GREMLIN Database
YPUA - Uncharacterized protein YpuA
UniProt: P31847 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (278)
Sequences: 449 (370)
Seq/√Len: 22.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
277_F281_I4.9251.00
272_Q276_D4.1491.00
223_T226_Q4.0491.00
284_A288_I3.4511.00
178_K226_Q3.2731.00
213_D216_S3.1631.00
35_L48_L3.1011.00
270_F274_V3.0461.00
191_I234_F3.0111.00
283_N287_S2.8500.99
84_A140_A2.8330.99
275_I279_V2.6890.99
265_D268_K2.6620.99
228_N232_S2.5820.98
243_D246_Q2.5760.98
268_K276_D2.5700.98
282_W286_V2.5200.98
33_V53_V2.5060.98
100_N127_K2.4740.98
105_N135_E2.4540.98
230_L234_F2.4200.98
66_E147_K2.3320.97
278_F281_I2.2460.96
272_Q275_I2.2400.96
204_K208_E2.2060.96
264_S267_G2.1720.95
34_T88_S2.1160.95
45_Q49_D2.0710.94
106_I130_V2.0490.94
9_L13_V2.0450.94
106_I114_Y2.0420.94
51_M129_Y1.9620.92
269_N272_Q1.9510.92
96_G125_D1.9460.92
275_I278_F1.9380.92
188_I230_L1.8830.91
234_F237_M1.8750.90
211_V230_L1.8200.89
208_E212_D1.8110.89
10_A54_P1.8040.88
209_K213_D1.7800.88
93_A127_K1.7690.87
93_A97_S1.7560.87
91_T127_K1.7480.87
270_F273_K1.7420.87
285_I288_I1.7380.87
226_Q229_Q1.7380.87
212_D227_K1.7310.86
118_L128_V1.6620.84
67_E139_T1.6620.84
44_K61_T1.6580.84
168_E192_K1.6160.82
150_E162_K1.5910.81
85_I132_A1.5790.81
212_D216_S1.5690.80
204_K235_N1.5500.79
64_N68_H1.5490.79
283_N286_V1.5290.78
167_Q236_K1.5280.78
224_D228_N1.4720.76
108_G173_S1.4470.74
234_F247_V1.4420.74
113_M133_P1.4320.74
50_E131_T1.4310.74
223_T227_K1.4060.72
271_I275_I1.3890.71
114_Y130_V1.3800.71
33_V44_K1.3630.70
65_K69_E1.3600.70
158_S162_K1.3510.69
90_I99_L1.3490.69
41_E45_Q1.3260.68
276_D279_V1.3140.67
269_N274_V1.3020.66
120_T192_K1.2980.66
120_T168_E1.2950.66
233_L237_M1.2890.65
253_K256_D1.2860.65
67_E137_S1.2810.65
95_K125_D1.2670.64
278_F282_W1.2600.64
69_E281_I1.2590.63
108_G177_D1.2590.63
104_H131_T1.2520.63
128_V195_F1.2370.62
164_V237_M1.2350.62
188_I233_L1.2240.61
221_T225_S1.2200.61
67_E80_I1.2130.60
7_G11_A1.2120.60
32_I88_S1.2020.60
109_I113_M1.1960.59
32_I149_Y1.1890.59
158_S161_V1.1830.59
19_P24_A1.1820.58
67_E84_A1.1780.58
109_I166_N1.1740.58
84_A139_T1.1730.58
274_V278_F1.1660.57
67_E81_G1.1580.57
199_G213_D1.1580.57
123_V126_A1.1520.56
137_S140_A1.1430.56
71_L172_T1.1250.55
39_L120_T1.1200.54
207_I211_V1.1020.53
81_G139_T1.1010.53
280_S283_N1.0990.53
206_D209_K1.0990.53
191_I211_V1.0970.53
282_W285_I1.0950.53
51_M131_T1.0950.53
99_L112_E1.0890.52
157_I161_V1.0830.52
43_D46_K1.0760.51
193_E255_K1.0730.51
281_I284_A1.0710.51
48_L59_T1.0700.51
182_E222_L1.0690.51
132_A150_E1.0680.51
206_D219_N1.0620.50
179_I184_A1.0560.50
159_E162_K1.0530.50
88_S145_L1.0520.50
39_L168_E1.0470.49
260_K263_E1.0380.49
130_V196_A1.0360.49
213_D219_N1.0360.49
283_N288_I1.0350.49
107_S135_E1.0310.48
194_E197_K1.0290.48
47_V51_M1.0290.48
191_I210_Q1.0260.48
275_I283_N1.0180.47
103_T131_T1.0130.47
210_Q213_D0.9840.45
64_N67_E0.9830.45
56_N241_D0.9820.45
38_D81_G0.9760.45
