GREMLIN Database
CSPB - Cold shock protein CspB
UniProt: P32081 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 67 (62)
Sequences: 4302 (1607)
Seq/√Len: 204.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_V63_V3.7471.00
52_V61_A3.4371.00
50_E62_N2.7541.00
48_S64_T2.2521.00
3_E48_S2.1571.00
5_K46_A2.1031.00
11_S42_E1.9961.00
34_Q64_T1.9371.00
3_E46_A1.8341.00
20_V24_D1.7261.00
28_V41_L1.7061.00
54_G59_Q1.6771.00
42_E45_Q1.6731.00
34_Q62_N1.6031.00
53_E58_P1.6021.00
20_V23_Q1.5701.00
32_A61_A1.5361.00
11_S38_F1.5021.00
21_E46_A1.3931.00
20_V49_F1.3871.00
54_G58_P1.3201.00
11_S40_T1.3081.00
26_V51_I1.2881.00
5_K19_E1.2281.00
9_F30_F1.2151.00
51_I58_P1.1741.00
33_I38_F1.1721.00
24_D58_P1.1701.00
30_F39_K1.0901.00
18_I49_F1.0711.00
54_G57_G1.0701.00
52_V59_Q1.0371.00
33_I39_K0.9921.00
4_G18_I0.9731.00
32_A52_V0.9681.00
41_L47_V0.9520.99
49_F60_A0.8670.99
33_I36_E0.8160.98
4_G60_A0.8120.98
8_W28_V0.8050.98
32_A62_N0.7910.98
19_E44_G0.7870.98
30_F56_R0.7730.98
18_I60_A0.7370.97
30_F33_I0.7360.97
35_G39_K0.7310.97
7_K25_D0.7100.96
3_E21_E0.7090.96
7_K13_K0.7050.96
13_K25_D0.6940.95
10_N27_F0.6910.95
36_E64_T0.6830.95
18_I47_V0.6740.95
20_V51_I0.6610.94
14_G25_D0.6490.94
5_K21_E0.6440.93
26_V60_A0.6390.93
30_F38_F0.6280.92
33_I41_L0.6240.92
4_G49_F0.6230.92
12_E45_Q0.6220.92
13_K37_G0.6150.92
15_F26_V0.6090.91
30_F63_V0.6040.91
26_V52_V0.6030.91
55_N59_Q0.5990.91
33_I63_V0.5980.91
17_F44_G0.5950.90
35_G38_F0.5830.89
22_G55_N0.5810.89
18_I28_V0.5750.89
16_G28_V0.5750.89
38_F42_E0.5540.87
31_S56_R0.5520.87
17_F29_H0.5460.86
7_K19_E0.5450.86
35_G40_T0.5420.86
50_E61_A0.5400.86
53_E56_R0.5390.85
5_K44_G0.5360.85
8_W13_K0.5330.85
4_G31_S0.5260.84
41_L45_Q0.5230.84
12_E20_V0.5220.84
9_F14_G0.5210.83
53_E59_Q0.5180.83
26_V32_A0.5170.83
34_Q39_K0.5080.82
31_S50_E0.5040.81
36_E39_K0.5030.81
8_W43_E0.5010.81
32_A49_F0.5010.81
12_E56_R0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lxjA 1 0.9851 99.8 0.132 Contact Map
1c9oA 2 0.9851 99.8 0.142 Contact Map
3camA 2 0.9851 99.8 0.144 Contact Map
3a0jA 1 1 99.7 0.156 Contact Map
3i2zB 2 0.9851 99.7 0.169 Contact Map
1g6pA 1 0.9851 99.7 0.172 Contact Map
2mqhA 1 0.9552 99.7 0.184 Contact Map
3uljA 3 1 99.7 0.186 Contact Map
2lssA 1 0.9851 99.7 0.194 Contact Map
3ts2A 1 1 99.7 0.199 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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