8148 100 0.394 Contact Map
2w4lA 3 0.7725 100 0.395 Contact Map
1z3aA 2 0.7989 100 0.415 Contact Map
2nx8A 2 0.8519 100 0.42 Contact Map
4p9cA 5 0.7143 100 0.427 Contact Map
2b3jA 2 0.7884 100 0.433 Contact Map
1wwrA 3 0.8042 100 0.449 Contact Map
3dh1A 2 0.7778 100 0.453 Contact Map
1p6oA 2 0.7937 100 0.464 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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