279_V288_I0.9760.45
12_A22_S0.9720.44
109_I136_V0.9670.44
39_L192_K0.9610.43
212_D224_D0.9610.43
52_N272_Q0.9570.43
87_S114_Y0.9490.43
114_Y196_A0.9490.43
85_I140_A0.9420.42
208_E228_N0.9410.42
80_I137_S0.9350.42
279_V282_W0.9320.42
108_G139_T0.9310.41
34_T129_Y0.9310.41
6_I14_L0.9250.41
210_Q219_N0.9170.41
16_L249_D0.9110.40
57_A251_L0.9060.40
68_H72_G0.9050.40
80_I170_V0.9050.40
27_A123_V0.8980.39
132_A166_N0.8940.39
225_S232_S0.8940.39
64_N80_I0.8830.38
56_N263_E0.8820.38
81_G137_S0.8760.38
97_S125_D0.8730.38
174_E248_S0.8680.37
43_D134_F0.8660.37
276_D280_S0.8660.37
116_N120_T0.8650.37
74_Y137_S0.8650.37
23_L243_D0.8620.37
155_E258_I0.8610.37
266_E274_V0.8590.37
112_E115_L0.8580.37
32_I148_A0.8570.37
42_S167_Q0.8570.37
51_M89_S0.8540.36
112_E185_A0.8490.36
113_M118_L0.8490.36
116_N168_E0.8470.36
205_A209_K0.8450.36
10_A13_V0.8370.35
124_K246_Q0.8340.35
128_V185_A0.8310.35
139_T172_T0.8300.35
177_D285_I0.8250.35
228_N248_S0.8230.35
115_L211_V0.8190.34
70_Y121_A0.8140.34
16_L49_D0.8140.34
249_D281_I0.8120.34
67_E74_Y0.8120.34
207_I230_L0.8110.34
278_F286_V0.8090.34
47_V114_Y0.8080.34
118_L187_L0.8050.33
224_D227_K0.8010.33
8_M13_V0.8010.33
20_K177_D0.8000.33
81_G84_A0.7960.33
139_T176_G0.7960.33
248_S281_I0.7950.33
143_T170_V0.7940.33
187_L220_V0.7930.33
163_Q278_F0.7930.33
110_T228_N0.7930.33
6_I167_Q0.7920.33
41_E225_S0.7910.33
64_N84_A0.7910.33
64_N81_G0.7880.32
35_L134_F0.7880.32
272_Q279_V0.7820.32
177_D265_D0.7820.32
279_V286_V0.7790.32
278_F285_I0.7770.32
39_L116_N0.7720.31
11_A14_L0.7680.31
13_V279_V0.7640.31
47_V153_S0.7640.31
245_G249_D0.7610.31
45_Q156_A0.7560.31
88_S214_A0.7520.30
201_P206_D0.7510.30
71_L84_A0.7500.30
99_L102_E0.7460.30
47_V131_T0.7440.30
260_K271_I0.7440.30
87_S106_I0.7420.30
117_A242_I0.7400.30
24_A27_A0.7390.30
195_F210_Q0.7360.29
26_A31_V0.7350.29
225_S279_V0.7340.29
184_A187_L0.7320.29
15_L223_T0.7310.29
38_D134_F0.7280.29
269_N279_V0.7270.29
47_V133_P0.7250.29
80_I139_T0.7250.29
31_V92_I0.7240.29
98_G125_D0.7210.29
8_M12_A0.7110.28
6_I17_M0.7100.28
158_S223_T0.7100.28
272_Q288_I0.7090.28
262_I268_K0.7060.28
45_Q52_N0.7050.28
164_V240_A0.7030.28
274_V277_F0.7000.27
159_E167_Q0.6980.27
67_E71_L0.6970.27
12_A15_L0.6960.27
51_M87_S0.6960.27
81_G170_V0.6960.27
90_I148_A0.6930.27
99_L119_M0.6910.27
29_G164_V0.6910.27
118_L236_K0.6890.27
175_L184_A0.6890.27
113_M185_A0.6880.27
31_V87_S0.6880.27
132_A136_V0.6880.27
169_L225_S0.6870.27
271_I274_V0.6830.26
156_A163_Q0.6790.26
44_K197_K0.6760.26
46_K282_W0.6760.26
70_Y143_T0.6720.26
158_S171_T0.6720.26
40_S43_D0.6720.26
113_M184_A0.6700.26
196_A242_I0.6680.26
85_I149_Y0.6680.26
275_I282_W0.6620.25
203_N206_D0.6610.25
34_T71_L0.6590.25
176_G179_I0.6560.25
84_A137_S0.6560.25
90_I149_Y0.6540.25
53_V147_K0.6530.25
13_V124_K0.6510.25
99_L219_N0.6510.25
116_N258_I0.6510.25
29_G125_D0.6500.25
38_D84_A0.6490.25
10_A22_S0.6490.25
28_V92_I0.6480.25
48_L81_G0.6440.24
208_E219_N0.6440.24
28_V94_K0.6430.24
188_I191_I0.6420.24
111_D115_L0.6410.24
7_G18_V0.6410.24
34_T140_A0.6400.24
114_Y148_A0.6390.24
178_K188_I0.6390.24
242_I247_V0.6380.24
109_I176_G0.6380.24
53_V89_S0.6370.24
60_V83_R0.6340.24
169_L183_N0.6310.24
113_M128_V0.6290.24
96_G237_M0.6280.24
54_P256_D0.6280.24
14_L17_M0.6270.24
12_A42_S0.6230.23
132_A162_K0.6200.23
282_W288_I0.6200.23
53_V57_A0.6190.23
168_E222_L0.6190.23
195_F230_L0.6170.23
271_I282_W0.6160.23
211_V261_F0.6150.23
17_M177_D0.6150.23
119_M250_Q0.6150.23
186_A235_N0.6140.23
239_N249_D0.6140.23
282_W287_S0.6120.23
278_F288_I0.6100.23
41_E44_K0.6090.23
148_A218_L0.6080.23
115_L157_I0.6080.23
193_E272_Q0.6060.23
208_E211_V0.6040.23
95_K273_K0.6040.23
274_V279_V0.6020.22
85_I136_V0.6010.22
176_G184_A0.5990.22
121_A196_A0.5970.22
62_V70_Y0.5960.22
25_D29_G0.5940.22
94_K220_V0.5930.22
268_K272_Q0.5890.22
190_K218_L0.5890.22
162_K167_Q0.5870.22
273_K280_S0.5840.22
182_E239_N0.5810.21
195_F199_G0.5810.21
146_I153_S0.5770.21
10_A219_N0.5770.21
71_L121_A0.5750.21
31_V131_T0.5750.21
99_L140_A0.5750.21
100_N205_A0.5720.21
107_S145_L0.5710.21
187_L218_L0.5670.21
35_L268_K0.5660.21
114_Y146_I0.5640.21
143_T163_Q0.5640.21
198_N204_K0.5610.21
91_T242_I0.5600.20
39_L43_D0.5590.20
120_T133_P0.5530.20
176_G181_N0.5530.20
42_S197_K0.5530.20
266_E271_I0.5520.20
149_Y233_L0.5520.20
256_D281_I0.5500.20
225_S262_I0.5460.20
121_A147_K0.5440.20
108_G176_G0.5430.20
109_I185_A0.5430.20
63_T252_D0.5420.20
42_S124_K0.5410.20
26_A34_T0.5410.20
137_S222_L0.5400.20
265_D276_D0.5390.20
139_T179_I0.5370.19
32_I152_S0.5370.19
65_K95_K0.5350.19
181_N185_A0.5340.19
70_Y98_G0.5330.19
66_E84_A0.5320.19
78_A107_S0.5320.19
11_A18_V0.5310.19
214_A278_F0.5300.19
50_E157_I0.5300.19
99_L126_A0.5300.19
37_A63_T0.5300.19
143_T162_K0.5290.19
116_N192_K0.5290.19
199_G238_K0.5290.19
81_G108_G0.5280.19
160_D259_T0.5280.19
105_N126_A0.5270.19
50_E104_H0.5240.19
213_D217_D0.5230.19
114_Y117_A0.5220.19
230_L237_M0.5220.19
266_E288_I0.5220.19
85_I281_I0.5210.19
52_N279_V0.5210.19
281_I285_I0.5190.19
99_L237_M0.5170.19
169_L173_S0.5170.19
269_N273_K0.5160.19
85_I134_F0.5160.19
21_V188_I0.5150.19
44_K216_S0.5150.19
136_V139_T0.5130.18
18_V110_T0.5130.18
88_S130_V0.5120.18
40_S287_S0.5120.18
71_L82_S0.5090.18
41_E280_S0.5090.18
33_V147_K0.5080.18
263_E270_F0.5080.18
7_G10_A0.5060.18
67_E109_I0.5050.18
113_M176_G0.5040.18
274_V286_V0.5040.18
149_Y234_F0.5020.18
279_V287_S0.5010.18
230_L247_V0.5010.18
177_D203_N0.5000.18
221_T224_D0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1m5yA 1 0.4414 52 0.96 Contact Map
1y1xA 2 0.6069 40 0.963 Contact Map
1iojA 1 0.1862 33.7 0.965 Contact Map
2w9yA 1 0.2862 29.9 0.965 Contact Map
4il1A 1 0 24.1 0.967 Contact Map
2o36A 1 0.6207 23.8 0.967 Contact Map
3eabG 1 0.1448 22.6 0.967 Contact Map
3sjsA 2 0.6724 22.4 0.968 Contact Map
2fcgF 1 0.0586 21.7 0.968 Contact Map
1k8uA 2 0.2966 21.2 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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